Mitochondrial chaperone BCS1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone BCS1, putative

Species:

Leishmania mexicana

UniProt:

E9ATX5_LEIMU

TriTrypDb:

LmxM.36.5400

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ATX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATX5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	287	289	PF00675	0.390
CLV_NRD_NRD_1	330	332	PF00675	0.316
CLV_NRD_NRD_1	367	369	PF00675	0.360
CLV_NRD_NRD_1	38	40	PF00675	0.685
CLV_NRD_NRD_1	419	421	PF00675	0.519
CLV_NRD_NRD_1	523	525	PF00675	0.439
CLV_NRD_NRD_1	62	64	PF00675	0.533
CLV_NRD_NRD_1	87	89	PF00675	0.674
CLV_NRD_NRD_1	93	95	PF00675	0.648
CLV_PCSK_FUR_1	328	332	PF00082	0.351
CLV_PCSK_FUR_1	90	94	PF00082	0.624
CLV_PCSK_KEX2_1	286	288	PF00082	0.392
CLV_PCSK_KEX2_1	330	332	PF00082	0.304
CLV_PCSK_KEX2_1	367	369	PF00082	0.360
CLV_PCSK_KEX2_1	38	40	PF00082	0.686
CLV_PCSK_KEX2_1	419	421	PF00082	0.552
CLV_PCSK_KEX2_1	523	525	PF00082	0.439
CLV_PCSK_KEX2_1	62	64	PF00082	0.533
CLV_PCSK_KEX2_1	87	89	PF00082	0.668
CLV_PCSK_KEX2_1	92	94	PF00082	0.657
CLV_PCSK_PC7_1	88	94	PF00082	0.668
CLV_PCSK_SKI1_1	133	137	PF00082	0.446
CLV_PCSK_SKI1_1	202	206	PF00082	0.420
CLV_PCSK_SKI1_1	234	238	PF00082	0.427
CLV_PCSK_SKI1_1	350	354	PF00082	0.382
CLV_PCSK_SKI1_1	420	424	PF00082	0.361
CLV_PCSK_SKI1_1	497	501	PF00082	0.492
DEG_APCC_DBOX_1	329	337	PF00400	0.332
DEG_MDM2_SWIB_1	248	255	PF02201	0.420
DEG_Nend_UBRbox_3	1	3	PF02207	0.504
DEG_SCF_FBW7_1	431	438	PF00400	0.369
DEG_SCF_FBW7_1	77	82	PF00400	0.491
DEG_SPOP_SBC_1	173	177	PF00917	0.403
DOC_CKS1_1	432	437	PF01111	0.588
DOC_CKS1_1	49	54	PF01111	0.668
DOC_CYCLIN_RxL_1	192	205	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.603
DOC_MAPK_DCC_7	197	206	PF00069	0.328
DOC_MAPK_gen_1	192	201	PF00069	0.388
DOC_MAPK_gen_1	271	281	PF00069	0.351
DOC_MAPK_gen_1	328	338	PF00069	0.311
DOC_MAPK_gen_1	419	425	PF00069	0.518
DOC_MAPK_gen_1	517	527	PF00069	0.421
DOC_MAPK_MEF2A_6	133	142	PF00069	0.424
DOC_MAPK_MEF2A_6	274	283	PF00069	0.328
DOC_MAPK_MEF2A_6	307	314	PF00069	0.330
DOC_PP1_RVXF_1	154	161	PF00149	0.239
DOC_PP1_RVXF_1	521	528	PF00149	0.438
DOC_PP2B_LxvP_1	336	339	PF13499	0.396
DOC_PP2B_LxvP_1	362	365	PF13499	0.416
DOC_PP2B_LxvP_1	391	394	PF13499	0.351
DOC_PP2B_LxvP_1	50	53	PF13499	0.654
DOC_PP2B_LxvP_1	557	560	PF13499	0.540
DOC_PP4_FxxP_1	41	44	PF00568	0.671
DOC_USP7_MATH_1	125	129	PF00917	0.684
