Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KHARON

Species:

Leishmania mexicana

UniProt:

E9AU20_LEIMU

TriTrypDb:

LmxM.36.5850

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.621
CLV_NRD_NRD_1	154	156	PF00675	0.598
CLV_NRD_NRD_1	22	24	PF00675	0.552
CLV_NRD_NRD_1	289	291	PF00675	0.558
CLV_NRD_NRD_1	299	301	PF00675	0.532
CLV_NRD_NRD_1	392	394	PF00675	0.619
CLV_NRD_NRD_1	47	49	PF00675	0.619
CLV_NRD_NRD_1	481	483	PF00675	0.600
CLV_NRD_NRD_1	84	86	PF00675	0.555
CLV_PCSK_KEX2_1	121	123	PF00082	0.648
CLV_PCSK_KEX2_1	141	143	PF00082	0.601
CLV_PCSK_KEX2_1	154	156	PF00082	0.647
CLV_PCSK_KEX2_1	220	222	PF00082	0.603
CLV_PCSK_KEX2_1	392	394	PF00082	0.619
CLV_PCSK_KEX2_1	438	440	PF00082	0.601
CLV_PCSK_KEX2_1	47	49	PF00082	0.619
CLV_PCSK_KEX2_1	481	483	PF00082	0.587
CLV_PCSK_KEX2_1	84	86	PF00082	0.555
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.581
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.603
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.665
CLV_PCSK_SKI1_1	228	232	PF00082	0.585
CLV_PCSK_SKI1_1	452	456	PF00082	0.694
CLV_PCSK_SKI1_1	67	71	PF00082	0.521
CLV_PCSK_SKI1_1	78	82	PF00082	0.572
DOC_CKS1_1	308	313	PF01111	0.590
DOC_CKS1_1	496	501	PF01111	0.562
DOC_CYCLIN_RxL_1	33	44	PF00134	0.417
DOC_MAPK_gen_1	511	519	PF00069	0.620
DOC_PP4_FxxP_1	63	66	PF00568	0.550
DOC_PP4_FxxP_1	70	73	PF00568	0.475
DOC_USP7_MATH_1	135	139	PF00917	0.691
DOC_USP7_MATH_1	260	264	PF00917	0.498
DOC_USP7_MATH_1	388	392	PF00917	0.561
DOC_USP7_MATH_1	397	401	PF00917	0.524
DOC_USP7_MATH_1	411	415	PF00917	0.530
DOC_USP7_MATH_1	418	422	PF00917	0.611
DOC_USP7_MATH_1	71	75	PF00917	0.492
DOC_USP7_UBL2_3	255	259	PF12436	0.627
DOC_WW_Pin1_4	124	129	PF00397	0.543
DOC_WW_Pin1_4	3	8	PF00397	0.641
DOC_WW_Pin1_4	307	312	PF00397	0.589
DOC_WW_Pin1_4	393	398	PF00397	0.535
DOC_WW_Pin1_4	432	437	PF00397	0.620
DOC_WW_Pin1_4	495	500	PF00397	0.566
DOC_WW_Pin1_4	62	67	PF00397	0.592
LIG_14-3-3_CanoR_1	432	436	PF00244	0.517
LIG_EVH1_2	76	80	PF00568	0.571
LIG_FHA_1	344	350	PF00498	0.545
LIG_FHA_1	49	55	PF00498	0.507
LIG_FHA_1	514	520	PF00498	0.506
LIG_FHA_2	103	109	PF00498	0.539
LIG_FHA_2	177	183	PF00498	0.537
LIG_FHA_2	271	277	PF00498	0.544
LIG_LIR_Apic_2	321	327	PF02991	0.576
LIG_LIR_Apic_2	68	73	PF02991	0.501
LIG_LIR_Nem_3	133	139	PF02991	0.557
LIG_PTB_Apo_2	265	272	PF02174	0.377
LIG_PTB_Phospho_1	265	271	PF10480	0.379
LIG_SH2_CRK	136	140	PF00017	0.579
LIG_SH2_SRC	107	110	PF00017	0.451
LIG_SH2_STAT3	409	412	PF00017	0.580
LIG_SH2_STAT5	102	105	PF00017	0.481
LIG_SH2_STAT5	202	205	PF00017	0.598
LIG_SH2_STAT5	272	275	PF00017	0.543
LIG_SH3_2	181	186	PF14604	0.601
LIG_SH3_2	476	481	PF14604	0.461
LIG_SH3_2	73	78	PF14604	0.505
LIG_SH3_3	175	181	PF00018	0.681
LIG_SH3_3	205	211	PF00018	0.678
LIG_SH3_3	220	226	PF00018	0.505
LIG_SH3_3	233	239	PF00018	0.581
LIG_SH3_3	296	302	PF00018	0.535
LIG_SH3_3	473	479	PF00018	0.542
