A44l protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

a44l protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AU21_LEIMU

TriTrypDb:

LmxM.36.5860

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AU21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU21

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.611
CLV_C14_Caspase3-7	460	464	PF00656	0.694
CLV_C14_Caspase3-7	628	632	PF00656	0.622
CLV_C14_Caspase3-7	695	699	PF00656	0.527
CLV_MEL_PAP_1	290	296	PF00089	0.249
CLV_NRD_NRD_1	115	117	PF00675	0.303
CLV_NRD_NRD_1	204	206	PF00675	0.420
CLV_NRD_NRD_1	211	213	PF00675	0.391
CLV_NRD_NRD_1	228	230	PF00675	0.341
CLV_NRD_NRD_1	449	451	PF00675	0.480
CLV_NRD_NRD_1	596	598	PF00675	0.455
CLV_PCSK_KEX2_1	204	206	PF00082	0.418
CLV_PCSK_KEX2_1	228	230	PF00082	0.335
CLV_PCSK_KEX2_1	322	324	PF00082	0.281
CLV_PCSK_KEX2_1	596	598	PF00082	0.389
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.293
CLV_PCSK_PC7_1	318	324	PF00082	0.306
CLV_PCSK_SKI1_1	122	126	PF00082	0.423
CLV_PCSK_SKI1_1	205	209	PF00082	0.387
CLV_PCSK_SKI1_1	288	292	PF00082	0.379
CLV_PCSK_SKI1_1	375	379	PF00082	0.306
CLV_PCSK_SKI1_1	405	409	PF00082	0.445
CLV_PCSK_SKI1_1	446	450	PF00082	0.524
CLV_PCSK_SKI1_1	564	568	PF00082	0.423
CLV_PCSK_SKI1_1	597	601	PF00082	0.413
DEG_APCC_DBOX_1	479	487	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.427
DEG_SPOP_SBC_1	360	364	PF00917	0.443
DEG_SPOP_SBC_1	457	461	PF00917	0.617
DOC_CKS1_1	677	682	PF01111	0.734
DOC_CKS1_1	96	101	PF01111	0.552
DOC_CYCLIN_RxL_1	284	295	PF00134	0.444
DOC_CYCLIN_yClb1_LxF_4	307	312	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.586
DOC_MAPK_gen_1	130	138	PF00069	0.558
DOC_MAPK_gen_1	204	211	PF00069	0.615
DOC_MAPK_gen_1	517	527	PF00069	0.570
DOC_MAPK_MEF2A_6	162	171	PF00069	0.599
DOC_MAPK_MEF2A_6	204	211	PF00069	0.592
DOC_MAPK_MEF2A_6	335	342	PF00069	0.501
DOC_PP1_RVXF_1	307	313	PF00149	0.533
DOC_PP1_RVXF_1	372	379	PF00149	0.506
DOC_PP2B_LxvP_1	165	168	PF13499	0.601
DOC_PP4_FxxP_1	2	5	PF00568	0.364
DOC_SPAK_OSR1_1	300	304	PF12202	0.572
DOC_USP7_MATH_1	203	207	PF00917	0.556
DOC_USP7_MATH_1	341	345	PF00917	0.443
DOC_USP7_MATH_1	392	396	PF00917	0.644
DOC_USP7_MATH_1	457	461	PF00917	0.606
DOC_USP7_MATH_1	605	609	PF00917	0.707
DOC_USP7_MATH_1	91	95	PF00917	0.547
DOC_WW_Pin1_4	213	218	PF00397	0.573
