DUF2336 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATZ3_LEIMU

TriTrypDb:

LmxM.36.5580

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.572
CLV_NRD_NRD_1	12	14	PF00675	0.534
CLV_NRD_NRD_1	196	198	PF00675	0.667
CLV_NRD_NRD_1	29	31	PF00675	0.387
CLV_NRD_NRD_1	47	49	PF00675	0.409
CLV_PCSK_KEX2_1	118	120	PF00082	0.617
CLV_PCSK_KEX2_1	12	14	PF00082	0.455
CLV_PCSK_KEX2_1	196	198	PF00082	0.665
CLV_PCSK_KEX2_1	29	31	PF00082	0.512
CLV_PCSK_KEX2_1	312	314	PF00082	0.605
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.637
CLV_PCSK_SKI1_1	196	200	PF00082	0.772
CLV_PCSK_SKI1_1	259	263	PF00082	0.476
CLV_PCSK_SKI1_1	350	354	PF00082	0.709
DEG_APCC_DBOX_1	29	37	PF00400	0.467
DEG_SPOP_SBC_1	142	146	PF00917	0.667
DEG_SPOP_SBC_1	188	192	PF00917	0.755
DOC_CKS1_1	135	140	PF01111	0.541
DOC_CYCLIN_RxL_1	43	53	PF00134	0.560
DOC_MAPK_gen_1	43	52	PF00069	0.511
DOC_MAPK_MEF2A_6	214	222	PF00069	0.508
DOC_MIT_MIM_1	7	17	PF04212	0.461
DOC_PP2B_LxvP_1	222	225	PF13499	0.434
DOC_PP4_FxxP_1	135	138	PF00568	0.675
DOC_USP7_MATH_1	142	146	PF00917	0.736
DOC_USP7_MATH_1	188	192	PF00917	0.755
DOC_WW_Pin1_4	134	139	PF00397	0.709
LIG_14-3-3_CanoR_1	196	201	PF00244	0.746
LIG_14-3-3_CanoR_1	244	250	PF00244	0.465
LIG_14-3-3_CanoR_1	259	269	PF00244	0.431
LIG_14-3-3_CanoR_1	29	34	PF00244	0.502
LIG_14-3-3_CanoR_1	338	343	PF00244	0.649
LIG_14-3-3_CanoR_1	48	53	PF00244	0.406
LIG_Actin_WH2_2	191	206	PF00022	0.685
LIG_APCC_ABBA_1	331	336	PF00400	0.640
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_BRCT_BRCA1_1	324	328	PF00533	0.621
LIG_FHA_1	135	141	PF00498	0.467
LIG_FHA_1	231	237	PF00498	0.516
LIG_FHA_1	241	247	PF00498	0.430
LIG_FHA_1	97	103	PF00498	0.473
LIG_FHA_2	181	187	PF00498	0.711
LIG_FHA_2	282	288	PF00498	0.551
LIG_FHA_2	357	363	PF00498	0.700
LIG_LIR_Gen_1	157	162	PF02991	0.713
LIG_LIR_Gen_1	172	179	PF02991	0.727
LIG_LIR_Gen_1	276	286	PF02991	0.481
LIG_LIR_Gen_1	325	334	PF02991	0.674
LIG_LIR_Nem_3	157	161	PF02991	0.672
LIG_LIR_Nem_3	172	176	PF02991	0.690
LIG_LIR_Nem_3	276	282	PF02991	0.482
LIG_LIR_Nem_3	325	331	PF02991	0.630
LIG_MYND_1	201	205	PF01753	0.683
LIG_Pex14_2	261	265	PF04695	0.531
LIG_Pex14_2	368	372	PF04695	0.659
LIG_SH2_CRK	158	162	PF00017	0.712
LIG_SH2_GRB2like	279	282	PF00017	0.572
LIG_SH2_NCK_1	87	91	PF00017	0.502
LIG_SH2_SRC	279	282	PF00017	0.547
LIG_SH2_SRC	87	90	PF00017	0.498
LIG_SH2_STAP1	158	162	PF00017	0.712
LIG_SH2_STAP1	249	253	PF00017	0.463
LIG_SH2_STAP1	279	283	PF00017	0.570
LIG_SH2_STAT3	307	310	PF00017	0.662
LIG_SH2_STAT5	193	196	PF00017	0.569
LIG_SH2_STAT5	249	252	PF00017	0.529
LIG_SH2_STAT5	316	319	PF00017	0.567
LIG_SH2_STAT5	56	59	PF00017	0.397
LIG_SH3_3	130	136	PF00018	0.666
