Putative RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA helicase, putative

Species:

Leishmania mexicana

UniProt:

E9AU01_LEIMU

TriTrypDb:

LmxM.36.5670

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU01

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	7
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	536	540	PF00656	0.440
CLV_NRD_NRD_1	21	23	PF00675	0.287
CLV_NRD_NRD_1	279	281	PF00675	0.209
CLV_NRD_NRD_1	367	369	PF00675	0.470
CLV_NRD_NRD_1	505	507	PF00675	0.384
CLV_NRD_NRD_1	603	605	PF00675	0.476
CLV_NRD_NRD_1	613	615	PF00675	0.226
CLV_NRD_NRD_1	65	67	PF00675	0.230
CLV_NRD_NRD_1	655	657	PF00675	0.239
CLV_PCSK_KEX2_1	237	239	PF00082	0.213
CLV_PCSK_KEX2_1	367	369	PF00082	0.470
CLV_PCSK_KEX2_1	52	54	PF00082	0.302
CLV_PCSK_KEX2_1	568	570	PF00082	0.682
CLV_PCSK_KEX2_1	613	615	PF00082	0.240
CLV_PCSK_KEX2_1	65	67	PF00082	0.163
CLV_PCSK_KEX2_1	655	657	PF00082	0.187
CLV_PCSK_KEX2_1	671	673	PF00082	0.236
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.208
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.311
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.622
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.275
CLV_PCSK_SKI1_1	105	109	PF00082	0.249
CLV_PCSK_SKI1_1	237	241	PF00082	0.208
CLV_PCSK_SKI1_1	281	285	PF00082	0.232
CLV_PCSK_SKI1_1	468	472	PF00082	0.262
CLV_PCSK_SKI1_1	478	482	PF00082	0.370
CLV_PCSK_SKI1_1	518	522	PF00082	0.387
CLV_PCSK_SKI1_1	604	608	PF00082	0.395
CLV_PCSK_SKI1_1	613	617	PF00082	0.205
CLV_PCSK_SKI1_1	657	661	PF00082	0.216
CLV_PCSK_SKI1_1	672	676	PF00082	0.186
CLV_Separin_Metazoa	610	614	PF03568	0.298
DEG_APCC_DBOX_1	237	245	PF00400	0.456
DEG_APCC_DBOX_1	367	375	PF00400	0.301
DOC_CYCLIN_RxL_1	235	242	PF00134	0.456
DOC_CYCLIN_RxL_1	601	610	PF00134	0.287
DOC_MAPK_gen_1	152	160	PF00069	0.408
DOC_MAPK_gen_1	19	29	PF00069	0.469
DOC_MAPK_gen_1	367	374	PF00069	0.407
DOC_MAPK_gen_1	65	72	PF00069	0.418
DOC_MAPK_gen_1	655	663	PF00069	0.408
DOC_MAPK_gen_1	671	679	PF00069	0.408
DOC_MAPK_MEF2A_6	154	162	PF00069	0.411
DOC_MAPK_MEF2A_6	367	376	PF00069	0.316
DOC_MAPK_MEF2A_6	449	457	PF00069	0.433
DOC_MAPK_MEF2A_6	655	662	PF00069	0.408
DOC_PP1_RVXF_1	101	107	PF00149	0.450
DOC_PP1_RVXF_1	612	619	PF00149	0.511
DOC_USP7_MATH_1	13	17	PF00917	0.555
DOC_USP7_MATH_1	289	293	PF00917	0.436
DOC_USP7_MATH_1	456	460	PF00917	0.475
DOC_USP7_MATH_1	68	72	PF00917	0.403
DOC_USP7_UBL2_3	671	675	PF12436	0.475
DOC_WW_Pin1_4	2	7	PF00397	0.576
DOC_WW_Pin1_4	498	503	PF00397	0.406
LIG_14-3-3_CanoR_1	348	355	PF00244	0.365
