SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATX9_LEIMU

TriTrypDb:

LmxM.36.5440partial

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ATX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATX9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.692
CLV_C14_Caspase3-7	226	230	PF00656	0.648
CLV_C14_Caspase3-7	461	465	PF00656	0.576
CLV_NRD_NRD_1	409	411	PF00675	0.742
CLV_NRD_NRD_1	45	47	PF00675	0.550
CLV_NRD_NRD_1	501	503	PF00675	0.536
CLV_NRD_NRD_1	554	556	PF00675	0.421
CLV_NRD_NRD_1	56	58	PF00675	0.652
CLV_NRD_NRD_1	6	8	PF00675	0.758
CLV_PCSK_FUR_1	54	58	PF00082	0.721
CLV_PCSK_KEX2_1	409	411	PF00082	0.742
CLV_PCSK_KEX2_1	45	47	PF00082	0.549
CLV_PCSK_KEX2_1	5	7	PF00082	0.760
CLV_PCSK_KEX2_1	500	502	PF00082	0.526
CLV_PCSK_KEX2_1	56	58	PF00082	0.655
CLV_PCSK_SKI1_1	159	163	PF00082	0.560
CLV_PCSK_SKI1_1	211	215	PF00082	0.720
CLV_PCSK_SKI1_1	303	307	PF00082	0.521
CLV_PCSK_SKI1_1	46	50	PF00082	0.573
CLV_PCSK_SKI1_1	603	607	PF00082	0.613
DEG_APCC_DBOX_1	45	53	PF00400	0.614
DOC_AGCK_PIF_2	355	360	PF00069	0.517
DOC_CKS1_1	206	211	PF01111	0.733
DOC_CYCLIN_RxL_1	43	51	PF00134	0.638
DOC_CYCLIN_yClb5_NLxxxL_5	523	532	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.685
DOC_MAPK_gen_1	315	324	PF00069	0.460
DOC_MAPK_MEF2A_6	315	324	PF00069	0.422
DOC_MAPK_MEF2A_6	596	604	PF00069	0.528
DOC_USP7_MATH_1	174	178	PF00917	0.688
DOC_USP7_MATH_1	200	204	PF00917	0.802
DOC_USP7_MATH_1	207	211	PF00917	0.645
DOC_USP7_MATH_1	268	272	PF00917	0.592
DOC_USP7_MATH_1	519	523	PF00917	0.710
DOC_USP7_MATH_1	561	565	PF00917	0.482
DOC_USP7_MATH_1	58	62	PF00917	0.704
DOC_USP7_UBL2_3	232	236	PF12436	0.801
DOC_USP7_UBL2_3	303	307	PF12436	0.559
DOC_WW_Pin1_4	11	16	PF00397	0.734
DOC_WW_Pin1_4	183	188	PF00397	0.678
DOC_WW_Pin1_4	198	203	PF00397	0.655
DOC_WW_Pin1_4	205	210	PF00397	0.644
DOC_WW_Pin1_4	33	38	PF00397	0.705
DOC_WW_Pin1_4	434	439	PF00397	0.613
DOC_WW_Pin1_4	56	61	PF00397	0.724
LIG_14-3-3_CanoR_1	277	282	PF00244	0.604
LIG_14-3-3_CanoR_1	294	302	PF00244	0.397
LIG_14-3-3_CanoR_1	424	429	PF00244	0.729
LIG_14-3-3_CanoR_1	587	593	PF00244	0.492
LIG_APCC_ABBA_1	153	158	PF00400	0.480
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BRCT_BRCA1_1	218	222	PF00533	0.669
LIG_BRCT_BRCA1_1	520	524	PF00533	0.677
LIG_deltaCOP1_diTrp_1	581	589	PF00928	0.572
LIG_eIF4E_1	156	162	PF01652	0.611
LIG_FHA_1	148	154	PF00498	0.510
LIG_FHA_1	238	244	PF00498	0.766
LIG_FHA_1	383	389	PF00498	0.522
LIG_FHA_1	429	435	PF00498	0.431
LIG_FHA_1	597	603	PF00498	0.427
LIG_FHA_2	152	158	PF00498	0.584
LIG_FHA_2	232	238	PF00498	0.605
LIG_FHA_2	42	48	PF00498	0.623
LIG_FHA_2	425	431	PF00498	0.720
LIG_Integrin_isoDGR_2	3	5	PF01839	0.808
LIG_LIR_Gen_1	588	594	PF02991	0.512
LIG_LIR_Nem_3	353	358	PF02991	0.476
LIG_LIR_Nem_3	564	568	PF02991	0.536
LIG_LIR_Nem_3	588	592	PF02991	0.522
LIG_Pex14_1	302	306	PF04695	0.527
LIG_Pex14_2	218	222	PF04695	0.739
LIG_Rb_pABgroove_1	150	158	PF01858	0.584
LIG_SH2_CRK	131	135	PF00017	0.595
LIG_SH2_CRK	436	440	PF00017	0.582
LIG_SH2_STAT5	299	302	PF00017	0.557
LIG_SH2_STAT5	436	439	PF00017	0.641
LIG_SH3_2	206	211	PF14604	0.793
LIG_SH3_2	415	420	PF14604	0.700
LIG_SH3_3	181	187	PF00018	0.769
LIG_SH3_3	203	209	PF00018	0.778
LIG_SH3_3	332	338	PF00018	0.476
LIG_SH3_3	398	404	PF00018	0.729
