Putative aminopeptidase P1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MG, Family M24

Species:

Leishmania mexicana

UniProt:

E9ATZ1_LEIMU

TriTrypDb:

LmxM.36.5560

Length:

821

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATZ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0030145	manganese ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0070006	metalloaminopeptidase activity	6	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.400
CLV_NRD_NRD_1	3	5	PF00675	0.556
CLV_NRD_NRD_1	332	334	PF00675	0.498
CLV_NRD_NRD_1	362	364	PF00675	0.378
CLV_NRD_NRD_1	45	47	PF00675	0.313
CLV_NRD_NRD_1	504	506	PF00675	0.336
CLV_NRD_NRD_1	540	542	PF00675	0.312
CLV_NRD_NRD_1	611	613	PF00675	0.207
CLV_NRD_NRD_1	93	95	PF00675	0.447
CLV_PCSK_KEX2_1	152	154	PF00082	0.414
CLV_PCSK_KEX2_1	3	5	PF00082	0.557
CLV_PCSK_KEX2_1	332	334	PF00082	0.571
CLV_PCSK_KEX2_1	362	364	PF00082	0.378
CLV_PCSK_KEX2_1	44	46	PF00082	0.312
CLV_PCSK_KEX2_1	540	542	PF00082	0.328
CLV_PCSK_KEX2_1	611	613	PF00082	0.207
CLV_PCSK_KEX2_1	93	95	PF00082	0.447
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.414
CLV_PCSK_PC7_1	89	95	PF00082	0.437
CLV_PCSK_SKI1_1	116	120	PF00082	0.578
CLV_PCSK_SKI1_1	152	156	PF00082	0.409
CLV_PCSK_SKI1_1	187	191	PF00082	0.535
CLV_PCSK_SKI1_1	293	297	PF00082	0.406
CLV_PCSK_SKI1_1	372	376	PF00082	0.345
CLV_PCSK_SKI1_1	46	50	PF00082	0.464
CLV_PCSK_SKI1_1	505	509	PF00082	0.312
CLV_PCSK_SKI1_1	529	533	PF00082	0.300
CLV_PCSK_SKI1_1	598	602	PF00082	0.207
CLV_PCSK_SKI1_1	639	643	PF00082	0.376
CLV_PCSK_SKI1_1	745	749	PF00082	0.402
DEG_APCC_DBOX_1	45	53	PF00400	0.340
DEG_APCC_DBOX_1	504	512	PF00400	0.312
DEG_APCC_DBOX_1	528	536	PF00400	0.291
DEG_APCC_DBOX_1	638	646	PF00400	0.312
DEG_COP1_1	722	731	PF00400	0.341
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_ODPH_VHL_1	96	109	PF01847	0.587
DEG_SPOP_SBC_1	265	269	PF00917	0.627
DOC_ANK_TNKS_1	479	486	PF00023	0.312
DOC_CYCLIN_RxL_1	149	158	PF00134	0.374
DOC_CYCLIN_RxL_1	290	299	PF00134	0.625
DOC_CYCLIN_yClb1_LxF_4	741	747	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.491
DOC_MAPK_MEF2A_6	13	22	PF00069	0.536
DOC_MAPK_MEF2A_6	647	654	PF00069	0.340
DOC_PP2B_LxvP_1	127	130	PF13499	0.396
DOC_PP2B_LxvP_1	357	360	PF13499	0.468
DOC_PP2B_LxvP_1	667	670	PF13499	0.360
DOC_PP2B_LxvP_1	96	99	PF13499	0.593
DOC_PP4_FxxP_1	271	274	PF00568	0.438
DOC_USP7_MATH_1	201	205	PF00917	0.536
DOC_USP7_MATH_1	252	256	PF00917	0.613
DOC_USP7_MATH_1	264	268	PF00917	0.517
DOC_USP7_MATH_1	341	345	PF00917	0.562
DOC_USP7_MATH_1	483	487	PF00917	0.344
DOC_USP7_MATH_1	513	517	PF00917	0.388
DOC_USP7_MATH_1	53	57	PF00917	0.388
DOC_USP7_MATH_1	542	546	PF00917	0.385
DOC_USP7_MATH_1	553	557	PF00917	0.277
DOC_USP7_MATH_1	559	563	PF00917	0.216
DOC_USP7_MATH_1	63	67	PF00917	0.285