LIG_14-3-3_CanoR_1	367	372	PF00244	0.350
LIG_14-3-3_CanoR_1	425	433	PF00244	0.439
LIG_14-3-3_CterR_2	694	697	PF00244	0.347
LIG_Actin_WH2_2	100	116	PF00022	0.432
LIG_Actin_WH2_2	135	150	PF00022	0.412
LIG_Actin_WH2_2	539	557	PF00022	0.532
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_2	687	691	PF00653	0.475
LIG_BRCT_BRCA1_1	466	470	PF00533	0.511
LIG_BRCT_BRCA1_1	648	652	PF00533	0.418
LIG_Clathr_ClatBox_1	269	273	PF01394	0.475
LIG_eIF4E_1	265	271	PF01652	0.511
LIG_FHA_1	106	112	PF00498	0.447
LIG_FHA_1	208	214	PF00498	0.405
LIG_FHA_1	36	42	PF00498	0.428
LIG_FHA_1	404	410	PF00498	0.456
LIG_FHA_1	458	464	PF00498	0.401
LIG_FHA_1	576	582	PF00498	0.624
LIG_FHA_1	601	607	PF00498	0.380
LIG_FHA_2	226	232	PF00498	0.408
LIG_FHA_2	320	326	PF00498	0.481
LIG_FHA_2	360	366	PF00498	0.341
LIG_FHA_2	464	470	PF00498	0.432
LIG_FXI_DFP_1	426	430	PF00024	0.218
LIG_LIR_Gen_1	170	180	PF02991	0.460
LIG_LIR_Gen_1	253	262	PF02991	0.411
LIG_LIR_Gen_1	390	399	PF02991	0.331
LIG_LIR_Nem_3	123	128	PF02991	0.437
LIG_LIR_Nem_3	141	147	PF02991	0.449
LIG_LIR_Nem_3	170	175	PF02991	0.466
LIG_LIR_Nem_3	253	257	PF02991	0.429
LIG_LIR_Nem_3	467	473	PF02991	0.399
LIG_LIR_Nem_3	493	498	PF02991	0.325
LIG_LIR_Nem_3	550	556	PF02991	0.439
LIG_LIR_Nem_3	583	588	PF02991	0.695
LIG_NRBOX	142	148	PF00104	0.408
LIG_Pex14_2	172	176	PF04695	0.285
LIG_PTB_Apo_2	620	627	PF02174	0.450
LIG_RPA_C_Fungi	444	456	PF08784	0.255
LIG_SH2_CRK	125	129	PF00017	0.243
LIG_SH2_CRK	634	638	PF00017	0.258
LIG_SH2_GRB2like	311	314	PF00017	0.388
LIG_SH2_SRC	203	206	PF00017	0.307
LIG_SH2_STAP1	265	269	PF00017	0.259
LIG_SH2_STAP1	350	354	PF00017	0.312
LIG_SH2_STAP1	90	94	PF00017	0.258
LIG_SH2_STAT3	265	268	PF00017	0.243
LIG_SH2_STAT5	203	206	PF00017	0.307
LIG_SH2_STAT5	300	303	PF00017	0.243
LIG_SH2_STAT5	350	353	PF00017	0.355
LIG_SH2_STAT5	44	47	PF00017	0.277
LIG_SH2_STAT5	498	501	PF00017	0.540
LIG_SH2_STAT5	553	556	PF00017	0.583
LIG_SH2_STAT5	620	623	PF00017	0.312
LIG_SH3_3	268	274	PF00018	0.295
LIG_SH3_3	3	9	PF00018	0.591
LIG_SH3_3	427	433	PF00018	0.245
LIG_SH3_5	199	203	PF00018	0.360
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.311
LIG_SUMO_SIM_anti_2	369	376	PF11976	0.303
LIG_SUMO_SIM_anti_2	404	411	PF11976	0.258
LIG_SUMO_SIM_anti_2	450	456	PF11976	0.388
LIG_SUMO_SIM_anti_2	676	683	PF11976	0.277
LIG_SUMO_SIM_par_1	26	33	PF11976	0.277
LIG_TRAF2_1	228	231	PF00917	0.258
LIG_TYR_ITIM	551	556	PF00017	0.442
LIG_UBA3_1	143	148	PF00899	0.243
LIG_UBA3_1	240	245	PF00899	0.311
