Macrocin-O-methyltransferase_(TylF)/Methyltransferase_domain_containing_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Macrocin-O-methyltransferase (TylF), putative

Species:

Leishmania mexicana

UniProt:

E9ATX8_LEIMU

TriTrypDb:

LmxM.36.5430

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATX8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.519
CLV_NRD_NRD_1	190	192	PF00675	0.319
CLV_NRD_NRD_1	313	315	PF00675	0.449
CLV_PCSK_KEX2_1	189	191	PF00082	0.390
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.398
CLV_PCSK_SKI1_1	190	194	PF00082	0.413
CLV_PCSK_SKI1_1	301	305	PF00082	0.340
CLV_PCSK_SKI1_1	97	101	PF00082	0.517
DEG_APCC_DBOX_1	300	308	PF00400	0.391
DEG_Nend_Nbox_1	1	3	PF02207	0.664
DEG_SPOP_SBC_1	215	219	PF00917	0.397
DOC_CYCLIN_RxL_1	49	59	PF00134	0.437
DOC_CYCLIN_RxL_1	94	104	PF00134	0.552
DOC_MAPK_MEF2A_6	301	310	PF00069	0.443
DOC_MAPK_NFAT4_5	301	309	PF00069	0.449
DOC_PP1_RVXF_1	50	57	PF00149	0.394
DOC_PP2B_LxvP_1	306	309	PF13499	0.449
DOC_PP2B_LxvP_1	99	102	PF13499	0.419
DOC_PP4_MxPP_1	201	204	PF00568	0.396
DOC_USP7_MATH_1	178	182	PF00917	0.475
DOC_USP7_MATH_1	194	198	PF00917	0.319
DOC_USP7_MATH_1	225	229	PF00917	0.458
DOC_USP7_MATH_1	232	236	PF00917	0.420
DOC_USP7_MATH_1	316	320	PF00917	0.447
DOC_USP7_MATH_1	68	72	PF00917	0.511
DOC_WW_Pin1_4	184	189	PF00397	0.455
DOC_WW_Pin1_4	2	7	PF00397	0.386
DOC_WW_Pin1_4	240	245	PF00397	0.427
LIG_14-3-3_CanoR_1	253	258	PF00244	0.433
LIG_14-3-3_CanoR_1	69	73	PF00244	0.533
LIG_Actin_WH2_2	25	41	PF00022	0.480
LIG_Clathr_ClatBox_1	261	265	PF01394	0.475
LIG_Clathr_ClatBox_1	289	293	PF01394	0.449
LIG_eIF4E_1	110	116	PF01652	0.312
LIG_FHA_1	136	142	PF00498	0.326
LIG_FHA_1	2	8	PF00498	0.668
LIG_FHA_1	267	273	PF00498	0.478
LIG_FHA_1	93	99	PF00498	0.537
LIG_FHA_2	203	209	PF00498	0.346
LIG_FHA_2	300	306	PF00498	0.442
LIG_LIR_LC3C_4	258	263	PF02991	0.413
LIG_LIR_Nem_3	127	131	PF02991	0.328
LIG_PCNA_yPIPBox_3	107	116	PF02747	0.510
LIG_Pex14_2	113	117	PF04695	0.511
LIG_SH2_STAP1	50	54	PF00017	0.460
LIG_SH3_3	352	358	PF00018	0.281
LIG_SUMO_SIM_anti_2	258	265	PF11976	0.385
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.449
LIG_SUMO_SIM_anti_2	302	308	PF11976	0.449
LIG_SUMO_SIM_par_1	258	265	PF11976	0.475
LIG_WRC_WIRS_1	195	200	PF05994	0.328
MOD_CDC14_SPxK_1	187	190	PF00782	0.475
MOD_CDK_SPK_2	184	189	PF00069	0.398
MOD_CDK_SPxK_1	184	190	PF00069	0.475
MOD_CDK_SPxxK_3	184	191	PF00069	0.475
MOD_CK1_1	148	154	PF00069	0.464
MOD_CK1_1	218	224	PF00069	0.425
MOD_CK1_1	299	305	PF00069	0.423
MOD_CK2_1	225	231	PF00069	0.428
MOD_CK2_1	299	305	PF00069	0.437
MOD_CK2_1	68	74	PF00069	0.518
MOD_GlcNHglycan	148	151	PF01048	0.459
MOD_GlcNHglycan	166	169	PF01048	0.268
MOD_GlcNHglycan	181	184	PF01048	0.344
MOD_GlcNHglycan	211	214	PF01048	0.429
MOD_GlcNHglycan	317	321	PF01048	0.449
MOD_GSK3_1	120	127	PF00069	0.428
MOD_GSK3_1	179	186	PF00069	0.405
MOD_GSK3_1	214	221	PF00069	0.363
MOD_N-GLC_1	92	97	PF02516	0.557
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	120	125	PF00069	0.390
MOD_NEK2_1	268	273	PF00069	0.339
MOD_NEK2_2	237	242	PF00069	0.475
MOD_PIKK_1	218	224	PF00454	0.475
MOD_PK_1	253	259	PF00069	0.398
MOD_PKA_2	68	74	PF00069	0.518
MOD_Plk_1	121	127	PF00069	0.381
MOD_Plk_1	230	236	PF00069	0.207
MOD_Plk_4	121	127	PF00069	0.361
MOD_Plk_4	68	74	PF00069	0.508
MOD_Plk_4	84	90	PF00069	0.302
MOD_ProDKin_1	184	190	PF00069	0.455
MOD_ProDKin_1	2	8	PF00069	0.376
MOD_ProDKin_1	240	246	PF00069	0.427
TRG_DiLeu_BaEn_1	61	66	PF01217	0.510
TRG_DiLeu_BaEn_1	84	89	PF01217	0.511
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.451
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.529
TRG_ENDOCYTIC_2	110	113	PF00928	0.469
TRG_ER_diArg_1	190	192	PF00400	0.392
TRG_ER_diArg_1	311	314	PF00400	0.449
TRG_NLS_MonoExtN_4	188	193	PF00514	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC88	Leptomonas seymouri	58%	99%
A0A0S4JTC1	Bodo saltans	39%	100%
A0A1X0P072	Trypanosomatidae	42%	100%
A0A3S5IRD0	Trypanosoma rangeli	45%	100%
A0A3S7XBX8	Leishmania donovani	93%	100%
A4HQ58	Leishmania braziliensis	81%	100%
A4IDV7	Leishmania infantum	94%	100%
D0A459	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q0L8	Leishmania major	91%	100%
V5DLQ3	Trypanosoma cruzi	43%	100%