Paraflagellar_rod_protein_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania mexicana

UniProt:

E9AU22_LEIMU

TriTrypDb:

LmxM.36.5870

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AU22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.525
CLV_C14_Caspase3-7	172	176	PF00656	0.416
CLV_C14_Caspase3-7	287	291	PF00656	0.710
CLV_C14_Caspase3-7	475	479	PF00656	0.712
CLV_C14_Caspase3-7	480	484	PF00656	0.695
CLV_MEL_PAP_1	267	273	PF00089	0.591
CLV_NRD_NRD_1	164	166	PF00675	0.448
CLV_NRD_NRD_1	325	327	PF00675	0.686
CLV_NRD_NRD_1	438	440	PF00675	0.640
CLV_NRD_NRD_1	503	505	PF00675	0.574
CLV_NRD_NRD_1	579	581	PF00675	0.637
CLV_NRD_NRD_1	724	726	PF00675	0.734
CLV_PCSK_FUR_1	436	440	PF00082	0.638
CLV_PCSK_FUR_1	501	505	PF00082	0.609
CLV_PCSK_KEX2_1	269	271	PF00082	0.625
CLV_PCSK_KEX2_1	327	329	PF00082	0.654
CLV_PCSK_KEX2_1	438	440	PF00082	0.640
CLV_PCSK_KEX2_1	503	505	PF00082	0.575
CLV_PCSK_KEX2_1	723	725	PF00082	0.607
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.423
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.635
CLV_PCSK_SKI1_1	161	165	PF00082	0.462
CLV_PCSK_SKI1_1	388	392	PF00082	0.585
CLV_PCSK_SKI1_1	439	443	PF00082	0.537
CLV_PCSK_SKI1_1	503	507	PF00082	0.597
CLV_PCSK_SKI1_1	560	564	PF00082	0.632
CLV_PCSK_SKI1_1	68	72	PF00082	0.619
CLV_PCSK_SKI1_1	748	752	PF00082	0.575
DEG_APCC_DBOX_1	438	446	PF00400	0.531
DEG_APCC_DBOX_1	502	510	PF00400	0.605
DEG_APCC_DBOX_1	53	61	PF00400	0.625
DEG_APCC_DBOX_1	724	732	PF00400	0.614
DEG_APCC_DBOX_1	747	755	PF00400	0.627
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DEG_SCF_FBW7_1	354	359	PF00400	0.453
DEG_SPOP_SBC_1	189	193	PF00917	0.559
DEG_SPOP_SBC_1	227	231	PF00917	0.799
DEG_SPOP_SBC_1	633	637	PF00917	0.620
DOC_CKS1_1	353	358	PF01111	0.581
DOC_CYCLIN_RxL_1	382	394	PF00134	0.692
DOC_CYCLIN_RxL_1	644	657	PF00134	0.387
DOC_MAPK_DCC_7	748	756	PF00069	0.629
DOC_MAPK_gen_1	324	331	PF00069	0.604
DOC_MAPK_gen_1	340	349	PF00069	0.582
DOC_MAPK_gen_1	501	508	PF00069	0.608
DOC_MAPK_gen_1	545	554	PF00069	0.466
DOC_MAPK_gen_1	580	586	PF00069	0.602
DOC_MAPK_gen_1	721	730	PF00069	0.631
DOC_MAPK_gen_1	745	753	PF00069	0.628
DOC_MAPK_MEF2A_6	371	379	PF00069	0.756
DOC_MAPK_MEF2A_6	547	556	PF00069	0.462
DOC_MAPK_MEF2A_6	721	730	PF00069	0.707
DOC_MAPK_MEF2A_6	748	756	PF00069	0.605
DOC_MAPK_NFAT4_5	723	731	PF00069	0.521
DOC_PP1_RVXF_1	159	165	PF00149	0.502
DOC_PP2B_LxvP_1	390	393	PF13499	0.683
DOC_PP2B_LxvP_1	465	468	PF13499	0.589
DOC_PP4_FxxP_1	49	52	PF00568	0.658
DOC_PP4_FxxP_1	53	56	PF00568	0.656
DOC_PP4_FxxP_1	749	752	PF00568	0.593
DOC_USP7_MATH_1	150	154	PF00917	0.538
