HMG box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU18_LEIMU

TriTrypDb:

LmxM.36.5840

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AU18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU18

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.569
CLV_NRD_NRD_1	121	123	PF00675	0.474
CLV_NRD_NRD_1	150	152	PF00675	0.638
CLV_NRD_NRD_1	178	180	PF00675	0.782
CLV_NRD_NRD_1	39	41	PF00675	0.438
CLV_PCSK_FUR_1	151	155	PF00082	0.482
CLV_PCSK_KEX2_1	153	155	PF00082	0.639
CLV_PCSK_KEX2_1	203	205	PF00082	0.634
CLV_PCSK_KEX2_1	207	209	PF00082	0.579
CLV_PCSK_KEX2_1	39	41	PF00082	0.441
CLV_PCSK_KEX2_1	48	50	PF00082	0.410
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.639
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.681
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.647
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.357
CLV_PCSK_SKI1_1	106	110	PF00082	0.456
CLV_PCSK_SKI1_1	139	143	PF00082	0.698
CLV_PCSK_SKI1_1	180	184	PF00082	0.538
CLV_PCSK_SKI1_1	204	208	PF00082	0.650
CLV_PCSK_SKI1_1	242	246	PF00082	0.536
CLV_PCSK_SKI1_1	32	36	PF00082	0.625
CLV_PCSK_SKI1_1	80	84	PF00082	0.445
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DEG_SPOP_SBC_1	288	292	PF00917	0.806
DEG_SPOP_SBC_1	301	305	PF00917	0.730
DEG_SPOP_SBC_1	308	312	PF00917	0.674
DEG_SPOP_SBC_1	327	331	PF00917	0.664
DOC_ANK_TNKS_1	232	239	PF00023	0.550
DOC_CKS1_1	140	145	PF01111	0.579
DOC_CKS1_1	320	325	PF01111	0.654
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.422
DOC_MAPK_gen_1	104	113	PF00069	0.524
DOC_MAPK_MEF2A_6	139	147	PF00069	0.591
DOC_MAPK_RevD_3	108	123	PF00069	0.411
DOC_MAPK_RevD_3	138	154	PF00069	0.518
DOC_USP7_MATH_1	158	162	PF00917	0.695
DOC_USP7_MATH_1	191	195	PF00917	0.811
DOC_USP7_MATH_1	288	292	PF00917	0.812
DOC_USP7_MATH_1	309	313	PF00917	0.771
DOC_USP7_MATH_1	340	344	PF00917	0.745
DOC_USP7_UBL2_3	164	168	PF12436	0.687
DOC_USP7_UBL2_3	172	176	PF12436	0.656
DOC_USP7_UBL2_3	203	207	PF12436	0.578
DOC_WW_Pin1_4	139	144	PF00397	0.652
DOC_WW_Pin1_4	170	175	PF00397	0.507
DOC_WW_Pin1_4	209	214	PF00397	0.526
DOC_WW_Pin1_4	270	275	PF00397	0.743
DOC_WW_Pin1_4	289	294	PF00397	0.721
DOC_WW_Pin1_4	319	324	PF00397	0.736
DOC_WW_Pin1_4	333	338	PF00397	0.687
DOC_WW_Pin1_4	99	104	PF00397	0.516
LIG_14-3-3_CanoR_1	240	245	PF00244	0.577
LIG_14-3-3_CanoR_1	40	50	PF00244	0.433
LIG_14-3-3_CanoR_1	6	16	PF00244	0.545
LIG_BRCT_BRCA1_1	43	47	PF00533	0.532
LIG_DCNL_PONY_1	1	4	PF03556	0.627
LIG_FHA_1	140	146	PF00498	0.726
LIG_FHA_1	311	317	PF00498	0.735
LIG_FHA_1	82	88	PF00498	0.441
LIG_FHA_2	243	249	PF00498	0.547
LIG_FHA_2	279	285	PF00498	0.774
LIG_FHA_2	33	39	PF00498	0.636
LIG_FHA_2	81	87	PF00498	0.396
LIG_LIR_Gen_1	212	222	PF02991	0.488
LIG_LIR_Gen_1	83	89	PF02991	0.391
LIG_LIR_Nem_3	212	217	PF02991	0.455
LIG_LIR_Nem_3	239	244	PF02991	0.588
LIG_LIR_Nem_3	44	50	PF02991	0.463
LIG_LIR_Nem_3	83	88	PF02991	0.396