LIG_SH3_3	70	76	PF00018	0.513
LIG_SH3_CIN85_PxpxPR_1	476	481	PF14604	0.461
LIG_SUMO_SIM_anti_2	262	268	PF11976	0.493
LIG_TRAF2_1	312	315	PF00917	0.509
LIG_WW_3	209	213	PF00397	0.642
LIG_WW_3	297	301	PF00397	0.504
LIG_WW_3	478	482	PF00397	0.472
LIG_WW_3	75	79	PF00397	0.449
MOD_CDC14_SPxK_1	127	130	PF00782	0.538
MOD_CDC14_SPxK_1	435	438	PF00782	0.621
MOD_CDK_SPK_2	432	437	PF00069	0.580
MOD_CDK_SPK_2	62	67	PF00069	0.592
MOD_CDK_SPxK_1	124	130	PF00069	0.545
MOD_CDK_SPxK_1	307	313	PF00069	0.591
MOD_CDK_SPxK_1	432	438	PF00069	0.618
MOD_CDK_SPxxK_3	432	439	PF00069	0.618
MOD_CK1_1	110	116	PF00069	0.557
MOD_CK1_1	124	130	PF00069	0.514
MOD_CK1_1	369	375	PF00069	0.613
MOD_CK1_1	378	384	PF00069	0.615
MOD_CK1_1	391	397	PF00069	0.594
MOD_CK1_1	402	408	PF00069	0.571
MOD_CK1_1	430	436	PF00069	0.526
MOD_CK1_1	513	519	PF00069	0.552
MOD_CK2_1	176	182	PF00069	0.546
MOD_CK2_1	270	276	PF00069	0.484
MOD_CK2_1	484	490	PF00069	0.668
MOD_CK2_1	62	68	PF00069	0.524
MOD_Cter_Amidation	218	221	PF01082	0.596
MOD_DYRK1A_RPxSP_1	432	436	PF00069	0.583
MOD_GlcNHglycan	132	135	PF01048	0.612
MOD_GlcNHglycan	26	29	PF01048	0.566
MOD_GlcNHglycan	362	365	PF01048	0.625
MOD_GlcNHglycan	377	380	PF01048	0.596
MOD_GlcNHglycan	397	400	PF01048	0.509
MOD_GlcNHglycan	401	404	PF01048	0.592
MOD_GlcNHglycan	43	46	PF01048	0.567
MOD_GSK3_1	369	376	PF00069	0.611
MOD_GSK3_1	391	398	PF00069	0.605
MOD_GSK3_1	427	434	PF00069	0.651
MOD_GSK3_1	484	491	PF00069	0.611
MOD_LATS_1	153	159	PF00433	0.505
MOD_N-GLC_1	24	29	PF02516	0.619
MOD_N-GLC_1	260	265	PF02516	0.513
MOD_N-GLC_1	61	66	PF02516	0.508
MOD_N-GLC_2	174	176	PF02516	0.642
MOD_NEK2_1	246	251	PF00069	0.590
MOD_PIKK_1	291	297	PF00454	0.445
MOD_PK_1	155	161	PF00069	0.626
MOD_PKA_1	121	127	PF00069	0.641
MOD_PKA_2	121	127	PF00069	0.641
MOD_PKA_2	391	397	PF00069	0.625
MOD_PKA_2	431	437	PF00069	0.545
MOD_PKA_2	513	519	PF00069	0.655
MOD_PKA_2	90	96	PF00069	0.498
MOD_PKB_1	393	401	PF00069	0.524
MOD_Plk_1	107	113	PF00069	0.584
MOD_Plk_1	260	266	PF00069	0.514
MOD_ProDKin_1	124	130	PF00069	0.545
MOD_ProDKin_1	3	9	PF00069	0.644
MOD_ProDKin_1	307	313	PF00069	0.591
MOD_ProDKin_1	393	399	PF00069	0.536
MOD_ProDKin_1	432	438	PF00069	0.618
MOD_ProDKin_1	495	501	PF00069	0.565
MOD_ProDKin_1	62	68	PF00069	0.589
MOD_SUMO_for_1	312	315	PF00179	0.513
TRG_ENDOCYTIC_2	136	139	PF00928	0.584
TRG_ENDOCYTIC_2	351	354	PF00928	0.529
TRG_ER_diArg_1	120	122	PF00400	0.627
TRG_ER_diArg_1	166	169	PF00400	0.561
TRG_ER_diArg_1	392	395	PF00400	0.528
TRG_ER_diArg_1	47	49	PF00400	0.610
TRG_ER_diArg_1	480	482	PF00400	0.657
TRG_ER_diArg_1	83	85	PF00400	0.564
TRG_NLS_MonoExtN_4	21	27	PF00514	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C6	Leptomonas seymouri	60%	100%
A0A3Q8IL75	Leishmania donovani	81%	98%
A4HQA3	Leishmania braziliensis	62%	97%
A4IDZ8	Leishmania infantum	81%	98%
Q4Q0H5	Leishmania major	73%	100%