DOC_WW_Pin1_4	45	50	PF00397	0.471
DOC_WW_Pin1_4	558	563	PF00397	0.639
DOC_WW_Pin1_4	577	582	PF00397	0.630
DOC_WW_Pin1_4	676	681	PF00397	0.684
DOC_WW_Pin1_4	95	100	PF00397	0.554
LIG_14-3-3_CanoR_1	130	135	PF00244	0.617
LIG_14-3-3_CanoR_1	15	19	PF00244	0.412
LIG_14-3-3_CanoR_1	204	208	PF00244	0.659
LIG_14-3-3_CanoR_1	255	265	PF00244	0.602
LIG_14-3-3_CanoR_1	293	301	PF00244	0.478
LIG_14-3-3_CanoR_1	405	411	PF00244	0.726
LIG_14-3-3_CanoR_1	468	472	PF00244	0.734
LIG_14-3-3_CanoR_1	480	490	PF00244	0.505
LIG_14-3-3_CanoR_1	520	529	PF00244	0.559
LIG_14-3-3_CanoR_1	622	630	PF00244	0.636
LIG_14-3-3_CanoR_1	644	654	PF00244	0.531
LIG_14-3-3_CanoR_1	669	675	PF00244	0.615
LIG_Actin_WH2_2	2	17	PF00022	0.481
LIG_APCC_ABBA_1	158	163	PF00400	0.570
LIG_BIR_III_2	214	218	PF00653	0.518
LIG_BIR_III_4	463	467	PF00653	0.605
LIG_BRCT_BRCA1_1	672	676	PF00533	0.661
LIG_FHA_1	106	112	PF00498	0.490
LIG_FHA_1	447	453	PF00498	0.668
LIG_FHA_1	457	463	PF00498	0.622
LIG_FHA_1	520	526	PF00498	0.544
LIG_FHA_1	96	102	PF00498	0.635
LIG_FHA_2	123	129	PF00498	0.602
LIG_FHA_2	14	20	PF00498	0.352
LIG_FHA_2	178	184	PF00498	0.530
LIG_FHA_2	344	350	PF00498	0.505
LIG_FHA_2	383	389	PF00498	0.547
LIG_FHA_2	609	615	PF00498	0.626
LIG_Integrin_RGD_1	347	349	PF01839	0.243
LIG_LIR_Apic_2	140	145	PF02991	0.658
LIG_LIR_Apic_2	93	99	PF02991	0.553
LIG_LIR_Gen_1	206	215	PF02991	0.536
LIG_LIR_Gen_1	365	376	PF02991	0.503
LIG_LIR_Gen_1	528	536	PF02991	0.571
LIG_LIR_Gen_1	672	680	PF02991	0.685
LIG_LIR_Nem_3	206	211	PF02991	0.519
LIG_LIR_Nem_3	365	371	PF02991	0.440
LIG_LIR_Nem_3	528	532	PF02991	0.523
LIG_LIR_Nem_3	672	677	PF02991	0.650
LIG_LIR_Nem_3	94	100	PF02991	0.615
LIG_NRBOX	309	315	PF00104	0.514
LIG_NRBOX	482	488	PF00104	0.583
LIG_PCNA_PIPBox_1	135	144	PF02747	0.530
LIG_PTB_Apo_2	128	135	PF02174	0.603
LIG_RPA_C_Fungi	17	29	PF08784	0.465
LIG_SH2_CRK	142	146	PF00017	0.602
LIG_SH2_CRK	674	678	PF00017	0.616
LIG_SH2_NCK_1	142	146	PF00017	0.576
LIG_SH2_PTP2	529	532	PF00017	0.383
LIG_SH2_PTP2	63	66	PF00017	0.274
LIG_SH2_SRC	100	103	PF00017	0.523
LIG_SH2_STAP1	249	253	PF00017	0.358
LIG_SH2_STAP1	73	77	PF00017	0.502
LIG_SH2_STAT5	238	241	PF00017	0.415
LIG_SH2_STAT5	356	359	PF00017	0.268
LIG_SH2_STAT5	529	532	PF00017	0.405
LIG_SH2_STAT5	63	66	PF00017	0.390
LIG_SH2_STAT5	703	706	PF00017	0.459
LIG_SH2_STAT5	83	86	PF00017	0.499