LIG_UBA3_1	407	415	PF00899	0.404
MOD_CDK_SPK_2	498	503	PF00069	0.401
MOD_CK1_1	255	261	PF00069	0.415
MOD_CK1_1	35	41	PF00069	0.289
MOD_CK1_1	359	365	PF00069	0.411
MOD_CK1_1	370	376	PF00069	0.248
MOD_CK2_1	1	7	PF00069	0.527
MOD_CK2_1	225	231	PF00069	0.243
MOD_CK2_1	313	319	PF00069	0.257
MOD_CK2_1	359	365	PF00069	0.366
MOD_CK2_1	463	469	PF00069	0.277
MOD_CK2_1	529	535	PF00069	0.486
MOD_GlcNHglycan	163	166	PF01048	0.243
MOD_GlcNHglycan	303	306	PF01048	0.273
MOD_GlcNHglycan	315	318	PF01048	0.303
MOD_GlcNHglycan	34	37	PF01048	0.293
MOD_GlcNHglycan	483	486	PF01048	0.296
MOD_GlcNHglycan	573	576	PF01048	0.549
MOD_GSK3_1	189	196	PF00069	0.345
MOD_GSK3_1	32	39	PF00069	0.285
MOD_GSK3_1	366	373	PF00069	0.329
MOD_GSK3_1	509	516	PF00069	0.440
MOD_GSK3_1	525	532	PF00069	0.358
MOD_GSK3_1	571	578	PF00069	0.729
MOD_GSK3_1	593	600	PF00069	0.523
MOD_GSK3_1	646	653	PF00069	0.253
MOD_GSK3_1	662	669	PF00069	0.297
MOD_N-GLC_1	356	361	PF02516	0.461
MOD_N-GLC_1	99	104	PF02516	0.142
MOD_NEK2_1	1	6	PF00069	0.678
MOD_NEK2_1	146	151	PF00069	0.383
MOD_NEK2_1	163	168	PF00069	0.265
MOD_NEK2_1	463	468	PF00069	0.258
MOD_NEK2_1	481	486	PF00069	0.344
MOD_NEK2_1	94	99	PF00069	0.304
MOD_PIKK_1	329	335	PF00454	0.243
MOD_PIKK_1	36	42	PF00454	0.272
MOD_PIKK_1	525	531	PF00454	0.354
MOD_PIKK_1	59	65	PF00454	0.258
MOD_PK_1	675	681	PF00069	0.277
MOD_PKA_1	367	373	PF00069	0.453
MOD_PKA_2	13	19	PF00069	0.368
MOD_PKA_2	366	372	PF00069	0.348
MOD_PKA_2	424	430	PF00069	0.303
MOD_PKA_2	667	673	PF00069	0.258
MOD_PKB_1	152	160	PF00069	0.277
MOD_PKB_1	569	577	PF00069	0.448
MOD_Plk_1	134	140	PF00069	0.297
MOD_Plk_1	154	160	PF00069	0.167
MOD_Plk_1	252	258	PF00069	0.388
MOD_Plk_1	289	295	PF00069	0.243
MOD_Plk_1	359	365	PF00069	0.370
MOD_Plk_1	403	409	PF00069	0.288
MOD_Plk_1	560	566	PF00069	0.664
MOD_Plk_1	675	681	PF00069	0.247
MOD_Plk_1	99	105	PF00069	0.307
MOD_Plk_2-3	319	325	PF00069	0.277
MOD_Plk_2-3	535	541	PF00069	0.334
MOD_Plk_4	13	19	PF00069	0.368
MOD_Plk_4	189	195	PF00069	0.373
MOD_Plk_4	207	213	PF00069	0.289
MOD_Plk_4	255	261	PF00069	0.258
MOD_Plk_4	367	373	PF00069	0.346
MOD_Plk_4	403	409	PF00069	0.279
MOD_Plk_4	487	493	PF00069	0.300
MOD_Plk_4	529	535	PF00069	0.327
MOD_Plk_4	633	639	PF00069	0.258
MOD_Plk_4	646	652	PF00069	0.240
MOD_Plk_4	662	668	PF00069	0.208
MOD_Plk_4	675	681	PF00069	0.256
MOD_ProDKin_1	2	8	PF00069	0.558
MOD_ProDKin_1	498	504	PF00069	0.415
MOD_SUMO_for_1	401	404	PF00179	0.424
MOD_SUMO_for_1	521	524	PF00179	0.355
MOD_SUMO_rev_2	231	239	PF00179	0.243
MOD_SUMO_rev_2	467	473	PF00179	0.311
