TRUD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pseudouridine synthase TruD, putative

Species:

Leishmania mexicana

UniProt:

E9AU09_LEIMU

TriTrypDb:

LmxM.36.5750

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AU09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU09

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	10
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.277
CLV_NRD_NRD_1	15	17	PF00675	0.557
CLV_NRD_NRD_1	202	204	PF00675	0.487
CLV_NRD_NRD_1	207	209	PF00675	0.507
CLV_NRD_NRD_1	28	30	PF00675	0.440
CLV_NRD_NRD_1	512	514	PF00675	0.406
CLV_PCSK_KEX2_1	100	102	PF00082	0.607
CLV_PCSK_KEX2_1	15	17	PF00082	0.467
CLV_PCSK_KEX2_1	167	169	PF00082	0.553
CLV_PCSK_KEX2_1	202	204	PF00082	0.487
CLV_PCSK_KEX2_1	206	208	PF00082	0.524
CLV_PCSK_KEX2_1	256	258	PF00082	0.283
CLV_PCSK_KEX2_1	27	29	PF00082	0.400
CLV_PCSK_KEX2_1	512	514	PF00082	0.395
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.621
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.553
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.277
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.474
CLV_PCSK_PC7_1	202	208	PF00082	0.501
CLV_PCSK_SKI1_1	168	172	PF00082	0.475
CLV_PCSK_SKI1_1	173	177	PF00082	0.433
CLV_PCSK_SKI1_1	257	261	PF00082	0.312
CLV_PCSK_SKI1_1	311	315	PF00082	0.408
CLV_PCSK_SKI1_1	384	388	PF00082	0.259
CLV_PCSK_SKI1_1	424	428	PF00082	0.277
CLV_PCSK_SKI1_1	512	516	PF00082	0.382
CLV_PCSK_SKI1_1	566	570	PF00082	0.382
DEG_APCC_DBOX_1	379	387	PF00400	0.403
DEG_APCC_DBOX_1	423	431	PF00400	0.277
DEG_APCC_KENBOX_2	224	228	PF00400	0.277
DEG_Nend_UBRbox_3	1	3	PF02207	0.560
DEG_SCF_FBW7_1	619	625	PF00400	0.591
DOC_CKS1_1	601	606	PF01111	0.480
DOC_CKS1_1	619	624	PF01111	0.603
DOC_MAPK_gen_1	254	261	PF00069	0.277
DOC_MAPK_gen_1	27	33	PF00069	0.428
DOC_MAPK_gen_1	378	387	PF00069	0.395
DOC_MAPK_HePTP_8	375	387	PF00069	0.316
DOC_MAPK_MEF2A_6	378	387	PF00069	0.336
DOC_MAPK_MEF2A_6	39	48	PF00069	0.368
DOC_MAPK_NFAT4_5	380	388	PF00069	0.327
DOC_PP1_RVXF_1	244	251	PF00149	0.277
DOC_PP2B_LxvP_1	44	47	PF13499	0.262
DOC_PP2B_LxvP_1	530	533	PF13499	0.277
DOC_PP4_FxxP_1	647	650	PF00568	0.326
DOC_PP4_FxxP_1	662	665	PF00568	0.427
DOC_USP7_MATH_1	105	109	PF00917	0.692
DOC_USP7_MATH_1	119	123	PF00917	0.687
DOC_USP7_MATH_1	153	157	PF00917	0.593
DOC_USP7_MATH_1	158	162	PF00917	0.522
DOC_USP7_MATH_1	319	323	PF00917	0.331
DOC_USP7_MATH_1	47	51	PF00917	0.348
DOC_USP7_MATH_1	623	627	PF00917	0.660
DOC_WW_Pin1_4	497	502	PF00397	0.443
DOC_WW_Pin1_4	600	605	PF00397	0.485
DOC_WW_Pin1_4	618	623	PF00397	0.595
DOC_WW_Pin1_4	95	100	PF00397	0.579
LIG_14-3-3_CanoR_1	15	24	PF00244	0.541
LIG_14-3-3_CanoR_1	207	216	PF00244	0.459
LIG_14-3-3_CanoR_1	257	262	PF00244	0.277
LIG_Actin_WH2_2	368	386	PF00022	0.387
LIG_APCC_ABBA_1	221	226	PF00400	0.277
LIG_APCC_ABBA_1	31	36	PF00400	0.254
LIG_BIR_III_2	496	500	PF00653	0.332
LIG_BIR_III_4	304	308	PF00653	0.355
LIG_BIR_III_4	615	619	PF00653	0.593
LIG_BRCT_BRCA1_1	278	282	PF00533	0.355
LIG_EH1_1	453	461	PF00400	0.277
LIG_FHA_1	138	144	PF00498	0.532
