Putative aminoalcoholphosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine phosphotransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AU25_LEIMU

TriTrypDb:

LmxM.36.5900

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AU25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU25

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0006644	phospholipid metabolic process	4	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0008654	phospholipid biosynthetic process	5	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0019637	organophosphate metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004307	ethanolaminephosphotransferase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	8
GO:0004142	diacylglycerol cholinephosphotransferase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.431
CLV_NRD_NRD_1	119	121	PF00675	0.228
CLV_NRD_NRD_1	28	30	PF00675	0.291
CLV_PCSK_KEX2_1	119	121	PF00082	0.228
CLV_PCSK_SKI1_1	245	249	PF00082	0.482
CLV_PCSK_SKI1_1	43	47	PF00082	0.340
DEG_APCC_DBOX_1	157	165	PF00400	0.275
DEG_APCC_DBOX_1	325	333	PF00400	0.346
DEG_ODPH_VHL_1	61	73	PF01847	0.466
DOC_CKS1_1	138	143	PF01111	0.247
DOC_MAPK_MEF2A_6	245	252	PF00069	0.283
DOC_MAPK_MEF2A_6	277	284	PF00069	0.430
DOC_PP1_RVXF_1	243	250	PF00149	0.269
DOC_PP4_FxxP_1	138	141	PF00568	0.262
DOC_USP7_MATH_1	352	356	PF00917	0.427
DOC_USP7_MATH_1	361	365	PF00917	0.371
DOC_USP7_MATH_1	413	417	PF00917	0.606
DOC_WW_Pin1_4	122	127	PF00397	0.453
DOC_WW_Pin1_4	137	142	PF00397	0.175
DOC_WW_Pin1_4	276	281	PF00397	0.442
LIG_14-3-3_CanoR_1	326	330	PF00244	0.262
LIG_Actin_WH2_2	254	272	PF00022	0.338
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BRCT_BRCA1_1	228	232	PF00533	0.365
LIG_BRCT_BRCA1_1	245	249	PF00533	0.235
LIG_BRCT_BRCA1_1	254	258	PF00533	0.275
LIG_CaM_NSCaTE_8	160	167	PF13499	0.142
LIG_eIF4E_1	99	105	PF01652	0.247
LIG_FHA_1	138	144	PF00498	0.249
LIG_FHA_1	179	185	PF00498	0.467
LIG_FHA_1	212	218	PF00498	0.336
LIG_FHA_1	236	242	PF00498	0.342
LIG_FHA_1	257	263	PF00498	0.320
LIG_FHA_1	277	283	PF00498	0.405
LIG_FHA_1	375	381	PF00498	0.224
LIG_FHA_1	67	73	PF00498	0.279
LIG_FHA_1	76	82	PF00498	0.250
LIG_GBD_Chelix_1	261	269	PF00786	0.203
LIG_IRF3_LxIS_1	141	148	PF10401	0.142
LIG_IRF3_LxIS_1	159	165	PF10401	0.118
LIG_IRF3_LxIS_1	400	407	PF10401	0.533
LIG_LIR_Apic_2	136	141	PF02991	0.421
LIG_LIR_Apic_2	151	155	PF02991	0.262
LIG_LIR_Apic_2	18	22	PF02991	0.561
LIG_LIR_Gen_1	140	150	PF02991	0.301
LIG_LIR_Gen_1	167	177	PF02991	0.326
LIG_LIR_Gen_1	246	257	PF02991	0.294
LIG_LIR_Gen_1	382	392	PF02991	0.376
