PCIF1_WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATY8_LEIMU

TriTrypDb:

LmxM.36.5530

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATY8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	7
GO:0001098	basal transcription machinery binding	3	7
GO:0001099	basal RNA polymerase II transcription machinery binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0008168	methyltransferase activity	4	7
GO:0008173	RNA methyltransferase activity	4	7
GO:0008174	mRNA methyltransferase activity	5	7
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	7
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	7
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	7
GO:0019899	enzyme binding	3	7
GO:0043175	RNA polymerase core enzyme binding	5	7
GO:0070063	RNA polymerase binding	4	7
GO:0099122	RNA polymerase II C-terminal domain binding	6	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.363
CLV_NRD_NRD_1	195	197	PF00675	0.435
CLV_NRD_NRD_1	213	215	PF00675	0.392
CLV_NRD_NRD_1	587	589	PF00675	0.678
CLV_NRD_NRD_1	82	84	PF00675	0.479
CLV_PCSK_KEX2_1	195	197	PF00082	0.433
CLV_PCSK_KEX2_1	589	591	PF00082	0.695
CLV_PCSK_KEX2_1	82	84	PF00082	0.479
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.433
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.701
CLV_PCSK_SKI1_1	12	16	PF00082	0.358
CLV_PCSK_SKI1_1	145	149	PF00082	0.466
CLV_PCSK_SKI1_1	171	175	PF00082	0.520
CLV_PCSK_SKI1_1	2	6	PF00082	0.441
CLV_PCSK_SKI1_1	361	365	PF00082	0.369
CLV_PCSK_SKI1_1	38	42	PF00082	0.450
CLV_PCSK_SKI1_1	420	424	PF00082	0.369
CLV_Separin_Metazoa	7	11	PF03568	0.337
DEG_APCC_DBOX_1	99	107	PF00400	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.332
DEG_SPOP_SBC_1	132	136	PF00917	0.458
DEG_SPOP_SBC_1	30	34	PF00917	0.410
DEG_SPOP_SBC_1	520	524	PF00917	0.325
DEG_SPOP_SBC_1	93	97	PF00917	0.456
DOC_CKS1_1	146	151	PF01111	0.463
DOC_CKS1_1	295	300	PF01111	0.486
DOC_CYCLIN_RxL_1	167	175	PF00134	0.471
DOC_CYCLIN_RxL_1	488	496	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.414
DOC_MAPK_gen_1	10	17	PF00069	0.408
DOC_MAPK_gen_1	235	243	PF00069	0.461
DOC_MAPK_gen_1	82	90	PF00069	0.462
DOC_MAPK_HePTP_8	322	334	PF00069	0.417
DOC_MAPK_MEF2A_6	171	178	PF00069	0.445
DOC_MAPK_MEF2A_6	235	243	PF00069	0.476
DOC_MAPK_MEF2A_6	325	334	PF00069	0.417
DOC_MAPK_MEF2A_6	72	81	PF00069	0.380
DOC_MAPK_NFAT4_5	171	179	PF00069	0.451
DOC_PP2B_LxvP_1	324	327	PF13499	0.406
DOC_PP2B_LxvP_1	559	562	PF13499	0.325
DOC_PP4_FxxP_1	412	415	PF00568	0.304
DOC_USP7_MATH_1	133	137	PF00917	0.435
DOC_USP7_MATH_1	253	257	PF00917	0.481
DOC_USP7_MATH_1	30	34	PF00917	0.525
DOC_USP7_MATH_1	303	307	PF00917	0.591
