Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU08_LEIMU

TriTrypDb:

LmxM.36.5740

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.584
CLV_C14_Caspase3-7	462	466	PF00656	0.660
CLV_NRD_NRD_1	102	104	PF00675	0.792
CLV_NRD_NRD_1	108	110	PF00675	0.733
CLV_NRD_NRD_1	111	113	PF00675	0.692
CLV_NRD_NRD_1	118	120	PF00675	0.597
CLV_NRD_NRD_1	123	125	PF00675	0.529
CLV_NRD_NRD_1	219	221	PF00675	0.637
CLV_PCSK_FUR_1	109	113	PF00082	0.730
CLV_PCSK_KEX2_1	102	104	PF00082	0.792
CLV_PCSK_KEX2_1	108	110	PF00082	0.712
CLV_PCSK_KEX2_1	111	113	PF00082	0.670
CLV_PCSK_KEX2_1	118	120	PF00082	0.576
CLV_PCSK_KEX2_1	123	125	PF00082	0.742
CLV_PCSK_KEX2_1	200	202	PF00082	0.741
CLV_PCSK_KEX2_1	219	221	PF00082	0.598
CLV_PCSK_KEX2_1	359	361	PF00082	0.703
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.741
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.838
CLV_PCSK_PC7_1	119	125	PF00082	0.553
CLV_PCSK_SKI1_1	259	263	PF00082	0.681
CLV_PCSK_SKI1_1	73	77	PF00082	0.674
CLV_Separin_Metazoa	16	20	PF03568	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.590
DEG_SCF_FBW7_1	250	255	PF00400	0.565
DEG_SCF_FBW7_2	226	233	PF00400	0.571
DEG_SPOP_SBC_1	152	156	PF00917	0.562
DEG_SPOP_SBC_1	175	179	PF00917	0.688
DEG_SPOP_SBC_1	413	417	PF00917	0.560
DEG_SPOP_SBC_1	454	458	PF00917	0.823
DEG_SPOP_SBC_1	551	555	PF00917	0.752
DOC_CKS1_1	498	503	PF01111	0.538
DOC_CKS1_1	660	665	PF01111	0.489
DOC_CYCLIN_yClb5_NLxxxL_5	535	542	PF00134	0.758
DOC_PP4_FxxP_1	182	185	PF00568	0.572
DOC_PP4_FxxP_1	562	565	PF00568	0.815
DOC_USP7_MATH_1	125	129	PF00917	0.674
DOC_USP7_MATH_1	136	140	PF00917	0.595
DOC_USP7_MATH_1	152	156	PF00917	0.676
DOC_USP7_MATH_1	175	179	PF00917	0.848
DOC_USP7_MATH_1	245	249	PF00917	0.846
DOC_USP7_MATH_1	261	265	PF00917	0.589
DOC_USP7_MATH_1	279	283	PF00917	0.622
DOC_USP7_MATH_1	301	305	PF00917	0.673
DOC_USP7_MATH_1	389	393	PF00917	0.631
DOC_USP7_MATH_1	421	425	PF00917	0.777
DOC_USP7_MATH_1	505	509	PF00917	0.687
DOC_USP7_MATH_1	513	517	PF00917	0.670
DOC_USP7_MATH_1	544	548	PF00917	0.817
DOC_USP7_MATH_1	551	555	PF00917	0.752
DOC_USP7_MATH_1	608	612	PF00917	0.790
DOC_USP7_MATH_1	637	641	PF00917	0.707
DOC_WW_Pin1_4	176	181	PF00397	0.840
DOC_WW_Pin1_4	184	189	PF00397	0.729
DOC_WW_Pin1_4	226	231	PF00397	0.634
DOC_WW_Pin1_4	241	246	PF00397	0.781
DOC_WW_Pin1_4	248	253	PF00397	0.686
DOC_WW_Pin1_4	280	285	PF00397	0.801
DOC_WW_Pin1_4	296	301	PF00397	0.627
DOC_WW_Pin1_4	339	344	PF00397	0.789
DOC_WW_Pin1_4	351	356	PF00397	0.740
DOC_WW_Pin1_4	393	398	PF00397	0.813
DOC_WW_Pin1_4	415	420	PF00397	0.846