DOC_USP7_MATH_1	760	764	PF00917	0.395
DOC_USP7_MATH_1	791	795	PF00917	0.415
DOC_USP7_MATH_1	798	802	PF00917	0.364
DOC_WW_Pin1_4	162	167	PF00397	0.750
DOC_WW_Pin1_4	320	325	PF00397	0.542
DOC_WW_Pin1_4	333	338	PF00397	0.658
DOC_WW_Pin1_4	547	552	PF00397	0.296
DOC_WW_Pin1_4	613	618	PF00397	0.291
DOC_WW_Pin1_4	668	673	PF00397	0.524
LIG_14-3-3_CanoR_1	13	19	PF00244	0.518
LIG_14-3-3_CanoR_1	362	370	PF00244	0.488
LIG_14-3-3_CanoR_1	388	395	PF00244	0.315
LIG_14-3-3_CanoR_1	4	10	PF00244	0.576
LIG_14-3-3_CanoR_1	400	406	PF00244	0.327
LIG_14-3-3_CanoR_1	488	494	PF00244	0.340
LIG_14-3-3_CanoR_1	512	518	PF00244	0.267
LIG_14-3-3_CanoR_1	611	617	PF00244	0.226
LIG_14-3-3_CanoR_1	735	743	PF00244	0.298
LIG_Actin_WH2_2	586	603	PF00022	0.253
LIG_APCC_ABBA_1	587	592	PF00400	0.312
LIG_BIR_III_4	158	162	PF00653	0.498
LIG_BRCT_BRCA1_1	267	271	PF00533	0.410
LIG_BRCT_BRCA1_1	485	489	PF00533	0.340
LIG_CaM_IQ_9	737	753	PF13499	0.383
LIG_Clathr_ClatBox_1	642	646	PF01394	0.388
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.312
LIG_FHA_1	102	108	PF00498	0.527
LIG_FHA_1	134	140	PF00498	0.531
LIG_FHA_1	17	23	PF00498	0.483
LIG_FHA_1	173	179	PF00498	0.527
LIG_FHA_1	321	327	PF00498	0.498
LIG_FHA_1	352	358	PF00498	0.644
LIG_FHA_1	477	483	PF00498	0.318
LIG_FHA_1	526	532	PF00498	0.312
LIG_FHA_1	6	12	PF00498	0.495
LIG_FHA_1	614	620	PF00498	0.454
LIG_FHA_1	738	744	PF00498	0.530
LIG_FHA_1	803	809	PF00498	0.335
LIG_FHA_2	172	178	PF00498	0.454
LIG_FHA_2	340	346	PF00498	0.487
LIG_FHA_2	402	408	PF00498	0.390
LIG_FHA_2	415	421	PF00498	0.255
LIG_FHA_2	449	455	PF00498	0.388
LIG_Integrin_RGD_1	693	695	PF01839	0.342
LIG_LIR_Apic_2	268	274	PF02991	0.482
LIG_LIR_Gen_1	276	287	PF02991	0.374
LIG_LIR_Gen_1	313	324	PF02991	0.409
LIG_LIR_Gen_1	364	374	PF02991	0.571
LIG_LIR_Gen_1	391	401	PF02991	0.331
LIG_LIR_Gen_1	80	91	PF02991	0.312
LIG_LIR_Nem_3	149	154	PF02991	0.416
LIG_LIR_Nem_3	276	282	PF02991	0.384
LIG_LIR_Nem_3	313	319	PF02991	0.362
LIG_LIR_Nem_3	364	370	PF02991	0.577
LIG_LIR_Nem_3	391	397	PF02991	0.312
LIG_LIR_Nem_3	433	438	PF02991	0.248
LIG_LIR_Nem_3	491	496	PF02991	0.412
LIG_LIR_Nem_3	580	584	PF02991	0.205
LIG_LIR_Nem_3	79	85	PF02991	0.312
LIG_LIR_Nem_3	794	799	PF02991	0.408
LIG_MYND_1	324	328	PF01753	0.621
LIG_Pex14_1	82	86	PF04695	0.312
LIG_Pex14_2	581	585	PF04695	0.388
LIG_PTB_Apo_2	776	783	PF02174	0.509
LIG_PTB_Phospho_1	776	782	PF10480	0.498
LIG_SH2_CRK	151	155	PF00017	0.399
LIG_SH2_CRK	316	320	PF00017	0.474
LIG_SH2_CRK	371	375	PF00017	0.305
LIG_SH2_CRK	799	803	PF00017	0.335
LIG_SH2_NCK_1	316	320	PF00017	0.523
LIG_SH2_PTP2	435	438	PF00017	0.312
LIG_SH2_PTP2	493	496	PF00017	0.388
LIG_SH2_SRC	435	438	PF00017	0.312
LIG_SH2_SRC	633	636	PF00017	0.388
LIG_SH2_SRC	782	785	PF00017	0.411
LIG_SH2_STAP1	316	320	PF00017	0.414
