Mechanosensitive ion channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mechanosensitive ion channel MscS, putative

Species:

Leishmania mexicana

UniProt:

E9AU11_LEIMU

TriTrypDb:

LmxM.36.5770

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AU11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU11

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0008381	mechanosensitive monoatomic ion channel activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022836	gated channel activity	5	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	2	4	PF00082	0.547
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.547
CLV_PCSK_SKI1_1	2	6	PF00082	0.538
DEG_Nend_UBRbox_1	1	4	PF02207	0.551
DOC_MAPK_gen_1	83	93	PF00069	0.362
DOC_MAPK_MEF2A_6	86	95	PF00069	0.399
DOC_USP7_MATH_1	144	148	PF00917	0.742
DOC_USP7_MATH_1	153	157	PF00917	0.659
DOC_USP7_MATH_1	161	165	PF00917	0.640
DOC_WW_Pin1_4	46	51	PF00397	0.275
LIG_14-3-3_CanoR_1	26	32	PF00244	0.503
LIG_14-3-3_CanoR_1	3	9	PF00244	0.564
LIG_Actin_WH2_2	70	88	PF00022	0.313
LIG_eIF4E_1	9	15	PF01652	0.468
LIG_FHA_1	10	16	PF00498	0.499
LIG_FHA_1	107	113	PF00498	0.332
LIG_FHA_1	41	47	PF00498	0.309
LIG_FHA_2	101	107	PF00498	0.433
LIG_LIR_Gen_1	108	118	PF02991	0.297
LIG_LIR_Nem_3	108	114	PF02991	0.297
LIG_PCNA_yPIPBox_3	127	137	PF02747	0.309
LIG_Pex14_1	107	111	PF04695	0.297
LIG_Pex14_2	69	73	PF04695	0.313
LIG_SH2_PTP2	111	114	PF00017	0.415
LIG_SH2_STAT5	111	114	PF00017	0.299
LIG_SH3_3	119	125	PF00018	0.418
MOD_CK1_1	22	28	PF00069	0.544
MOD_CK2_1	161	167	PF00069	0.650
MOD_CK2_1	4	10	PF00069	0.631
MOD_GlcNHglycan	100	103	PF01048	0.401
MOD_GlcNHglycan	163	166	PF01048	0.589
MOD_GlcNHglycan	79	82	PF01048	0.333
MOD_GSK3_1	36	43	PF00069	0.335
MOD_GSK3_1	4	11	PF00069	0.533
MOD_GSK3_1	73	80	PF00069	0.313
MOD_NEK2_1	4	9	PF00069	0.570
MOD_NEK2_1	73	78	PF00069	0.317
MOD_PKA_2	25	31	PF00069	0.523
MOD_Plk_4	100	106	PF00069	0.399
MOD_Plk_4	129	135	PF00069	0.316
MOD_Plk_4	4	10	PF00069	0.626
MOD_ProDKin_1	46	52	PF00069	0.275
TRG_DiLeu_BaEn_1	10	15	PF01217	0.375
TRG_DiLeu_BaEn_1	117	122	PF01217	0.176
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.357
TRG_ENDOCYTIC_2	111	114	PF00928	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C9	Leptomonas seymouri	73%	100%
A0A0S4JFG0	Bodo saltans	55%	78%
A0A1X0NLP4	Trypanosomatidae	70%	100%
A0A3S7XBY0	Leishmania donovani	91%	100%
A0A422NSI6	Trypanosoma rangeli	60%	100%
A4HQ93	Leishmania braziliensis	81%	100%
A4IDZ1	Leishmania infantum	91%	100%
D0A418	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q4Q0I4	Leishmania major	90%	100%
V5B3P8	Trypanosoma cruzi	70%	100%