Hemolysin-III channel protein-like protein Izh2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania mexicana

UniProt:

E9ATY5_LEIMU

TriTrypDb:

LmxM.36.5500

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	30
GO:0110165	cellular anatomical entity	1	30

Expansion

Sequence features

E9ATY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATY5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	3
GO:0060089	molecular transducer activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.554
CLV_NRD_NRD_1	3	5	PF00675	0.475
CLV_NRD_NRD_1	50	52	PF00675	0.373
CLV_PCSK_KEX2_1	18	20	PF00082	0.577
CLV_PCSK_SKI1_1	264	268	PF00082	0.322
CLV_PCSK_SKI1_1	296	300	PF00082	0.524
CLV_PCSK_SKI1_1	84	88	PF00082	0.242
DOC_CYCLIN_RxL_1	293	300	PF00134	0.325
DOC_MAPK_MEF2A_6	161	169	PF00069	0.333
DOC_PP1_RVXF_1	261	268	PF00149	0.475
DOC_PP4_FxxP_1	247	250	PF00568	0.451
DOC_PP4_FxxP_1	314	317	PF00568	0.323
DOC_WW_Pin1_4	10	15	PF00397	0.762
DOC_WW_Pin1_4	318	323	PF00397	0.392
DOC_WW_Pin1_4	34	39	PF00397	0.687
DOC_WW_Pin1_4	57	62	PF00397	0.487
LIG_14-3-3_CanoR_1	253	260	PF00244	0.462
LIG_14-3-3_CanoR_1	4	14	PF00244	0.733
LIG_14-3-3_CanoR_1	91	97	PF00244	0.474
LIG_APCC_ABBA_1	104	109	PF00400	0.415
LIG_BRCT_BRCA1_1	182	186	PF00533	0.242
LIG_BRCT_BRCA1_1	256	260	PF00533	0.480
LIG_eIF4E_1	207	213	PF01652	0.338
LIG_FHA_1	108	114	PF00498	0.428
LIG_FHA_1	130	136	PF00498	0.359
LIG_FHA_1	169	175	PF00498	0.325
LIG_FHA_1	208	214	PF00498	0.305
LIG_FHA_1	260	266	PF00498	0.453
LIG_FHA_1	277	283	PF00498	0.270
LIG_FHA_1	65	71	PF00498	0.537
LIG_FHA_1	99	105	PF00498	0.497
LIG_IRF3_LxIS_1	286	291	PF10401	0.333
LIG_LIR_Gen_1	183	193	PF02991	0.218
LIG_LIR_Gen_1	195	206	PF02991	0.419
LIG_LIR_Gen_1	210	219	PF02991	0.183
LIG_LIR_Gen_1	345	355	PF02991	0.319
LIG_LIR_LC3C_4	210	214	PF02991	0.295
LIG_LIR_Nem_3	162	167	PF02991	0.235
LIG_LIR_Nem_3	183	189	PF02991	0.307
LIG_LIR_Nem_3	205	209	PF02991	0.285
LIG_LIR_Nem_3	210	214	PF02991	0.288
LIG_LIR_Nem_3	216	220	PF02991	0.302
LIG_LIR_Nem_3	241	245	PF02991	0.242
LIG_LIR_Nem_3	324	328	PF02991	0.492
LIG_LIR_Nem_3	345	351	PF02991	0.319
LIG_PDZ_Class_2	358	363	PF00595	0.277
LIG_Pex14_1	231	235	PF04695	0.237
LIG_Pex14_1	96	100	PF04695	0.574
LIG_Pex14_2	247	251	PF04695	0.301
LIG_Pex14_2	310	314	PF04695	0.303
LIG_Pex14_2	325	329	PF04695	0.415
LIG_REV1ctd_RIR_1	249	257	PF16727	0.301
LIG_SH2_CRK	348	352	PF00017	0.219
LIG_SH2_NCK_1	348	352	PF00017	0.219
LIG_SH2_STAP1	312	316	PF00017	0.266
LIG_SH2_STAT5	139	142	PF00017	0.284
LIG_SH2_STAT5	223	226	PF00017	0.255
LIG_SH2_STAT5	235	238	PF00017	0.278
LIG_SH2_STAT5	268	271	PF00017	0.204
LIG_SH2_STAT5	294	297	PF00017	0.245
LIG_SH2_STAT5	328	331	PF00017	0.437
LIG_SH2_STAT5	354	357	PF00017	0.277
LIG_SH2_STAT5	71	74	PF00017	0.435
LIG_SH2_STAT5	79	82	PF00017	0.501
LIG_SH2_STAT5	85	88	PF00017	0.493
LIG_SH2_STAT5	94	97	PF00017	0.481
LIG_TYR_ITIM	204	209	PF00017	0.286
LIG_WRC_WIRS_1	169	174	PF05994	0.313
LIG_WRC_WIRS_1	186	191	PF05994	0.483
LIG_WRC_WIRS_1	214	219	PF05994	0.290
LIG_WRC_WIRS_1	239	244	PF05994	0.375
MOD_CDC14_SPxK_1	15	18	PF00782	0.571
MOD_CDK_SPxK_1	12	18	PF00069	0.574
MOD_CDK_SPxxK_3	12	19	PF00069	0.600
MOD_CK1_1	24	30	PF00069	0.698
MOD_CK1_1	3	9	PF00069	0.710
MOD_CK1_1	321	327	PF00069	0.547
MOD_CK1_1	356	362	PF00069	0.404
MOD_CK1_1	39	45	PF00069	0.598
MOD_GlcNHglycan	182	185	PF01048	0.303
MOD_GlcNHglycan	273	276	PF01048	0.279
MOD_GlcNHglycan	290	293	PF01048	0.435
MOD_GlcNHglycan	32	35	PF01048	0.566
MOD_GlcNHglycan	8	11	PF01048	0.503
MOD_GSK3_1	234	241	PF00069	0.351
