Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATZ4_LEIMU

TriTrypDb:

LmxM.36.5600

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.527
CLV_NRD_NRD_1	229	231	PF00675	0.421
CLV_NRD_NRD_1	28	30	PF00675	0.684
CLV_NRD_NRD_1	318	320	PF00675	0.444
CLV_NRD_NRD_1	375	377	PF00675	0.562
CLV_NRD_NRD_1	447	449	PF00675	0.480
CLV_NRD_NRD_1	477	479	PF00675	0.470
CLV_PCSK_FUR_1	475	479	PF00082	0.458
CLV_PCSK_KEX2_1	142	144	PF00082	0.515
CLV_PCSK_KEX2_1	229	231	PF00082	0.380
CLV_PCSK_KEX2_1	27	29	PF00082	0.691
CLV_PCSK_KEX2_1	318	320	PF00082	0.444
CLV_PCSK_KEX2_1	375	377	PF00082	0.484
CLV_PCSK_KEX2_1	447	449	PF00082	0.480
CLV_PCSK_KEX2_1	477	479	PF00082	0.470
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.659
CLV_PCSK_PC7_1	23	29	PF00082	0.682
CLV_PCSK_SKI1_1	143	147	PF00082	0.428
CLV_PCSK_SKI1_1	150	154	PF00082	0.433
CLV_PCSK_SKI1_1	230	234	PF00082	0.395
CLV_PCSK_SKI1_1	269	273	PF00082	0.779
CLV_PCSK_SKI1_1	319	323	PF00082	0.534
CLV_PCSK_SKI1_1	378	382	PF00082	0.437
CLV_PCSK_SKI1_1	503	507	PF00082	0.387
DEG_APCC_DBOX_1	142	150	PF00400	0.442
DEG_APCC_DBOX_1	171	179	PF00400	0.449
DEG_APCC_DBOX_1	228	236	PF00400	0.366
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DEG_SPOP_SBC_1	523	527	PF00917	0.415
DOC_CKS1_1	364	369	PF01111	0.311
DOC_CKS1_1	388	393	PF01111	0.496
DOC_CKS1_1	9	14	PF01111	0.561
DOC_CYCLIN_RxL_1	227	237	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	152	155	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.401
DOC_MAPK_gen_1	170	178	PF00069	0.612
DOC_MAPK_gen_1	447	454	PF00069	0.376
DOC_MAPK_gen_1	503	513	PF00069	0.349
DOC_PP2B_LxvP_1	152	155	PF13499	0.547
DOC_PP2B_LxvP_1	283	286	PF13499	0.396
DOC_PP4_FxxP_1	9	12	PF00568	0.446
DOC_USP7_MATH_1	157	161	PF00917	0.667
DOC_USP7_MATH_1	278	282	PF00917	0.437
DOC_USP7_MATH_1	38	42	PF00917	0.639
DOC_USP7_MATH_1	542	546	PF00917	0.593
DOC_USP7_UBL2_3	353	357	PF12436	0.381
DOC_USP7_UBL2_3	65	69	PF12436	0.639
DOC_WW_Pin1_4	126	131	PF00397	0.573
DOC_WW_Pin1_4	2	7	PF00397	0.572
DOC_WW_Pin1_4	363	368	PF00397	0.333
DOC_WW_Pin1_4	387	392	PF00397	0.588
DOC_WW_Pin1_4	476	481	PF00397	0.622
DOC_WW_Pin1_4	67	72	PF00397	0.656
DOC_WW_Pin1_4	75	80	PF00397	0.595
DOC_WW_Pin1_4	8	13	PF00397	0.514
DOC_WW_Pin1_4	92	97	PF00397	0.775
LIG_14-3-3_CanoR_1	246	252	PF00244	0.679
