DAO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative

Species:

Leishmania mexicana

UniProt:

E9ATY1_LEIMU

TriTrypDb:

LmxM.36.5460

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0003973	(S)-2-hydroxy-acid oxidase activity	5	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	4	1
GO:0047545	2-hydroxyglutarate dehydrogenase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.262
CLV_NRD_NRD_1	28	30	PF00675	0.570
CLV_NRD_NRD_1	315	317	PF00675	0.281
CLV_NRD_NRD_1	329	331	PF00675	0.384
CLV_NRD_NRD_1	346	348	PF00675	0.254
CLV_NRD_NRD_1	53	55	PF00675	0.441
CLV_NRD_NRD_1	80	82	PF00675	0.308
CLV_PCSK_KEX2_1	28	30	PF00082	0.570
CLV_PCSK_KEX2_1	296	298	PF00082	0.364
CLV_PCSK_KEX2_1	315	317	PF00082	0.425
CLV_PCSK_KEX2_1	346	348	PF00082	0.254
CLV_PCSK_KEX2_1	406	408	PF00082	0.329
CLV_PCSK_KEX2_1	53	55	PF00082	0.441
CLV_PCSK_KEX2_1	82	84	PF00082	0.272
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.336
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.329
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.272
CLV_PCSK_SKI1_1	209	213	PF00082	0.272
CLV_PCSK_SKI1_1	265	269	PF00082	0.385
CLV_PCSK_SKI1_1	407	411	PF00082	0.277
CLV_PCSK_SKI1_1	465	469	PF00082	0.568
CLV_PCSK_SKI1_1	83	87	PF00082	0.272
DEG_APCC_DBOX_1	208	216	PF00400	0.272
DOC_CKS1_1	310	315	PF01111	0.329
DOC_MAPK_gen_1	315	323	PF00069	0.281
DOC_MAPK_gen_1	330	337	PF00069	0.385
DOC_MAPK_gen_1	346	353	PF00069	0.254
DOC_MAPK_gen_1	53	61	PF00069	0.389
DOC_MAPK_gen_1	78	87	PF00069	0.366
DOC_MAPK_JIP1_4	488	494	PF00069	0.352
DOC_MAPK_MEF2A_6	330	339	PF00069	0.276
DOC_MAPK_RevD_3	333	347	PF00069	0.254
DOC_PP4_FxxP_1	110	113	PF00568	0.385
DOC_PP4_FxxP_1	451	454	PF00568	0.372
DOC_USP7_MATH_1	284	288	PF00917	0.284
DOC_USP7_MATH_1	502	506	PF00917	0.244
DOC_USP7_MATH_1	515	519	PF00917	0.314
DOC_USP7_UBL2_3	78	82	PF12436	0.332
DOC_WW_Pin1_4	193	198	PF00397	0.254
DOC_WW_Pin1_4	309	314	PF00397	0.329
DOC_WW_Pin1_4	337	342	PF00397	0.265
DOC_WW_Pin1_4	364	369	PF00397	0.272
DOC_WW_Pin1_4	496	501	PF00397	0.317
LIG_14-3-3_CanoR_1	123	128	PF00244	0.281
LIG_14-3-3_CanoR_1	297	303	PF00244	0.382
LIG_14-3-3_CanoR_1	330	336	PF00244	0.334
LIG_14-3-3_CanoR_1	453	459	PF00244	0.383
LIG_14-3-3_CanoR_1	476	482	PF00244	0.387
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BRCT_BRCA1_1	516	520	PF00533	0.415
LIG_CSL_BTD_1	194	197	PF09270	0.332
LIG_FHA_1	338	344	PF00498	0.303
LIG_FHA_1	481	487	PF00498	0.387
LIG_FHA_2	477	483	PF00498	0.398
LIG_FHA_2	69	75	PF00498	0.297
LIG_LIR_Apic_2	450	454	PF02991	0.336
LIG_LIR_Gen_1	203	212	PF02991	0.254
LIG_LIR_Gen_1	391	401	PF02991	0.324
LIG_LIR_Nem_3	192	198	PF02991	0.339
LIG_LIR_Nem_3	203	207	PF02991	0.200
LIG_LIR_Nem_3	233	237	PF02991	0.266
LIG_LIR_Nem_3	391	396	PF02991	0.295
LIG_LIR_Nem_3	399	404	PF02991	0.284
LIG_LIR_Nem_3	427	432	PF02991	0.286
LIG_Pex14_2	223	227	PF04695	0.254
LIG_Pex14_2	377	381	PF04695	0.351
LIG_Pex14_2	393	397	PF04695	0.204
LIG_Rb_pABgroove_1	155	163	PF01858	0.385
LIG_SH2_CRK	429	433	PF00017	0.354
LIG_SH2_STAP1	369	373	PF00017	0.385
LIG_SH2_STAP1	57	61	PF00017	0.312
LIG_SH2_STAT5	131	134	PF00017	0.272
LIG_SH2_STAT5	366	369	PF00017	0.267
LIG_SH2_STAT5	375	378	PF00017	0.253
LIG_SH2_STAT5	429	432	PF00017	0.354
LIG_SH3_3	453	459	PF00018	0.430
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.512
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.294
LIG_SUMO_SIM_par_1	83	88	PF11976	0.272
LIG_TRFH_1	309	313	PF08558	0.293
LIG_TYR_ITSM	397	404	PF00017	0.281
