RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU07_LEIMU

TriTrypDb:

LmxM.36.5730

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.408
CLV_NRD_NRD_1	23	25	PF00675	0.453
CLV_NRD_NRD_1	240	242	PF00675	0.472
CLV_NRD_NRD_1	437	439	PF00675	0.436
CLV_NRD_NRD_1	635	637	PF00675	0.414
CLV_PCSK_KEX2_1	23	25	PF00082	0.428
CLV_PCSK_KEX2_1	382	384	PF00082	0.595
CLV_PCSK_KEX2_1	437	439	PF00082	0.436
CLV_PCSK_KEX2_1	635	637	PF00082	0.417
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.527
CLV_PCSK_PC7_1	378	384	PF00082	0.527
CLV_PCSK_SKI1_1	234	238	PF00082	0.336
CLV_PCSK_SKI1_1	429	433	PF00082	0.419
CLV_PCSK_SKI1_1	606	610	PF00082	0.581
CLV_PCSK_SKI1_1	626	630	PF00082	0.405
DEG_APCC_DBOX_1	233	241	PF00400	0.330
DEG_APCC_DBOX_1	38	46	PF00400	0.466
DEG_APCC_DBOX_1	625	633	PF00400	0.402
DOC_CDC14_PxL_1	512	520	PF14671	0.573
DOC_CYCLIN_RxL_1	123	131	PF00134	0.518
DOC_CYCLIN_RxL_1	536	545	PF00134	0.466
DOC_CYCLIN_RxL_1	659	669	PF00134	0.385
DOC_MAPK_DCC_7	39	47	PF00069	0.497
DOC_MAPK_FxFP_2	202	205	PF00069	0.508
DOC_MAPK_gen_1	23	30	PF00069	0.506
DOC_MAPK_JIP1_4	181	187	PF00069	0.419
DOC_MAPK_MEF2A_6	322	330	PF00069	0.348
DOC_MAPK_MEF2A_6	39	47	PF00069	0.501
DOC_PP1_RVXF_1	660	667	PF00149	0.429
DOC_PP2B_LxvP_1	350	353	PF13499	0.471
DOC_PP4_FxxP_1	202	205	PF00568	0.508
DOC_USP7_MATH_1	134	138	PF00917	0.664
DOC_USP7_MATH_1	144	148	PF00917	0.577
DOC_USP7_MATH_1	363	367	PF00917	0.704
DOC_USP7_MATH_1	369	373	PF00917	0.691
DOC_USP7_UBL2_3	470	474	PF12436	0.276
DOC_WW_Pin1_4	359	364	PF00397	0.595
DOC_WW_Pin1_4	365	370	PF00397	0.596
DOC_WW_Pin1_4	385	390	PF00397	0.643
LIG_14-3-3_CanoR_1	146	153	PF00244	0.554
LIG_14-3-3_CanoR_1	181	186	PF00244	0.381
LIG_14-3-3_CanoR_1	234	243	PF00244	0.406
LIG_14-3-3_CanoR_1	340	346	PF00244	0.506
LIG_14-3-3_CanoR_1	393	398	PF00244	0.463
LIG_14-3-3_CanoR_1	442	451	PF00244	0.472
LIG_14-3-3_CanoR_1	530	536	PF00244	0.464
LIG_14-3-3_CanoR_1	553	557	PF00244	0.674
LIG_14-3-3_CanoR_1	569	575	PF00244	0.577
LIG_14-3-3_CanoR_1	64	70	PF00244	0.297
LIG_Actin_WH2_2	540	555	PF00022	0.576
LIG_Actin_WH2_2	56	73	PF00022	0.454
LIG_CtBP_PxDLS_1	464	468	PF00389	0.533
LIG_EH1_1	495	503	PF00400	0.403
LIG_eIF4E_1	496	502	PF01652	0.454
LIG_FHA_1	115	121	PF00498	0.278
LIG_FHA_1	152	158	PF00498	0.564
LIG_FHA_1	182	188	PF00498	0.359
LIG_FHA_1	192	198	PF00498	0.312
LIG_FHA_1	476	482	PF00498	0.370
LIG_FHA_1	542	548	PF00498	0.431
