LeishMANIAdb
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TRP domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TRP domain-containing protein
Gene product:
Flagellum attachment zone protein 5
Species:
Leishmania mexicana
UniProt:
E9AU32_LEIMU
TriTrypDb:
LmxM.36.5970
Length:
635

Annotations

LeishMANIAdb annotations

Very tentatively might be a transmembrane chaperone for some unknown protein secretion process. Not unique to kinetoplastids, also found in fungi and other Eukaryotes.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

E9AU32
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU32

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.690
CLV_C14_Caspase3-7 421 425 PF00656 0.637
CLV_C14_Caspase3-7 479 483 PF00656 0.688
CLV_NRD_NRD_1 221 223 PF00675 0.307
CLV_NRD_NRD_1 33 35 PF00675 0.350
CLV_NRD_NRD_1 373 375 PF00675 0.357
CLV_NRD_NRD_1 379 381 PF00675 0.419
CLV_NRD_NRD_1 464 466 PF00675 0.625
CLV_NRD_NRD_1 53 55 PF00675 0.189
CLV_NRD_NRD_1 532 534 PF00675 0.620
CLV_NRD_NRD_1 632 634 PF00675 0.516
CLV_NRD_NRD_1 7 9 PF00675 0.368
CLV_PCSK_KEX2_1 221 223 PF00082 0.307
CLV_PCSK_KEX2_1 372 374 PF00082 0.376
CLV_PCSK_KEX2_1 379 381 PF00082 0.429
CLV_PCSK_KEX2_1 464 466 PF00082 0.625
CLV_PCSK_KEX2_1 495 497 PF00082 0.572
CLV_PCSK_KEX2_1 532 534 PF00082 0.620
CLV_PCSK_KEX2_1 9 11 PF00082 0.416
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.400
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.416
CLV_PCSK_SKI1_1 27 31 PF00082 0.338
CLV_PCSK_SKI1_1 34 38 PF00082 0.347
CLV_PCSK_SKI1_1 411 415 PF00082 0.488
DEG_Nend_UBRbox_4 1 3 PF02207 0.682
DOC_CKS1_1 146 151 PF01111 0.537
DOC_MAPK_DCC_7 341 351 PF00069 0.296
DOC_MAPK_gen_1 221 229 PF00069 0.484
DOC_MAPK_gen_1 267 277 PF00069 0.286
DOC_MAPK_gen_1 332 342 PF00069 0.349
DOC_MAPK_gen_1 460 468 PF00069 0.608
DOC_MAPK_gen_1 8 20 PF00069 0.594
DOC_MAPK_HePTP_8 215 227 PF00069 0.364
DOC_MAPK_MEF2A_6 218 227 PF00069 0.478
DOC_MAPK_MEF2A_6 270 279 PF00069 0.317
DOC_MAPK_MEF2A_6 303 310 PF00069 0.504
DOC_MAPK_RevD_3 358 373 PF00069 0.384
DOC_PP1_RVXF_1 25 32 PF00149 0.517
DOC_PP2B_LxvP_1 466 469 PF13499 0.630
DOC_PP4_FxxP_1 175 178 PF00568 0.335
DOC_USP7_MATH_1 23 27 PF00917 0.553
DOC_USP7_MATH_1 515 519 PF00917 0.704
DOC_USP7_MATH_1 83 87 PF00917 0.486
DOC_WW_Pin1_4 145 150 PF00397 0.652
DOC_WW_Pin1_4 160 165 PF00397 0.533
DOC_WW_Pin1_4 19 24 PF00397 0.539
DOC_WW_Pin1_4 232 237 PF00397 0.558
DOC_WW_Pin1_4 383 388 PF00397 0.617
DOC_WW_Pin1_4 469 474 PF00397 0.676
DOC_WW_Pin1_4 483 488 PF00397 0.682
DOC_WW_Pin1_4 532 537 PF00397 0.717
LIG_14-3-3_CanoR_1 267 273 PF00244 0.351
LIG_14-3-3_CanoR_1 34 39 PF00244 0.567
LIG_14-3-3_CanoR_1 496 500 PF00244 0.611
LIG_14-3-3_CanoR_1 519 526 PF00244 0.621
LIG_14-3-3_CanoR_1 580 585 PF00244 0.749
