C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

A distinct subfamily of CDD/CDA-like deaminases, putative

Species:

Leishmania mexicana

UniProt:

E9AU29_LEIMU

TriTrypDb:

LmxM.36.5940

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU29

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.732
CLV_C14_Caspase3-7	480	484	PF00656	0.424
CLV_C14_Caspase3-7	605	609	PF00656	0.555
CLV_NRD_NRD_1	443	445	PF00675	0.329
CLV_NRD_NRD_1	505	507	PF00675	0.418
CLV_NRD_NRD_1	569	571	PF00675	0.348
CLV_NRD_NRD_1	593	595	PF00675	0.441
CLV_PCSK_KEX2_1	149	151	PF00082	0.500
CLV_PCSK_KEX2_1	505	507	PF00082	0.418
CLV_PCSK_KEX2_1	569	571	PF00082	0.377
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.504
CLV_PCSK_SKI1_1	231	235	PF00082	0.510
CLV_PCSK_SKI1_1	347	351	PF00082	0.422
CLV_PCSK_SKI1_1	543	547	PF00082	0.329
CLV_PCSK_SKI1_1	569	573	PF00082	0.367
CLV_PCSK_SKI1_1	595	599	PF00082	0.436
CLV_PCSK_SKI1_1	69	73	PF00082	0.697
DEG_APCC_DBOX_1	190	198	PF00400	0.525
DEG_SCF_FBW7_1	493	499	PF00400	0.400
DEG_SCF_FBW7_1	515	521	PF00400	0.329
DOC_CDC14_PxL_1	194	202	PF14671	0.529
DOC_CKS1_1	264	269	PF01111	0.370
DOC_CKS1_1	493	498	PF01111	0.470
DOC_CKS1_1	515	520	PF01111	0.329
DOC_CKS1_1	70	75	PF01111	0.640
DOC_MAPK_DCC_7	149	159	PF00069	0.537
DOC_MAPK_DCC_7	193	202	PF00069	0.531
DOC_MAPK_gen_1	505	511	PF00069	0.418
DOC_MAPK_gen_1	594	601	PF00069	0.329
DOC_MAPK_MEF2A_6	150	159	PF00069	0.543
DOC_MAPK_MEF2A_6	193	202	PF00069	0.531
DOC_MAPK_MEF2A_6	594	601	PF00069	0.329
DOC_PP1_RVXF_1	180	186	PF00149	0.517
DOC_PP1_RVXF_1	592	599	PF00149	0.441
DOC_PP2B_LxvP_1	535	538	PF13499	0.523
DOC_PP4_MxPP_1	93	96	PF00568	0.493
DOC_SPAK_OSR1_1	158	162	PF12202	0.588
DOC_USP7_MATH_1	319	323	PF00917	0.502
DOC_USP7_MATH_1	439	443	PF00917	0.362
DOC_USP7_MATH_1	496	500	PF00917	0.374
DOC_USP7_MATH_1	50	54	PF00917	0.683
DOC_USP7_MATH_1	518	522	PF00917	0.329
DOC_WW_Pin1_4	112	117	PF00397	0.768
DOC_WW_Pin1_4	159	164	PF00397	0.561
DOC_WW_Pin1_4	263	268	PF00397	0.581
DOC_WW_Pin1_4	492	497	PF00397	0.470
DOC_WW_Pin1_4	514	519	PF00397	0.329
DOC_WW_Pin1_4	589	594	PF00397	0.470
DOC_WW_Pin1_4	63	68	PF00397	0.731
DOC_WW_Pin1_4	69	74	PF00397	0.658
DOC_WW_Pin1_4	87	92	PF00397	0.564
DOC_WW_Pin1_4	96	101	PF00397	0.779
LIG_14-3-3_CanoR_1	199	205	PF00244	0.519
LIG_14-3-3_CanoR_1	245	254	PF00244	0.528
LIG_14-3-3_CanoR_1	450	460	PF00244	0.299
LIG_14-3-3_CanoR_1	522	529	PF00244	0.345
LIG_Actin_WH2_2	556	571	PF00022	0.319
LIG_APCC_ABBA_1	257	262	PF00400	0.399
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BRCT_BRCA1_1	10	14	PF00533	0.459
LIG_BRCT_BRCA1_1	294	298	PF00533	0.248
LIG_BRCT_BRCA1_1	5	9	PF00533	0.482
LIG_BRCT_BRCA1_2	10	16	PF00533	0.482
LIG_EVH1_2	155	159	PF00568	0.571
LIG_FHA_1	230	236	PF00498	0.440
LIG_FHA_1	270	276	PF00498	0.626
LIG_FHA_1	335	341	PF00498	0.473