DOC_USP7_MATH_1	154	158	PF00917	0.402
DOC_USP7_MATH_1	418	422	PF00917	0.509
DOC_USP7_MATH_1	44	48	PF00917	0.694
DOC_USP7_MATH_1	445	449	PF00917	0.666
DOC_USP7_MATH_1	456	460	PF00917	0.696
DOC_USP7_MATH_1	560	564	PF00917	0.580
DOC_USP7_MATH_1	79	83	PF00917	0.512
DOC_WW_Pin1_4	216	221	PF00397	0.354
DOC_WW_Pin1_4	431	436	PF00397	0.573
DOC_WW_Pin1_4	447	452	PF00397	0.630
DOC_WW_Pin1_4	459	464	PF00397	0.695
DOC_WW_Pin1_4	48	53	PF00397	0.536
DOC_WW_Pin1_4	546	551	PF00397	0.538
DOC_WW_Pin1_4	573	578	PF00397	0.469
DOC_WW_Pin1_4	73	78	PF00397	0.727
LIG_14-3-3_CanoR_1	13	22	PF00244	0.559
LIG_14-3-3_CanoR_1	174	183	PF00244	0.418
LIG_14-3-3_CanoR_1	307	311	PF00244	0.337
LIG_14-3-3_CanoR_1	330	339	PF00244	0.321
LIG_14-3-3_CanoR_1	440	444	PF00244	0.469
LIG_14-3-3_CanoR_1	476	482	PF00244	0.571
LIG_BRCT_BRCA1_1	126	130	PF00533	0.529
LIG_BRCT_BRCA1_1	176	180	PF00533	0.403
LIG_Clathr_ClatBox_1	245	249	PF01394	0.162
LIG_FHA_1	135	141	PF00498	0.354
LIG_FHA_1	168	174	PF00498	0.323
LIG_FHA_1	226	232	PF00498	0.162
LIG_FHA_1	307	313	PF00498	0.351
LIG_FHA_1	333	339	PF00498	0.400
LIG_FHA_1	340	346	PF00498	0.380
LIG_FHA_1	379	385	PF00498	0.338
LIG_FHA_1	412	418	PF00498	0.546
LIG_FHA_1	448	454	PF00498	0.671
LIG_FHA_1	504	510	PF00498	0.502
LIG_FHA_1	62	68	PF00498	0.707
LIG_FHA_2	167	173	PF00498	0.377
LIG_FHA_2	203	209	PF00498	0.390
LIG_FHA_2	254	260	PF00498	0.420
LIG_FHA_2	500	506	PF00498	0.394
LIG_GBD_Chelix_1	140	148	PF00786	0.481
LIG_LIR_Gen_1	146	154	PF02991	0.326
LIG_LIR_Gen_1	157	168	PF02991	0.251
LIG_LIR_Gen_1	177	187	PF02991	0.333
LIG_LIR_Gen_1	249	258	PF02991	0.337
LIG_LIR_Gen_1	357	365	PF02991	0.405
LIG_LIR_Gen_1	586	596	PF02991	0.553
LIG_LIR_Nem_3	146	152	PF02991	0.363
LIG_LIR_Nem_3	157	163	PF02991	0.242
LIG_LIR_Nem_3	177	183	PF02991	0.333
LIG_LIR_Nem_3	249	255	PF02991	0.309
LIG_LIR_Nem_3	357	362	PF02991	0.399
LIG_LIR_Nem_3	586	592	PF02991	0.547
LIG_NRBOX	480	486	PF00104	0.421
LIG_NRBOX	55	61	PF00104	0.496
LIG_Pex14_1	366	370	PF04695	0.370
LIG_Pex14_2	248	252	PF04695	0.370
LIG_REV1ctd_RIR_1	281	292	PF16727	0.351
LIG_SH2_CRK	359	363	PF00017	0.423
LIG_SH2_CRK	589	593	PF00017	0.525
LIG_SH2_PTP2	4	7	PF00017	0.433
LIG_SH2_SRC	337	340	PF00017	0.512
LIG_SH2_STAP1	467	471	PF00017	0.634
LIG_SH2_STAT5	254	257	PF00017	0.383
LIG_SH2_STAT5	313	316	PF00017	0.328
LIG_SH2_STAT5	337	340	PF00017	0.456
LIG_SH2_STAT5	370	373	PF00017	0.319
