NERD domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nuclease-related domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATZ5_LEIMU

TriTrypDb:

LmxM.36.5610

Length:

525

Annotations

LeishMANIAdb annotations

A conserved signal-anchored protein family of obscure function also found in plants and bacteria.. Some of the Leishmaniid proteins might have 3 TM segments instead of 1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ATZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.523
CLV_NRD_NRD_1	134	136	PF00675	0.423
CLV_NRD_NRD_1	160	162	PF00675	0.321
CLV_NRD_NRD_1	172	174	PF00675	0.235
CLV_NRD_NRD_1	218	220	PF00675	0.355
CLV_NRD_NRD_1	242	244	PF00675	0.234
CLV_NRD_NRD_1	249	251	PF00675	0.234
CLV_NRD_NRD_1	40	42	PF00675	0.605
CLV_NRD_NRD_1	419	421	PF00675	0.296
CLV_NRD_NRD_1	462	464	PF00675	0.448
CLV_NRD_NRD_1	465	467	PF00675	0.407
CLV_PCSK_KEX2_1	134	136	PF00082	0.423
CLV_PCSK_KEX2_1	171	173	PF00082	0.235
CLV_PCSK_KEX2_1	220	222	PF00082	0.300
CLV_PCSK_KEX2_1	242	244	PF00082	0.234
CLV_PCSK_KEX2_1	249	251	PF00082	0.234
CLV_PCSK_KEX2_1	275	277	PF00082	0.316
CLV_PCSK_KEX2_1	40	42	PF00082	0.563
CLV_PCSK_KEX2_1	457	459	PF00082	0.394
CLV_PCSK_KEX2_1	462	464	PF00082	0.438
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.307
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.349
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.415
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.467
CLV_PCSK_PC7_1	458	464	PF00082	0.440
CLV_PCSK_SKI1_1	275	279	PF00082	0.372
CLV_PCSK_SKI1_1	315	319	PF00082	0.371
CLV_PCSK_SKI1_1	400	404	PF00082	0.404
CLV_PCSK_SKI1_1	421	425	PF00082	0.312
CLV_PCSK_SKI1_1	439	443	PF00082	0.455
CLV_PCSK_SKI1_1	458	462	PF00082	0.320
DEG_APCC_DBOX_1	419	427	PF00400	0.544
DEG_APCC_KENBOX_2	484	488	PF00400	0.606
DEG_COP1_1	405	414	PF00400	0.492
DOC_CYCLIN_RxL_1	436	445	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	66	69	PF00134	0.337
DOC_MAPK_DCC_7	291	299	PF00069	0.537
DOC_MAPK_gen_1	217	227	PF00069	0.537
DOC_MAPK_gen_1	420	428	PF00069	0.498
DOC_MAPK_gen_1	429	437	PF00069	0.538
DOC_MAPK_MEF2A_6	291	299	PF00069	0.469
DOC_MAPK_MEF2A_6	420	428	PF00069	0.486
DOC_MAPK_RevD_3	302	315	PF00069	0.603
DOC_MAPK_RevD_3	449	463	PF00069	0.584
DOC_PP2B_LxvP_1	22	25	PF13499	0.408
DOC_PP2B_LxvP_1	65	68	PF13499	0.349
DOC_PP2B_PxIxI_1	191	197	PF00149	0.537
DOC_PP4_FxxP_1	21	24	PF00568	0.171
DOC_PP4_FxxP_1	299	302	PF00568	0.491
DOC_USP7_MATH_1	29	33	PF00917	0.333
DOC_USP7_MATH_1	344	348	PF00917	0.674
DOC_USP7_MATH_1	363	367	PF00917	0.589
DOC_USP7_MATH_1	51	55	PF00917	0.336
DOC_USP7_MATH_1	74	78	PF00917	0.359
DOC_USP7_UBL2_3	283	287	PF12436	0.546
DOC_USP7_UBL2_3	457	461	PF12436	0.621
DOC_WW_Pin1_4	16	21	PF00397	0.219
DOC_WW_Pin1_4	39	44	PF00397	0.413
LIG_14-3-3_CanoR_1	14	22	PF00244	0.174
LIG_14-3-3_CanoR_1	276	280	PF00244	0.539
LIG_14-3-3_CanoR_1	510	514	PF00244	0.515
LIG_CaM_IQ_9	147	163	PF13499	0.537
LIG_eIF4E_1	418	424	PF01652	0.543
LIG_FHA_1	103	109	PF00498	0.276
LIG_FHA_1	320	326	PF00498	0.526
LIG_FHA_1	388	394	PF00498	0.554
LIG_FHA_1	401	407	PF00498	0.574
LIG_FHA_1	441	447	PF00498	0.554
LIG_FHA_1	495	501	PF00498	0.533
LIG_GBD_Chelix_1	393	401	PF00786	0.386
LIG_LIR_Apic_2	19	24	PF02991	0.171
LIG_LIR_Gen_1	224	235	PF02991	0.439
LIG_LIR_Gen_1	390	397	PF02991	0.465
LIG_LIR_Gen_1	486	495	PF02991	0.556
LIG_LIR_Gen_1	96	107	PF02991	0.331
LIG_LIR_Nem_3	224	230	PF02991	0.445
LIG_LIR_Nem_3	321	326	PF02991	0.493
LIG_LIR_Nem_3	34	39	PF02991	0.343
LIG_LIR_Nem_3	350	355	PF02991	0.645