DOC_WW_Pin1_4	442	447	PF00397	0.768
DOC_WW_Pin1_4	450	455	PF00397	0.686
DOC_WW_Pin1_4	476	481	PF00397	0.796
DOC_WW_Pin1_4	497	502	PF00397	0.620
DOC_WW_Pin1_4	601	606	PF00397	0.751
DOC_WW_Pin1_4	624	629	PF00397	0.596
DOC_WW_Pin1_4	633	638	PF00397	0.705
DOC_WW_Pin1_4	659	664	PF00397	0.744
DOC_WW_Pin1_4	668	673	PF00397	0.687
LIG_14-3-3_CanoR_1	109	117	PF00244	0.585
LIG_14-3-3_CanoR_1	131	138	PF00244	0.701
LIG_14-3-3_CanoR_1	145	153	PF00244	0.728
LIG_14-3-3_CanoR_1	176	180	PF00244	0.763
LIG_14-3-3_CanoR_1	219	228	PF00244	0.818
LIG_14-3-3_CanoR_1	26	34	PF00244	0.719
LIG_14-3-3_CanoR_1	360	364	PF00244	0.798
LIG_14-3-3_CanoR_1	411	421	PF00244	0.559
LIG_14-3-3_CanoR_1	490	496	PF00244	0.814
LIG_14-3-3_CanoR_1	599	605	PF00244	0.851
LIG_BIR_III_2	171	175	PF00653	0.564
LIG_BIR_III_2	634	638	PF00653	0.730
LIG_BRCT_BRCA1_1	178	182	PF00533	0.570
LIG_FHA_1	187	193	PF00498	0.780
LIG_FHA_1	260	266	PF00498	0.564
LIG_FHA_1	363	369	PF00498	0.630
LIG_FHA_1	439	445	PF00498	0.673
LIG_FHA_1	660	666	PF00498	0.491
LIG_FHA_2	229	235	PF00498	0.805
LIG_FHA_2	237	243	PF00498	0.686
LIG_FHA_2	348	354	PF00498	0.559
LIG_FHA_2	455	461	PF00498	0.863
LIG_LIR_Apic_2	179	185	PF02991	0.572
LIG_LIR_Apic_2	333	339	PF02991	0.541
LIG_LIR_Apic_2	392	397	PF02991	0.802
LIG_LIR_Apic_2	561	565	PF02991	0.686
LIG_LIR_Nem_3	577	583	PF02991	0.826
LIG_LIR_Nem_3	70	75	PF02991	0.682
LIG_LYPXL_SIV_4	616	624	PF13949	0.741
LIG_PCNA_yPIPBox_3	470	482	PF02747	0.726
LIG_RPA_C_Plants	112	123	PF08784	0.542
LIG_SH2_CRK	336	340	PF00017	0.612
LIG_SH2_CRK	387	391	PF00017	0.801
LIG_SH2_CRK	394	398	PF00017	0.700
LIG_SH2_NCK_1	336	340	PF00017	0.539
LIG_SH2_NCK_1	394	398	PF00017	0.719
LIG_SH2_NCK_1	617	621	PF00017	0.642
LIG_SH2_STAP1	583	587	PF00017	0.846
LIG_SH2_STAT3	609	612	PF00017	0.778
LIG_SH2_STAT3	622	625	PF00017	0.660
LIG_SH3_3	182	188	PF00018	0.574
LIG_SH3_3	278	284	PF00018	0.763
LIG_SH3_3	422	428	PF00018	0.564
LIG_SH3_3	602	608	PF00018	0.838
LIG_SUMO_SIM_par_1	491	497	PF11976	0.819
LIG_TRAF2_1	231	234	PF00917	0.873
LIG_TRAF2_1	239	242	PF00917	0.575
LIG_TRAF2_1	317	320	PF00917	0.837
LIG_TRAF2_1	457	460	PF00917	0.746
MOD_CDC14_SPxK_1	244	247	PF00782	0.607
MOD_CDC14_SPxK_1	283	286	PF00782	0.558
MOD_CDC14_SPxK_1	479	482	PF00782	0.723
MOD_CDK_SPK_2	280	285	PF00069	0.764
MOD_CDK_SPK_2	450	455	PF00069	0.574
MOD_CDK_SPxK_1	226	232	PF00069	0.570
MOD_CDK_SPxK_1	241	247	PF00069	0.783
MOD_CDK_SPxK_1	280	286	PF00069	0.766
MOD_CDK_SPxK_1	476	482	PF00069	0.800
MOD_CDK_SPxxK_3	280	287	PF00069	0.766
MOD_CDK_SPxxK_3	624	631	PF00069	0.542
