Myosin_tail_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU28_LEIMU

TriTrypDb:

LmxM.36.5930

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU28

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	6
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0019905	syntaxin binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.666
CLV_NRD_NRD_1	112	114	PF00675	0.449
CLV_NRD_NRD_1	158	160	PF00675	0.299
CLV_NRD_NRD_1	163	165	PF00675	0.322
CLV_NRD_NRD_1	235	237	PF00675	0.413
CLV_NRD_NRD_1	39	41	PF00675	0.453
CLV_NRD_NRD_1	54	56	PF00675	0.425
CLV_NRD_NRD_1	81	83	PF00675	0.398
CLV_PCSK_KEX2_1	141	143	PF00082	0.389
CLV_PCSK_KEX2_1	158	160	PF00082	0.238
CLV_PCSK_KEX2_1	234	236	PF00082	0.406
CLV_PCSK_KEX2_1	54	56	PF00082	0.355
CLV_PCSK_KEX2_1	91	93	PF00082	0.471
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.389
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.471
CLV_PCSK_SKI1_1	114	118	PF00082	0.381
CLV_PCSK_SKI1_1	141	145	PF00082	0.303
CLV_PCSK_SKI1_1	221	225	PF00082	0.435
CLV_PCSK_SKI1_1	236	240	PF00082	0.308
CLV_PCSK_SKI1_1	49	53	PF00082	0.417
CLV_PCSK_SKI1_1	72	76	PF00082	0.484
CLV_Separin_Metazoa	231	235	PF03568	0.434
DOC_CYCLIN_RxL_1	14	24	PF00134	0.417
DOC_MAPK_gen_1	14	22	PF00069	0.445
DOC_MAPK_gen_1	141	148	PF00069	0.188
DOC_SPAK_OSR1_1	194	198	PF12202	0.480
DOC_USP7_MATH_1	225	229	PF00917	0.447
DOC_USP7_MATH_1	237	241	PF00917	0.298
DOC_USP7_MATH_1	260	264	PF00917	0.488
DOC_USP7_MATH_1	284	288	PF00917	0.758
DOC_USP7_UBL2_3	246	250	PF12436	0.335
DOC_WW_Pin1_4	157	162	PF00397	0.305
LIG_14-3-3_CanoR_1	142	149	PF00244	0.414
LIG_14-3-3_CanoR_1	194	198	PF00244	0.424
LIG_AP2alpha_1	191	195	PF02296	0.188
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_FHA_1	158	164	PF00498	0.452
LIG_FHA_1	169	175	PF00498	0.371
LIG_FHA_1	218	224	PF00498	0.473
LIG_FHA_1	270	276	PF00498	0.435
LIG_FHA_2	142	148	PF00498	0.188
LIG_FHA_2	167	173	PF00498	0.466
LIG_FHA_2	212	218	PF00498	0.480
LIG_LIR_Gen_1	133	143	PF02991	0.389
LIG_LIR_Gen_1	193	202	PF02991	0.368
LIG_LIR_Gen_1	267	275	PF02991	0.435
LIG_LIR_Nem_3	133	138	PF02991	0.376
LIG_LIR_Nem_3	193	198	PF02991	0.368
LIG_LIR_Nem_3	267	271	PF02991	0.435
LIG_LIR_Nem_3	68	74	PF02991	0.447
LIG_PCNA_PIPBox_1	185	194	PF02747	0.402
LIG_PCNA_yPIPBox_3	178	192	PF02747	0.393
LIG_Pex14_2	191	195	PF04695	0.490
LIG_SH2_CRK	71	75	PF00017	0.447
LIG_SH2_NCK_1	209	213	PF00017	0.447
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.188
LIG_WRC_WIRS_1	265	270	PF05994	0.402
MOD_CDK_SPxxK_3	157	164	PF00069	0.305
MOD_CK1_1	2	8	PF00069	0.628
MOD_CK1_1	211	217	PF00069	0.402
MOD_CK2_1	109	115	PF00069	0.381
MOD_CK2_1	127	133	PF00069	0.411
MOD_CK2_1	141	147	PF00069	0.402
MOD_CK2_1	166	172	PF00069	0.466
MOD_CK2_1	225	231	PF00069	0.394
MOD_CK2_1	237	243	PF00069	0.337
MOD_CK2_1	273	279	PF00069	0.348
MOD_GlcNHglycan	1	4	PF01048	0.619
MOD_GlcNHglycan	129	132	PF01048	0.445
MOD_GlcNHglycan	210	213	PF01048	0.363
MOD_GlcNHglycan	275	278	PF01048	0.402
MOD_GSK3_1	153	160	PF00069	0.364
MOD_GSK3_1	168	175	PF00069	0.390
MOD_GSK3_1	193	200	PF00069	0.480
MOD_GSK3_1	260	267	PF00069	0.455
MOD_GSK3_1	269	276	PF00069	0.385
MOD_N-GLC_1	269	274	PF02516	0.305
MOD_PIKK_1	197	203	PF00454	0.410
MOD_PIKK_1	260	266	PF00454	0.401
MOD_PK_1	153	159	PF00069	0.188
MOD_PKA_1	141	147	PF00069	0.466
MOD_PKA_2	141	147	PF00069	0.414
MOD_PKA_2	193	199	PF00069	0.402
MOD_PKA_2	217	223	PF00069	0.438
MOD_PKB_1	234	242	PF00069	0.447
MOD_ProDKin_1	157	163	PF00069	0.305
MOD_SUMO_rev_2	200	208	PF00179	0.402
MOD_SUMO_rev_2	28	33	PF00179	0.426
TRG_AP2beta_CARGO_1	133	142	PF09066	0.447
TRG_ENDOCYTIC_2	71	74	PF00928	0.447
TRG_ER_diArg_1	13	16	PF00400	0.381
TRG_ER_diArg_1	157	159	PF00400	0.397
TRG_ER_diArg_1	233	236	PF00400	0.418
TRG_ER_diArg_1	53	55	PF00400	0.211
TRG_NLS_MonoExtC_3	89	95	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB0	Leptomonas seymouri	66%	100%
A0A1X0NMA0	Trypanosomatidae	36%	100%
A0A3Q8IK37	Leishmania donovani	90%	100%
A0A3R7KFM9	Trypanosoma rangeli	37%	100%
A4HQB1	Leishmania braziliensis	74%	100%
A4IE06	Leishmania infantum	91%	100%
D0A3Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q0G7	Leishmania major	88%	100%
V5BNM8	Trypanosoma cruzi	36%	100%