LIG_SH2_STAT5	4	7	PF00017	0.433
LIG_SH3_3	460	466	PF00018	0.738
LIG_SUMO_SIM_anti_2	421	427	PF11976	0.389
LIG_SUMO_SIM_par_1	169	177	PF11976	0.323
LIG_SUMO_SIM_par_1	202	209	PF11976	0.328
LIG_SUMO_SIM_par_1	396	403	PF11976	0.339
LIG_SUMO_SIM_par_1	406	416	PF11976	0.416
LIG_SUMO_SIM_par_1	421	427	PF11976	0.290
LIG_SUMO_SIM_par_1	497	503	PF11976	0.396
LIG_TRAF2_1	111	114	PF00917	0.750
LIG_TRAF2_1	176	179	PF00917	0.323
LIG_UBA3_1	147	156	PF00899	0.263
LIG_UBA3_1	351	356	PF00899	0.498
LIG_UBA3_1	424	433	PF00899	0.559
MOD_CK1_1	107	113	PF00069	0.757
MOD_CK1_1	17	23	PF00069	0.610
MOD_CK1_1	219	225	PF00069	0.453
MOD_CK1_1	399	405	PF00069	0.488
MOD_CK1_1	412	418	PF00069	0.421
MOD_CK1_1	459	465	PF00069	0.554
MOD_CK1_1	477	483	PF00069	0.307
MOD_CK1_1	549	555	PF00069	0.580
MOD_CK1_1	591	597	PF00069	0.649
MOD_CK2_1	108	114	PF00069	0.692
MOD_CK2_1	166	172	PF00069	0.349
MOD_CK2_1	173	179	PF00069	0.282
MOD_CK2_1	253	259	PF00069	0.420
MOD_CK2_1	489	495	PF00069	0.532
MOD_CK2_1	549	555	PF00069	0.587
MOD_CK2_1	562	568	PF00069	0.587
MOD_GlcNHglycan	116	119	PF01048	0.645
MOD_GlcNHglycan	127	130	PF01048	0.555
MOD_GlcNHglycan	221	224	PF01048	0.382
MOD_GlcNHglycan	28	31	PF01048	0.594
MOD_GlcNHglycan	445	448	PF01048	0.683
MOD_GlcNHglycan	457	461	PF01048	0.574
MOD_GlcNHglycan	476	479	PF01048	0.403
MOD_GlcNHglycan	481	484	PF01048	0.333
MOD_GlcNHglycan	551	554	PF01048	0.565
MOD_GlcNHglycan	560	563	PF01048	0.494
MOD_GlcNHglycan	564	567	PF01048	0.656
MOD_GlcNHglycan	593	596	PF01048	0.447
MOD_GSK3_1	103	110	PF00069	0.671
MOD_GSK3_1	120	127	PF00069	0.504
MOD_GSK3_1	129	136	PF00069	0.593
MOD_GSK3_1	14	21	PF00069	0.573
MOD_GSK3_1	150	157	PF00069	0.403
MOD_GSK3_1	163	170	PF00069	0.438
MOD_GSK3_1	375	382	PF00069	0.309
MOD_GSK3_1	409	416	PF00069	0.550
MOD_GSK3_1	431	438	PF00069	0.531
MOD_GSK3_1	439	446	PF00069	0.690
MOD_GSK3_1	44	51	PF00069	0.587
MOD_GSK3_1	455	462	PF00069	0.587
MOD_GSK3_1	499	506	PF00069	0.409
MOD_GSK3_1	558	565	PF00069	0.608
MOD_GSK3_1	569	576	PF00069	0.554
MOD_GSK3_1	71	78	PF00069	0.591
MOD_N-GLC_1	503	508	PF02516	0.487
MOD_N-GLC_2	165	167	PF02516	0.162
MOD_NEK2_1	143	148	PF00069	0.369
MOD_NEK2_1	248	253	PF00069	0.332
MOD_NEK2_1	279	284	PF00069	0.369
MOD_NEK2_1	355	360	PF00069	0.428
MOD_NEK2_1	411	416	PF00069	0.467
MOD_NEK2_1	479	484	PF00069	0.528
MOD_NEK2_1	499	504	PF00069	0.378
MOD_NEK2_1	538	543	PF00069	0.452
MOD_NEK2_2	332	337	PF00069	0.351