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.757
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.458
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.465
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.534
LIG_TRAF2_1	352	355	PF00917	0.637
MOD_CK1_1	177	183	PF00069	0.705
MOD_CK1_1	189	195	PF00069	0.629
MOD_CK1_1	96	102	PF00069	0.532
MOD_CK2_1	141	147	PF00069	0.767
MOD_CK2_1	180	186	PF00069	0.692
MOD_CK2_1	231	237	PF00069	0.514
MOD_CK2_1	281	287	PF00069	0.584
MOD_GlcNHglycan	127	130	PF01048	0.587
MOD_GlcNHglycan	179	182	PF01048	0.755
MOD_GlcNHglycan	253	256	PF01048	0.542
MOD_GlcNHglycan	262	265	PF01048	0.509
MOD_GlcNHglycan	284	287	PF01048	0.558
MOD_GlcNHglycan	318	321	PF01048	0.691
MOD_GSK3_1	188	195	PF00069	0.689
MOD_GSK3_1	245	252	PF00069	0.550
MOD_GSK3_1	297	304	PF00069	0.603
MOD_GSK3_1	308	315	PF00069	0.442
MOD_N-GLC_1	297	302	PF02516	0.639
MOD_N-GLC_1	338	343	PF02516	0.601
MOD_N-GLC_1	357	362	PF02516	0.638
MOD_N-GLC_1	96	101	PF02516	0.492
MOD_NEK2_1	103	108	PF00069	0.332
MOD_NEK2_1	187	192	PF00069	0.669
MOD_NEK2_1	230	235	PF00069	0.548
MOD_NEK2_1	240	245	PF00069	0.414
MOD_NEK2_1	247	252	PF00069	0.475
MOD_NEK2_1	301	306	PF00069	0.698
MOD_NEK2_1	327	332	PF00069	0.587
MOD_PKA_1	196	202	PF00069	0.744
MOD_PKA_1	29	35	PF00069	0.480
MOD_PKA_1	312	318	PF00069	0.596
MOD_PKA_1	48	54	PF00069	0.404
MOD_PKA_2	196	202	PF00069	0.743
MOD_PKA_2	203	209	PF00069	0.675
MOD_PKA_2	29	35	PF00069	0.463
MOD_PKA_2	312	318	PF00069	0.572
MOD_Plk_1	231	237	PF00069	0.571
MOD_Plk_1	297	303	PF00069	0.639
MOD_Plk_1	338	344	PF00069	0.543
MOD_Plk_1	6	12	PF00069	0.533
MOD_Plk_1	96	102	PF00069	0.496
MOD_Plk_4	157	163	PF00069	0.658
MOD_Plk_4	174	180	PF00069	0.754
MOD_Plk_4	189	195	PF00069	0.715
MOD_Plk_4	216	222	PF00069	0.437
MOD_Plk_4	301	307	PF00069	0.629
MOD_Plk_4	312	318	PF00069	0.523
MOD_Plk_4	327	333	PF00069	0.534
MOD_Plk_4	6	12	PF00069	0.533
MOD_ProDKin_1	134	140	PF00069	0.710
MOD_SUMO_for_1	352	355	PF00179	0.655
TRG_DiLeu_BaEn_1	53	58	PF01217	0.443
TRG_DiLeu_BaEn_1	63	68	PF01217	0.405
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.522
TRG_ENDOCYTIC_2	158	161	PF00928	0.712
TRG_ENDOCYTIC_2	279	282	PF00928	0.572
TRG_ER_diArg_1	11	13	PF00400	0.541
TRG_ER_diArg_1	196	198	PF00400	0.667
TRG_ER_diArg_1	288	291	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9D5	Leptomonas seymouri	74%	99%
A0A3R7RKF3	Trypanosoma rangeli	36%	100%
A0A3S7XBW0	Leishmania donovani	94%	100%
A4HQ74	Leishmania braziliensis	81%	98%
A4IDX2	Leishmania infantum	95%	100%
D0A445	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q0K3	Leishmania major	93%	100%
V5B3M7	Trypanosoma cruzi	35%	100%