MOD_CDK_SPxxK_3	659	666	PF00069	0.704
MOD_CK1_1	127	133	PF00069	0.688
MOD_CK1_1	143	149	PF00069	0.611
MOD_CK1_1	165	171	PF00069	0.635
MOD_CK1_1	178	184	PF00069	0.849
MOD_CK1_1	186	192	PF00069	0.702
MOD_CK1_1	222	228	PF00069	0.594
MOD_CK1_1	248	254	PF00069	0.718
MOD_CK1_1	260	266	PF00069	0.793
MOD_CK1_1	306	312	PF00069	0.668
MOD_CK1_1	354	360	PF00069	0.657
MOD_CK1_1	362	368	PF00069	0.718
MOD_CK1_1	372	378	PF00069	0.533
MOD_CK1_1	392	398	PF00069	0.481
MOD_CK1_1	417	423	PF00069	0.768
MOD_CK1_1	442	448	PF00069	0.846
MOD_CK1_1	453	459	PF00069	0.685
MOD_CK1_1	494	500	PF00069	0.832
MOD_CK1_1	516	522	PF00069	0.589
MOD_CK1_1	531	537	PF00069	0.663
MOD_CK1_1	547	553	PF00069	0.710
MOD_CK1_1	554	560	PF00069	0.819
MOD_CK1_1	586	592	PF00069	0.833
MOD_CK1_1	601	607	PF00069	0.612
MOD_CK1_1	618	624	PF00069	0.622
MOD_CK1_1	633	639	PF00069	0.594
MOD_CK1_1	664	670	PF00069	0.796
MOD_CK2_1	228	234	PF00069	0.842
MOD_CK2_1	236	242	PF00069	0.707
MOD_CK2_1	314	320	PF00069	0.816
MOD_CK2_1	347	353	PF00069	0.557
MOD_CK2_1	40	46	PF00069	0.535
MOD_CK2_1	453	459	PF00069	0.858
MOD_CK2_1	68	74	PF00069	0.522
MOD_GlcNHglycan	13	16	PF01048	0.634
MOD_GlcNHglycan	203	206	PF01048	0.794
MOD_GlcNHglycan	259	262	PF01048	0.708
MOD_GlcNHglycan	387	390	PF01048	0.622
MOD_GlcNHglycan	391	394	PF01048	0.595
MOD_GlcNHglycan	441	444	PF01048	0.657
MOD_GlcNHglycan	530	533	PF01048	0.656
MOD_GlcNHglycan	548	552	PF01048	0.619
MOD_GlcNHglycan	58	61	PF01048	0.790
MOD_GlcNHglycan	585	588	PF01048	0.793
MOD_GlcNHglycan	647	650	PF01048	0.711
MOD_GSK3_1	125	132	PF00069	0.713
MOD_GSK3_1	136	143	PF00069	0.633
MOD_GSK3_1	147	154	PF00069	0.674
MOD_GSK3_1	161	168	PF00069	0.618
MOD_GSK3_1	174	181	PF00069	0.860
MOD_GSK3_1	222	229	PF00069	0.701
MOD_GSK3_1	241	248	PF00069	0.780
MOD_GSK3_1	253	260	PF00069	0.822
MOD_GSK3_1	261	268	PF00069	0.721
MOD_GSK3_1	301	308	PF00069	0.729
MOD_GSK3_1	330	337	PF00069	0.737
MOD_GSK3_1	347	354	PF00069	0.610
MOD_GSK3_1	35	42	PF00069	0.523
MOD_GSK3_1	369	376	PF00069	0.560
MOD_GSK3_1	385	392	PF00069	0.638
MOD_GSK3_1	393	400	PF00069	0.685
MOD_GSK3_1	413	420	PF00069	0.518
MOD_GSK3_1	438	445	PF00069	0.746
MOD_GSK3_1	449	456	PF00069	0.859
MOD_GSK3_1	499	506	PF00069	0.764
MOD_GSK3_1	51	58	PF00069	0.807
MOD_GSK3_1	546	553	PF00069	0.768
MOD_GSK3_1	563	570	PF00069	0.656
MOD_GSK3_1	581	588	PF00069	0.685
MOD_GSK3_1	620	627	PF00069	0.810
MOD_GSK3_1	633	640	PF00069	0.577
MOD_GSK3_1	664	671	PF00069	0.794
MOD_LATS_1	574	580	PF00433	0.819
MOD_N-GLC_1	248	253	PF02516	0.565
MOD_N-GLC_1	385	390	PF02516	0.796
MOD_N-GLC_1	581	586	PF02516	0.742