LIG_UBA3_1	211	220	PF00899	0.309
LIG_UBA3_1	416	423	PF00899	0.381
LIG_Vh1_VBS_1	1	19	PF01044	0.548
LIG_WRC_WIRS_1	45	50	PF05994	0.482
MOD_CDK_SPxK_1	309	315	PF00069	0.329
MOD_CDK_SPxxK_3	309	316	PF00069	0.281
MOD_CK1_1	10	16	PF00069	0.631
MOD_CK1_1	196	202	PF00069	0.254
MOD_CK1_1	205	211	PF00069	0.254
MOD_CK1_1	33	39	PF00069	0.425
MOD_CK1_1	388	394	PF00069	0.324
MOD_CK1_1	44	50	PF00069	0.333
MOD_CK1_1	477	483	PF00069	0.597
MOD_CK1_1	484	490	PF00069	0.529
MOD_CK2_1	476	482	PF00069	0.384
MOD_CK2_1	68	74	PF00069	0.330
MOD_Cter_Amidation	294	297	PF01082	0.272
MOD_GlcNHglycan	101	104	PF01048	0.258
MOD_GlcNHglycan	114	117	PF01048	0.317
MOD_GlcNHglycan	191	194	PF01048	0.344
MOD_GlcNHglycan	198	201	PF01048	0.270
MOD_GlcNHglycan	286	289	PF01048	0.278
MOD_GlcNHglycan	356	359	PF01048	0.296
MOD_GlcNHglycan	476	479	PF01048	0.545
MOD_GlcNHglycan	9	12	PF01048	0.597
MOD_GlcNHglycan	97	100	PF01048	0.286
MOD_GSK3_1	149	156	PF00069	0.305
MOD_GSK3_1	189	196	PF00069	0.332
MOD_GSK3_1	235	242	PF00069	0.330
MOD_GSK3_1	33	40	PF00069	0.493
MOD_GSK3_1	454	461	PF00069	0.394
MOD_GSK3_1	476	483	PF00069	0.428
MOD_GSK3_1	496	503	PF00069	0.304
MOD_GSK3_1	95	102	PF00069	0.254
MOD_NEK2_1	149	154	PF00069	0.148
MOD_NEK2_1	396	401	PF00069	0.445
MOD_NEK2_1	402	407	PF00069	0.322
MOD_NEK2_1	481	486	PF00069	0.453
MOD_PIKK_1	10	16	PF00454	0.649
MOD_PIKK_1	149	155	PF00454	0.385
MOD_PIKK_1	222	228	PF00454	0.309
MOD_PK_1	331	337	PF00069	0.272
MOD_PKA_2	153	159	PF00069	0.352
MOD_PKA_2	454	460	PF00069	0.453
MOD_Plk_1	263	269	PF00069	0.297
MOD_Plk_1	481	487	PF00069	0.387
MOD_Plk_4	123	129	PF00069	0.368
MOD_Plk_4	263	269	PF00069	0.332
MOD_Plk_4	385	391	PF00069	0.316
MOD_Plk_4	396	402	PF00069	0.381
MOD_Plk_4	41	47	PF00069	0.443
MOD_ProDKin_1	193	199	PF00069	0.254
MOD_ProDKin_1	309	315	PF00069	0.329
MOD_ProDKin_1	337	343	PF00069	0.265
MOD_ProDKin_1	364	370	PF00069	0.272
MOD_ProDKin_1	496	502	PF00069	0.317
MOD_SUMO_rev_2	419	425	PF00179	0.381
TRG_DiLeu_BaEn_1	248	253	PF01217	0.369
TRG_DiLeu_BaEn_1	412	417	PF01217	0.249
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.374
TRG_ENDOCYTIC_2	308	311	PF00928	0.293
TRG_ENDOCYTIC_2	31	34	PF00928	0.430
TRG_ENDOCYTIC_2	401	404	PF00928	0.385
TRG_ENDOCYTIC_2	429	432	PF00928	0.354
TRG_ER_diArg_1	253	256	PF00400	0.281
TRG_ER_diArg_1	27	29	PF00400	0.570
TRG_ER_diArg_1	304	307	PF00400	0.254
TRG_ER_diArg_1	345	347	PF00400	0.324
TRG_ER_diArg_1	453	456	PF00400	0.397
TRG_ER_diArg_1	80	83	PF00400	0.366
TRG_NLS_MonoExtN_4	78	85	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.159

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P3	Leptomonas seymouri	23%	100%
A0A0N1PEN9	Leptomonas seymouri	78%	100%
A0A0S4JUB7	Bodo saltans	44%	100%
A0A1X0P066	Trypanosomatidae	58%	100%
A0A3Q8IJT1	Leishmania donovani	96%	100%
A0A5Y6MCT2	Salmonella houtenae	29%	100%
A4HQ61	Leishmania braziliensis	86%	100%
A4IDW0	Leishmania infantum	96%	100%
A7MBI3	Bos taurus	33%	100%
A7SMW7	Nematostella vectensis	35%	100%
A8X2R1	Caenorhabditis briggsae	33%	100%
B7N6P4	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	30%	100%
D0A456	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
P37339	Escherichia coli (strain K12)	30%	100%
Q4Q0L5	Leishmania major	94%	100%
Q55GI5	Dictyostelium discoideum	31%	100%
Q91YP0	Mus musculus	32%	100%
Q9H9P8	Homo sapiens	32%	100%
Q9LES4	Arabidopsis thaliana	25%	100%
Q9N4Z0	Caenorhabditis elegans	33%	100%
S2DJ52	Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1)	29%	100%
V5DK53	Trypanosoma cruzi	56%	100%