LIG_LIR_Gen_1	395	404	PF02991	0.463
LIG_LIR_Gen_1	96	107	PF02991	0.190
LIG_LIR_Nem_3	140	145	PF02991	0.351
LIG_LIR_Nem_3	157	162	PF02991	0.204
LIG_LIR_Nem_3	167	173	PF02991	0.340
LIG_LIR_Nem_3	246	252	PF02991	0.256
LIG_LIR_Nem_3	255	261	PF02991	0.275
LIG_LIR_Nem_3	313	319	PF02991	0.323
LIG_LIR_Nem_3	382	387	PF02991	0.349
LIG_LIR_Nem_3	395	400	PF02991	0.447
LIG_LIR_Nem_3	401	406	PF02991	0.453
LIG_LIR_Nem_3	67	71	PF02991	0.390
LIG_LIR_Nem_3	94	98	PF02991	0.390
LIG_MLH1_MIPbox_1	228	232	PF16413	0.290
LIG_PCNA_PIPBox_1	153	162	PF02747	0.264
LIG_PCNA_yPIPBox_3	146	158	PF02747	0.323
LIG_Pex14_1	95	99	PF04695	0.247
LIG_Pex14_2	138	142	PF04695	0.367
LIG_Pex14_2	170	174	PF04695	0.262
LIG_Rb_pABgroove_1	125	133	PF01858	0.410
LIG_SH2_CRK	152	156	PF00017	0.263
LIG_SH2_CRK	316	320	PF00017	0.358
LIG_SH2_GRB2like	49	52	PF00017	0.461
LIG_SH2_NCK_1	220	224	PF00017	0.377
LIG_SH2_PTP2	19	22	PF00017	0.551
LIG_SH2_SRC	19	22	PF00017	0.551
LIG_SH2_STAP1	220	224	PF00017	0.341
LIG_SH2_STAP1	99	103	PF00017	0.262
LIG_SH2_STAT3	44	47	PF00017	0.473
LIG_SH2_STAT5	186	189	PF00017	0.510
LIG_SH2_STAT5	19	22	PF00017	0.486
LIG_SH2_STAT5	24	27	PF00017	0.460
LIG_SH2_STAT5	359	362	PF00017	0.246
LIG_SH2_STAT5	403	406	PF00017	0.505
LIG_SH2_STAT5	44	47	PF00017	0.479
LIG_SH2_STAT5	85	88	PF00017	0.234
LIG_SH3_3	184	190	PF00018	0.594
LIG_SH3_3	219	225	PF00018	0.311
LIG_SH3_3	265	271	PF00018	0.504
LIG_SH3_3	296	302	PF00018	0.351
LIG_SH3_3	303	309	PF00018	0.340
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.489
LIG_SUMO_SIM_anti_2	377	382	PF11976	0.142
LIG_SUMO_SIM_anti_2	405	410	PF11976	0.479
LIG_SUMO_SIM_par_1	160	168	PF11976	0.220
LIG_SUMO_SIM_par_1	376	382	PF11976	0.220
LIG_TYR_ITIM	314	319	PF00017	0.404
LIG_TYR_ITIM	82	87	PF00017	0.142
LIG_UBA3_1	408	415	PF00899	0.537
LIG_WW_1	21	24	PF00397	0.508
MOD_CK1_1	148	154	PF00069	0.374
MOD_CK1_1	165	171	PF00069	0.188
MOD_CK1_1	178	184	PF00069	0.402
MOD_CK1_1	185	191	PF00069	0.497
MOD_CK1_1	2	8	PF00069	0.615
MOD_CK1_1	243	249	PF00069	0.263
MOD_CK1_1	276	282	PF00069	0.468
MOD_CK1_1	39	45	PF00069	0.483
MOD_CK1_1	407	413	PF00069	0.491
MOD_GlcNHglycan	187	190	PF01048	0.272
MOD_GlcNHglycan	203	206	PF01048	0.351
MOD_GlcNHglycan	213	217	PF01048	0.488
MOD_GlcNHglycan	354	357	PF01048	0.362
MOD_GlcNHglycan	394	397	PF01048	0.388
MOD_GSK3_1	118	125	PF00069	0.458
MOD_GSK3_1	160	167	PF00069	0.378
MOD_GSK3_1	178	185	PF00069	0.365
MOD_GSK3_1	207	214	PF00069	0.282
MOD_GSK3_1	252	259	PF00069	0.323
MOD_GSK3_1	269	276	PF00069	0.585
MOD_GSK3_1	318	325	PF00069	0.252
MOD_GSK3_1	32	39	PF00069	0.513