LIG_FHA_1	360	366	PF00498	0.290
LIG_FHA_1	601	607	PF00498	0.427
LIG_FHA_1	619	625	PF00498	0.426
LIG_FHA_1	635	641	PF00498	0.431
LIG_FHA_1	644	650	PF00498	0.456
LIG_FHA_1	654	660	PF00498	0.252
LIG_FHA_2	127	133	PF00498	0.576
LIG_FHA_2	16	22	PF00498	0.524
LIG_FHA_2	161	167	PF00498	0.543
LIG_FHA_2	267	273	PF00498	0.403
LIG_FHA_2	333	339	PF00498	0.332
LIG_FHA_2	485	491	PF00498	0.448
LIG_FHA_2	513	519	PF00498	0.292
LIG_FHA_2	54	60	PF00498	0.444
LIG_FHA_2	546	552	PF00498	0.403
LIG_FHA_2	630	636	PF00498	0.380
LIG_FHA_2	83	89	PF00498	0.627
LIG_LIR_Apic_2	646	650	PF02991	0.330
LIG_LIR_Apic_2	661	665	PF02991	0.401
LIG_LIR_Gen_1	215	224	PF02991	0.390
LIG_LIR_Gen_1	458	469	PF02991	0.277
LIG_LIR_Gen_1	53	63	PF02991	0.338
LIG_LIR_Gen_1	550	559	PF02991	0.395
LIG_LIR_Nem_3	215	221	PF02991	0.390
LIG_LIR_Nem_3	458	464	PF02991	0.395
LIG_LIR_Nem_3	53	58	PF02991	0.350
LIG_LIR_Nem_3	550	555	PF02991	0.366
LIG_LIR_Nem_3	580	584	PF02991	0.403
LIG_PCNA_PIPBox_1	397	406	PF02747	0.395
LIG_PCNA_yPIPBox_3	457	468	PF02747	0.377
LIG_Rb_pABgroove_1	398	406	PF01858	0.332
LIG_SH2_CRK	552	556	PF00017	0.403
LIG_SH2_CRK	581	585	PF00017	0.297
LIG_SH2_NCK_1	127	131	PF00017	0.319
LIG_SH2_STAP1	552	556	PF00017	0.395
LIG_SH2_STAP1	654	658	PF00017	0.329
LIG_SH2_STAT3	419	422	PF00017	0.218
LIG_SH2_STAT5	354	357	PF00017	0.392
LIG_SH2_STAT5	419	422	PF00017	0.268
LIG_SH2_STAT5	437	440	PF00017	0.248
LIG_SH2_STAT5	452	455	PF00017	0.190
LIG_SH2_STAT5	55	58	PF00017	0.446
LIG_SH3_3	130	136	PF00018	0.576
LIG_SH3_3	525	531	PF00018	0.297
LIG_SH3_3	633	639	PF00018	0.497
LIG_SH3_3	93	99	PF00018	0.562
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.362
LIG_SUMO_SIM_par_1	399	405	PF11976	0.332
LIG_SUMO_SIM_par_1	71	76	PF11976	0.355
LIG_TRAF2_1	129	132	PF00917	0.539
LIG_TRAF2_1	19	22	PF00917	0.434
LIG_TRAF2_1	487	490	PF00917	0.332
LIG_TRFH_1	647	651	PF08558	0.337
LIG_TYR_ITIM	125	130	PF00017	0.334
LIG_WRC_WIRS_1	290	295	PF05994	0.234
LIG_WRC_WIRS_1	644	649	PF05994	0.429
MOD_CDC14_SPxK_1	98	101	PF00782	0.477
MOD_CDK_SPK_2	95	100	PF00069	0.473
MOD_CDK_SPxK_1	95	101	PF00069	0.475
MOD_CDK_SPxxK_3	600	607	PF00069	0.477
MOD_CK1_1	209	215	PF00069	0.163
MOD_CK1_1	326	332	PF00069	0.356
MOD_CK1_1	364	370	PF00069	0.252
MOD_CK1_1	455	461	PF00069	0.370
MOD_CK1_1	467	473	PF00069	0.459
MOD_CK1_1	50	56	PF00069	0.336
MOD_CK1_1	503	509	PF00069	0.271
MOD_CK1_1	653	659	PF00069	0.352
MOD_CK1_1	80	86	PF00069	0.700
MOD_CK2_1	105	111	PF00069	0.575
MOD_CK2_1	125	131	PF00069	0.521
MOD_CK2_1	15	21	PF00069	0.526
MOD_CK2_1	160	166	PF00069	0.547
MOD_CK2_1	209	215	PF00069	0.226
MOD_CK2_1	266	272	PF00069	0.408
MOD_CK2_1	289	295	PF00069	0.278
MOD_CK2_1	319	325	PF00069	0.441
MOD_CK2_1	484	490	PF00069	0.429
MOD_CK2_1	513	519	PF00069	0.289
MOD_CK2_1	53	59	PF00069	0.446
MOD_CK2_1	605	611	PF00069	0.351
MOD_CK2_1	629	635	PF00069	0.622
MOD_CK2_1	672	678	PF00069	0.701
MOD_GlcNHglycan	120	124	PF01048	0.691
MOD_GlcNHglycan	317	320	PF01048	0.251
MOD_GlcNHglycan	321	324	PF01048	0.420
MOD_GlcNHglycan	625	628	PF01048	0.689
MOD_GlcNHglycan	674	677	PF01048	0.703