DOC_USP7_MATH_1	179	183	PF00917	0.519
DOC_USP7_MATH_1	297	301	PF00917	0.644
DOC_USP7_MATH_1	369	373	PF00917	0.697
DOC_USP7_MATH_1	585	589	PF00917	0.623
DOC_USP7_MATH_1	633	637	PF00917	0.745
DOC_USP7_MATH_1	658	662	PF00917	0.667
DOC_USP7_MATH_1	733	737	PF00917	0.615
DOC_USP7_MATH_1	765	769	PF00917	0.461
DOC_WW_Pin1_4	118	123	PF00397	0.481
DOC_WW_Pin1_4	21	26	PF00397	0.536
DOC_WW_Pin1_4	230	235	PF00397	0.756
DOC_WW_Pin1_4	252	257	PF00397	0.664
DOC_WW_Pin1_4	269	274	PF00397	0.690
DOC_WW_Pin1_4	332	337	PF00397	0.718
DOC_WW_Pin1_4	352	357	PF00397	0.410
DOC_WW_Pin1_4	69	74	PF00397	0.609
DOC_WW_Pin1_4	716	721	PF00397	0.657
DOC_WW_Pin1_4	9	14	PF00397	0.527
DOC_WW_Pin1_4	94	99	PF00397	0.543
LIG_14-3-3_CanoR_1	165	173	PF00244	0.676
LIG_14-3-3_CanoR_1	59	65	PF00244	0.589
LIG_14-3-3_CanoR_1	660	664	PF00244	0.654
LIG_Actin_WH2_2	53	70	PF00022	0.637
LIG_AP2alpha_2	312	314	PF02296	0.735
LIG_BRCT_BRCA1_1	398	402	PF00533	0.693
LIG_eIF4E_1	61	67	PF01652	0.661
LIG_FHA_1	133	139	PF00498	0.537
LIG_FHA_1	333	339	PF00498	0.650
LIG_FHA_1	357	363	PF00498	0.720
LIG_FHA_1	371	377	PF00498	0.689
LIG_FHA_1	406	412	PF00498	0.682
LIG_FHA_1	514	520	PF00498	0.652
LIG_FHA_1	529	535	PF00498	0.557
LIG_FHA_1	551	557	PF00498	0.610
LIG_FHA_1	61	67	PF00498	0.508
LIG_FHA_1	635	641	PF00498	0.531
LIG_FHA_1	660	666	PF00498	0.691
LIG_FHA_1	758	764	PF00498	0.622
LIG_FHA_2	274	280	PF00498	0.647
LIG_LIR_Apic_2	47	52	PF02991	0.623
LIG_LIR_Gen_1	110	119	PF02991	0.545
LIG_LIR_Gen_1	12	22	PF02991	0.659
LIG_LIR_Gen_1	133	142	PF02991	0.465
LIG_LIR_Gen_1	182	190	PF02991	0.375
LIG_LIR_Gen_1	24	35	PF02991	0.597
LIG_LIR_Gen_1	39	50	PF02991	0.449
LIG_LIR_Gen_1	779	790	PF02991	0.481
LIG_LIR_Nem_3	110	114	PF02991	0.551
LIG_LIR_Nem_3	12	17	PF02991	0.648
LIG_LIR_Nem_3	133	139	PF02991	0.465
LIG_LIR_Nem_3	157	163	PF02991	0.490
LIG_LIR_Nem_3	182	187	PF02991	0.382
LIG_LIR_Nem_3	24	30	PF02991	0.603
LIG_LIR_Nem_3	279	283	PF02991	0.775
LIG_LIR_Nem_3	39	45	PF02991	0.452
LIG_LIR_Nem_3	683	689	PF02991	0.445
LIG_LIR_Nem_3	779	785	PF02991	0.499
LIG_LYPXL_S_1	685	689	PF13949	0.443
LIG_LYPXL_yS_3	642	645	PF13949	0.385
LIG_Pex14_1	314	318	PF04695	0.717
LIG_Pex14_2	160	164	PF04695	0.461
LIG_Pex14_2	49	53	PF04695	0.687
LIG_Pex14_2	749	753	PF04695	0.476
LIG_PTB_Apo_2	562	569	PF02174	0.623
LIG_SH2_CRK	111	115	PF00017	0.548
LIG_SH2_CRK	134	138	PF00017	0.462
LIG_SH2_CRK	139	143	PF00017	0.479
LIG_SH2_CRK	184	188	PF00017	0.591
LIG_SH2_CRK	27	31	PF00017	0.628
LIG_SH2_CRK	81	85	PF00017	0.496
LIG_SH2_GRB2like	27	30	PF00017	0.624
LIG_SH2_GRB2like	429	432	PF00017	0.648
LIG_SH2_NCK_1	27	31	PF00017	0.530
