tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gcd10p family, putative

Species:

Leishmania mexicana

UniProt:

E9AU12_LEIMU

TriTrypDb:

LmxM.36.5780

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0031515	tRNA (m1A) methyltransferase complex	6	12
GO:0032991	protein-containing complex	1	12
GO:0034708	methyltransferase complex	4	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0043527	tRNA methyltransferase complex	5	12
GO:0110165	cellular anatomical entity	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005643	nuclear pore	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AU12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU12

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0030488	tRNA methylation	5	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.630
CLV_C14_Caspase3-7	76	80	PF00656	0.335
CLV_C14_Caspase3-7	82	86	PF00656	0.278
CLV_NRD_NRD_1	107	109	PF00675	0.391
CLV_NRD_NRD_1	139	141	PF00675	0.164
CLV_NRD_NRD_1	59	61	PF00675	0.416
CLV_PCSK_KEX2_1	107	109	PF00082	0.391
CLV_PCSK_KEX2_1	139	141	PF00082	0.169
CLV_PCSK_KEX2_1	389	391	PF00082	0.540
CLV_PCSK_KEX2_1	437	439	PF00082	0.645
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.179
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.540
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.645
CLV_PCSK_SKI1_1	136	140	PF00082	0.392
CLV_PCSK_SKI1_1	201	205	PF00082	0.452
CLV_PCSK_SKI1_1	243	247	PF00082	0.519
CLV_PCSK_SKI1_1	28	32	PF00082	0.363
CLV_PCSK_SKI1_1	314	318	PF00082	0.397
CLV_PCSK_SKI1_1	438	442	PF00082	0.727
DOC_CDC14_PxL_1	422	430	PF14671	0.430
DOC_CKS1_1	414	419	PF01111	0.627
DOC_MAPK_gen_1	181	189	PF00069	0.305
DOC_MAPK_gen_1	27	34	PF00069	0.391
DOC_MAPK_MEF2A_6	183	191	PF00069	0.305
DOC_MAPK_MEF2A_6	27	34	PF00069	0.426
DOC_MAPK_MEF2A_6	368	376	PF00069	0.393
DOC_MAPK_MEF2A_6	389	397	PF00069	0.454
DOC_PP2B_LxvP_1	162	165	PF13499	0.452
DOC_PP2B_LxvP_1	245	248	PF13499	0.545
DOC_PP2B_LxvP_1	423	426	PF13499	0.428
DOC_USP7_MATH_1	321	325	PF00917	0.347
DOC_USP7_UBL2_3	139	143	PF12436	0.307
DOC_USP7_UBL2_3	251	255	PF12436	0.461
DOC_WW_Pin1_4	317	322	PF00397	0.510
DOC_WW_Pin1_4	351	356	PF00397	0.398
DOC_WW_Pin1_4	413	418	PF00397	0.617
LIG_14-3-3_CanoR_1	153	159	PF00244	0.426
LIG_14-3-3_CanoR_1	181	190	PF00244	0.275
LIG_14-3-3_CanoR_1	219	227	PF00244	0.375
LIG_14-3-3_CanoR_1	253	258	PF00244	0.212
LIG_14-3-3_CanoR_1	438	447	PF00244	0.569
LIG_14-3-3_CanoR_1	60	64	PF00244	0.284
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_Clathr_ClatBox_1	148	152	PF01394	0.426
LIG_CtBP_PxDLS_1	357	361	PF00389	0.423
LIG_FAT_LD_1	112	120	PF03623	0.426
LIG_FHA_1	182	188	PF00498	0.328
LIG_FHA_1	206	212	PF00498	0.391
LIG_FHA_1	237	243	PF00498	0.426
LIG_FHA_1	29	35	PF00498	0.378
LIG_FHA_1	303	309	PF00498	0.535
LIG_FHA_1	41	47	PF00498	0.343
LIG_FHA_1	439	445	PF00498	0.569
LIG_FHA_2	116	122	PF00498	0.335
LIG_FHA_2	60	66	PF00498	0.335
LIG_IRF3_LxIS_1	372	377	PF10401	0.452
LIG_LIR_Gen_1	361	372	PF02991	0.364
LIG_LIR_Nem_3	252	257	PF02991	0.376
LIG_LIR_Nem_3	339	344	PF02991	0.281
LIG_LIR_Nem_3	361	367	PF02991	0.363
LIG_LIR_Nem_3	66	72	PF02991	0.301
LIG_LIR_Nem_3	9	15	PF02991	0.365
LIG_LYPXL_yS_3	69	72	PF13949	0.321
LIG_NRBOX	111	117	PF00104	0.426
LIG_PCNA_PIPBox_1	334	343	PF02747	0.220
LIG_SH2_CRK	145	149	PF00017	0.324
LIG_SH2_CRK	50	54	PF00017	0.424
LIG_SH2_PTP2	12	15	PF00017	0.363
LIG_SH2_STAT5	12	15	PF00017	0.342
LIG_SH2_STAT5	137	140	PF00017	0.292
LIG_SH2_STAT5	163	166	PF00017	0.251
LIG_SH2_STAT5	403	406	PF00017	0.344
LIG_SH3_1	255	261	PF00018	0.424