MOD_NEK2_2	439	444	PF00069	0.468
MOD_PIKK_1	14	20	PF00454	0.444
MOD_PIKK_1	174	180	PF00454	0.403
MOD_PKA_2	108	114	PF00069	0.722
MOD_PKA_2	173	179	PF00069	0.320
MOD_PKA_2	306	312	PF00069	0.347
MOD_PKA_2	418	424	PF00069	0.496
MOD_PKA_2	439	445	PF00069	0.464
MOD_PKA_2	61	67	PF00069	0.620
MOD_Plk_1	248	254	PF00069	0.162
MOD_Plk_1	504	510	PF00069	0.473
MOD_Plk_1	538	544	PF00069	0.544
MOD_Plk_1	569	575	PF00069	0.673
MOD_Plk_2-3	108	114	PF00069	0.572
MOD_Plk_4	143	149	PF00069	0.504
MOD_Plk_4	154	160	PF00069	0.383
MOD_Plk_4	209	215	PF00069	0.366
MOD_Plk_4	248	254	PF00069	0.453
MOD_Plk_4	279	285	PF00069	0.420
MOD_Plk_4	332	338	PF00069	0.338
MOD_Plk_4	379	385	PF00069	0.309
MOD_Plk_4	439	445	PF00069	0.617
MOD_ProDKin_1	216	222	PF00069	0.354
MOD_ProDKin_1	431	437	PF00069	0.582
MOD_ProDKin_1	447	453	PF00069	0.632
MOD_ProDKin_1	459	465	PF00069	0.691
MOD_ProDKin_1	48	54	PF00069	0.534
MOD_ProDKin_1	546	552	PF00069	0.542
MOD_ProDKin_1	573	579	PF00069	0.468
MOD_ProDKin_1	73	79	PF00069	0.721
MOD_SUMO_rev_2	114	123	PF00179	0.687
MOD_SUMO_rev_2	208	213	PF00179	0.407
TRG_DiLeu_BaEn_1	495	500	PF01217	0.393
TRG_DiLeu_BaEn_3	347	353	PF01217	0.447
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.445
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.502
TRG_ENDOCYTIC_2	359	362	PF00928	0.398
TRG_ENDOCYTIC_2	4	7	PF00928	0.433
TRG_ENDOCYTIC_2	589	592	PF00928	0.596
TRG_ER_diArg_1	286	288	PF00400	0.392
TRG_ER_diArg_1	328	331	PF00400	0.331
TRG_ER_diArg_1	366	368	PF00400	0.370
TRG_ER_diArg_1	418	420	PF00400	0.577
TRG_ER_diArg_1	523	526	PF00400	0.448
TRG_ER_diArg_1	61	63	PF00400	0.524
TRG_ER_diArg_1	86	88	PF00400	0.648
TRG_ER_diArg_1	92	94	PF00400	0.647
TRG_NES_CRM1_1	327	341	PF08389	0.420
TRG_NES_CRM1_1	390	403	PF08389	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFP5	Leptomonas seymouri	69%	100%
A0A0S4IXD9	Bodo saltans	31%	100%
A0A1X0P1R2	Trypanosomatidae	43%	100%
A0A3Q8IUI9	Leishmania donovani	28%	100%
A0A3S7XBS4	Leishmania donovani	94%	100%
A4HAQ0	Leishmania braziliensis	27%	100%
A4HQ55	Leishmania braziliensis	79%	100%
A4IDV4	Leishmania infantum	88%	100%
D0A462	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q0M1	Leishmania major	93%	99%
Q54DY9	Dictyostelium discoideum	30%	100%
Q54HY8	Dictyostelium discoideum	27%	100%
Q7ZV60	Danio rerio	28%	100%
Q9CZP5	Mus musculus	27%	100%
V5BUW7	Trypanosoma cruzi	41%	100%