LIG_SH2_STAP1	367	371	PF00017	0.468
LIG_SH2_STAP1	68	72	PF00017	0.312
LIG_SH2_STAP1	799	803	PF00017	0.335
LIG_SH2_STAT3	236	239	PF00017	0.452
LIG_SH2_STAT5	411	414	PF00017	0.207
LIG_SH2_STAT5	435	438	PF00017	0.339
LIG_SH2_STAT5	493	496	PF00017	0.388
LIG_SH2_STAT5	633	636	PF00017	0.388
LIG_SH2_STAT5	696	699	PF00017	0.351
LIG_SH2_STAT5	782	785	PF00017	0.411
LIG_SH3_3	286	292	PF00018	0.396
LIG_SH3_3	331	337	PF00018	0.628
LIG_SH3_3	371	377	PF00018	0.260
LIG_SH3_3	453	459	PF00018	0.327
LIG_SH3_3	55	61	PF00018	0.388
LIG_SH3_3	593	599	PF00018	0.340
LIG_SH3_3	629	635	PF00018	0.388
LIG_SH3_3	684	690	PF00018	0.465
LIG_SH3_3	774	780	PF00018	0.415
LIG_SH3_3	783	789	PF00018	0.429
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.312
LIG_SUMO_SIM_anti_2	663	671	PF11976	0.312
LIG_SUMO_SIM_anti_2	811	816	PF11976	0.421
LIG_SUMO_SIM_par_1	293	299	PF11976	0.387
LIG_SUMO_SIM_par_1	663	671	PF11976	0.388
LIG_SUMO_SIM_par_1	718	725	PF11976	0.398
LIG_TRAF2_1	37	40	PF00917	0.481
LIG_TRAF2_1	561	564	PF00917	0.326
LIG_UBA3_1	500	506	PF00899	0.388
LIG_UBA3_1	642	647	PF00899	0.267
LIG_WRC_WIRS_1	311	316	PF05994	0.301
MOD_CDK_SPK_2	162	167	PF00069	0.498
MOD_CDK_SPK_2	613	618	PF00069	0.340
MOD_CK1_1	101	107	PF00069	0.546
MOD_CK1_1	165	171	PF00069	0.488
MOD_CK1_1	280	286	PF00069	0.541
MOD_CK1_1	307	313	PF00069	0.380
MOD_CK1_1	66	72	PF00069	0.388
MOD_CK1_1	763	769	PF00069	0.386
MOD_CK2_1	171	177	PF00069	0.460
MOD_CK2_1	201	207	PF00069	0.553
MOD_CK2_1	339	345	PF00069	0.476
MOD_CK2_1	34	40	PF00069	0.415
MOD_CK2_1	401	407	PF00069	0.417
MOD_CK2_1	558	564	PF00069	0.397
MOD_DYRK1A_RPxSP_1	333	337	PF00069	0.492
MOD_GlcNHglycan	100	103	PF01048	0.626
MOD_GlcNHglycan	207	211	PF01048	0.527
MOD_GlcNHglycan	282	285	PF01048	0.482
MOD_GlcNHglycan	306	309	PF01048	0.476
MOD_GlcNHglycan	316	319	PF01048	0.464
MOD_GlcNHglycan	34	39	PF01048	0.426
MOD_GlcNHglycan	385	388	PF01048	0.325
MOD_GlcNHglycan	401	404	PF01048	0.221
MOD_GlcNHglycan	432	435	PF01048	0.381
MOD_GlcNHglycan	440	443	PF01048	0.255
MOD_GlcNHglycan	545	548	PF01048	0.304
MOD_GlcNHglycan	555	558	PF01048	0.319
MOD_GlcNHglycan	635	638	PF01048	0.424
MOD_GlcNHglycan	709	712	PF01048	0.566
MOD_GSK3_1	12	19	PF00069	0.595
MOD_GSK3_1	131	138	PF00069	0.633
MOD_GSK3_1	310	317	PF00069	0.320
MOD_GSK3_1	335	342	PF00069	0.568
MOD_GSK3_1	351	358	PF00069	0.447
MOD_GSK3_1	383	390	PF00069	0.315
MOD_GSK3_1	399	406	PF00069	0.323
MOD_GSK3_1	484	491	PF00069	0.340
MOD_GSK3_1	543	550	PF00069	0.341
MOD_GSK3_1	553	560	PF00069	0.366
MOD_GSK3_1	715	722	PF00069	0.547
MOD_GSK3_1	798	805	PF00069	0.494
MOD_GSK3_1	97	104	PF00069	0.562
MOD_NEK2_1	14	19	PF00069	0.438
MOD_NEK2_1	206	211	PF00069	0.471
MOD_NEK2_1	278	283	PF00069	0.403
MOD_NEK2_1	296	301	PF00069	0.707
MOD_NEK2_1	314	319	PF00069	0.502