LIG_SH2_PTP2	429	432	PF00017	0.609
LIG_SH2_SRC	27	30	PF00017	0.624
LIG_SH2_SRC	429	432	PF00017	0.650
LIG_SH2_STAP1	134	138	PF00017	0.562
LIG_SH2_STAP1	27	31	PF00017	0.721
LIG_SH2_STAT5	134	137	PF00017	0.441
LIG_SH2_STAT5	318	321	PF00017	0.618
LIG_SH2_STAT5	429	432	PF00017	0.609
LIG_SH3_3	126	132	PF00018	0.518
LIG_SH3_3	549	555	PF00018	0.690
LIG_SH3_3	637	643	PF00018	0.696
LIG_SH3_3	661	667	PF00018	0.672
LIG_SH3_3	7	13	PF00018	0.540
LIG_SUMO_SIM_anti_2	461	467	PF11976	0.677
LIG_SUMO_SIM_anti_2	574	580	PF11976	0.627
LIG_SUMO_SIM_anti_2	86	95	PF11976	0.505
LIG_SUMO_SIM_par_1	375	381	PF11976	0.750
LIG_SUMO_SIM_par_1	388	394	PF11976	0.513
LIG_SUMO_SIM_par_1	530	536	PF11976	0.610
LIG_TRAF2_1	18	21	PF00917	0.684
LIG_TRAF2_1	272	275	PF00917	0.724
LIG_TYR_ITIM	640	645	PF00017	0.398
LIG_TYR_ITIM	79	84	PF00017	0.552
LIG_UBA3_1	159	166	PF00899	0.307
LIG_UBA3_1	376	382	PF00899	0.670
LIG_UBA3_1	575	581	PF00899	0.593
LIG_UBA3_1	789	794	PF00899	0.599
LIG_WRC_WIRS_1	407	412	PF05994	0.683
MOD_CDK_SPK_2	69	74	PF00069	0.609
MOD_CDK_SPK_2	716	721	PF00069	0.626
MOD_CDK_SPxK_1	352	358	PF00069	0.568
MOD_CDK_SPxxK_3	232	239	PF00069	0.658
MOD_CDK_SPxxK_3	716	723	PF00069	0.633
MOD_CK1_1	12	18	PF00069	0.608
MOD_CK1_1	121	127	PF00069	0.661
MOD_CK1_1	180	186	PF00069	0.480
MOD_CK1_1	225	231	PF00069	0.749
MOD_CK1_1	232	238	PF00069	0.673
MOD_CK1_1	255	261	PF00069	0.616
MOD_CK1_1	334	340	PF00069	0.617
MOD_CK1_1	378	384	PF00069	0.746
MOD_CK1_1	588	594	PF00069	0.430
MOD_CK1_1	69	75	PF00069	0.616
MOD_CK1_1	719	725	PF00069	0.660
MOD_CK1_1	768	774	PF00069	0.537
MOD_CK2_1	269	275	PF00069	0.691
MOD_CK2_1	391	397	PF00069	0.701
MOD_CK2_1	474	480	PF00069	0.658
MOD_GlcNHglycan	102	105	PF01048	0.574
MOD_GlcNHglycan	179	182	PF01048	0.605
MOD_GlcNHglycan	192	195	PF01048	0.593
MOD_GlcNHglycan	363	366	PF01048	0.730
MOD_GlcNHglycan	523	526	PF01048	0.535
MOD_GlcNHglycan	602	605	PF01048	0.668
MOD_GlcNHglycan	654	657	PF01048	0.691
MOD_GlcNHglycan	68	71	PF01048	0.448
MOD_GlcNHglycan	704	707	PF01048	0.490
MOD_GSK3_1	222	229	PF00069	0.738
MOD_GSK3_1	255	262	PF00069	0.577
MOD_GSK3_1	269	276	PF00069	0.523
MOD_GSK3_1	330	337	PF00069	0.530
MOD_GSK3_1	352	359	PF00069	0.563
MOD_GSK3_1	546	553	PF00069	0.660
MOD_GSK3_1	587	594	PF00069	0.688
MOD_GSK3_1	698	705	PF00069	0.510
MOD_GSK3_1	764	771	PF00069	0.607
MOD_N-GLC_1	550	555	PF02516	0.595
MOD_N-GLC_1	741	746	PF02516	0.596
MOD_NEK2_1	190	195	PF00069	0.568
MOD_NEK2_1	214	219	PF00069	0.651
MOD_NEK2_1	260	265	PF00069	0.600
MOD_NEK2_1	331	336	PF00069	0.547
MOD_NEK2_1	377	382	PF00069	0.697
MOD_NEK2_1	66	71	PF00069	0.642
MOD_NEK2_1	757	762	PF00069	0.488