LIG_LIR_Nem_3	390	394	PF02991	0.462
LIG_LIR_Nem_3	413	418	PF02991	0.586
LIG_LIR_Nem_3	96	102	PF02991	0.331
LIG_MYND_1	20	24	PF01753	0.171
LIG_NRBOX	392	398	PF00104	0.573
LIG_Pex14_1	165	169	PF04695	0.445
LIG_Pex14_1	391	395	PF04695	0.472
LIG_RPA_C_Fungi	167	179	PF08784	0.414
LIG_SH2_CRK	99	103	PF00017	0.252
LIG_SH2_STAT5	244	247	PF00017	0.425
LIG_SH2_STAT5	316	319	PF00017	0.403
LIG_SH2_STAT5	36	39	PF00017	0.424
LIG_SH2_STAT5	395	398	PF00017	0.350
LIG_SH2_STAT5	489	492	PF00017	0.416
LIG_SH2_STAT5	5	8	PF00017	0.413
LIG_SH2_STAT5	99	102	PF00017	0.364
LIG_SH3_2	478	483	PF14604	0.566
LIG_SH3_3	17	23	PF00018	0.273
LIG_SH3_3	248	254	PF00018	0.364
LIG_SH3_3	475	481	PF00018	0.420
LIG_SUMO_SIM_anti_2	184	189	PF11976	0.270
LIG_SUMO_SIM_anti_2	448	455	PF11976	0.479
LIG_SUMO_SIM_anti_2	89	97	PF11976	0.503
LIG_SUMO_SIM_par_1	192	198	PF11976	0.274
LIG_SUMO_SIM_par_1	294	300	PF11976	0.285
LIG_SUMO_SIM_par_1	501	507	PF11976	0.360
LIG_SUMO_SIM_par_1	89	97	PF11976	0.580
LIG_WRC_WIRS_1	320	325	PF05994	0.368
MOD_CDK_SPxK_1	39	45	PF00069	0.460
MOD_CK1_1	16	22	PF00069	0.171
MOD_CK1_1	281	287	PF00069	0.406
MOD_CK1_1	347	353	PF00069	0.603
MOD_CK1_1	445	451	PF00069	0.518
MOD_CK1_1	77	83	PF00069	0.439
MOD_CMANNOS	349	352	PF00535	0.627
MOD_Cter_Amidation	273	276	PF01082	0.469
MOD_GlcNHglycan	31	34	PF01048	0.450
MOD_GlcNHglycan	365	368	PF01048	0.592
MOD_GlcNHglycan	412	415	PF01048	0.451
MOD_GlcNHglycan	79	82	PF01048	0.607
MOD_GSK3_1	344	351	PF00069	0.565
MOD_GSK3_1	73	80	PF00069	0.489
MOD_NEK2_1	102	107	PF00069	0.364
MOD_NEK2_1	114	119	PF00069	0.389
MOD_NEK2_1	146	151	PF00069	0.452
MOD_NEK2_1	205	210	PF00069	0.443
MOD_NEK2_1	362	367	PF00069	0.493
MOD_NEK2_1	437	442	PF00069	0.412
MOD_NEK2_1	451	456	PF00069	0.371
MOD_NEK2_1	494	499	PF00069	0.474
MOD_NEK2_1	94	99	PF00069	0.533
MOD_NEK2_2	121	126	PF00069	0.576
MOD_NEK2_2	74	79	PF00069	0.405
MOD_PKA_1	275	281	PF00069	0.339
MOD_PKA_2	114	120	PF00069	0.447
MOD_PKA_2	121	127	PF00069	0.419
MOD_PKA_2	13	19	PF00069	0.171
MOD_PKA_2	275	281	PF00069	0.409
MOD_PKA_2	509	515	PF00069	0.381
MOD_PKB_1	219	227	PF00069	0.339
MOD_Plk_1	281	287	PF00069	0.223
MOD_Plk_1	74	80	PF00069	0.445
MOD_Plk_1	94	100	PF00069	0.469
MOD_Plk_4	103	109	PF00069	0.214
MOD_Plk_4	275	281	PF00069	0.285
MOD_Plk_4	344	350	PF00069	0.546
MOD_Plk_4	437	443	PF00069	0.483
MOD_Plk_4	499	505	PF00069	0.527
MOD_Plk_4	86	92	PF00069	0.561
MOD_Plk_4	94	100	PF00069	0.441
MOD_ProDKin_1	16	22	PF00069	0.219
MOD_ProDKin_1	39	45	PF00069	0.520
MOD_SUMO_rev_2	149	156	PF00179	0.394
TRG_DiLeu_BaEn_1	486	491	PF01217	0.448
TRG_DiLeu_BaEn_2	141	147	PF01217	0.431
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.493
TRG_ENDOCYTIC_2	36	39	PF00928	0.424
TRG_ENDOCYTIC_2	489	492	PF00928	0.442
TRG_ENDOCYTIC_2	5	8	PF00928	0.413
TRG_ENDOCYTIC_2	62	65	PF00928	0.432
TRG_ENDOCYTIC_2	99	102	PF00928	0.364
TRG_ER_diArg_1	133	135	PF00400	0.518
TRG_ER_diArg_1	170	173	PF00400	0.311
TRG_ER_diArg_1	219	222	PF00400	0.401
TRG_ER_diArg_1	241	243	PF00400	0.270
TRG_ER_diArg_1	249	251	PF00400	0.270
TRG_ER_diArg_1	39	41	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN0	Leptomonas seymouri	73%	100%
A0A0S4J7E4	Bodo saltans	35%	100%
A0A1X0P0I4	Trypanosomatidae	42%	100%
A0A3R7R7J3	Trypanosoma rangeli	43%	100%
A0A3S7XC13	Leishmania donovani	89%	100%
A4HQ77	Leishmania braziliensis	87%	100%
A4IDX5	Leishmania infantum	92%	97%
D0A437	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q0K0	Leishmania major	91%	100%
V5B3M2	Trypanosoma cruzi	41%	100%