Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein (LRRP), putative

Species:

Leishmania mexicana

UniProt:

E9AU13_LEIMU

TriTrypDb:

LmxM.36.5790

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

E9AU13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.484
CLV_NRD_NRD_1	10	12	PF00675	0.569
CLV_NRD_NRD_1	146	148	PF00675	0.638
CLV_NRD_NRD_1	241	243	PF00675	0.362
CLV_NRD_NRD_1	34	36	PF00675	0.547
CLV_PCSK_KEX2_1	146	148	PF00082	0.531
CLV_PCSK_KEX2_1	241	243	PF00082	0.362
CLV_PCSK_KEX2_1	34	36	PF00082	0.542
CLV_PCSK_SKI1_1	12	16	PF00082	0.592
CLV_PCSK_SKI1_1	211	215	PF00082	0.575
CLV_PCSK_SKI1_1	261	265	PF00082	0.687
CLV_PCSK_SKI1_1	34	38	PF00082	0.472
DEG_APCC_DBOX_1	241	249	PF00400	0.419
DEG_APCC_DBOX_1	90	98	PF00400	0.488
DEG_SPOP_SBC_1	303	307	PF00917	0.698
DOC_CDC14_PxL_1	228	236	PF14671	0.599
DOC_MAPK_RevD_3	227	242	PF00069	0.314
DOC_PP4_FxxP_1	141	144	PF00568	0.560
DOC_USP7_MATH_1	227	231	PF00917	0.543
DOC_USP7_MATH_1	255	259	PF00917	0.570
DOC_USP7_MATH_1	282	286	PF00917	0.635
DOC_USP7_MATH_1	325	329	PF00917	0.587
DOC_WW_Pin1_4	251	256	PF00397	0.723
LIG_14-3-3_CanoR_1	122	129	PF00244	0.530
LIG_14-3-3_CanoR_1	27	31	PF00244	0.579
LIG_14-3-3_CanoR_1	283	290	PF00244	0.539
LIG_14-3-3_CanoR_1	298	303	PF00244	0.533
LIG_14-3-3_CanoR_1	34	41	PF00244	0.494
LIG_14-3-3_CanoR_1	50	54	PF00244	0.421
LIG_14-3-3_CanoR_1	74	84	PF00244	0.487
LIG_BRCT_BRCA1_1	67	71	PF00533	0.441
LIG_Clathr_ClatBox_1	262	266	PF01394	0.658
LIG_DLG_GKlike_1	298	306	PF00625	0.670
LIG_FHA_1	16	22	PF00498	0.587
LIG_FHA_1	26	32	PF00498	0.494
LIG_FHA_1	316	322	PF00498	0.681
LIG_FHA_1	50	56	PF00498	0.507
LIG_FHA_1	79	85	PF00498	0.566
LIG_FHA_1	96	102	PF00498	0.453
LIG_FHA_2	122	128	PF00498	0.620
LIG_FHA_2	304	310	PF00498	0.741
LIG_FHA_2	336	342	PF00498	0.685
LIG_FHA_2	35	41	PF00498	0.529
LIG_FHA_2	58	64	PF00498	0.497
LIG_HP1_1	227	231	PF01393	0.543
LIG_IRF3_LxIS_1	164	170	PF10401	0.283
LIG_IRF3_LxIS_1	49	56	PF10401	0.447
LIG_LIR_Gen_1	328	336	PF02991	0.679
LIG_LIR_Gen_1	56	66	PF02991	0.495
LIG_LIR_Nem_3	328	332	PF02991	0.665
LIG_LIR_Nem_3	56	61	PF02991	0.477
LIG_SH2_STAP1	58	62	PF00017	0.485
LIG_SH2_STAT3	135	138	PF00017	0.583
LIG_SH2_STAT3	276	279	PF00017	0.402
LIG_SH2_STAT5	296	299	PF00017	0.648
LIG_SH3_3	226	232	PF00018	0.599
LIG_SH3_3	43	49	PF00018	0.469
LIG_SUMO_SIM_anti_2	258	266	PF11976	0.645
LIG_SUMO_SIM_par_1	165	170	PF11976	0.570
LIG_SUMO_SIM_par_1	258	266	PF11976	0.682
LIG_SUMO_SIM_par_1	51	56	PF11976	0.498