LIG_FHA_1	562	568	PF00498	0.305
LIG_FHA_2	442	448	PF00498	0.496
LIG_FHA_2	598	604	PF00498	0.452
LIG_LIR_Apic_2	401	407	PF02991	0.508
LIG_LIR_Gen_1	531	540	PF02991	0.499
LIG_LIR_Nem_3	531	535	PF02991	0.503
LIG_NRBOX	109	115	PF00104	0.375
LIG_NRBOX	607	613	PF00104	0.564
LIG_Pex14_1	633	637	PF04695	0.457
LIG_PTAP_UEV_1	152	157	PF05743	0.403
LIG_PTB_Apo_2	340	347	PF02174	0.497
LIG_RPA_C_Fungi	10	22	PF08784	0.397
LIG_SH2_CRK	404	408	PF00017	0.418
LIG_SH2_CRK	503	507	PF00017	0.505
LIG_SH2_NCK_1	404	408	PF00017	0.418
LIG_SH2_PTP2	411	414	PF00017	0.427
LIG_SH2_SRC	411	414	PF00017	0.433
LIG_SH2_SRC	95	98	PF00017	0.397
LIG_SH2_STAP1	263	267	PF00017	0.338
LIG_SH2_STAP1	637	641	PF00017	0.407
LIG_SH2_STAT3	637	640	PF00017	0.282
LIG_SH2_STAT5	293	296	PF00017	0.475
LIG_SH2_STAT5	404	407	PF00017	0.484
LIG_SH2_STAT5	411	414	PF00017	0.307
LIG_SH2_STAT5	496	499	PF00017	0.519
LIG_SH2_STAT5	503	506	PF00017	0.462
LIG_SH3_2	153	158	PF14604	0.381
LIG_SH3_3	150	156	PF00018	0.449
LIG_SH3_3	507	513	PF00018	0.437
LIG_SH3_3	554	560	PF00018	0.526
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.354
LIG_SUMO_SIM_par_1	126	131	PF11976	0.441
LIG_SUMO_SIM_par_1	183	189	PF11976	0.466
LIG_SUMO_SIM_par_1	538	545	PF11976	0.483
LIG_TRAF2_1	372	375	PF00917	0.486
LIG_TRAF2_1	578	581	PF00917	0.522
LIG_TRFH_1	404	408	PF08558	0.530
LIG_TYR_ITIM	501	506	PF00017	0.492
LIG_UBA3_1	236	242	PF00899	0.357
LIG_UBA3_1	604	609	PF00899	0.431
LIG_WRC_WIRS_1	160	165	PF05994	0.361
MOD_CDK_SPK_2	385	390	PF00069	0.572
MOD_CK1_1	142	148	PF00069	0.656
MOD_CK1_1	186	192	PF00069	0.376
MOD_CK1_1	367	373	PF00069	0.796
MOD_CK1_1	402	408	PF00069	0.630
MOD_CK1_1	53	59	PF00069	0.369
MOD_CK1_1	561	567	PF00069	0.382
MOD_CK1_1	65	71	PF00069	0.292
MOD_CK2_1	186	192	PF00069	0.381
MOD_CK2_1	306	312	PF00069	0.423
MOD_CK2_1	369	375	PF00069	0.578
MOD_CK2_1	441	447	PF00069	0.449
MOD_CK2_1	575	581	PF00069	0.639
MOD_Cter_Amidation	380	383	PF01082	0.525
MOD_GlcNHglycan	117	120	PF01048	0.358
MOD_GlcNHglycan	374	378	PF01048	0.720
MOD_GlcNHglycan	401	404	PF01048	0.377
MOD_GlcNHglycan	560	563	PF01048	0.606
MOD_GSK3_1	109	116	PF00069	0.348
MOD_GSK3_1	128	135	PF00069	0.450
MOD_GSK3_1	142	149	PF00069	0.607
MOD_GSK3_1	159	166	PF00069	0.448
MOD_GSK3_1	186	193	PF00069	0.344
MOD_GSK3_1	253	260	PF00069	0.446
MOD_GSK3_1	359	366	PF00069	0.724
MOD_GSK3_1	369	376	PF00069	0.707
MOD_GSK3_1	429	436	PF00069	0.413
