HAD-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

HAD-like protein

Gene product:

2,3-diketo-5-methylthio-1-phosphopentane phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AU26_LEIMU

TriTrypDb:

LmxM.36.5910

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU26

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	3
GO:0000097	sulfur amino acid biosynthetic process	5	3
GO:0006082	organic acid metabolic process	3	3
GO:0006520	amino acid metabolic process	3	3
GO:0006555	methionine metabolic process	5	3
GO:0006790	sulfur compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0008652	amino acid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009066	aspartate family amino acid metabolic process	5	3
GO:0009067	aspartate family amino acid biosynthetic process	6	3
GO:0009086	methionine biosynthetic process	6	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019509	L-methionine salvage from methylthioadenosine	6	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0043094	cellular metabolic compound salvage	3	3
GO:0043102	amino acid salvage	4	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044272	sulfur compound biosynthetic process	4	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071265	L-methionine biosynthetic process	7	3
GO:0071267	L-methionine salvage	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901566	organonitrogen compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3
GO:1901605	alpha-amino acid metabolic process	4	3
GO:1901607	alpha-amino acid biosynthetic process	5	3

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0043874	acireductone synthase activity	6	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.361
CLV_NRD_NRD_1	94	96	PF00675	0.357
CLV_PCSK_SKI1_1	144	148	PF00082	0.550
CLV_PCSK_SKI1_1	230	234	PF00082	0.576
CLV_PCSK_SKI1_1	280	284	PF00082	0.576
CLV_PCSK_SKI1_1	3	7	PF00082	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.632
DOC_CYCLIN_RxL_1	274	285	PF00134	0.595
DOC_MAPK_gen_1	95	101	PF00069	0.335
DOC_PP2B_LxvP_1	287	290	PF13499	0.540
DOC_USP7_MATH_1	309	313	PF00917	0.532
DOC_USP7_MATH_1	314	318	PF00917	0.480
DOC_USP7_MATH_1	69	73	PF00917	0.698
DOC_USP7_UBL2_3	270	274	PF12436	0.505
DOC_USP7_UBL2_3	365	369	PF12436	0.584
DOC_WW_Pin1_4	130	135	PF00397	0.735
DOC_WW_Pin1_4	246	251	PF00397	0.465
DOC_WW_Pin1_4	86	91	PF00397	0.460
LIG_14-3-3_CanoR_1	123	130	PF00244	0.373
LIG_14-3-3_CanoR_1	17	23	PF00244	0.369
LIG_14-3-3_CanoR_1	3	13	PF00244	0.492
LIG_BRCT_BRCA1_1	142	146	PF00533	0.572
LIG_BRCT_BRCA1_1	206	210	PF00533	0.577
LIG_Clathr_ClatBox_1	81	85	PF01394	0.570
LIG_deltaCOP1_diTrp_1	327	331	PF00928	0.493
LIG_EH_1	254	258	PF12763	0.477
LIG_eIF4E_1	261	267	PF01652	0.586
LIG_FHA_1	145	151	PF00498	0.535
LIG_FHA_1	17	23	PF00498	0.522
LIG_FHA_1	224	230	PF00498	0.359
LIG_FHA_1	44	50	PF00498	0.613
LIG_FHA_1	76	82	PF00498	0.520
LIG_FHA_1	86	92	PF00498	0.408
LIG_FHA_2	165	171	PF00498	0.492
LIG_FHA_2	19	25	PF00498	0.356
LIG_LIR_Apic_2	259	264	PF02991	0.469
LIG_LIR_Gen_1	169	179	PF02991	0.602
LIG_LIR_Gen_1	27	35	PF02991	0.620
LIG_LIR_Gen_1	275	284	PF02991	0.483
LIG_LIR_Gen_1	327	335	PF02991	0.599
LIG_LIR_Gen_1	344	349	PF02991	0.468
LIG_LIR_Nem_3	169	174	PF02991	0.603
LIG_LIR_Nem_3	207	213	PF02991	0.452
LIG_LIR_Nem_3	215	219	PF02991	0.453
LIG_LIR_Nem_3	249	254	PF02991	0.461
LIG_LIR_Nem_3	259	265	PF02991	0.389
LIG_LIR_Nem_3	27	31	PF02991	0.551
LIG_LIR_Nem_3	275	279	PF02991	0.332
LIG_LIR_Nem_3	327	331	PF02991	0.595
LIG_LIR_Nem_3	344	348	PF02991	0.462
LIG_Pex14_1	196	200	PF04695	0.480
LIG_Pex14_2	171	175	PF04695	0.595
LIG_PTB_Apo_2	245	252	PF02174	0.305
LIG_PTB_Phospho_1	245	251	PF10480	0.302
LIG_REV1ctd_RIR_1	214	222	PF16727	0.490
LIG_SH2_CRK	276	280	PF00017	0.485
LIG_SH2_NCK_1	142	146	PF00017	0.572
LIG_SH2_NCK_1	68	72	PF00017	0.688