MOD_SUMO_rev_2	532	538	PF00179	0.257
TRG_DiLeu_BaEn_1	242	247	PF01217	0.388
TRG_DiLeu_BaEn_1	266	271	PF01217	0.388
TRG_DiLeu_BaEn_1	405	410	PF01217	0.252
TRG_ENDOCYTIC_2	125	128	PF00928	0.246
TRG_ENDOCYTIC_2	260	263	PF00928	0.246
TRG_ENDOCYTIC_2	553	556	PF00928	0.468
TRG_ENDOCYTIC_2	585	588	PF00928	0.615
TRG_ENDOCYTIC_2	634	637	PF00928	0.258
TRG_ER_diArg_1	366	368	PF00400	0.468
TRG_ER_diArg_1	395	398	PF00400	0.487
TRG_ER_diArg_1	612	614	PF00400	0.289
TRG_ER_diArg_1	64	66	PF00400	0.258
TRG_NLS_MonoCore_2	567	572	PF00514	0.598
TRG_NLS_MonoExtC_3	567	573	PF00514	0.541
TRG_NLS_MonoExtN_4	566	572	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V0	Leptomonas seymouri	37%	99%
A0A0N0P8Y1	Leptomonas seymouri	36%	90%
A0A0N0P9D2	Leptomonas seymouri	85%	98%
A0A0N1IKA7	Leptomonas seymouri	39%	77%
A0A0N1PEU4	Leptomonas seymouri	34%	73%
A0A0S4IQ76	Bodo saltans	37%	98%
A0A0S4IR78	Bodo saltans	39%	79%
A0A0S4IS51	Bodo saltans	61%	90%
A0A0S4IWU8	Bodo saltans	39%	82%
A0A0S4J157	Bodo saltans	42%	100%
A0A0S4JCY8	Bodo saltans	42%	68%
A0A1X0NJ46	Trypanosomatidae	36%	98%
A0A1X0P0D7	Trypanosomatidae	72%	99%
A0A1X0P872	Trypanosomatidae	35%	79%
A0A1X0P9K6	Trypanosomatidae	38%	97%
A0A3Q8II71	Leishmania donovani	32%	87%
A0A3Q8IJ24	Leishmania donovani	36%	74%
A0A3Q8IWG4	Leishmania donovani	95%	100%
A0A3R7MA90	Trypanosoma rangeli	37%	97%
A0A3R7MM88	Trypanosoma rangeli	69%	100%
A0A3R7NT42	Trypanosoma rangeli	34%	98%
A0A3S7X3U3	Leishmania donovani	30%	68%
A0A3S7X433	Leishmania donovani	26%	76%
A0A3S7X8Z5	Leishmania donovani	38%	99%
A0A422N8L3	Trypanosoma rangeli	38%	68%
A0A422NK53	Trypanosoma rangeli	34%	100%
A0A422P0V6	Trypanosoma rangeli	34%	86%
A4HAT8	Leishmania braziliensis	37%	100%
A4HIR4	Leishmania braziliensis	29%	68%
A4HME2	Leishmania braziliensis	37%	100%
A4HNU7	Leishmania braziliensis	36%	100%
A4HQ83	Leishmania braziliensis	90%	100%
A4I609	Leishmania infantum	30%	68%
A4I6B7	Leishmania infantum	26%	76%
A4IA06	Leishmania infantum	32%	86%
A4IB14	Leishmania infantum	38%	99%
A4ICP7	Leishmania infantum	36%	74%
A4IDY1	Leishmania infantum	95%	100%
C9ZMN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
C9ZNP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	95%
D0A2R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	79%
D0A429	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	92%
D0A778	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	67%
D4A2Z8	Rattus norvegicus	29%	70%
E9AEU3	Leishmania major	37%	100%