LIG_SH2_STAT5	97	100	PF00017	0.578
LIG_SH3_1	96	102	PF00018	0.422
LIG_SH3_3	166	172	PF00018	0.410
LIG_SH3_3	265	271	PF00018	0.509
LIG_SH3_3	335	341	PF00018	0.413
LIG_SH3_3	96	102	PF00018	0.543
LIG_SH3_4	429	436	PF00018	0.562
LIG_SUMO_SIM_anti_2	495	504	PF11976	0.366
LIG_SUMO_SIM_par_1	121	128	PF11976	0.447
LIG_SUMO_SIM_par_1	137	143	PF11976	0.454
LIG_SUMO_SIM_par_1	500	506	PF11976	0.428
LIG_TRAF2_1	364	367	PF00917	0.456
LIG_TRAF2_1	656	659	PF00917	0.467
LIG_UBA3_1	110	117	PF00899	0.417
LIG_UBA3_1	135	144	PF00899	0.422
LIG_WRC_WIRS_1	342	347	PF05994	0.355
MOD_CDK_SPxK_1	558	564	PF00069	0.534
MOD_CK1_1	140	146	PF00069	0.515
MOD_CK1_1	343	349	PF00069	0.313
MOD_CK1_1	359	365	PF00069	0.352
MOD_CK1_1	437	443	PF00069	0.625
MOD_CK1_1	482	488	PF00069	0.457
MOD_CK1_1	577	583	PF00069	0.673
MOD_CK1_1	608	614	PF00069	0.504
MOD_CK1_1	663	669	PF00069	0.554
MOD_CK2_1	122	128	PF00069	0.502
MOD_CK2_1	13	19	PF00069	0.606
MOD_CK2_1	143	149	PF00069	0.501
MOD_CK2_1	360	366	PF00069	0.417
MOD_CK2_1	437	443	PF00069	0.746
MOD_Cter_Amidation	320	323	PF01082	0.355
MOD_GlcNHglycan	200	203	PF01048	0.637
MOD_GlcNHglycan	394	397	PF01048	0.514
MOD_GlcNHglycan	418	421	PF01048	0.681
MOD_GlcNHglycan	439	442	PF01048	0.783
MOD_GlcNHglycan	546	549	PF01048	0.614
MOD_GlcNHglycan	575	579	PF01048	0.619
MOD_GlcNHglycan	625	628	PF01048	0.719
MOD_GlcNHglycan	700	703	PF01048	0.430
MOD_GlcNHglycan	705	708	PF01048	0.445
MOD_GlcNHglycan	93	96	PF01048	0.666
MOD_GSK3_1	189	196	PF00069	0.606
MOD_GSK3_1	317	324	PF00069	0.323
MOD_GSK3_1	356	363	PF00069	0.363
MOD_GSK3_1	401	408	PF00069	0.586
MOD_GSK3_1	409	416	PF00069	0.649
MOD_GSK3_1	429	436	PF00069	0.548
MOD_GSK3_1	437	444	PF00069	0.747
MOD_GSK3_1	550	557	PF00069	0.666
MOD_GSK3_1	659	666	PF00069	0.568
MOD_GSK3_1	703	710	PF00069	0.407
MOD_GSK3_1	711	718	PF00069	0.499
MOD_GSK3_1	72	79	PF00069	0.546
MOD_GSK3_1	9	16	PF00069	0.651
MOD_GSK3_1	91	98	PF00069	0.621
MOD_N-GLC_1	130	135	PF02516	0.587
MOD_N-GLC_1	45	50	PF02516	0.408
MOD_N-GLC_2	593	595	PF02516	0.468
MOD_NEK2_1	176	181	PF00069	0.419
MOD_NEK2_1	18	23	PF00069	0.567
MOD_NEK2_1	237	242	PF00069	0.322
MOD_NEK2_1	264	269	PF00069	0.410
MOD_NEK2_1	370	375	PF00069	0.306
MOD_NEK2_1	467	472	PF00069	0.471
MOD_NEK2_1	574	579	PF00069	0.571
MOD_NEK2_1	625	630	PF00069	0.534
MOD_NEK2_1	645	650	PF00069	0.360
MOD_NEK2_2	203	208	PF00069	0.410