LIG_FHA_1	344	350	PF00498	0.465
LIG_FHA_1	407	413	PF00498	0.639
LIG_FHA_1	420	426	PF00498	0.359
LIG_FHA_1	452	458	PF00498	0.333
LIG_FHA_1	537	543	PF00498	0.329
LIG_FHA_1	570	576	PF00498	0.348
LIG_FHA_1	80	86	PF00498	0.726
LIG_FHA_2	105	111	PF00498	0.808
LIG_FHA_2	306	312	PF00498	0.398
LIG_FHA_2	34	40	PF00498	0.478
LIG_FHA_2	370	376	PF00498	0.521
LIG_FHA_2	456	462	PF00498	0.329
LIG_FHA_2	475	481	PF00498	0.329
LIG_FHA_2	598	604	PF00498	0.377
LIG_FHA_2	63	69	PF00498	0.692
LIG_IRF3_LxIS_1	596	602	PF10401	0.190
LIG_LIR_Gen_1	29	35	PF02991	0.407
LIG_LIR_Gen_1	295	306	PF02991	0.309
LIG_LIR_Gen_1	333	341	PF02991	0.461
LIG_LIR_Gen_1	382	392	PF02991	0.511
LIG_LIR_Gen_1	407	415	PF02991	0.541
LIG_LIR_Gen_1	6	15	PF02991	0.337
LIG_LIR_Nem_3	141	147	PF02991	0.412
LIG_LIR_Nem_3	29	33	PF02991	0.414
LIG_LIR_Nem_3	295	301	PF02991	0.281
LIG_LIR_Nem_3	333	338	PF02991	0.455
LIG_LIR_Nem_3	382	387	PF02991	0.486
LIG_LIR_Nem_3	407	413	PF02991	0.526
LIG_LIR_Nem_3	458	462	PF02991	0.441
LIG_LIR_Nem_3	48	54	PF02991	0.688
LIG_LIR_Nem_3	6	12	PF02991	0.483
LIG_MLH1_MIPbox_1	294	298	PF16413	0.248
LIG_NRP_CendR_1	621	623	PF00754	0.570
LIG_Pex14_1	331	335	PF04695	0.481
LIG_PTB_Apo_2	314	321	PF02174	0.485
LIG_PTB_Apo_2	553	560	PF02174	0.329
LIG_SH2_PTP2	160	163	PF00017	0.602
LIG_SH2_PTP2	30	33	PF00017	0.395
LIG_SH2_SRC	258	261	PF00017	0.440
LIG_SH2_STAT5	145	148	PF00017	0.461
LIG_SH2_STAT5	160	163	PF00017	0.466
LIG_SH2_STAT5	18	21	PF00017	0.428
LIG_SH2_STAT5	224	227	PF00017	0.441
LIG_SH2_STAT5	258	261	PF00017	0.478
LIG_SH2_STAT5	30	33	PF00017	0.402
LIG_SH3_1	445	451	PF00018	0.335
LIG_SH3_3	149	155	PF00018	0.425
LIG_SH3_3	195	201	PF00018	0.541
LIG_SH3_3	361	367	PF00018	0.464
LIG_SH3_3	445	451	PF00018	0.335
LIG_SH3_3	554	560	PF00018	0.329
LIG_SH3_3	64	70	PF00018	0.665
LIG_SH3_3	88	94	PF00018	0.746
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.535
LIG_SUMO_SIM_par_1	31	39	PF11976	0.428
LIG_SxIP_EBH_1	5	16	PF03271	0.282
LIG_TRAF2_1	477	480	PF00917	0.418
LIG_UBA3_1	412	417	PF00899	0.470
LIG_WRC_WIRS_1	456	461	PF05994	0.441
MOD_CDC14_SPxK_1	162	165	PF00782	0.605
MOD_CDK_SPK_2	159	164	PF00069	0.605
MOD_CDK_SPK_2	263	268	PF00069	0.609
MOD_CDK_SPK_2	589	594	PF00069	0.470
MOD_CDK_SPxK_1	159	165	PF00069	0.605
MOD_CDK_SPxK_1	589	595	PF00069	0.470
MOD_CDK_SPxK_1	63	69	PF00069	0.760
MOD_CK1_1	112	118	PF00069	0.643
MOD_CK1_1	122	128	PF00069	0.600
MOD_CK1_1	273	279	PF00069	0.570
MOD_CK1_1	455	461	PF00069	0.329
MOD_CK1_1	516	522	PF00069	0.364
MOD_CK1_1	53	59	PF00069	0.672
MOD_CK1_1	602	608	PF00069	0.328
MOD_CK1_1	75	81	PF00069	0.694
MOD_CK1_1	87	93	PF00069	0.715
MOD_CK1_1	99	105	PF00069	0.733
MOD_CK2_1	104	110	PF00069	0.801
MOD_CK2_1	287	293	PF00069	0.541
MOD_CK2_1	474	480	PF00069	0.470
MOD_CK2_1	597	603	PF00069	0.377
MOD_CK2_1	62	68	PF00069	0.765
MOD_DYRK1A_RPxSP_1	69	73	PF00069	0.768
