Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU15_LEIMU

TriTrypDb:

LmxM.36.5810

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.561
CLV_C14_Caspase3-7	333	337	PF00656	0.470
CLV_C14_Caspase3-7	392	396	PF00656	0.583
CLV_NRD_NRD_1	169	171	PF00675	0.568
CLV_NRD_NRD_1	274	276	PF00675	0.471
CLV_NRD_NRD_1	286	288	PF00675	0.504
CLV_NRD_NRD_1	388	390	PF00675	0.671
CLV_PCSK_FUR_1	384	388	PF00082	0.629
CLV_PCSK_KEX2_1	274	276	PF00082	0.495
CLV_PCSK_KEX2_1	282	284	PF00082	0.547
CLV_PCSK_KEX2_1	286	288	PF00082	0.526
CLV_PCSK_KEX2_1	386	388	PF00082	0.642
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.638
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.642
CLV_PCSK_PC7_1	384	390	PF00082	0.678
CLV_PCSK_SKI1_1	165	169	PF00082	0.329
CLV_PCSK_SKI1_1	267	271	PF00082	0.486
CLV_PCSK_SKI1_1	305	309	PF00082	0.505
CLV_PCSK_SKI1_1	33	37	PF00082	0.608
CLV_PCSK_SKI1_1	376	380	PF00082	0.574
DEG_APCC_DBOX_1	177	185	PF00400	0.436
DEG_APCC_DBOX_1	266	274	PF00400	0.531
DEG_Kelch_Keap1_1	232	237	PF01344	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.443
DEG_SPOP_SBC_1	200	204	PF00917	0.659
DOC_CKS1_1	34	39	PF01111	0.457
DOC_MAPK_gen_1	142	149	PF00069	0.516
DOC_MAPK_MEF2A_6	316	325	PF00069	0.469
DOC_PP1_RVXF_1	265	272	PF00149	0.310
DOC_PP2B_LxvP_1	122	125	PF13499	0.547
DOC_PP2B_LxvP_1	261	264	PF13499	0.531
DOC_PP2B_LxvP_1	345	348	PF13499	0.507
DOC_USP7_MATH_1	51	55	PF00917	0.576
DOC_USP7_UBL2_3	377	381	PF12436	0.708
DOC_WW_Pin1_4	100	105	PF00397	0.500
DOC_WW_Pin1_4	116	121	PF00397	0.636
DOC_WW_Pin1_4	127	132	PF00397	0.652
DOC_WW_Pin1_4	201	206	PF00397	0.700
DOC_WW_Pin1_4	33	38	PF00397	0.646
LIG_14-3-3_CanoR_1	133	138	PF00244	0.771
LIG_14-3-3_CanoR_1	146	155	PF00244	0.504
LIG_14-3-3_CanoR_1	258	264	PF00244	0.428
LIG_14-3-3_CanoR_1	286	293	PF00244	0.565
LIG_14-3-3_CanoR_1	296	304	PF00244	0.431
LIG_14-3-3_CanoR_1	316	322	PF00244	0.489
LIG_14-3-3_CanoR_1	67	75	PF00244	0.461
LIG_14-3-3_CanoR_1	92	96	PF00244	0.523
LIG_Actin_WH2_2	150	167	PF00022	0.476
LIG_Actin_WH2_2	406	424	PF00022	0.455
LIG_FHA_1	195	201	PF00498	0.554
LIG_FHA_1	222	228	PF00498	0.610
LIG_FHA_1	430	436	PF00498	0.502
LIG_FHA_1	70	76	PF00498	0.394
LIG_FHA_2	238	244	PF00498	0.678
LIG_FHA_2	403	409	PF00498	0.578
LIG_FHA_2	72	78	PF00498	0.543
LIG_Integrin_isoDGR_2	314	316	PF01839	0.328
LIG_LIR_Gen_1	298	308	PF02991	0.458
LIG_LIR_Gen_1	66	75	PF02991	0.514
LIG_LIR_Nem_3	188	193	PF02991	0.552
LIG_LIR_Nem_3	298	304	PF02991	0.448
LIG_LIR_Nem_3	66	71	PF02991	0.497
LIG_LYPXL_SIV_4	300	308	PF13949	0.471
LIG_NBox_RRM_1	331	341	PF00076	0.442
LIG_NRBOX	226	232	PF00104	0.478
LIG_NRBOX	265	271	PF00104	0.530
LIG_NRBOX	340	346	PF00104	0.505
LIG_SH2_CRK	17	21	PF00017	0.562
LIG_SH2_SRC	193	196	PF00017	0.381