LIG_PDZ_Class_2	343	348	PF00595	0.636
LIG_Rb_LxCxE_1	18	35	PF01857	0.501
LIG_SH2_STAP1	214	218	PF00017	0.475
LIG_SH2_STAP1	85	89	PF00017	0.387
LIG_SH2_STAT5	78	81	PF00017	0.556
LIG_SH3_1	168	174	PF00018	0.538
LIG_SH3_2	146	151	PF14604	0.688
LIG_SH3_2	171	176	PF14604	0.498
LIG_SH3_3	140	146	PF00018	0.555
LIG_SH3_3	168	174	PF00018	0.538
LIG_SH3_3	207	213	PF00018	0.604
LIG_SH3_3	290	296	PF00018	0.736
LIG_SH3_3	314	320	PF00018	0.651
LIG_SH3_3	334	340	PF00018	0.539
LIG_TRAF2_1	245	248	PF00917	0.608
LIG_UBA3_1	55	59	PF00899	0.521
MOD_CDC14_SPxK_1	173	176	PF00782	0.495
MOD_CDK_SPK_2	333	338	PF00069	0.677
MOD_CDK_SPK_2	99	104	PF00069	0.572
MOD_CDK_SPxK_1	170	176	PF00069	0.497
MOD_CDK_SPxxK_3	270	277	PF00069	0.494
MOD_CDK_SPxxK_3	99	106	PF00069	0.504
MOD_CK1_1	159	165	PF00069	0.801
MOD_CK1_1	209	215	PF00069	0.526
MOD_CK1_1	278	284	PF00069	0.722
MOD_CK1_1	303	309	PF00069	0.826
MOD_CK1_1	310	316	PF00069	0.689
MOD_CK2_1	242	248	PF00069	0.545
MOD_CK2_1	278	284	PF00069	0.773
MOD_CK2_1	32	38	PF00069	0.550
MOD_CK2_1	80	86	PF00069	0.407
MOD_CK2_1	99	105	PF00069	0.579
MOD_GlcNHglycan	192	196	PF01048	0.644
MOD_GlcNHglycan	9	12	PF01048	0.366
MOD_GSK3_1	156	163	PF00069	0.716
MOD_GSK3_1	191	198	PF00069	0.659
MOD_GSK3_1	202	209	PF00069	0.619
MOD_GSK3_1	284	291	PF00069	0.675
MOD_GSK3_1	297	304	PF00069	0.775
MOD_GSK3_1	308	315	PF00069	0.832
MOD_GSK3_1	340	347	PF00069	0.739
MOD_N-GLC_1	327	332	PF02516	0.795
MOD_NEK2_1	2	7	PF00069	0.562
MOD_PIKK_1	303	309	PF00454	0.757
MOD_PIKK_1	32	38	PF00454	0.463
MOD_PIKK_1	340	346	PF00454	0.648
MOD_PIKK_1	41	47	PF00454	0.423
MOD_PKA_1	202	208	PF00069	0.692
MOD_PKA_1	48	54	PF00069	0.548
MOD_PKA_2	2	8	PF00069	0.567
MOD_PKA_2	48	54	PF00069	0.471
MOD_PKB_1	240	248	PF00069	0.589
MOD_Plk_4	212	218	PF00069	0.455
MOD_ProDKin_1	139	145	PF00069	0.647
MOD_ProDKin_1	170	176	PF00069	0.507
MOD_ProDKin_1	209	215	PF00069	0.522
MOD_ProDKin_1	270	276	PF00069	0.745
MOD_ProDKin_1	289	295	PF00069	0.721
MOD_ProDKin_1	319	325	PF00069	0.740
MOD_ProDKin_1	333	339	PF00069	0.678
MOD_ProDKin_1	99	105	PF00069	0.511
MOD_SUMO_rev_2	102	111	PF00179	0.529
MOD_SUMO_rev_2	271	279	PF00179	0.770
TRG_ENDOCYTIC_2	114	117	PF00928	0.502
TRG_ENDOCYTIC_2	214	217	PF00928	0.445
TRG_ENDOCYTIC_2	85	88	PF00928	0.386
TRG_ER_diArg_1	233	236	PF00400	0.555
TRG_NLS_Bipartite_1	151	171	PF00514	0.657
TRG_NLS_MonoCore_2	150	155	PF00514	0.559
TRG_NLS_MonoCore_2	165	170	PF00514	0.588
TRG_NLS_MonoExtC_3	166	171	PF00514	0.720
TRG_NLS_MonoExtN_4	149	156	PF00514	0.642
TRG_NLS_MonoExtN_4	164	171	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	249	254	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P908	Leptomonas seymouri	53%	97%
A0A1X0NMA4	Trypanosomatidae	31%	100%
A0A3Q8IGP8	Leishmania donovani	82%	100%
A4HQA0	Leishmania braziliensis	69%	99%
A4IDZ6	Leishmania infantum	82%	100%
D0A409	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q0H7	Leishmania major	84%	100%