MOD_GSK3_1	46	53	PF00069	0.508
MOD_GSK3_1	561	568	PF00069	0.446
MOD_GSK3_1	575	582	PF00069	0.532
MOD_GSK3_1	593	600	PF00069	0.449
MOD_LATS_1	303	309	PF00433	0.362
MOD_N-GLC_1	245	250	PF02516	0.400
MOD_N-GLC_1	268	273	PF02516	0.445
MOD_N-GLC_1	399	404	PF02516	0.630
MOD_NEK2_1	113	118	PF00069	0.417
MOD_NEK2_1	128	133	PF00069	0.419
MOD_NEK2_1	163	168	PF00069	0.365
MOD_NEK2_1	190	195	PF00069	0.370
MOD_NEK2_1	236	241	PF00069	0.439
MOD_NEK2_1	257	262	PF00069	0.398
MOD_NEK2_1	306	311	PF00069	0.363
MOD_NEK2_1	373	378	PF00069	0.785
MOD_NEK2_1	399	404	PF00069	0.403
MOD_NEK2_1	528	533	PF00069	0.485
MOD_NEK2_1	552	557	PF00069	0.593
MOD_NEK2_1	604	609	PF00069	0.540
MOD_NEK2_1	614	619	PF00069	0.457
MOD_NEK2_1	62	67	PF00069	0.316
MOD_PIKK_1	274	280	PF00454	0.420
MOD_PIKK_1	281	287	PF00454	0.333
MOD_PIKK_1	367	373	PF00454	0.550
MOD_PIKK_1	50	56	PF00454	0.574
MOD_PK_1	477	483	PF00069	0.378
MOD_PKA_2	114	120	PF00069	0.328
MOD_PKA_2	145	151	PF00069	0.596
MOD_PKA_2	180	186	PF00069	0.433
MOD_PKA_2	433	439	PF00069	0.437
MOD_PKA_2	441	447	PF00069	0.431
MOD_PKA_2	552	558	PF00069	0.588
MOD_Plk_1	11	17	PF00069	0.367
MOD_Plk_1	475	481	PF00069	0.413
MOD_Plk_2-3	593	599	PF00069	0.410
MOD_Plk_4	109	115	PF00069	0.356
MOD_Plk_4	159	165	PF00069	0.469
MOD_Plk_4	183	189	PF00069	0.351
MOD_Plk_4	210	216	PF00069	0.409
MOD_Plk_4	306	312	PF00069	0.350
MOD_Plk_4	341	347	PF00069	0.260
MOD_Plk_4	65	71	PF00069	0.311
MOD_ProDKin_1	359	365	PF00069	0.594
MOD_ProDKin_1	385	391	PF00069	0.656
MOD_SUMO_for_1	473	476	PF00179	0.515
TRG_DiLeu_BaEn_1	109	114	PF01217	0.420
TRG_DiLeu_BaEn_1	33	38	PF01217	0.399
TRG_DiLeu_BaEn_1	447	452	PF01217	0.403
TRG_DiLeu_BaEn_1	659	664	PF01217	0.340
TRG_DiLeu_BaEn_4	580	586	PF01217	0.479
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.476
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.452
TRG_DiLeu_LyEn_5	659	664	PF01217	0.307
TRG_ENDOCYTIC_2	411	414	PF00928	0.372
TRG_ENDOCYTIC_2	428	431	PF00928	0.301
TRG_ENDOCYTIC_2	503	506	PF00928	0.495
TRG_ER_diArg_1	635	637	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS6	Leptomonas seymouri	65%	98%
A0A0S4IXA8	Bodo saltans	27%	94%
A0A1X0NNB6	Trypanosomatidae	43%	100%
A0A3Q8IHX9	Leishmania donovani	92%	100%
A4HQ89	Leishmania braziliensis	81%	100%
A4IDY7	Leishmania infantum	92%	100%
D0A422	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q0I8	Leishmania major	92%	100%
V5B3L6	Trypanosoma cruzi	42%	100%