MOD_GlcNHglycan	78	82	PF01048	0.689
MOD_GlcNHglycan	87	91	PF01048	0.641
MOD_GSK3_1	105	112	PF00069	0.554
MOD_GSK3_1	315	322	PF00069	0.248
MOD_GSK3_1	360	367	PF00069	0.289
MOD_GSK3_1	4	11	PF00069	0.292
MOD_GSK3_1	463	470	PF00069	0.405
MOD_GSK3_1	541	548	PF00069	0.440
MOD_GSK3_1	618	625	PF00069	0.574
MOD_GSK3_1	650	657	PF00069	0.396
MOD_GSK3_1	82	89	PF00069	0.660
MOD_LATS_1	240	246	PF00433	0.403
MOD_NEK2_1	179	184	PF00069	0.452
MOD_NEK2_1	241	246	PF00069	0.313
MOD_NEK2_1	360	365	PF00069	0.395
MOD_NEK2_1	463	468	PF00069	0.392
MOD_NEK2_1	484	489	PF00069	0.332
MOD_NEK2_1	577	582	PF00069	0.387
MOD_NEK2_1	77	82	PF00069	0.630
MOD_NEK2_1	9	14	PF00069	0.423
MOD_NEK2_2	47	52	PF00069	0.342
MOD_PIKK_1	4	10	PF00454	0.505
MOD_PK_1	20	26	PF00069	0.475
MOD_PKA_1	15	21	PF00069	0.438
MOD_PKA_1	206	212	PF00069	0.649
MOD_PKA_1	512	518	PF00069	0.403
MOD_PKA_2	15	21	PF00069	0.535
MOD_PKA_2	206	212	PF00069	0.533
MOD_PKA_2	266	272	PF00069	0.368
MOD_PKA_2	467	473	PF00069	0.395
MOD_PKA_2	512	518	PF00069	0.338
MOD_PKB_1	206	214	PF00069	0.541
MOD_Plk_1	109	115	PF00069	0.489
MOD_Plk_1	20	26	PF00069	0.446
MOD_Plk_1	267	273	PF00069	0.365
MOD_Plk_1	326	332	PF00069	0.332
MOD_Plk_1	484	490	PF00069	0.395
MOD_Plk_1	589	595	PF00069	0.338
MOD_Plk_2-3	674	680	PF00069	0.674
MOD_Plk_4	190	196	PF00069	0.504
MOD_Plk_4	361	367	PF00069	0.300
MOD_Plk_4	455	461	PF00069	0.311
MOD_Plk_4	50	56	PF00069	0.358
MOD_Plk_4	654	660	PF00069	0.374
MOD_Plk_4	9	15	PF00069	0.441
MOD_ProDKin_1	497	503	PF00069	0.443
MOD_ProDKin_1	600	606	PF00069	0.480
MOD_ProDKin_1	618	624	PF00069	0.598
MOD_ProDKin_1	95	101	PF00069	0.581
TRG_DiLeu_BaEn_1	381	386	PF01217	0.327
TRG_DiLeu_BaEn_1	478	483	PF01217	0.403
TRG_DiLeu_BaEn_1	567	572	PF01217	0.387
TRG_DiLeu_BaEn_4	295	301	PF01217	0.395
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.517
TRG_DiLeu_LyEn_5	381	386	PF01217	0.316
TRG_ENDOCYTIC_2	127	130	PF00928	0.322
TRG_ENDOCYTIC_2	218	221	PF00928	0.355
TRG_ENDOCYTIC_2	55	58	PF00928	0.329
TRG_ENDOCYTIC_2	552	555	PF00928	0.343
TRG_ENDOCYTIC_2	581	584	PF00928	0.277
TRG_ER_diArg_1	14	16	PF00400	0.570
TRG_ER_diArg_1	206	208	PF00400	0.542
TRG_ER_diArg_1	28	30	PF00400	0.432
TRG_ER_diArg_1	511	513	PF00400	0.387
TRG_NES_CRM1_1	373	388	PF08389	0.332
TRG_NLS_Bipartite_1	15	31	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P912	Leptomonas seymouri	60%	95%
A0A1X0NMC1	Trypanosomatidae	38%	94%
A0A3Q8IJ87	Leishmania donovani	91%	100%
A0A422NSE9	Trypanosoma rangeli	42%	100%
A4HQ91	Leishmania braziliensis	75%	100%
A4IDY9	Leishmania infantum	91%	100%
D0A420	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
O74343	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q08647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q08DI8	Bos taurus	27%	100%
Q17426	Caenorhabditis elegans	26%	100%
Q4Q0I6	Leishmania major	90%	100%
Q5V1E6	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	24%	100%
Q8CE46	Mus musculus	28%	97%
Q91VU7	Mus musculus	28%	100%
Q96PZ0	Homo sapiens	27%	100%
Q9VSK9	Drosophila melanogaster	28%	93%
V5BT95	Trypanosoma cruzi	43%	92%