DUF3456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATZ9_LEIMU

TriTrypDb:

LmxM.36.5650

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.571
CLV_C14_Caspase3-7	161	165	PF00656	0.548
CLV_C14_Caspase3-7	227	231	PF00656	0.535
CLV_NRD_NRD_1	122	124	PF00675	0.601
CLV_NRD_NRD_1	212	214	PF00675	0.606
CLV_NRD_NRD_1	268	270	PF00675	0.552
CLV_NRD_NRD_1	308	310	PF00675	0.716
CLV_NRD_NRD_1	318	320	PF00675	0.763
CLV_NRD_NRD_1	37	39	PF00675	0.679
CLV_NRD_NRD_1	79	81	PF00675	0.537
CLV_PCSK_FUR_1	316	320	PF00082	0.695
CLV_PCSK_KEX2_1	122	124	PF00082	0.703
CLV_PCSK_KEX2_1	268	270	PF00082	0.558
CLV_PCSK_KEX2_1	318	320	PF00082	0.742
CLV_PCSK_KEX2_1	74	76	PF00082	0.453
CLV_PCSK_KEX2_1	81	83	PF00082	0.490
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.501
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.579
CLV_PCSK_PC7_1	264	270	PF00082	0.634
CLV_PCSK_SKI1_1	174	178	PF00082	0.490
CLV_PCSK_SKI1_1	268	272	PF00082	0.590
DOC_CKS1_1	43	48	PF01111	0.516
DOC_CYCLIN_RxL_1	36	45	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.592
DOC_MAPK_gen_1	147	157	PF00069	0.536
DOC_MAPK_gen_1	213	219	PF00069	0.518
DOC_MAPK_gen_1	74	85	PF00069	0.479
DOC_MAPK_MEF2A_6	134	141	PF00069	0.617
DOC_PP4_FxxP_1	198	201	PF00568	0.514
DOC_WW_Pin1_4	129	134	PF00397	0.711
DOC_WW_Pin1_4	199	204	PF00397	0.467
DOC_WW_Pin1_4	2	7	PF00397	0.629
DOC_WW_Pin1_4	42	47	PF00397	0.534
LIG_14-3-3_CanoR_1	134	140	PF00244	0.578
LIG_14-3-3_CanoR_1	14	24	PF00244	0.619
LIG_Actin_WH2_2	212	228	PF00022	0.593
LIG_FHA_1	11	17	PF00498	0.657
LIG_FHA_1	152	158	PF00498	0.499
LIG_FHA_2	286	292	PF00498	0.635
LIG_FHA_2	297	303	PF00498	0.630
LIG_LIR_Apic_2	196	201	PF02991	0.569
LIG_LIR_Gen_1	192	203	PF02991	0.451
LIG_LIR_Gen_1	294	304	PF02991	0.539
LIG_LIR_Gen_1	61	69	PF02991	0.438
LIG_LIR_Nem_3	192	198	PF02991	0.573
LIG_LIR_Nem_3	294	300	PF02991	0.536
LIG_LIR_Nem_3	45	50	PF02991	0.490
LIG_LIR_Nem_3	61	65	PF02991	0.332
LIG_LYPXL_yS_3	47	50	PF13949	0.553
LIG_PDZ_Class_3	324	329	PF00595	0.739
LIG_PTAP_UEV_1	319	324	PF05743	0.703
LIG_PTB_Apo_2	63	70	PF02174	0.449
LIG_PTB_Phospho_1	63	69	PF10480	0.446
LIG_SH3_3	317	323	PF00018	0.699
LIG_SH3_3	43	49	PF00018	0.563
LIG_SH3_3	9	15	PF00018	0.657
LIG_SUMO_SIM_anti_2	153	161	PF11976	0.532
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.556
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.455
LIG_TYR_ITSM	43	50	PF00017	0.508
LIG_WRC_WIRS_1	195	200	PF05994	0.488
LIG_WRC_WIRS_1	59	64	PF05994	0.444
MOD_CDK_SPK_2	129	134	PF00069	0.631
MOD_CK1_1	321	327	PF00069	0.781
MOD_CK1_1	5	11	PF00069	0.683
MOD_CK2_1	260	266	PF00069	0.550
MOD_CK2_1	290	296	PF00069	0.557
MOD_GlcNHglycan	164	167	PF01048	0.513
MOD_GlcNHglycan	257	260	PF01048	0.668
MOD_GlcNHglycan	320	323	PF01048	0.728
MOD_GlcNHglycan	35	38	PF01048	0.570
MOD_N-GLC_1	183	188	PF02516	0.520
MOD_N-GLC_2	96	98	PF02516	0.517
MOD_NEK2_1	16	21	PF00069	0.534
MOD_NEK2_1	215	220	PF00069	0.521
MOD_PKA_1	318	324	PF00069	0.702
MOD_PKA_2	225	231	PF00069	0.545
MOD_PKA_2	249	255	PF00069	0.629
MOD_PKA_2	318	324	PF00069	0.747
MOD_PKB_1	316	324	PF00069	0.698
MOD_Plk_1	215	221	PF00069	0.385
MOD_Plk_1	295	301	PF00069	0.582
MOD_Plk_2-3	236	242	PF00069	0.630
MOD_Plk_2-3	296	302	PF00069	0.648
MOD_Plk_4	215	221	PF00069	0.351
MOD_Plk_4	243	249	PF00069	0.619
MOD_Plk_4	58	64	PF00069	0.418
MOD_ProDKin_1	129	135	PF00069	0.699
MOD_ProDKin_1	199	205	PF00069	0.464
MOD_ProDKin_1	2	8	PF00069	0.631
MOD_ProDKin_1	42	48	PF00069	0.528
MOD_SUMO_for_1	73	76	PF00179	0.487
TRG_ENDOCYTIC_2	47	50	PF00928	0.560
TRG_ER_diArg_1	267	269	PF00400	0.583
TRG_ER_diArg_1	316	319	PF00400	0.757
TRG_ER_diArg_1	80	83	PF00400	0.526
TRG_NES_CRM1_1	89	103	PF08389	0.576
TRG_NLS_MonoExtN_4	78	84	PF00514	0.327
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P915	Leptomonas seymouri	52%	100%
A0A0S4IVP5	Bodo saltans	27%	100%
A0A1X0P0S9	Trypanosomatidae	30%	100%
A0A3R7NVI0	Trypanosoma rangeli	30%	100%
A0A3S7XC03	Leishmania donovani	91%	100%
A4HQ81	Leishmania braziliensis	65%	99%
A4IDX9	Leishmania infantum	91%	100%
D0A431	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q0J6	Leishmania major	91%	100%
V5DK35	Trypanosoma cruzi	32%	100%