LIG_14-3-3_CanoR_1 607 612 PF00244 0.704
LIG_BRCT_BRCA1_1 116 120 PF00533 0.235
LIG_BRCT_BRCA1_1 324 328 PF00533 0.289
LIG_BRCT_BRCA1_1 426 430 PF00533 0.627
LIG_eIF4E_1 210 216 PF01652 0.314
LIG_eIF4E_1 42 48 PF01652 0.589
LIG_eIF4E_1 90 96 PF01652 0.349
LIG_FHA_1 210 216 PF00498 0.406
LIG_FHA_1 297 303 PF00498 0.521
LIG_FHA_1 361 367 PF00498 0.427
LIG_FHA_1 538 544 PF00498 0.722
LIG_FHA_1 588 594 PF00498 0.740
LIG_FHA_2 149 155 PF00498 0.599
LIG_FHA_2 449 455 PF00498 0.695
LIG_FHA_2 550 556 PF00498 0.662
LIG_FHA_2 572 578 PF00498 0.679
LIG_FHA_2 589 595 PF00498 0.686
LIG_GBD_Chelix_1 92 100 PF00786 0.243
LIG_LIR_Apic_2 173 178 PF02991 0.292
LIG_LIR_Apic_2 214 220 PF02991 0.330
LIG_LIR_Apic_2 494 500 PF02991 0.590
LIG_LIR_Gen_1 112 123 PF02991 0.316
LIG_LIR_Gen_1 271 281 PF02991 0.290
LIG_LIR_Gen_1 325 333 PF02991 0.282
LIG_LIR_Gen_1 352 362 PF02991 0.326
LIG_LIR_Gen_1 417 426 PF02991 0.609
LIG_LIR_Gen_1 427 437 PF02991 0.609
LIG_LIR_Gen_1 444 453 PF02991 0.702
LIG_LIR_Gen_1 555 565 PF02991 0.763
LIG_LIR_Gen_1 608 618 PF02991 0.746
LIG_LIR_Nem_3 112 118 PF02991 0.325
LIG_LIR_Nem_3 119 123 PF02991 0.275
LIG_LIR_Nem_3 173 177 PF02991 0.392
LIG_LIR_Nem_3 271 276 PF02991 0.306
LIG_LIR_Nem_3 325 331 PF02991 0.220
LIG_LIR_Nem_3 352 358 PF02991 0.375
LIG_LIR_Nem_3 417 423 PF02991 0.651
LIG_LIR_Nem_3 427 433 PF02991 0.643
LIG_LIR_Nem_3 444 449 PF02991 0.682
LIG_LIR_Nem_3 555 561 PF02991 0.692
LIG_LIR_Nem_3 608 614 PF02991 0.750
LIG_LIR_Nem_3 63 69 PF02991 0.521
LIG_LIR_Nem_3 71 77 PF02991 0.533
LIG_MLH1_MIPbox_1 324 328 PF16413 0.289
LIG_NRBOX 13 19 PF00104 0.506
LIG_NRP_CendR_1 633 635 PF00754 0.577
LIG_Pex14_1 12 16 PF04695 0.530
LIG_Pex14_1 272 276 PF04695 0.289
LIG_Pex14_2 175 179 PF04695 0.431
LIG_Pex14_2 243 247 PF04695 0.352
LIG_PTB_Apo_2 237 244 PF02174 0.384
LIG_SH2_CRK 115 119 PF00017 0.240
LIG_SH2_CRK 182 186 PF00017 0.422
LIG_SH2_CRK 239 243 PF00017 0.378
LIG_SH2_CRK 344 348 PF00017 0.232
LIG_SH2_CRK 470 474 PF00017 0.721
LIG_SH2_CRK 497 501 PF00017 0.587
LIG_SH2_CRK 58 62 PF00017 0.497
LIG_SH2_CRK 611 615 PF00017 0.748
LIG_SH2_CRK 66 70 PF00017 0.498
LIG_SH2_CRK 90 94 PF00017 0.404
LIG_SH2_GRB2like 564 567 PF00017 0.688
LIG_SH2_NCK_1 344 348 PF00017 0.218
LIG_SH2_NCK_1 558 562 PF00017 0.762
LIG_SH2_NCK_1 58 62 PF00017 0.523
LIG_SH2_NCK_1 611 615 PF00017 0.687
LIG_SH2_SRC 152 155 PF00017 0.597
LIG_SH2_SRC 592 595 PF00017 0.637
LIG_SH2_STAP1 211 215 PF00017 0.404
LIG_SH2_STAP1 392 396 PF00017 0.600
LIG_SH2_STAP1 511 515 PF00017 0.632
LIG_SH2_STAP1 584 588 PF00017 0.715
LIG_SH2_STAP1 90 94 PF00017 0.404
LIG_SH2_STAT3 586 589 PF00017 0.805
LIG_SH2_STAT5 16 19 PF00017 0.554
LIG_SH2_STAT5 174 177 PF00017 0.308
LIG_SH2_STAT5 182 185 PF00017 0.319
LIG_SH2_STAT5 196 199 PF00017 0.259
LIG_SH2_STAT5 211 214 PF00017 0.221