LIG_TRAF2_1	339	342	PF00917	0.419
LIG_TRAF2_1	363	366	PF00917	0.538
LIG_TRAF2_2	255	260	PF00917	0.716
LIG_WRC_WIRS_1	326	331	PF05994	0.663
LIG_WRC_WIRS_1	58	63	PF05994	0.427
MOD_CK1_1	193	199	PF00069	0.371
MOD_CK1_1	221	227	PF00069	0.560
MOD_CK1_1	26	32	PF00069	0.509
MOD_CK1_1	305	311	PF00069	0.602
MOD_CK1_1	328	334	PF00069	0.551
MOD_CK1_1	65	71	PF00069	0.441
MOD_CK1_1	75	81	PF00069	0.458
MOD_CK2_1	175	181	PF00069	0.626
MOD_CK2_1	298	304	PF00069	0.704
MOD_CK2_1	335	341	PF00069	0.645
MOD_CK2_1	57	63	PF00069	0.488
MOD_GlcNHglycan	168	172	PF01048	0.491
MOD_GlcNHglycan	177	180	PF01048	0.460
MOD_GlcNHglycan	181	184	PF01048	0.407
MOD_GlcNHglycan	199	203	PF01048	0.482
MOD_GlcNHglycan	74	77	PF01048	0.468
MOD_GlcNHglycan	98	101	PF01048	0.545
MOD_GSK3_1	104	111	PF00069	0.524
MOD_GSK3_1	17	24	PF00069	0.600
MOD_GSK3_1	175	182	PF00069	0.469
MOD_GSK3_1	198	205	PF00069	0.497
MOD_GSK3_1	251	258	PF00069	0.736
MOD_GSK3_1	298	305	PF00069	0.547
MOD_GSK3_1	357	364	PF00069	0.506
MOD_GSK3_1	49	56	PF00069	0.512
MOD_N-GLC_1	190	195	PF02516	0.293
MOD_N-GLC_1	21	26	PF02516	0.526
MOD_N-GLC_1	315	320	PF02516	0.691
MOD_NEK2_1	129	134	PF00069	0.625
MOD_NEK2_1	167	172	PF00069	0.324
MOD_NEK2_1	297	302	PF00069	0.648
MOD_NEK2_1	314	319	PF00069	0.438
MOD_NEK2_1	53	58	PF00069	0.488
MOD_NEK2_1	62	67	PF00069	0.467
MOD_NEK2_1	7	12	PF00069	0.572
MOD_NEK2_1	84	89	PF00069	0.567
MOD_PIKK_1	129	135	PF00454	0.631
MOD_PIKK_1	21	27	PF00454	0.545
MOD_PIKK_1	315	321	PF00454	0.429
MOD_PK_1	218	224	PF00069	0.578
MOD_PKA_1	34	40	PF00069	0.509
MOD_PKA_2	121	127	PF00069	0.498
MOD_PKA_2	26	32	PF00069	0.512
MOD_PKA_2	282	288	PF00069	0.547
MOD_PKA_2	297	303	PF00069	0.532
MOD_PKA_2	34	40	PF00069	0.489
MOD_PKA_2	49	55	PF00069	0.432
MOD_Plk_1	193	199	PF00069	0.467
MOD_Plk_1	341	347	PF00069	0.659
MOD_Plk_4	185	191	PF00069	0.479
MOD_Plk_4	26	32	PF00069	0.575
MOD_Plk_4	292	298	PF00069	0.498
MOD_Plk_4	57	63	PF00069	0.488
MOD_ProDKin_1	251	257	PF00069	0.722
TRG_DiLeu_BaEn_4	341	347	PF01217	0.419
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.624
TRG_ENDOCYTIC_2	150	153	PF00928	0.534
TRG_ENDOCYTIC_2	58	61	PF00928	0.478
TRG_ER_diArg_1	145	147	PF00400	0.609
TRG_ER_diArg_1	241	243	PF00400	0.362
TRG_ER_diArg_1	33	35	PF00400	0.558
TRG_ER_diArg_1	8	11	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBW4	Leishmania donovani	82%	100%
A4HQ95	Leishmania braziliensis	68%	100%
A4IDZ3	Leishmania infantum	83%	100%
Q4Q0I2	Leishmania major	76%	100%