LIG_14-3-3_CanoR_1	327	332	PF00244	0.421
LIG_14-3-3_CanoR_1	360	364	PF00244	0.405
LIG_14-3-3_CanoR_1	375	381	PF00244	0.416
LIG_14-3-3_CanoR_1	447	455	PF00244	0.355
LIG_Actin_WH2_2	490	505	PF00022	0.436
LIG_BRCT_BRCA1_1	421	425	PF00533	0.437
LIG_BRCT_BRCA1_1	518	522	PF00533	0.425
LIG_CSL_BTD_1	9	12	PF09270	0.556
LIG_DLG_GKlike_1	376	384	PF00625	0.346
LIG_EH1_1	328	336	PF00400	0.385
LIG_eIF4E_1	329	335	PF01652	0.348
LIG_FHA_1	350	356	PF00498	0.476
LIG_FHA_1	399	405	PF00498	0.621
LIG_FHA_1	447	453	PF00498	0.466
LIG_FHA_1	48	54	PF00498	0.605
LIG_FHA_1	553	559	PF00498	0.497
LIG_FHA_2	139	145	PF00498	0.321
LIG_FHA_2	256	262	PF00498	0.521
LIG_GBD_Chelix_1	355	363	PF00786	0.264
LIG_LIR_Apic_2	362	367	PF02991	0.294
LIG_NRBOX	333	339	PF00104	0.339
LIG_Pex14_1	10	14	PF04695	0.527
LIG_SH2_CRK	323	327	PF00017	0.491
LIG_SH2_CRK	364	368	PF00017	0.314
LIG_SH2_NCK_1	210	214	PF00017	0.483
LIG_SH2_NCK_1	329	333	PF00017	0.393
LIG_SH2_NCK_1	364	368	PF00017	0.314
LIG_SH2_NCK_1	551	555	PF00017	0.534
LIG_SH2_SRC	551	554	PF00017	0.599
LIG_SH2_STAT5	14	17	PF00017	0.602
LIG_SH2_STAT5	24	27	PF00017	0.676
LIG_SH2_STAT5	290	293	PF00017	0.380
LIG_SH3_2	183	188	PF14604	0.600
LIG_SH3_3	142	148	PF00018	0.487
LIG_SH3_3	180	186	PF00018	0.596
LIG_SH3_3	385	391	PF00018	0.457
LIG_SH3_3	60	66	PF00018	0.625
LIG_SH3_3	73	79	PF00018	0.551
LIG_SH3_4	65	72	PF00018	0.590
LIG_SH3_CIN85_PxpxPR_1	183	188	PF14604	0.480
LIG_SUMO_SIM_par_1	299	308	PF11976	0.388
LIG_SUMO_SIM_par_1	456	462	PF11976	0.394
LIG_TRFH_1	173	177	PF08558	0.455
LIG_TYR_ITIM	321	326	PF00017	0.433
LIG_WW_3	185	189	PF00397	0.637
MOD_CDK_SPK_2	8	13	PF00069	0.557
MOD_CDK_SPxK_1	2	8	PF00069	0.539
MOD_CK1_1	124	130	PF00069	0.617
MOD_CK1_1	250	256	PF00069	0.661
MOD_CK1_1	362	368	PF00069	0.426
MOD_CK1_1	77	83	PF00069	0.629
MOD_CK2_1	255	261	PF00069	0.675
MOD_CK2_1	389	395	PF00069	0.586
MOD_CK2_1	67	73	PF00069	0.689
MOD_Cter_Amidation	25	28	PF01082	0.651
MOD_Cter_Amidation	316	319	PF01082	0.488
MOD_Cter_Amidation	475	478	PF01082	0.457
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.540
MOD_GlcNHglycan	159	162	PF01048	0.560
MOD_GlcNHglycan	163	166	PF01048	0.681
MOD_GlcNHglycan	180	183	PF01048	0.637
MOD_GlcNHglycan	211	214	PF01048	0.427
MOD_GlcNHglycan	249	252	PF01048	0.587
MOD_GlcNHglycan	278	281	PF01048	0.638