LIG_SH2_STAT5 273 276 PF00017 0.347
LIG_SH2_STAT5 298 301 PF00017 0.568
LIG_SH2_STAT5 327 330 PF00017 0.351
LIG_SH2_STAT5 350 353 PF00017 0.315
LIG_SH2_STAT5 46 49 PF00017 0.490
LIG_SH2_STAT5 497 500 PF00017 0.631
LIG_SH2_STAT5 539 542 PF00017 0.820
LIG_SH2_STAT5 558 561 PF00017 0.647
LIG_SH2_STAT5 56 59 PF00017 0.483
LIG_SH2_STAT5 586 589 PF00017 0.710
LIG_SH2_STAT5 592 595 PF00017 0.687
LIG_SH2_STAT5 605 608 PF00017 0.619
LIG_SH3_2 456 461 PF14604 0.598
LIG_SH3_3 453 459 PF00018 0.789
LIG_SH3_3 73 79 PF00018 0.575
LIG_Sin3_3 99 106 PF02671 0.233
LIG_SUMO_SIM_anti_2 363 369 PF11976 0.292
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.335
LIG_SUMO_SIM_par_1 16 22 PF11976 0.553
LIG_SUMO_SIM_par_1 320 325 PF11976 0.277
LIG_SUMO_SIM_par_1 91 97 PF11976 0.398
LIG_TRAF2_1 151 154 PF00917 0.553
LIG_TRAF2_1 375 378 PF00917 0.544
LIG_TRAF2_1 451 454 PF00917 0.727
LIG_TRFH_1 344 348 PF08558 0.273
LIG_TYR_ITIM 172 177 PF00017 0.404
LIG_TYR_ITIM 180 185 PF00017 0.484
LIG_TYR_ITIM 237 242 PF00017 0.358
LIG_TYR_ITIM 342 347 PF00017 0.224
LIG_TYR_ITIM 88 93 PF00017 0.404
LIG_Vh1_VBS_1 128 146 PF01044 0.226
LIG_WRC_WIRS_1 313 318 PF05994 0.349
LIG_WW_3 5 9 PF00397 0.576
MOD_CDC14_SPxK_1 535 538 PF00782 0.681
MOD_CDK_SPK_2 145 150 PF00069 0.529
MOD_CDK_SPK_2 469 474 PF00069 0.746
MOD_CDK_SPxK_1 532 538 PF00069 0.717
MOD_CK1_1 22 28 PF00069 0.524
MOD_CK1_1 315 321 PF00069 0.404
MOD_CK1_1 401 407 PF00069 0.576
MOD_CK1_1 425 431 PF00069 0.659
MOD_CK1_1 527 533 PF00069 0.830
MOD_CK1_1 545 551 PF00069 0.658
MOD_CK1_1 582 588 PF00069 0.738
MOD_CK1_1 600 606 PF00069 0.680
MOD_CK1_1 610 616 PF00069 0.645
MOD_CK2_1 148 154 PF00069 0.591
MOD_CK2_1 372 378 PF00069 0.550
MOD_CK2_1 448 454 PF00069 0.686
MOD_CK2_1 506 512 PF00069 0.671
MOD_CK2_1 549 555 PF00069 0.737
MOD_CK2_1 57 63 PF00069 0.570
MOD_CK2_1 588 594 PF00069 0.618
MOD_GlcNHglycan 406 409 PF01048 0.489
MOD_GlcNHglycan 519 522 PF01048 0.478
MOD_GlcNHglycan 526 529 PF01048 0.500
MOD_GlcNHglycan 544 547 PF01048 0.525
MOD_GlcNHglycan 549 552 PF01048 0.550
MOD_GlcNHglycan 615 618 PF01048 0.454
MOD_GlcNHglycan 625 628 PF01048 0.511
MOD_GlcNHglycan 70 73 PF01048 0.313
MOD_GSK3_1 18 25 PF00069 0.524
MOD_GSK3_1 180 187 PF00069 0.455
MOD_GSK3_1 395 402 PF00069 0.725
MOD_GSK3_1 422 429 PF00069 0.713
MOD_GSK3_1 486 493 PF00069 0.703
MOD_GSK3_1 515 522 PF00069 0.708
MOD_GSK3_1 524 531 PF00069 0.759
MOD_GSK3_1 542 549 PF00069 0.659
MOD_GSK3_1 556 563 PF00069 0.723
MOD_GSK3_1 576 583 PF00069 0.576
MOD_GSK3_1 584 591 PF00069 0.674
MOD_GSK3_1 597 604 PF00069 0.634
MOD_GSK3_1 605 612 PF00069 0.666
MOD_N-GLC_1 268 273 PF02516 0.565
MOD_N-GLC_1 491 496 PF02516 0.396
MOD_N-GLC_1 50 55 PF02516 0.386
MOD_N-GLC_1 503 508 PF02516 0.463
MOD_NEK2_1 18 23 PF00069 0.451
MOD_NEK2_1 209 214 PF00069 0.375