LIG_SH2_STAP1	190	194	PF00017	0.522
LIG_SH2_STAT5	148	151	PF00017	0.541
LIG_SH2_STAT5	193	196	PF00017	0.570
LIG_SH2_STAT5	2	5	PF00017	0.515
LIG_SH3_3	31	37	PF00018	0.574
LIG_SH3_3	361	367	PF00018	0.636
LIG_SUMO_SIM_par_1	152	159	PF11976	0.484
LIG_SUMO_SIM_par_1	2	8	PF11976	0.483
LIG_TRAF2_1	156	159	PF00917	0.541
LIG_TYR_ITIM	15	20	PF00017	0.543
MOD_CDC14_SPxK_1	130	133	PF00782	0.554
MOD_CDK_SPxK_1	127	133	PF00069	0.559
MOD_CK1_1	114	120	PF00069	0.806
MOD_CK1_1	136	142	PF00069	0.548
MOD_CK1_1	201	207	PF00069	0.672
MOD_CK1_1	350	356	PF00069	0.459
MOD_CK1_1	69	75	PF00069	0.348
MOD_CK2_1	153	159	PF00069	0.420
MOD_CK2_1	2	8	PF00069	0.513
MOD_CK2_1	231	237	PF00069	0.625
MOD_CK2_1	296	302	PF00069	0.566
MOD_CK2_1	402	408	PF00069	0.610
MOD_GlcNHglycan	113	116	PF01048	0.783
MOD_GlcNHglycan	135	138	PF01048	0.682
MOD_GlcNHglycan	23	26	PF01048	0.715
MOD_GlcNHglycan	261	264	PF01048	0.460
MOD_GlcNHglycan	298	301	PF01048	0.566
MOD_GlcNHglycan	30	33	PF01048	0.701
MOD_GlcNHglycan	349	352	PF01048	0.365
MOD_GlcNHglycan	367	370	PF01048	0.557
MOD_GlcNHglycan	44	47	PF01048	0.658
MOD_GSK3_1	114	121	PF00069	0.653
MOD_GSK3_1	149	156	PF00069	0.563
MOD_GSK3_1	194	201	PF00069	0.543
MOD_GSK3_1	402	409	PF00069	0.645
MOD_NEK2_1	147	152	PF00069	0.501
MOD_NEK2_1	230	235	PF00069	0.470
MOD_NEK2_1	257	262	PF00069	0.441
MOD_NEK2_1	352	357	PF00069	0.518
MOD_NEK2_1	400	405	PF00069	0.668
MOD_NEK2_1	428	433	PF00069	0.501
MOD_PIKK_1	400	406	PF00454	0.684
MOD_PKA_1	170	176	PF00069	0.544
MOD_PKA_2	257	263	PF00069	0.431
MOD_PKA_2	28	34	PF00069	0.757
MOD_PKA_2	285	291	PF00069	0.421
MOD_PKA_2	295	301	PF00069	0.394
MOD_PKA_2	429	435	PF00069	0.407
MOD_PKA_2	66	72	PF00069	0.473
MOD_PKA_2	91	97	PF00069	0.525
MOD_Plk_1	326	332	PF00069	0.525
MOD_Plk_4	2	8	PF00069	0.405
MOD_Plk_4	352	358	PF00069	0.494
MOD_Plk_4	367	373	PF00069	0.640
MOD_ProDKin_1	100	106	PF00069	0.504
MOD_ProDKin_1	116	122	PF00069	0.636
MOD_ProDKin_1	127	133	PF00069	0.651
MOD_ProDKin_1	201	207	PF00069	0.700
MOD_ProDKin_1	33	39	PF00069	0.643
TRG_DiLeu_BaEn_1	419	424	PF01217	0.578
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.522
TRG_ENDOCYTIC_2	17	20	PF00928	0.555
TRG_ENDOCYTIC_2	301	304	PF00928	0.408
TRG_ENDOCYTIC_2	68	71	PF00928	0.428
TRG_ER_diArg_1	143	146	PF00400	0.441
TRG_ER_diArg_1	273	275	PF00400	0.475
TRG_ER_diArg_1	387	389	PF00400	0.494
TRG_NLS_MonoExtN_4	374	380	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF3	Leptomonas seymouri	45%	84%
A0A1X0NLI7	Trypanosomatidae	27%	100%
A0A3Q8IPS4	Leishmania donovani	87%	100%
A0A3R7NLX1	Trypanosoma rangeli	28%	100%
A4HQ97	Leishmania braziliensis	71%	100%
D0A414	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AHY4	Leishmania infantum	86%	100%
Q4Q0I0	Leishmania major	85%	100%