MOD_PIKK_1	143	149	PF00454	0.406
MOD_PIKK_1	409	415	PF00454	0.713
MOD_PIKK_1	429	435	PF00454	0.562
MOD_PIKK_1	645	651	PF00454	0.371
MOD_PIKK_1	660	666	PF00454	0.486
MOD_PKA_2	14	20	PF00069	0.498
MOD_PKA_2	203	209	PF00069	0.552
MOD_PKA_2	254	260	PF00069	0.368
MOD_PKA_2	292	298	PF00069	0.294
MOD_PKA_2	317	323	PF00069	0.355
MOD_PKA_2	392	398	PF00069	0.659
MOD_PKA_2	401	407	PF00069	0.645
MOD_PKA_2	467	473	PF00069	0.515
MOD_PKA_2	479	485	PF00069	0.417
MOD_PKA_2	519	525	PF00069	0.454
MOD_PKA_2	605	611	PF00069	0.505
MOD_PKA_2	670	676	PF00069	0.504
MOD_Plk_1	130	136	PF00069	0.554
MOD_Plk_4	130	136	PF00069	0.461
MOD_Plk_4	137	143	PF00069	0.458
MOD_Plk_4	275	281	PF00069	0.459
MOD_Plk_4	286	292	PF00069	0.440
MOD_Plk_4	356	362	PF00069	0.318
MOD_Plk_4	467	473	PF00069	0.528
MOD_Plk_4	482	488	PF00069	0.472
MOD_ProDKin_1	213	219	PF00069	0.444
MOD_ProDKin_1	45	51	PF00069	0.582
MOD_ProDKin_1	558	564	PF00069	0.542
MOD_ProDKin_1	577	583	PF00069	0.527
MOD_ProDKin_1	676	682	PF00069	0.603
MOD_ProDKin_1	95	101	PF00069	0.422
MOD_SUMO_rev_2	48	57	PF00179	0.195
MOD_SUMO_rev_2	628	638	PF00179	0.467
TRG_DiLeu_BaEn_1	19	24	PF01217	0.470
TRG_DiLeu_BaEn_1	366	371	PF01217	0.268
TRG_DiLeu_BaEn_1	531	536	PF01217	0.533
TRG_DiLeu_BaEn_2	154	160	PF01217	0.462
TRG_DiLeu_BaEn_4	366	372	PF01217	0.268
TRG_DiLeu_LyEn_5	19	24	PF01217	0.470
TRG_ENDOCYTIC_2	47	50	PF00928	0.649
TRG_ENDOCYTIC_2	529	532	PF00928	0.460
TRG_ENDOCYTIC_2	571	574	PF00928	0.575
TRG_ENDOCYTIC_2	63	66	PF00928	0.309
TRG_ENDOCYTIC_2	674	677	PF00928	0.623
TRG_ENDOCYTIC_2	85	88	PF00928	0.502
TRG_ER_diArg_1	209	212	PF00400	0.477
TRG_ER_diArg_1	227	229	PF00400	0.393
TRG_ER_diArg_1	390	393	PF00400	0.506
TRG_ER_diArg_1	399	402	PF00400	0.667
TRG_ER_diArg_1	668	671	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	47%	98%
A0A3Q8IC80	Leishmania donovani	29%	100%
A0A3Q8IC95	Leishmania donovani	29%	100%
A0A3Q8IHZ0	Leishmania donovani	86%	100%
A0A422NUH1	Trypanosoma rangeli	34%	100%
A4HCE5	Leishmania braziliensis	28%	97%
A4HLH5	Leishmania braziliensis	25%	100%
A4HZW7	Leishmania infantum	29%	100%
A4IDZ9	Leishmania infantum	86%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q0H4	Leishmania major	83%	100%
Q4Q470	Leishmania major	25%	100%
Q4QBQ3	Leishmania major	30%	100%
Q4QBQ4	Leishmania major	31%	100%
V5DMJ8	Trypanosoma cruzi	32%	100%