MOD_NEK2_1 268 273 PF00069 0.376
MOD_NEK2_1 296 301 PF00069 0.565
MOD_NEK2_1 322 327 PF00069 0.269
MOD_NEK2_1 360 365 PF00069 0.320
MOD_NEK2_1 57 62 PF00069 0.522
MOD_NEK2_1 578 583 PF00069 0.676
MOD_NEK2_1 68 73 PF00069 0.472
MOD_PIKK_1 180 186 PF00454 0.396
MOD_PIKK_1 519 525 PF00454 0.731
MOD_PIKK_1 597 603 PF00454 0.665
MOD_PKA_1 34 40 PF00069 0.566
MOD_PKA_1 372 378 PF00069 0.537
MOD_PKA_1 460 466 PF00069 0.609
MOD_PKA_1 495 501 PF00069 0.705
MOD_PKA_2 372 378 PF00069 0.560
MOD_PKA_2 495 501 PF00069 0.764
MOD_PKA_2 579 585 PF00069 0.769
MOD_Plk_1 268 274 PF00069 0.275
MOD_Plk_1 559 565 PF00069 0.729
MOD_Plk_1 566 572 PF00069 0.737
MOD_Plk_2-3 154 160 PF00069 0.609
MOD_Plk_2-3 448 454 PF00069 0.677
MOD_Plk_4 154 160 PF00069 0.554
MOD_Plk_4 170 176 PF00069 0.208
MOD_Plk_4 211 217 PF00069 0.259
MOD_Plk_4 312 318 PF00069 0.301
MOD_Plk_4 322 328 PF00069 0.233
MOD_Plk_4 349 355 PF00069 0.350
MOD_Plk_4 360 366 PF00069 0.354
MOD_Plk_4 506 512 PF00069 0.654
MOD_Plk_4 560 566 PF00069 0.749
MOD_Plk_4 588 594 PF00069 0.729
MOD_Plk_4 83 89 PF00069 0.469
MOD_ProDKin_1 145 151 PF00069 0.651
MOD_ProDKin_1 160 166 PF00069 0.529
MOD_ProDKin_1 19 25 PF00069 0.532
MOD_ProDKin_1 232 238 PF00069 0.550
MOD_ProDKin_1 383 389 PF00069 0.620
MOD_ProDKin_1 469 475 PF00069 0.678
MOD_ProDKin_1 483 489 PF00069 0.682
MOD_ProDKin_1 532 538 PF00069 0.717
TRG_DiLeu_BaEn_1 154 159 PF01217 0.501
TRG_DiLeu_BaEn_1 97 102 PF01217 0.404
TRG_DiLeu_BaLyEn_6 76 81 PF01217 0.537
TRG_ENDOCYTIC_2 115 118 PF00928 0.329
TRG_ENDOCYTIC_2 15 18 PF00928 0.504
TRG_ENDOCYTIC_2 174 177 PF00928 0.271
TRG_ENDOCYTIC_2 182 185 PF00928 0.309
TRG_ENDOCYTIC_2 199 202 PF00928 0.204
TRG_ENDOCYTIC_2 239 242 PF00928 0.286
TRG_ENDOCYTIC_2 273 276 PF00928 0.261
TRG_ENDOCYTIC_2 344 347 PF00928 0.292
TRG_ENDOCYTIC_2 350 353 PF00928 0.318
TRG_ENDOCYTIC_2 446 449 PF00928 0.683
TRG_ENDOCYTIC_2 46 49 PF00928 0.490
TRG_ENDOCYTIC_2 558 561 PF00928 0.753
TRG_ENDOCYTIC_2 58 61 PF00928 0.494
TRG_ENDOCYTIC_2 611 614 PF00928 0.749
TRG_ENDOCYTIC_2 66 69 PF00928 0.406
TRG_ENDOCYTIC_2 90 93 PF00928 0.404
TRG_ER_diArg_1 220 222 PF00400 0.507
TRG_ER_diArg_1 339 342 PF00400 0.395
TRG_ER_diArg_1 371 374 PF00400 0.572
TRG_ER_diArg_1 379 381 PF00400 0.631
TRG_ER_diArg_1 464 466 PF00400 0.684
TRG_ER_diArg_1 7 10 PF00400 0.568
TRG_NLS_MonoExtN_4 6 12 PF00514 0.546

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAE8 Leptomonas seymouri 60% 100%
A0A1X0NM96 Trypanosomatidae 38% 100%
A0A3S7XC04 Leishmania donovani 85% 100%
A0A422NJ92 Trypanosoma rangeli 44% 100%
A4HQB6 Leishmania braziliensis 66% 100%
A4IE10 Leishmania infantum 85% 100%
D0A3Y8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
Q4Q0G3 Leishmania major 86% 100%
V5DK11 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS