Putative tyrosine specific protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine specific protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9ATX2_LEIMU

TriTrypDb:

LmxM.36.5370

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATX2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016311	dephosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004725	protein tyrosine phosphatase activity	4	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.333
CLV_NRD_NRD_1	17	19	PF00675	0.572
CLV_NRD_NRD_1	180	182	PF00675	0.327
CLV_NRD_NRD_1	281	283	PF00675	0.320
CLV_NRD_NRD_1	39	41	PF00675	0.454
CLV_PCSK_FUR_1	484	488	PF00082	0.600
CLV_PCSK_KEX2_1	17	19	PF00082	0.485
CLV_PCSK_KEX2_1	180	182	PF00082	0.327
CLV_PCSK_KEX2_1	39	41	PF00082	0.454
CLV_PCSK_KEX2_1	486	488	PF00082	0.577
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.615
CLV_PCSK_SKI1_1	155	159	PF00082	0.256
CLV_PCSK_SKI1_1	180	184	PF00082	0.363
CLV_PCSK_SKI1_1	270	274	PF00082	0.339
CLV_PCSK_SKI1_1	299	303	PF00082	0.443
CLV_PCSK_SKI1_1	4	8	PF00082	0.489
DEG_APCC_DBOX_1	180	188	PF00400	0.339
DEG_APCC_KENBOX_2	140	144	PF00400	0.313
DEG_Nend_UBRbox_1	1	4	PF02207	0.355
DOC_CYCLIN_RxL_1	174	186	PF00134	0.379
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.663
DOC_MAPK_DCC_7	99	109	PF00069	0.363
DOC_MAPK_gen_1	282	289	PF00069	0.369
DOC_MAPK_gen_1	7	16	PF00069	0.433
DOC_MAPK_gen_1	99	106	PF00069	0.363
DOC_MAPK_MEF2A_6	101	109	PF00069	0.363
DOC_MAPK_MEF2A_6	242	251	PF00069	0.303
DOC_PP2B_LxvP_1	336	339	PF13499	0.762
DOC_PP4_FxxP_1	102	105	PF00568	0.303
DOC_PP4_FxxP_1	350	353	PF00568	0.506
DOC_SPAK_OSR1_1	101	105	PF12202	0.196
DOC_SPAK_OSR1_1	11	15	PF12202	0.413
DOC_USP7_MATH_1	208	212	PF00917	0.347
DOC_USP7_MATH_1	355	359	PF00917	0.646
DOC_USP7_MATH_2	364	370	PF00917	0.626
DOC_USP7_UBL2_3	141	145	PF12436	0.339
DOC_USP7_UBL2_3	5	9	PF12436	0.340
DOC_WW_Pin1_4	221	226	PF00397	0.371
DOC_WW_Pin1_4	227	232	PF00397	0.321
DOC_WW_Pin1_4	331	336	PF00397	0.643
DOC_WW_Pin1_4	394	399	PF00397	0.702
DOC_WW_Pin1_4	400	405	PF00397	0.725
DOC_WW_Pin1_4	426	431	PF00397	0.626
DOC_WW_Pin1_4	451	456	PF00397	0.718
DOC_WW_Pin1_4	486	491	PF00397	0.622
LIG_14-3-3_CanoR_1	155	160	PF00244	0.495
LIG_14-3-3_CanoR_1	226	234	PF00244	0.333
LIG_14-3-3_CanoR_1	299	308	PF00244	0.431
LIG_14-3-3_CanoR_1	357	367	PF00244	0.665
LIG_14-3-3_CanoR_1	412	417	PF00244	0.693
LIG_14-3-3_CanoR_1	424	429	PF00244	0.641
LIG_14-3-3_CanoR_1	467	472	PF00244	0.533
LIG_Actin_WH2_2	102	118	PF00022	0.196
LIG_BRCT_BRCA1_1	488	492	PF00533	0.600
LIG_DLG_GKlike_1	412	419	PF00625	0.503
LIG_FHA_1	275	281	PF00498	0.339
LIG_FHA_1	331	337	PF00498	0.659
LIG_FHA_1	460	466	PF00498	0.679
LIG_FHA_1	467	473	PF00498	0.557
LIG_FHA_2	116	122	PF00498	0.276
LIG_FHA_2	211	217	PF00498	0.382
LIG_FHA_2	321	327	PF00498	0.666
LIG_LIR_Apic_2	100	105	PF02991	0.363
LIG_LIR_Gen_1	130	140	PF02991	0.303
LIG_LIR_Gen_1	284	293	PF02991	0.303
LIG_LIR_Gen_1	344	355	PF02991	0.466
LIG_LIR_Nem_3	121	126	PF02991	0.284
LIG_LIR_Nem_3	21	27	PF02991	0.427
LIG_LIR_Nem_3	243	249	PF02991	0.363
LIG_LIR_Nem_3	284	289	PF02991	0.303
LIG_LIR_Nem_3	344	350	PF02991	0.547
LIG_LIR_Nem_3	442	448	PF02991	0.609
LIG_LYPXL_S_1	23	27	PF13949	0.491
LIG_LYPXL_yS_3	24	27	PF13949	0.493
LIG_OCRL_FandH_1	245	257	PF00620	0.363
LIG_PCNA_yPIPBox_3	294	305	PF02747	0.382
LIG_PDZ_Class_1	488	493	PF00595	0.604
LIG_Pex14_1	123	127	PF04695	0.303
LIG_Pex14_2	102	106	PF04695	0.303
LIG_Pex14_2	488	492	PF04695	0.600
LIG_PTAP_UEV_1	367	372	PF05743	0.507
LIG_PTB_Apo_2	89	96	PF02174	0.303
LIG_PTB_Phospho_1	89	95	PF10480	0.276
LIG_SH2_GRB2like	127	130	PF00017	0.363
LIG_SH2_GRB2like	90	93	PF00017	0.303
LIG_SH2_PTP2	286	289	PF00017	0.363
LIG_SH2_SRC	90	93	PF00017	0.339
LIG_SH2_SRC	95	98	PF00017	0.339
LIG_SH2_STAP1	53	57	PF00017	0.384
LIG_SH2_STAT3	195	198	PF00017	0.282
LIG_SH2_STAT3	291	294	PF00017	0.303
LIG_SH2_STAT5	108	111	PF00017	0.339
LIG_SH2_STAT5	199	202	PF00017	0.303
LIG_SH2_STAT5	286	289	PF00017	0.287
LIG_SH2_STAT5	390	393	PF00017	0.595
LIG_SH2_STAT5	44	47	PF00017	0.420
LIG_SH2_STAT5	90	93	PF00017	0.339
LIG_SH2_STAT5	95	98	PF00017	0.339
LIG_SH3_3	197	203	PF00018	0.339
LIG_SH3_3	365	371	PF00018	0.503
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.339
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.383
LIG_SUMO_SIM_par_1	162	167	PF11976	0.363
LIG_UBA3_1	214	223	PF00899	0.303
MOD_CDK_SPK_2	221	226	PF00069	0.383
MOD_CK1_1	210	216	PF00069	0.383
MOD_CK1_1	224	230	PF00069	0.303
MOD_CK1_1	303	309	PF00069	0.378
MOD_CK1_1	358	364	PF00069	0.676
MOD_CK1_1	396	402	PF00069	0.705
MOD_CK1_1	429	435	PF00069	0.709
MOD_CK1_1	451	457	PF00069	0.683
MOD_CK1_1	459	465	PF00069	0.636
MOD_CK1_1	56	62	PF00069	0.413
MOD_CK2_1	210	216	PF00069	0.363
MOD_CK2_1	320	326	PF00069	0.659
MOD_GlcNHglycan	130	133	PF01048	0.398
MOD_GlcNHglycan	236	239	PF01048	0.335
MOD_GlcNHglycan	360	363	PF01048	0.668
MOD_GlcNHglycan	368	371	PF01048	0.635