MOD_OFUCOSY	732	737	PF10250	0.614
MOD_PIKK_1	166	172	PF00454	0.663
MOD_PIKK_1	255	261	PF00454	0.676
MOD_PIKK_1	495	501	PF00454	0.603
MOD_PKA_2	521	527	PF00069	0.657
MOD_PKA_2	659	665	PF00069	0.677
MOD_PKA_2	757	763	PF00069	0.558
MOD_Plk_1	132	138	PF00069	0.552
MOD_Plk_1	396	402	PF00069	0.701
MOD_Plk_1	405	411	PF00069	0.572
MOD_Plk_1	550	556	PF00069	0.690
MOD_Plk_1	741	747	PF00069	0.522
MOD_Plk_4	132	138	PF00069	0.554
MOD_Plk_4	180	186	PF00069	0.485
MOD_Plk_4	334	340	PF00069	0.487
MOD_Plk_4	397	403	PF00069	0.690
MOD_Plk_4	4	10	PF00069	0.469
MOD_Plk_4	406	412	PF00069	0.657
MOD_Plk_4	765	771	PF00069	0.566
MOD_ProDKin_1	118	124	PF00069	0.489
MOD_ProDKin_1	21	27	PF00069	0.538
MOD_ProDKin_1	230	236	PF00069	0.756
MOD_ProDKin_1	252	258	PF00069	0.658
MOD_ProDKin_1	269	275	PF00069	0.693
MOD_ProDKin_1	332	338	PF00069	0.714
MOD_ProDKin_1	352	358	PF00069	0.412
MOD_ProDKin_1	69	75	PF00069	0.610
MOD_ProDKin_1	716	722	PF00069	0.661
MOD_ProDKin_1	9	15	PF00069	0.529
MOD_ProDKin_1	94	100	PF00069	0.542
MOD_SUMO_for_1	412	415	PF00179	0.710
TRG_DiLeu_BaEn_2	405	411	PF01217	0.589
TRG_DiLeu_BaEn_3	88	94	PF01217	0.618
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.478
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.760
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.650
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.666
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.681
TRG_ENDOCYTIC_2	111	114	PF00928	0.540
TRG_ENDOCYTIC_2	134	137	PF00928	0.441
TRG_ENDOCYTIC_2	184	187	PF00928	0.552
TRG_ENDOCYTIC_2	197	200	PF00928	0.477
TRG_ENDOCYTIC_2	27	30	PF00928	0.686
TRG_ENDOCYTIC_2	642	645	PF00928	0.640
TRG_ENDOCYTIC_2	686	689	PF00928	0.428
TRG_ENDOCYTIC_2	782	785	PF00928	0.463
TRG_ENDOCYTIC_2	81	84	PF00928	0.504
TRG_ER_diArg_1	323	326	PF00400	0.614
TRG_ER_diArg_1	436	439	PF00400	0.518
TRG_ER_diArg_1	502	504	PF00400	0.589
TRG_ER_diArg_1	723	725	PF00400	0.697
TRG_ER_diArg_1	743	746	PF00400	0.553
TRG_NES_CRM1_1	34	48	PF08389	0.572
TRG_NES_CRM1_1	480	492	PF08389	0.651
TRG_NES_CRM1_1	75	89	PF08389	0.605
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.629
TRG_PTS1	792	795	PF00515	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS3	Leptomonas seymouri	43%	97%
A0A0S4JAE8	Bodo saltans	27%	100%
A0A1X0NLN9	Trypanosomatidae	28%	100%
A0A3Q8IJ99	Leishmania donovani	85%	100%
A0A3R7K3C1	Trypanosoma rangeli	28%	100%
A4HQA5	Leishmania braziliensis	67%	99%
A4IE00	Leishmania infantum	85%	100%
D0A406	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q0H3	Leishmania major	86%	100%
V5BJ29	Trypanosoma cruzi	28%	100%