LIG_SH2_STAP1	142	146	PF00017	0.572
LIG_SH2_STAP1	28	32	PF00017	0.637
LIG_SH2_STAT5	261	264	PF00017	0.494
LIG_SH2_STAT5	28	31	PF00017	0.355
LIG_SH2_STAT5	341	344	PF00017	0.560
LIG_SH3_3	55	61	PF00018	0.573
LIG_SH3_3	94	100	PF00018	0.505
LIG_SUMO_SIM_par_1	263	269	PF11976	0.596
LIG_TYR_ITIM	26	31	PF00017	0.567
LIG_WRC_WIRS_1	213	218	PF05994	0.513
LIG_WRC_WIRS_1	342	347	PF05994	0.461
MOD_CDK_SPxxK_3	130	137	PF00069	0.737
MOD_CK1_1	235	241	PF00069	0.438
MOD_CK1_1	304	310	PF00069	0.515
MOD_CK2_1	101	107	PF00069	0.530
MOD_CK2_1	164	170	PF00069	0.334
MOD_CK2_1	174	180	PF00069	0.341
MOD_CK2_1	304	310	PF00069	0.617
MOD_GlcNHglycan	127	130	PF01048	0.386
MOD_GlcNHglycan	152	155	PF01048	0.558
MOD_GlcNHglycan	235	238	PF01048	0.556
MOD_GlcNHglycan	305	309	PF01048	0.503
MOD_GlcNHglycan	310	314	PF01048	0.531
MOD_GlcNHglycan	73	76	PF01048	0.455
MOD_GSK3_1	125	132	PF00069	0.404
MOD_GSK3_1	136	143	PF00069	0.602
MOD_GSK3_1	297	304	PF00069	0.501
MOD_GSK3_1	71	78	PF00069	0.542
MOD_N-GLC_1	301	306	PF02516	0.611
MOD_NEK2_1	13	18	PF00069	0.495
MOD_NEK2_1	140	145	PF00069	0.509
MOD_NEK2_1	150	155	PF00069	0.528
MOD_NEK2_1	233	238	PF00069	0.574
MOD_NEK2_1	266	271	PF00069	0.492
MOD_NEK2_1	343	348	PF00069	0.565
MOD_PIKK_1	204	210	PF00454	0.462
MOD_PIKK_1	343	349	PF00454	0.460
MOD_PKA_2	122	128	PF00069	0.418
MOD_PKA_2	16	22	PF00069	0.617
MOD_PKA_2	180	186	PF00069	0.484
MOD_Plk_1	13	19	PF00069	0.467
MOD_Plk_1	315	321	PF00069	0.280
MOD_Plk_2-3	327	333	PF00069	0.603
MOD_Plk_4	212	218	PF00069	0.510
MOD_Plk_4	272	278	PF00069	0.544
MOD_Plk_4	315	321	PF00069	0.445
MOD_Plk_4	330	336	PF00069	0.429
MOD_Plk_4	75	81	PF00069	0.457
MOD_ProDKin_1	130	136	PF00069	0.734
MOD_ProDKin_1	246	252	PF00069	0.468
MOD_ProDKin_1	86	92	PF00069	0.464
MOD_SUMO_rev_2	198	205	PF00179	0.618
TRG_DiLeu_BaEn_1	240	245	PF01217	0.305
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.511
TRG_ENDOCYTIC_2	251	254	PF00928	0.442
TRG_ENDOCYTIC_2	276	279	PF00928	0.431
TRG_ENDOCYTIC_2	28	31	PF00928	0.545
TRG_ER_diArg_1	228	231	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEN0	Leptomonas seymouri	45%	96%
A0A0S4JWP4	Bodo saltans	34%	100%
A0A1X0NM36	Trypanosomatidae	28%	100%
A0A3Q8IJW9	Leishmania donovani	88%	100%
A0A3R7M5E0	Trypanosoma rangeli	29%	100%
A4HQB3	Leishmania braziliensis	74%	100%
A4IE04	Leishmania infantum	88%	100%
A6SRT0	Botryotinia fuckeliana (strain B05.10)	26%	100%
A7E3Z4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	27%	100%
A9RBS1	Physcomitrium patens	29%	74%
A9V2Y9	Monosiga brevicollis	31%	100%
B3M173	Drosophila ananassae	33%	100%
B3P2A7	Drosophila erecta	33%	100%
B4G0F3	Zea mays	31%	72%
B4GFE6	Drosophila persimilis	31%	100%
B4I3X6	Drosophila sechellia	34%	100%
B4PV71	Drosophila yakuba	31%	100%
B4QW91	Drosophila simulans	33%	100%
B5X2D1	Salmo salar	31%	100%
B8BKI7	Oryza sativa subsp. indica	30%	72%
B9N1F9	Populus trichocarpa	29%	72%
B9SQI7	Ricinus communis	30%	71%
B9WAM8	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	23%	100%
C3XR70	Branchiostoma floridae	27%	100%
C4YJE1	Candida albicans (strain WO-1)	23%	100%
C9SUS0	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	27%	100%
D2UYP1	Naegleria gruberi	29%	100%
E0CTF3	Vitis vinifera	31%	70%
Q0VD27	Bos taurus	31%	100%
Q28C69	Xenopus tropicalis	29%	100%
Q296B0	Drosophila pseudoobscura pseudoobscura	31%	100%
Q2R483	Oryza sativa subsp. japonica	30%	72%
Q4Q0G9	Leishmania major	86%	100%
Q5AM80	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	100%
Q5PPH0	Rattus norvegicus	31%	100%
Q6FLR5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	100%
Q6GMI7	Danio rerio	30%	100%
Q7Q9C0	Anopheles gambiae	27%	100%
Q8BGB7	Mus musculus	31%	100%
Q9FN41	Arabidopsis thaliana	31%	74%
Q9UHY7	Homo sapiens	30%	100%
Q9VN95	Drosophila melanogaster	33%	100%
V5BJ24	Trypanosoma cruzi	26%	100%