SWIM-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATZ7_LEIMU

TriTrypDb:

LmxM.36.5630

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0097196	Shu complex	2	1

Expansion

Sequence features

E9ATZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATZ7

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0008270	zinc ion binding	6	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0046914	transition metal ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.751
CLV_NRD_NRD_1	123	125	PF00675	0.536
CLV_PCSK_FUR_1	121	125	PF00082	0.652
CLV_PCSK_KEX2_1	123	125	PF00082	0.652
CLV_PCSK_SKI1_1	196	200	PF00082	0.362
CLV_PCSK_SKI1_1	21	25	PF00082	0.533
CLV_PCSK_SKI1_1	71	75	PF00082	0.435
DEG_Nend_UBRbox_3	1	3	PF02207	0.445
DEG_SPOP_SBC_1	129	133	PF00917	0.760
DOC_MAPK_MEF2A_6	196	205	PF00069	0.356
DOC_MAPK_NFAT4_5	196	204	PF00069	0.359
DOC_USP7_MATH_1	122	126	PF00917	0.722
DOC_USP7_MATH_1	129	133	PF00917	0.671
DOC_USP7_MATH_1	149	153	PF00917	0.715
DOC_USP7_MATH_1	183	187	PF00917	0.616
DOC_WW_Pin1_4	170	175	PF00397	0.391
DOC_WW_Pin1_4	220	225	PF00397	0.482
LIG_14-3-3_CanoR_1	135	140	PF00244	0.764
LIG_FHA_1	18	24	PF00498	0.459
LIG_FHA_1	208	214	PF00498	0.446
LIG_FHA_1	82	88	PF00498	0.426
LIG_LIR_Apic_2	173	178	PF02991	0.429
LIG_LIR_Gen_1	226	235	PF02991	0.496
LIG_LIR_Nem_3	13	18	PF02991	0.514
LIG_LIR_Nem_3	170	175	PF02991	0.539
LIG_LIR_Nem_3	226	230	PF02991	0.512
LIG_LIR_Nem_3	25	30	PF02991	0.393
LIG_LYPXL_yS_3	15	18	PF13949	0.541
LIG_SH2_CRK	184	188	PF00017	0.534
LIG_SH2_SRC	90	93	PF00017	0.343
LIG_SH2_STAP1	227	231	PF00017	0.511
LIG_SH2_STAP1	27	31	PF00017	0.419
LIG_SH2_STAT3	182	185	PF00017	0.504
LIG_SH2_STAT5	176	179	PF00017	0.439
LIG_SH2_STAT5	30	33	PF00017	0.462
LIG_SH2_STAT5	90	93	PF00017	0.455
LIG_TRAF2_1	57	60	PF00917	0.497
LIG_WRC_WIRS_1	5	10	PF05994	0.679
MOD_CK1_1	35	41	PF00069	0.647
MOD_CK2_1	220	226	PF00069	0.526
MOD_CK2_1	54	60	PF00069	0.462
MOD_GlcNHglycan	124	127	PF01048	0.705
MOD_GlcNHglycan	146	149	PF01048	0.733
MOD_GlcNHglycan	179	182	PF01048	0.511
MOD_GlcNHglycan	74	77	PF01048	0.419
MOD_GSK3_1	101	108	PF00069	0.702
MOD_GSK3_1	129	136	PF00069	0.759
MOD_N-GLC_1	35	40	PF02516	0.461
MOD_NEK2_2	167	172	PF00069	0.503
MOD_PIKK_1	137	143	PF00454	0.776
MOD_PIKK_1	150	156	PF00454	0.516
MOD_PKA_2	122	128	PF00069	0.563
MOD_Plk_1	101	107	PF00069	0.684
MOD_Plk_1	167	173	PF00069	0.539
MOD_Plk_4	167	173	PF00069	0.497
MOD_ProDKin_1	170	176	PF00069	0.396
MOD_ProDKin_1	220	226	PF00069	0.482
TRG_DiLeu_BaEn_1	226	231	PF01217	0.500
TRG_ENDOCYTIC_2	15	18	PF00928	0.541
TRG_ENDOCYTIC_2	184	187	PF00928	0.509
TRG_ENDOCYTIC_2	227	230	PF00928	0.511
TRG_ER_diArg_1	121	124	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I274	Leptomonas seymouri	53%	95%
A0A1X0P068	Trypanosomatidae	36%	100%
A0A3R7L646	Trypanosoma rangeli	38%	100%
A0A3S7XBY1	Leishmania donovani	87%	100%
A4HQ79	Leishmania braziliensis	69%	100%
A4IDX7	Leishmania infantum	87%	100%
D0A433	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q0J8	Leishmania major	89%	100%
V5BTC7	Trypanosoma cruzi	37%	100%