MOD_GlcNHglycan	53	56	PF01048	0.534
MOD_GSK3_1	147	154	PF00069	0.196
MOD_GSK3_1	217	224	PF00069	0.370
MOD_GSK3_1	327	334	PF00069	0.668
MOD_GSK3_1	358	365	PF00069	0.579
MOD_GSK3_1	396	403	PF00069	0.777
MOD_GSK3_1	424	431	PF00069	0.631
MOD_GSK3_1	447	454	PF00069	0.652
MOD_GSK3_1	53	60	PF00069	0.395
MOD_N-GLC_1	128	133	PF02516	0.383
MOD_NEK2_1	115	120	PF00069	0.317
MOD_NEK2_1	164	169	PF00069	0.394
MOD_NEK2_1	183	188	PF00069	0.363
MOD_NEK2_1	217	222	PF00069	0.377
MOD_NEK2_1	300	305	PF00069	0.439
MOD_NEK2_1	310	315	PF00069	0.594
MOD_NEK2_1	356	361	PF00069	0.643
MOD_NEK2_1	423	428	PF00069	0.691
MOD_NEK2_1	433	438	PF00069	0.764
MOD_NEK2_1	458	463	PF00069	0.693
MOD_NEK2_1	466	471	PF00069	0.696
MOD_NEK2_1	57	62	PF00069	0.446
MOD_NEK2_1	79	84	PF00069	0.473
MOD_PIKK_1	108	114	PF00454	0.303
MOD_PIKK_1	225	231	PF00454	0.333
MOD_PIKK_1	300	306	PF00454	0.501
MOD_PIKK_1	327	333	PF00454	0.744
MOD_PIKK_1	81	87	PF00454	0.333
MOD_PK_1	174	180	PF00069	0.339
MOD_PKA_2	225	231	PF00069	0.383
MOD_PKA_2	315	321	PF00069	0.618
MOD_PKA_2	356	362	PF00069	0.637
MOD_PKA_2	423	429	PF00069	0.691
MOD_PKA_2	466	472	PF00069	0.508
MOD_Plk_1	128	134	PF00069	0.383
MOD_Plk_1	410	416	PF00069	0.722
MOD_Plk_2-3	383	389	PF00069	0.699
MOD_Plk_4	115	121	PF00069	0.319
MOD_Plk_4	147	153	PF00069	0.363
MOD_Plk_4	164	170	PF00069	0.363
MOD_Plk_4	210	216	PF00069	0.363
MOD_Plk_4	453	459	PF00069	0.657
MOD_Plk_4	467	473	PF00069	0.500
MOD_Plk_4	72	78	PF00069	0.379
MOD_Plk_4	86	92	PF00069	0.303
MOD_ProDKin_1	221	227	PF00069	0.371
MOD_ProDKin_1	331	337	PF00069	0.642
MOD_ProDKin_1	394	400	PF00069	0.705
MOD_ProDKin_1	426	432	PF00069	0.626
MOD_ProDKin_1	451	457	PF00069	0.719
MOD_ProDKin_1	486	492	PF00069	0.623
MOD_SUMO_for_1	146	149	PF00179	0.363
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.333
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.683
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.608
TRG_ENDOCYTIC_2	24	27	PF00928	0.493
TRG_ENDOCYTIC_2	286	289	PF00928	0.303
TRG_ENDOCYTIC_2	290	293	PF00928	0.303
TRG_ER_diArg_1	16	18	PF00400	0.512
TRG_ER_diArg_1	180	182	PF00400	0.327
TRG_ER_diArg_1	314	317	PF00400	0.587
TRG_ER_diArg_1	38	40	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9E1	Leptomonas seymouri	67%	96%
A0A3Q8ILM2	Leishmania donovani	92%	100%
A4HQ52	Leishmania braziliensis	76%	100%
A4IDV1	Leishmania infantum	91%	100%
Q4Q0M4	Leishmania major	91%	100%
V5B554	Trypanosoma cruzi	54%	74%