MOD_NEK2_1	355	360	PF00069	0.381
MOD_NEK2_1	414	419	PF00069	0.285
MOD_NEK2_1	531	536	PF00069	0.263
MOD_NEK2_1	571	576	PF00069	0.388
MOD_NEK2_1	719	724	PF00069	0.440
MOD_NEK2_1	804	809	PF00069	0.341
MOD_NEK2_2	513	518	PF00069	0.340
MOD_NEK2_2	63	68	PF00069	0.388
MOD_PIKK_1	146	152	PF00454	0.378
MOD_PIKK_1	258	264	PF00454	0.489
MOD_PIKK_1	375	381	PF00454	0.369
MOD_PIKK_1	559	565	PF00454	0.216
MOD_PIKK_1	737	743	PF00454	0.413
MOD_PKA_2	107	113	PF00069	0.363
MOD_PKA_2	12	18	PF00069	0.529
MOD_PKA_2	314	320	PF00069	0.482
MOD_PKA_2	361	367	PF00069	0.514
MOD_PKA_2	387	393	PF00069	0.312
MOD_PKA_2	399	405	PF00069	0.255
MOD_PKA_2	443	449	PF00069	0.312
MOD_PKA_2	734	740	PF00069	0.377
MOD_Plk_1	206	212	PF00069	0.607
MOD_Plk_1	351	357	PF00069	0.543
MOD_Plk_1	53	59	PF00069	0.365
MOD_Plk_1	591	597	PF00069	0.454
MOD_Plk_1	63	69	PF00069	0.265
MOD_Plk_4	122	128	PF00069	0.381
MOD_Plk_4	135	141	PF00069	0.557
MOD_Plk_4	252	258	PF00069	0.545
MOD_Plk_4	266	272	PF00069	0.515
MOD_Plk_4	307	313	PF00069	0.501
MOD_Plk_4	489	495	PF00069	0.388
MOD_Plk_4	53	59	PF00069	0.388
MOD_Plk_4	592	598	PF00069	0.321
MOD_Plk_4	63	69	PF00069	0.356
MOD_Plk_4	715	721	PF00069	0.474
MOD_Plk_4	77	83	PF00069	0.235
MOD_Plk_4	772	778	PF00069	0.452
MOD_Plk_4	798	804	PF00069	0.375
MOD_ProDKin_1	162	168	PF00069	0.747
MOD_ProDKin_1	320	326	PF00069	0.541
MOD_ProDKin_1	333	339	PF00069	0.649
MOD_ProDKin_1	547	553	PF00069	0.296
MOD_ProDKin_1	613	619	PF00069	0.291
MOD_ProDKin_1	668	674	PF00069	0.538
TRG_DiLeu_BaEn_1	527	532	PF01217	0.312
TRG_DiLeu_BaEn_1	663	668	PF01217	0.312
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.356
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.409
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.621
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.394
TRG_ENDOCYTIC_2	151	154	PF00928	0.405
TRG_ENDOCYTIC_2	316	319	PF00928	0.506
TRG_ENDOCYTIC_2	367	370	PF00928	0.407
TRG_ENDOCYTIC_2	371	374	PF00928	0.364
TRG_ENDOCYTIC_2	411	414	PF00928	0.207
TRG_ENDOCYTIC_2	435	438	PF00928	0.312
TRG_ENDOCYTIC_2	493	496	PF00928	0.331
TRG_ENDOCYTIC_2	497	500	PF00928	0.294
TRG_ENDOCYTIC_2	799	802	PF00928	0.339
TRG_ENDOCYTIC_2	83	86	PF00928	0.312
TRG_ER_diArg_1	2	4	PF00400	0.565
TRG_ER_diArg_1	247	250	PF00400	0.732
TRG_ER_diArg_1	331	333	PF00400	0.643
TRG_ER_diArg_1	361	363	PF00400	0.385
TRG_ER_diArg_1	44	46	PF00400	0.312
TRG_ER_diArg_1	539	541	PF00400	0.312
TRG_ER_diArg_1	611	614	PF00400	0.326
TRG_ER_diArg_1	92	94	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.207
TRG_Pf-PMV_PEXEL_1	745	750	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P918	Leptomonas seymouri	50%	96%
A0A3Q8IHX0	Leishmania donovani	88%	98%
A4HQ72	Leishmania braziliensis	73%	98%
A4IDX0	Leishmania infantum	87%	98%
Q4Q0K5	Leishmania major	87%	100%