DOC_USP7_MATH_1	346	350	PF00917	0.357
DOC_USP7_MATH_1	456	460	PF00917	0.431
DOC_USP7_MATH_1	470	474	PF00917	0.591
DOC_USP7_MATH_1	481	485	PF00917	0.564
DOC_USP7_MATH_1	57	61	PF00917	0.468
DOC_USP7_MATH_1	651	655	PF00917	0.484
DOC_WW_Pin1_4	145	150	PF00397	0.395
DOC_WW_Pin1_4	294	299	PF00397	0.454
DOC_WW_Pin1_4	411	416	PF00397	0.261
LIG_14-3-3_CanoR_1	137	142	PF00244	0.418
LIG_14-3-3_CanoR_1	404	410	PF00244	0.205
LIG_14-3-3_CanoR_1	554	560	PF00244	0.363
LIG_14-3-3_CanoR_1	613	617	PF00244	0.427
LIG_APCC_ABBA_1	424	429	PF00400	0.369
LIG_BIR_III_4	36	40	PF00653	0.473
LIG_BRCT_BRCA1_1	42	46	PF00533	0.387
LIG_Clathr_ClatBox_1	492	496	PF01394	0.410
LIG_deltaCOP1_diTrp_1	285	292	PF00928	0.448
LIG_FHA_1	268	274	PF00498	0.449
LIG_FHA_1	336	342	PF00498	0.447
LIG_FHA_1	404	410	PF00498	0.369
LIG_FHA_1	428	434	PF00498	0.253
LIG_FHA_1	521	527	PF00498	0.284
LIG_FHA_2	544	550	PF00498	0.270
LIG_LIR_Apic_2	410	415	PF02991	0.304
LIG_LIR_Apic_2	73	77	PF02991	0.388
LIG_LIR_Gen_1	284	293	PF02991	0.457
LIG_LIR_Gen_1	313	322	PF02991	0.614
LIG_LIR_Gen_1	602	611	PF02991	0.505
LIG_LIR_Nem_3	205	211	PF02991	0.421
LIG_LIR_Nem_3	284	289	PF02991	0.459
LIG_LIR_Nem_3	291	295	PF02991	0.408
LIG_LIR_Nem_3	313	317	PF02991	0.615
LIG_LIR_Nem_3	431	437	PF02991	0.363
LIG_LIR_Nem_3	602	606	PF02991	0.559
LIG_MYND_3	158	162	PF01753	0.456
LIG_NRBOX	358	364	PF00104	0.369
LIG_Pex14_2	412	416	PF04695	0.369
LIG_Pex14_2	423	427	PF04695	0.288
LIG_PTB_Apo_2	495	502	PF02174	0.304
LIG_SH2_CRK	366	370	PF00017	0.304
LIG_SH2_SRC	566	569	PF00017	0.304
LIG_SH2_STAT5	108	111	PF00017	0.464
LIG_SH2_STAT5	208	211	PF00017	0.419
LIG_SH2_STAT5	340	343	PF00017	0.609
LIG_SH2_STAT5	566	569	PF00017	0.335
LIG_SH3_3	113	119	PF00018	0.432
LIG_SH3_3	324	330	PF00018	0.370
LIG_SH3_3	381	387	PF00018	0.316
LIG_SH3_3	464	470	PF00018	0.482
LIG_SUMO_SIM_anti_2	521	530	PF11976	0.355
LIG_SUMO_SIM_anti_2	618	627	PF11976	0.438
LIG_SUMO_SIM_par_1	405	410	PF11976	0.383
LIG_SUMO_SIM_par_1	527	535	PF11976	0.369
LIG_SUMO_SIM_par_1	86	91	PF11976	0.429
LIG_TRAF2_1	16	19	PF00917	0.314
LIG_TRAF2_1	4	7	PF00917	0.412
LIG_TRAF2_1	466	469	PF00917	0.598
LIG_TRAF2_1	546	549	PF00917	0.325
LIG_TYR_ITIM	364	369	PF00017	0.352
LIG_UBA3_1	173	180	PF00899	0.447
MOD_CK1_1	135	141	PF00069	0.355
MOD_CK1_1	264	270	PF00069	0.590
MOD_CK1_1	296	302	PF00069	0.618
MOD_CK1_1	349	355	PF00069	0.205
MOD_CK1_1	399	405	PF00069	0.297
MOD_CK1_1	473	479	PF00069	0.693
MOD_CK1_1	484	490	PF00069	0.638
MOD_CK1_1	519	525	PF00069	0.362
MOD_CK1_1	596	602	PF00069	0.695
MOD_CK1_1	615	621	PF00069	0.339
MOD_CK1_1	646	652	PF00069	0.454
MOD_CK2_1	296	302	PF00069	0.572
MOD_CK2_1	307	313	PF00069	0.453
MOD_CK2_1	543	549	PF00069	0.312