MOD_GlcNHglycan	293	297	PF01048	0.391
MOD_GlcNHglycan	381	384	PF01048	0.585
MOD_GlcNHglycan	496	499	PF01048	0.484
MOD_GlcNHglycan	518	521	PF01048	0.329
MOD_GlcNHglycan	55	58	PF01048	0.756
MOD_GlcNHglycan	74	77	PF01048	0.561
MOD_GSK3_1	118	125	PF00069	0.617
MOD_GSK3_1	269	276	PF00069	0.580
MOD_GSK3_1	3	10	PF00069	0.580
MOD_GSK3_1	451	458	PF00069	0.329
MOD_GSK3_1	492	499	PF00069	0.377
MOD_GSK3_1	514	521	PF00069	0.409
MOD_GSK3_1	58	65	PF00069	0.623
MOD_GSK3_1	75	82	PF00069	0.643
MOD_GSK3_1	99	106	PF00069	0.706
MOD_N-GLC_1	246	251	PF02516	0.469
MOD_N-GLC_1	377	382	PF02516	0.505
MOD_N-GLC_1	425	430	PF02516	0.441
MOD_N-GLC_2	395	397	PF02516	0.440
MOD_N-GLC_2	433	435	PF02516	0.470
MOD_N-GLC_2	463	465	PF02516	0.441
MOD_NEK2_1	118	123	PF00069	0.704
MOD_NEK2_1	246	251	PF00069	0.469
MOD_NEK2_1	336	341	PF00069	0.420
MOD_NEK2_1	369	374	PF00069	0.498
MOD_NEK2_1	377	382	PF00069	0.493
MOD_NEK2_1	434	439	PF00069	0.404
MOD_NEK2_1	588	593	PF00069	0.351
MOD_NEK2_1	84	89	PF00069	0.704
MOD_NEK2_2	581	586	PF00069	0.441
MOD_OFUCOSY	244	250	PF10250	0.495
MOD_PIKK_1	109	115	PF00454	0.609
MOD_PIKK_1	3	9	PF00454	0.550
MOD_PKA_1	569	575	PF00069	0.344
MOD_PKA_2	104	110	PF00069	0.760
MOD_PKA_2	521	527	PF00069	0.345
MOD_PKA_2	569	575	PF00069	0.441
MOD_PKB_1	191	199	PF00069	0.528
MOD_PKB_1	401	409	PF00069	0.588
MOD_Plk_1	273	279	PF00069	0.493
MOD_Plk_1	292	298	PF00069	0.217
MOD_Plk_1	406	412	PF00069	0.540
MOD_Plk_1	425	431	PF00069	0.441
MOD_Plk_1	581	587	PF00069	0.392
MOD_Plk_2-3	408	414	PF00069	0.566
MOD_Plk_4	26	32	PF00069	0.523
MOD_Plk_4	260	266	PF00069	0.328
MOD_Plk_4	336	342	PF00069	0.526
MOD_Plk_4	395	401	PF00069	0.485
MOD_Plk_4	419	425	PF00069	0.348
MOD_Plk_4	452	458	PF00069	0.313
MOD_Plk_4	581	587	PF00069	0.424
MOD_ProDKin_1	112	118	PF00069	0.768
MOD_ProDKin_1	159	165	PF00069	0.561
MOD_ProDKin_1	263	269	PF00069	0.588
MOD_ProDKin_1	492	498	PF00069	0.470
MOD_ProDKin_1	514	520	PF00069	0.329
MOD_ProDKin_1	589	595	PF00069	0.470
MOD_ProDKin_1	63	69	PF00069	0.733
MOD_ProDKin_1	87	93	PF00069	0.739
MOD_ProDKin_1	96	102	PF00069	0.782
MOD_SUMO_for_1	415	418	PF00179	0.357
MOD_SUMO_rev_2	339	349	PF00179	0.516
TRG_AP2beta_CARGO_1	333	342	PF09066	0.488
TRG_DiLeu_LyEn_5	38	43	PF01217	0.372
TRG_ENDOCYTIC_2	18	21	PF00928	0.464
TRG_ENDOCYTIC_2	30	33	PF00928	0.340
TRG_ER_diArg_1	190	193	PF00400	0.536
TRG_ER_diArg_1	400	403	PF00400	0.417
TRG_ER_diArg_1	504	506	PF00400	0.354
TRG_ER_diArg_1	568	570	PF00400	0.424
TRG_ER_diArg_1	620	623	PF00400	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C3	Leptomonas seymouri	67%	98%
A0A1X0NLM5	Trypanosomatidae	41%	100%
A0A3Q8IWI0	Leishmania donovani	92%	100%
A0A3R7NP46	Trypanosoma rangeli	40%	100%
A4HQB2	Leishmania braziliensis	77%	100%
D0A3Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q0G6	Leishmania major	89%	100%
V5B3J9	Trypanosoma cruzi	38%	100%