MOD_GSK3_1	398	405	PF00069	0.388
MOD_N-GLC_1	145	150	PF02516	0.359
MOD_N-GLC_1	235	240	PF02516	0.471
MOD_N-GLC_1	286	291	PF02516	0.168
MOD_N-GLC_1	302	307	PF02516	0.458
MOD_NEK2_1	145	150	PF00069	0.441
MOD_NEK2_1	162	167	PF00069	0.244
MOD_NEK2_1	182	187	PF00069	0.412
MOD_NEK2_1	201	206	PF00069	0.276
MOD_NEK2_1	252	257	PF00069	0.278
MOD_NEK2_1	288	293	PF00069	0.219
MOD_NEK2_1	312	317	PF00069	0.296
MOD_NEK2_1	318	323	PF00069	0.248
MOD_NEK2_1	374	379	PF00069	0.409
MOD_NEK2_1	392	397	PF00069	0.281
MOD_NEK2_1	404	409	PF00069	0.462
MOD_NEK2_1	75	80	PF00069	0.265
MOD_NEK2_2	235	240	PF00069	0.313
MOD_NEK2_2	302	307	PF00069	0.272
MOD_NEK2_2	93	98	PF00069	0.169
MOD_PIKK_1	226	232	PF00454	0.201
MOD_PK_1	402	408	PF00069	0.474
MOD_PKA_2	118	124	PF00069	0.438
MOD_PKA_2	269	275	PF00069	0.549
MOD_PKA_2	325	331	PF00069	0.247
MOD_Plk_1	145	151	PF00069	0.404
MOD_Plk_1	182	188	PF00069	0.414
MOD_Plk_1	212	218	PF00069	0.319
MOD_Plk_1	286	292	PF00069	0.168
MOD_Plk_1	302	308	PF00069	0.299
MOD_Plk_1	312	318	PF00069	0.214
MOD_Plk_1	36	42	PF00069	0.475
MOD_Plk_1	361	367	PF00069	0.357
MOD_Plk_4	148	154	PF00069	0.377
MOD_Plk_4	165	171	PF00069	0.268
MOD_Plk_4	182	188	PF00069	0.408
MOD_Plk_4	207	213	PF00069	0.321
MOD_Plk_4	330	336	PF00069	0.457
MOD_Plk_4	36	42	PF00069	0.466
MOD_Plk_4	369	375	PF00069	0.308
MOD_Plk_4	376	382	PF00069	0.373
MOD_ProDKin_1	122	128	PF00069	0.453
MOD_ProDKin_1	137	143	PF00069	0.175
MOD_ProDKin_1	276	282	PF00069	0.442
MOD_SUMO_for_1	15	18	PF00179	0.435
MOD_SUMO_rev_2	111	118	PF00179	0.410
TRG_DiLeu_BaEn_1	157	162	PF01217	0.190
TRG_ENDOCYTIC_2	107	110	PF00928	0.162
TRG_ENDOCYTIC_2	316	319	PF00928	0.351
TRG_ENDOCYTIC_2	389	392	PF00928	0.273
TRG_ENDOCYTIC_2	403	406	PF00928	0.504
TRG_ENDOCYTIC_2	49	52	PF00928	0.487
TRG_ENDOCYTIC_2	83	86	PF00928	0.259
TRG_ENDOCYTIC_2	99	102	PF00928	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I260	Leptomonas seymouri	63%	100%
A0A0S4JA45	Bodo saltans	39%	95%
A0A1X0NLI0	Trypanosomatidae	48%	92%
A0A3Q8IRT0	Leishmania donovani	90%	100%
A0A3R7NAX1	Trypanosoma rangeli	46%	97%
A4HQA8	Leishmania braziliensis	80%	100%
A4IE03	Leishmania infantum	90%	100%
D0A400	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
O82567	Arabidopsis thaliana	30%	100%
O82568	Arabidopsis thaliana	31%	100%
P17898	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4Q0H0	Leishmania major	89%	100%
Q550W1	Dictyostelium discoideum	28%	100%
Q5ZKD1	Gallus gallus	27%	100%
Q6AXM5	Rattus norvegicus	27%	100%
Q8BGS7	Mus musculus	27%	100%
Q9Y6K0	Homo sapiens	28%	100%
V5B3K4	Trypanosoma cruzi	47%	96%