LIG_SH3_3	412	418	PF00018	0.771
LIG_SH3_3	60	66	PF00018	0.764
LIG_SUMO_SIM_par_1	149	158	PF11976	0.504
LIG_SUMO_SIM_par_1	30	36	PF11976	0.717
LIG_SUMO_SIM_par_1	368	374	PF11976	0.476
LIG_SUMO_SIM_par_1	458	464	PF11976	0.552
LIG_TYR_ITIM	434	439	PF00017	0.663
LIG_UBA3_1	532	540	PF00899	0.559
LIG_UBA3_1	600	606	PF00899	0.505
LIG_WRPW_2	336	339	PF00400	0.476
MOD_CDK_SPxK_1	205	211	PF00069	0.677
MOD_CDK_SPxK_1	434	440	PF00069	0.409
MOD_CDK_SPxxK_3	183	190	PF00069	0.719
MOD_CK1_1	178	184	PF00069	0.685
MOD_CK1_1	205	211	PF00069	0.684
MOD_CK1_1	280	286	PF00069	0.564
MOD_CK1_1	478	484	PF00069	0.720
MOD_CK1_1	509	515	PF00069	0.661
MOD_CK1_1	59	65	PF00069	0.774
MOD_CK1_1	9	15	PF00069	0.721
MOD_CK2_1	231	237	PF00069	0.608
MOD_CK2_1	41	47	PF00069	0.597
MOD_CK2_1	424	430	PF00069	0.688
MOD_CK2_1	490	496	PF00069	0.474
MOD_CK2_1	561	567	PF00069	0.436
MOD_CK2_1	75	81	PF00069	0.733
MOD_Cter_Amidation	3	6	PF01082	0.724
MOD_Cter_Amidation	407	410	PF01082	0.750
MOD_GlcNHglycan	11	14	PF01048	0.811
MOD_GlcNHglycan	177	180	PF01048	0.664
MOD_GlcNHglycan	218	221	PF01048	0.709
MOD_GlcNHglycan	264	267	PF01048	0.752
MOD_GlcNHglycan	270	273	PF01048	0.692
MOD_GlcNHglycan	455	458	PF01048	0.652
MOD_GlcNHglycan	480	483	PF01048	0.676
MOD_GlcNHglycan	492	495	PF01048	0.369
MOD_GlcNHglycan	508	511	PF01048	0.391
MOD_GlcNHglycan	516	519	PF01048	0.652
MOD_GlcNHglycan	92	95	PF01048	0.618
MOD_GSK3_1	147	154	PF00069	0.569
MOD_GSK3_1	174	181	PF00069	0.614
MOD_GSK3_1	198	205	PF00069	0.784
MOD_GSK3_1	216	223	PF00069	0.683
MOD_GSK3_1	424	431	PF00069	0.608
MOD_GSK3_1	514	521	PF00069	0.664
MOD_GSK3_1	86	93	PF00069	0.692
MOD_N-GLC_1	478	483	PF02516	0.534
MOD_NEK2_1	242	247	PF00069	0.670
MOD_NEK2_1	428	433	PF00069	0.440
MOD_NEK2_2	151	156	PF00069	0.584
MOD_NEK2_2	485	490	PF00069	0.583
MOD_NEK2_2	519	524	PF00069	0.588
MOD_PIKK_1	112	118	PF00454	0.604
MOD_PIKK_1	192	198	PF00454	0.786
MOD_PIKK_1	392	398	PF00454	0.691
MOD_PK_1	277	283	PF00069	0.590
MOD_PKA_1	6	12	PF00069	0.709
MOD_PKA_2	6	12	PF00069	0.804
MOD_PKA_2	64	70	PF00069	0.680
MOD_PKB_1	88	96	PF00069	0.659
MOD_Plk_1	547	553	PF00069	0.432
MOD_Plk_2-3	75	81	PF00069	0.729
MOD_Plk_4	151	157	PF00069	0.541
MOD_Plk_4	519	525	PF00069	0.643
MOD_Plk_4	596	602	PF00069	0.416
MOD_ProDKin_1	11	17	PF00069	0.734
MOD_ProDKin_1	183	189	PF00069	0.679
MOD_ProDKin_1	198	204	PF00069	0.656
MOD_ProDKin_1	205	211	PF00069	0.644
MOD_ProDKin_1	33	39	PF00069	0.699
MOD_ProDKin_1	434	440	PF00069	0.607
MOD_ProDKin_1	56	62	PF00069	0.727
MOD_SUMO_for_1	578	581	PF00179	0.623
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.687
TRG_ENDOCYTIC_2	131	134	PF00928	0.599
TRG_ENDOCYTIC_2	436	439	PF00928	0.589
TRG_ER_diArg_1	409	411	PF00400	0.762
TRG_ER_diArg_1	499	502	PF00400	0.558
TRG_ER_diArg_1	5	7	PF00400	0.796
TRG_ER_diArg_1	53	56	PF00400	0.628
TRG_ER_diArg_1	87	90	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT0	Leptomonas seymouri	55%	97%
A0A0S4JTW8	Bodo saltans	34%	100%
A0A1X0P060	Trypanosomatidae	34%	100%
A0A3R7LYT2	Trypanosoma rangeli	32%	100%
A0A3S7XBW1	Leishmania donovani	90%	99%
A4HQ59	Leishmania braziliensis	76%	100%
A4IDV8	Leishmania infantum	90%	99%
D0A458	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q0L7	Leishmania major	92%	100%
V5BQB1	Trypanosoma cruzi	34%	100%