MOD_GlcNHglycan	392	395	PF01048	0.651
MOD_GlcNHglycan	528	531	PF01048	0.496
MOD_GlcNHglycan	562	565	PF01048	0.752
MOD_GlcNHglycan	90	93	PF01048	0.727
MOD_GSK3_1	117	124	PF00069	0.556
MOD_GSK3_1	157	164	PF00069	0.707
MOD_GSK3_1	246	253	PF00069	0.635
MOD_GSK3_1	272	279	PF00069	0.657
MOD_GSK3_1	359	366	PF00069	0.362
MOD_GSK3_1	436	443	PF00069	0.472
MOD_GSK3_1	462	469	PF00069	0.483
MOD_GSK3_1	522	529	PF00069	0.407
MOD_GSK3_1	65	72	PF00069	0.533
MOD_GSK3_1	88	95	PF00069	0.697
MOD_LATS_1	374	380	PF00433	0.398
MOD_N-GLC_1	368	373	PF02516	0.302
MOD_NEK2_1	101	106	PF00069	0.542
MOD_NEK2_1	209	214	PF00069	0.421
MOD_NEK2_1	288	293	PF00069	0.316
MOD_NEK2_1	321	326	PF00069	0.538
MOD_NEK2_1	359	364	PF00069	0.406
MOD_NEK2_1	438	443	PF00069	0.430
MOD_NEK2_1	495	500	PF00069	0.434
MOD_NEK2_1	522	527	PF00069	0.441
MOD_PIKK_1	121	127	PF00454	0.589
MOD_PIKK_1	272	278	PF00454	0.528
MOD_PIKK_1	321	327	PF00454	0.415
MOD_PK_1	327	333	PF00069	0.364
MOD_PKA_2	359	365	PF00069	0.406
MOD_PKA_2	446	452	PF00069	0.370
MOD_PKA_2	88	94	PF00069	0.615
MOD_PKB_1	387	395	PF00069	0.447
MOD_Plk_1	196	202	PF00069	0.390
MOD_Plk_1	368	374	PF00069	0.265
MOD_Plk_1	418	424	PF00069	0.367
MOD_Plk_2-3	117	123	PF00069	0.470
MOD_Plk_4	278	284	PF00069	0.330
MOD_Plk_4	359	365	PF00069	0.464
MOD_ProDKin_1	126	132	PF00069	0.568
MOD_ProDKin_1	2	8	PF00069	0.569
MOD_ProDKin_1	363	369	PF00069	0.333
MOD_ProDKin_1	387	393	PF00069	0.594
MOD_ProDKin_1	476	482	PF00069	0.617
MOD_ProDKin_1	67	73	PF00069	0.658
MOD_ProDKin_1	75	81	PF00069	0.597
MOD_ProDKin_1	92	98	PF00069	0.771
TRG_DiLeu_BaEn_1	216	221	PF01217	0.423
TRG_DiLeu_BaEn_2	427	433	PF01217	0.346
TRG_DiLeu_BaEn_2	488	494	PF01217	0.424
TRG_DiLeu_BaEn_4	418	424	PF01217	0.411
TRG_ENDOCYTIC_2	323	326	PF00928	0.477
TRG_ENDOCYTIC_2	551	554	PF00928	0.505
TRG_ER_diArg_1	170	173	PF00400	0.570
TRG_ER_diArg_1	228	230	PF00400	0.413
TRG_ER_diArg_1	28	31	PF00400	0.724
TRG_ER_diArg_1	375	378	PF00400	0.574
TRG_ER_diArg_1	475	478	PF00400	0.457
TRG_NLS_MonoExtC_3	26	31	PF00514	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS8	Leptomonas seymouri	45%	95%
A0A1X0P1C1	Trypanosomatidae	28%	100%
A0A3Q8IJU5	Leishmania donovani	88%	100%
A0A3R7M711	Trypanosoma rangeli	33%	100%
A4HQ76	Leishmania braziliensis	71%	98%
A4IDX4	Leishmania infantum	88%	100%
Q4Q0K1	Leishmania major	87%	100%