E9ASK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	68%
E9B1H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9B512	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	86%
E9B5Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
F4IE66	Arabidopsis thaliana	37%	97%
F4IJV4	Arabidopsis thaliana	47%	67%
F4JMJ3	Arabidopsis thaliana	43%	79%
F4JRJ6	Arabidopsis thaliana	42%	100%
O22243	Arabidopsis thaliana	29%	69%
O22899	Arabidopsis thaliana	45%	96%
O35286	Mus musculus	43%	88%
O42945	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	95%
O43143	Homo sapiens	38%	88%
O45244	Caenorhabditis elegans	45%	69%
O51767	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	34%	85%
O60231	Homo sapiens	45%	67%
P0C9A2	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	25%	72%
P0C9A3	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	25%	72%
P20095	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	80%
P36009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	95%
P53131	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	91%
Q03319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	97%
Q10752	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	66%
Q20875	Caenorhabditis elegans	42%	94%
Q3ZBE0	Bos taurus	28%	97%
Q4Q0J4	Leishmania major	95%	100%
Q4Q1Y9	Leishmania major	36%	100%
Q4Q2X4	Leishmania major	32%	100%
Q4Q6N9	Leishmania major	26%	100%
Q4Q6W4	Leishmania major	30%	68%
Q54NJ4	Dictyostelium discoideum	44%	96%
Q5R864	Pongo abelii	36%	89%
Q5RAZ4	Pongo abelii	38%	88%
Q5RBD4	Pongo abelii	39%	97%
Q5UQ96	Acanthamoeba polyphaga mimivirus	28%	100%
Q5XH12	Xenopus laevis	30%	93%
Q5XI69	Rattus norvegicus	36%	89%
Q6PE54	Mus musculus	36%	89%
Q767K6	Sus scrofa	45%	67%
Q7K3M5	Drosophila melanogaster	45%	96%
Q7L7V1	Homo sapiens	27%	94%
Q7YR39	Pan troglodytes	45%	67%
Q80VY9	Mus musculus	44%	100%
Q89443	African swine fever virus (strain Badajoz 1971 Vero-adapted)	26%	72%
Q8BZS9	Mus musculus	28%	94%
Q8IX18	Homo sapiens	36%	89%
Q8TE96	Homo sapiens	31%	97%
Q8VHK9	Mus musculus	28%	70%
Q8VY00	Arabidopsis thaliana	46%	67%
Q924H9	Mus musculus	27%	97%
Q93Y16	Arabidopsis thaliana	36%	100%
Q9BKQ8	Caenorhabditis elegans	35%	95%
Q9H5Z1	Homo sapiens	39%	99%
Q9H6R0	Homo sapiens	44%	99%
Q9HE06	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q9LZQ9	Arabidopsis thaliana	45%	96%
V5B3L7	Trypanosoma cruzi	69%	100%
V5BKH2	Trypanosoma cruzi	34%	91%
V5BPV3	Trypanosoma cruzi	37%	66%
V5BV22	Trypanosoma cruzi	37%	79%
V5C0I9	Trypanosoma cruzi	38%	89%
V5D886	Trypanosoma cruzi	36%	98%