LIG_SH3_3	255	261	PF00018	0.504
LIG_SH3_3	349	355	PF00018	0.378
LIG_SH3_3	411	417	PF00018	0.601
LIG_SUMO_SIM_anti_2	184	191	PF11976	0.305
LIG_TRAF2_1	440	443	PF00917	0.700
LIG_TRAF2_1	458	461	PF00917	0.495
LIG_UBA3_1	115	122	PF00899	0.391
LIG_UBA3_1	226	232	PF00899	0.309
LIG_UBA3_1	404	409	PF00899	0.379
MOD_CDK_SPK_2	413	418	PF00069	0.347
MOD_CK1_1	125	131	PF00069	0.395
MOD_CK1_1	215	221	PF00069	0.452
MOD_CK2_1	115	121	PF00069	0.305
MOD_CK2_1	436	442	PF00069	0.701
MOD_CK2_1	455	461	PF00069	0.612
MOD_CK2_1	59	65	PF00069	0.335
MOD_CK2_1	96	102	PF00069	0.305
MOD_GlcNHglycan	121	125	PF01048	0.373
MOD_GlcNHglycan	15	18	PF01048	0.426
MOD_GlcNHglycan	273	276	PF01048	0.643
MOD_GlcNHglycan	302	305	PF01048	0.347
MOD_GlcNHglycan	36	39	PF01048	0.338
MOD_GlcNHglycan	418	421	PF01048	0.575
MOD_GlcNHglycan	428	431	PF01048	0.666
MOD_GlcNHglycan	438	441	PF01048	0.758
MOD_GSK3_1	13	20	PF00069	0.355
MOD_GSK3_1	163	170	PF00069	0.308
MOD_GSK3_1	271	278	PF00069	0.700
MOD_GSK3_1	317	324	PF00069	0.468
MOD_GSK3_1	391	398	PF00069	0.454
MOD_GSK3_1	59	66	PF00069	0.377
MOD_LATS_1	436	442	PF00433	0.561
MOD_N-GLC_1	395	400	PF02516	0.477
MOD_N-GLC_2	172	174	PF02516	0.374
MOD_N-GLC_2	369	371	PF02516	0.299
MOD_NEK2_1	115	120	PF00069	0.278
MOD_NEK2_1	34	39	PF00069	0.321
MOD_NEK2_1	41	46	PF00069	0.316
MOD_NEK2_1	428	433	PF00069	0.712
MOD_PIKK_1	302	308	PF00454	0.449
MOD_PK_1	253	259	PF00069	0.216
MOD_PKA_2	152	158	PF00069	0.426
MOD_PKA_2	218	224	PF00069	0.375
MOD_PKA_2	275	281	PF00069	0.737
MOD_PKA_2	59	65	PF00069	0.161
MOD_PKB_1	181	189	PF00069	0.305
MOD_Plk_1	28	34	PF00069	0.414
MOD_Plk_4	115	121	PF00069	0.335
MOD_Plk_4	144	150	PF00069	0.335
MOD_Plk_4	212	218	PF00069	0.426
MOD_Plk_4	321	327	PF00069	0.370
MOD_Plk_4	376	382	PF00069	0.441
MOD_Plk_4	41	47	PF00069	0.391
MOD_Plk_4	59	65	PF00069	0.391
MOD_ProDKin_1	317	323	PF00069	0.513
MOD_ProDKin_1	351	357	PF00069	0.402
MOD_ProDKin_1	413	419	PF00069	0.619
MOD_SUMO_for_1	149	152	PF00179	0.391
TRG_DiLeu_BaEn_1	312	317	PF01217	0.522
TRG_ENDOCYTIC_2	12	15	PF00928	0.342
TRG_ENDOCYTIC_2	145	148	PF00928	0.324
TRG_ENDOCYTIC_2	353	356	PF00928	0.421
TRG_ENDOCYTIC_2	50	53	PF00928	0.416
TRG_ENDOCYTIC_2	69	72	PF00928	0.143
TRG_ER_diArg_1	106	108	PF00400	0.391
TRG_ER_diArg_1	180	183	PF00400	0.305
TRG_NLS_MonoExtC_3	138	143	PF00514	0.306
TRG_NLS_MonoExtN_4	136	143	PF00514	0.305
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.194
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I267	Leptomonas seymouri	76%	98%
A0A0S4JAT8	Bodo saltans	47%	100%
A0A1X0NLQ1	Trypanosomatidae	53%	99%
A0A3Q8IJV9	Leishmania donovani	91%	100%
A0A422NSE7	Trypanosoma rangeli	52%	99%
A4HQ94	Leishmania braziliensis	81%	100%
A4IDZ2	Leishmania infantum	91%	100%
D0A417	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
P0CS06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	83%
P0CS07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	83%
P41814	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	97%
Q2T9V5	Bos taurus	26%	93%
Q4Q0I3	Leishmania major	90%	100%
Q54UB1	Dictyostelium discoideum	29%	89%
Q5A6Q4	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	100%
Q6BKK7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	98%
Q6CF35	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	95%
Q6CLF6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	97%
Q6FNP9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	23%	98%
Q75B32	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q8CE96	Mus musculus	26%	93%
Q9UJA5	Homo sapiens	27%	93%
V5B3L2	Trypanosoma cruzi	52%	99%