MOD_GSK3_1	276	283	PF00069	0.313
MOD_GSK3_1	30	37	PF00069	0.663
MOD_GSK3_1	4	11	PF00069	0.707
MOD_N-GLC_1	107	112	PF02516	0.237
MOD_N-GLC_1	148	153	PF02516	0.510
MOD_N-GLC_1	39	44	PF02516	0.449
MOD_N-GLC_1	63	68	PF02516	0.372
MOD_NEK2_1	180	185	PF00069	0.227
MOD_NEK2_1	238	243	PF00069	0.289
MOD_NEK2_1	271	276	PF00069	0.283
MOD_NEK2_1	288	293	PF00069	0.277
MOD_NEK2_1	327	332	PF00069	0.451
MOD_OFUCOSY	221	227	PF10250	0.376
MOD_PIKK_1	280	286	PF00454	0.423
MOD_PKA_1	4	10	PF00069	0.756
MOD_PKA_2	3	9	PF00069	0.645
MOD_PKA_2	356	362	PF00069	0.339
MOD_Plk_1	107	113	PF00069	0.453
MOD_Plk_1	21	27	PF00069	0.782
MOD_Plk_1	63	69	PF00069	0.603
MOD_Plk_4	185	191	PF00069	0.281
MOD_Plk_4	213	219	PF00069	0.282
MOD_Plk_4	234	240	PF00069	0.264
MOD_Plk_4	297	303	PF00069	0.335
MOD_Plk_4	356	362	PF00069	0.305
MOD_Plk_4	99	105	PF00069	0.541
MOD_ProDKin_1	10	16	PF00069	0.759
MOD_ProDKin_1	318	324	PF00069	0.392
MOD_ProDKin_1	34	40	PF00069	0.692
MOD_ProDKin_1	57	63	PF00069	0.479
MOD_SUMO_rev_2	39	47	PF00179	0.551
TRG_ENDOCYTIC_2	198	201	PF00928	0.442
TRG_ENDOCYTIC_2	206	209	PF00928	0.211
TRG_ENDOCYTIC_2	235	238	PF00928	0.297
TRG_ENDOCYTIC_2	268	271	PF00928	0.276
TRG_ENDOCYTIC_2	348	351	PF00928	0.296
TRG_ER_diArg_1	18	20	PF00400	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I280	Leptomonas seymouri	64%	100%
A0A0N1I909	Leptomonas seymouri	34%	100%
A0A0N1PEB9	Leptomonas seymouri	37%	67%
A0A0S4J7T5	Bodo saltans	34%	98%
A0A0S4J8V2	Bodo saltans	42%	100%
A0A0S4JQM0	Bodo saltans	41%	100%
A0A0S4JWI8	Bodo saltans	37%	100%
A0A0S4KIQ2	Bodo saltans	36%	100%
A0A1X0P1D6	Trypanosomatidae	34%	100%
A0A1X0P1Q2	Trypanosomatidae	48%	100%
A0A3R7L1Y6	Trypanosoma rangeli	46%	100%
A0A3S7XBT4	Leishmania donovani	92%	100%
A0A3S7XBU6	Leishmania donovani	36%	71%
A0A3S7XC05	Leishmania donovani	35%	100%
A4HQ64	Leishmania braziliensis	36%	71%
A4HQ67	Leishmania braziliensis	79%	100%
A4HQ68	Leishmania braziliensis	33%	100%
A4IDW4	Leishmania infantum	92%	100%
A4IDW5	Leishmania infantum	35%	71%
A4IDW6	Leishmania infantum	35%	100%
B7F9G7	Oryza sativa subsp. japonica	29%	97%
D0A450	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A451	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	73%
E9ATY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q03419	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q07959	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	67%
Q09749	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q09910	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	82%
Q12442	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4Q0K9	Leishmania major	35%	100%
Q4Q0L0	Leishmania major	35%	72%
Q4Q0L1	Leishmania major	91%	100%
Q6DC77	Danio rerio	25%	100%
Q6TCG8	Mus musculus	30%	100%
Q6TCH4	Homo sapiens	26%	100%
Q6TCH7	Homo sapiens	31%	100%
Q753H5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q75F81	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	87%
Q801D8	Cynoscion nebulosus	26%	100%
Q801G2	Danio rerio	23%	100%
Q84N34	Arabidopsis thaliana	30%	100%
Q86V24	Homo sapiens	33%	94%
Q8BQS5	Mus musculus	34%	94%
Q91VH1	Mus musculus	29%	97%
Q93ZH9	Arabidopsis thaliana	32%	100%
Q94177	Caenorhabditis elegans	32%	84%
Q96A54	Homo sapiens	33%	97%
Q9DCU0	Mus musculus	26%	100%
Q9JJE4	Mus musculus	28%	100%
Q9NXK6	Homo sapiens	26%	100%
Q9SVF3	Arabidopsis thaliana	31%	97%
Q9SZG0	Arabidopsis thaliana	31%	94%
Q9VCY8	Drosophila melanogaster	31%	82%
Q9ZUH8	Arabidopsis thaliana	30%	100%
V5BJ57	Trypanosoma cruzi	36%	100%
V5DK49	Trypanosoma cruzi	47%	100%