MOD_N-GLC_1	637	642	PF02516	0.751
MOD_NEK2_1	253	258	PF00069	0.709
MOD_NEK2_1	265	270	PF00069	0.849
MOD_NEK2_1	439	444	PF00069	0.849
MOD_PIKK_1	138	144	PF00454	0.767
MOD_PIKK_1	25	31	PF00454	0.690
MOD_PIKK_1	253	259	PF00454	0.664
MOD_PIKK_1	427	433	PF00454	0.747
MOD_PIKK_1	586	592	PF00454	0.844
MOD_PIKK_1	608	614	PF00454	0.777
MOD_PK_1	359	365	PF00069	0.545
MOD_PKA_1	111	117	PF00069	0.638
MOD_PKA_1	118	124	PF00069	0.584
MOD_PKA_1	219	225	PF00069	0.638
MOD_PKA_1	359	365	PF00069	0.837
MOD_PKA_2	110	116	PF00069	0.645
MOD_PKA_2	118	124	PF00069	0.582
MOD_PKA_2	130	136	PF00069	0.559
MOD_PKA_2	144	150	PF00069	0.744
MOD_PKA_2	175	181	PF00069	0.687
MOD_PKA_2	219	225	PF00069	0.837
MOD_PKA_2	25	31	PF00069	0.676
MOD_PKA_2	359	365	PF00069	0.717
MOD_PKA_2	369	375	PF00069	0.802
MOD_PKA_2	454	460	PF00069	0.574
MOD_PKA_2	528	534	PF00069	0.532
MOD_PKA_2	567	573	PF00069	0.768
MOD_PKA_2	575	581	PF00069	0.700
MOD_PKA_2	598	604	PF00069	0.859
MOD_PKA_2	630	636	PF00069	0.649
MOD_PKB_1	109	117	PF00069	0.666
MOD_Plk_1	147	153	PF00069	0.658
MOD_Plk_1	222	228	PF00069	0.601
MOD_Plk_1	385	391	PF00069	0.798
MOD_Plk_1	576	582	PF00069	0.666
MOD_Plk_1	637	643	PF00069	0.537
MOD_Plk_2-3	459	465	PF00069	0.670
MOD_Plk_4	210	216	PF00069	0.783
MOD_Plk_4	373	379	PF00069	0.807
MOD_ProDKin_1	176	182	PF00069	0.841
MOD_ProDKin_1	184	190	PF00069	0.726
MOD_ProDKin_1	226	232	PF00069	0.635
MOD_ProDKin_1	241	247	PF00069	0.783
MOD_ProDKin_1	248	254	PF00069	0.684
MOD_ProDKin_1	280	286	PF00069	0.803
MOD_ProDKin_1	296	302	PF00069	0.626
MOD_ProDKin_1	339	345	PF00069	0.789
MOD_ProDKin_1	351	357	PF00069	0.741
MOD_ProDKin_1	393	399	PF00069	0.816
MOD_ProDKin_1	415	421	PF00069	0.846
MOD_ProDKin_1	442	448	PF00069	0.768
MOD_ProDKin_1	450	456	PF00069	0.686
MOD_ProDKin_1	476	482	PF00069	0.800
MOD_ProDKin_1	497	503	PF00069	0.617
MOD_ProDKin_1	601	607	PF00069	0.751
MOD_ProDKin_1	624	630	PF00069	0.599
MOD_ProDKin_1	633	639	PF00069	0.703
MOD_ProDKin_1	659	665	PF00069	0.745
MOD_ProDKin_1	668	674	PF00069	0.684
MOD_SUMO_rev_2	58	68	PF00179	0.462
TRG_ENDOCYTIC_2	2	5	PF00928	0.667
TRG_ENDOCYTIC_2	387	390	PF00928	0.797
TRG_ENDOCYTIC_2	72	75	PF00928	0.681
TRG_ER_diArg_1	108	111	PF00400	0.722
TRG_ER_diArg_1	117	119	PF00400	0.642
TRG_ER_diArg_1	18	21	PF00400	0.650
TRG_ER_FFAT_2	178	187	PF00635	0.572
TRG_NES_CRM1_1	74	87	PF08389	0.606
TRG_NLS_MonoExtN_4	284	289	PF00514	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBV2	Leishmania donovani	72%	93%
A4HQ90	Leishmania braziliensis	49%	100%
A4IDY8	Leishmania infantum	72%	93%
Q4Q0I7	Leishmania major	71%	100%