Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU03_LEIMU

TriTrypDb:

LmxM.36.5690

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.454
CLV_C14_Caspase3-7	96	100	PF00656	0.621
CLV_NRD_NRD_1	291	293	PF00675	0.502
CLV_NRD_NRD_1	39	41	PF00675	0.641
CLV_PCSK_KEX2_1	215	217	PF00082	0.367
CLV_PCSK_KEX2_1	281	283	PF00082	0.574
CLV_PCSK_KEX2_1	39	41	PF00082	0.641
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.367
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.527
CLV_PCSK_PC7_1	211	217	PF00082	0.398
CLV_PCSK_SKI1_1	143	147	PF00082	0.345
CLV_PCSK_SKI1_1	292	296	PF00082	0.551
CLV_PCSK_SKI1_1	306	310	PF00082	0.497
CLV_PCSK_SKI1_1	85	89	PF00082	0.535
DEG_APCC_DBOX_1	38	46	PF00400	0.724
DEG_Nend_UBRbox_3	1	3	PF02207	0.645
DOC_CYCLIN_RxL_1	137	150	PF00134	0.357
DOC_MAPK_MEF2A_6	118	125	PF00069	0.515
DOC_PP2B_LxvP_1	246	249	PF13499	0.553
DOC_PP2B_LxvP_1	309	312	PF13499	0.570
DOC_PP4_FxxP_1	286	289	PF00568	0.557
DOC_PP4_FxxP_1	295	298	PF00568	0.600
DOC_USP7_MATH_1	18	22	PF00917	0.616
DOC_USP7_MATH_1	233	237	PF00917	0.568
DOC_USP7_MATH_1	31	35	PF00917	0.550
DOC_USP7_UBL2_3	143	147	PF12436	0.478
DOC_USP7_UBL2_3	293	297	PF12436	0.543
DOC_USP7_UBL2_3	54	58	PF12436	0.497
LIG_14-3-3_CanoR_1	232	240	PF00244	0.612
LIG_14-3-3_CanoR_1	52	57	PF00244	0.495
LIG_APCC_ABBA_1	161	166	PF00400	0.531
LIG_FHA_1	105	111	PF00498	0.506
LIG_FHA_1	241	247	PF00498	0.483
LIG_FHA_1	278	284	PF00498	0.402
LIG_LIR_Apic_2	284	289	PF02991	0.560
LIG_LIR_Gen_1	150	157	PF02991	0.355
LIG_LIR_Gen_1	88	97	PF02991	0.620
LIG_LIR_Nem_3	173	178	PF02991	0.431
LIG_LIR_Nem_3	88	94	PF02991	0.505
LIG_Pex14_2	63	67	PF04695	0.494
LIG_SH2_CRK	53	57	PF00017	0.625
LIG_SH2_NCK_1	75	79	PF00017	0.612
LIG_SH2_SRC	178	181	PF00017	0.342
LIG_SH2_STAT5	103	106	PF00017	0.568
LIG_SH2_STAT5	178	181	PF00017	0.398
LIG_SH2_STAT5	285	288	PF00017	0.481
LIG_SH3_3	273	279	PF00018	0.452
LIG_SH3_3	309	315	PF00018	0.515
LIG_SH3_4	297	304	PF00018	0.377
LIG_SUMO_SIM_par_1	121	128	PF11976	0.455
MOD_CK1_1	21	27	PF00069	0.603
MOD_CK2_1	247	253	PF00069	0.500
MOD_GlcNHglycan	157	160	PF01048	0.422
MOD_GlcNHglycan	235	238	PF01048	0.586
MOD_GlcNHglycan	255	258	PF01048	0.322
MOD_GlcNHglycan	5	8	PF01048	0.411
MOD_GSK3_1	18	25	PF00069	0.608
MOD_GSK3_1	249	256	PF00069	0.591
MOD_GSK3_1	26	33	PF00069	0.593
MOD_GSK3_1	3	10	PF00069	0.520
MOD_LATS_1	50	56	PF00433	0.580
MOD_LATS_1	83	89	PF00433	0.497
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	155	160	PF00069	0.410
MOD_NEK2_1	240	245	PF00069	0.414
MOD_PK_1	247	253	PF00069	0.380
MOD_PKA_2	155	161	PF00069	0.429
MOD_Plk_1	217	223	PF00069	0.436
MOD_Plk_4	171	177	PF00069	0.395
MOD_Plk_4	23	29	PF00069	0.601
MOD_Plk_4	31	37	PF00069	0.534
MOD_Plk_4	52	58	PF00069	0.498
TRG_ENDOCYTIC_2	53	56	PF00928	0.627
TRG_ENDOCYTIC_2	75	78	PF00928	0.522
TRG_ER_diArg_1	289	292	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGJ4	Leptomonas seymouri	78%	99%
A0A0S4IS55	Bodo saltans	45%	100%
A0A1X0P0I2	Trypanosomatidae	58%	100%
A0A3R7M3K5	Trypanosoma rangeli	59%	100%
A0A3S7XBV5	Leishmania donovani	94%	100%
A4HQ85	Leishmania braziliensis	84%	100%
A4IDY3	Leishmania infantum	94%	100%
D0A426	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q4Q0J2	Leishmania major	93%	100%