MOD_Cter_Amidation	586	589	PF01082	0.656
MOD_GlcNHglycan	2	5	PF01048	0.458
MOD_GlcNHglycan	263	266	PF01048	0.483
MOD_GlcNHglycan	308	312	PF01048	0.431
MOD_GlcNHglycan	317	320	PF01048	0.371
MOD_GlcNHglycan	347	351	PF01048	0.445
MOD_GlcNHglycan	377	380	PF01048	0.347
MOD_GlcNHglycan	42	45	PF01048	0.382
MOD_GlcNHglycan	468	473	PF01048	0.632
MOD_GlcNHglycan	475	478	PF01048	0.596
MOD_GlcNHglycan	518	521	PF01048	0.412
MOD_GlcNHglycan	574	578	PF01048	0.548
MOD_GlcNHglycan	595	598	PF01048	0.567
MOD_GlcNHglycan	653	656	PF01048	0.513
MOD_GSK3_1	127	134	PF00069	0.600
MOD_GSK3_1	200	207	PF00069	0.495
MOD_GSK3_1	253	260	PF00069	0.507
MOD_GSK3_1	281	288	PF00069	0.500
MOD_GSK3_1	303	310	PF00069	0.548
MOD_GSK3_1	342	349	PF00069	0.254
MOD_GSK3_1	399	406	PF00069	0.434
MOD_GSK3_1	48	55	PF00069	0.452
MOD_GSK3_1	516	523	PF00069	0.280
MOD_GSK3_1	539	546	PF00069	0.206
MOD_GSK3_1	646	653	PF00069	0.494
MOD_GSK3_1	88	95	PF00069	0.487
MOD_N-GLC_1	416	421	PF02516	0.304
MOD_NEK2_1	188	193	PF00069	0.425
MOD_NEK2_1	293	298	PF00069	0.553
MOD_NEK2_1	416	421	PF00069	0.304
MOD_NEK2_1	422	427	PF00069	0.304
MOD_NEK2_1	52	57	PF00069	0.471
MOD_PIKK_1	296	302	PF00454	0.454
MOD_PIKK_1	399	405	PF00454	0.205
MOD_PIKK_1	484	490	PF00454	0.581
MOD_PIKK_1	88	94	PF00454	0.369
MOD_PK_1	137	143	PF00069	0.421
MOD_PKA_2	342	348	PF00069	0.259
MOD_PKA_2	403	409	PF00069	0.369
MOD_PKA_2	543	549	PF00069	0.253
MOD_PKA_2	591	597	PF00069	0.700
MOD_PKA_2	612	618	PF00069	0.415
MOD_PKA_2	646	652	PF00069	0.410
MOD_Plk_1	188	194	PF00069	0.486
MOD_Plk_1	204	210	PF00069	0.312
MOD_Plk_1	312	318	PF00069	0.596
MOD_Plk_1	481	487	PF00069	0.495
MOD_Plk_1	547	553	PF00069	0.304
MOD_Plk_2-3	285	291	PF00069	0.559
MOD_Plk_4	204	210	PF00069	0.425
MOD_Plk_4	351	357	PF00069	0.212
MOD_Plk_4	524	530	PF00069	0.304
MOD_Plk_4	599	605	PF00069	0.547
MOD_Plk_4	607	613	PF00069	0.408
MOD_ProDKin_1	145	151	PF00069	0.399
MOD_ProDKin_1	294	300	PF00069	0.467
MOD_ProDKin_1	411	417	PF00069	0.261
MOD_SUMO_rev_2	32	40	PF00179	0.343
TRG_DiLeu_BaEn_4	19	25	PF01217	0.336
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.369
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.440
TRG_ENDOCYTIC_2	366	369	PF00928	0.352
TRG_ER_diArg_1	100	103	PF00400	0.571
TRG_ER_diArg_1	322	325	PF00400	0.417
TRG_ER_diArg_1	588	591	PF00400	0.679
TRG_ER_diArg_1	62	65	PF00400	0.505
TRG_ER_diArg_1	81	83	PF00400	0.382
TRG_NLS_MonoExtC_3	587	592	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGM5	Leishmania donovani	88%	100%
A0A422NKA3	Trypanosoma rangeli	33%	100%
A4HQ69	Leishmania braziliensis	74%	100%
A4IDW7	Leishmania infantum	88%	100%
Q4Q0K8	Leishmania major	88%	100%