WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATX1_LEIMU

TriTrypDb:

LmxM.36.5365

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.735
CLV_C14_Caspase3-7	394	398	PF00656	0.641
CLV_NRD_NRD_1	297	299	PF00675	0.657
CLV_NRD_NRD_1	33	35	PF00675	0.601
CLV_NRD_NRD_1	333	335	PF00675	0.552
CLV_NRD_NRD_1	399	401	PF00675	0.496
CLV_NRD_NRD_1	75	77	PF00675	0.681
CLV_PCSK_KEX2_1	20	22	PF00082	0.666
CLV_PCSK_KEX2_1	297	299	PF00082	0.611
CLV_PCSK_KEX2_1	33	35	PF00082	0.586
CLV_PCSK_KEX2_1	335	337	PF00082	0.640
CLV_PCSK_KEX2_1	399	401	PF00082	0.521
CLV_PCSK_KEX2_1	75	77	PF00082	0.676
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.703
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.640
CLV_PCSK_SKI1_1	14	18	PF00082	0.588
CLV_PCSK_SKI1_1	161	165	PF00082	0.614
CLV_PCSK_SKI1_1	475	479	PF00082	0.655
CLV_Separin_Metazoa	221	225	PF03568	0.517
DEG_Nend_UBRbox_3	1	3	PF02207	0.686
DOC_CYCLIN_RxL_1	472	482	PF00134	0.620
DOC_MAPK_gen_1	334	342	PF00069	0.497
DOC_MAPK_MEF2A_6	362	370	PF00069	0.525
DOC_MAPK_MEF2A_6	496	505	PF00069	0.624
DOC_PP1_RVXF_1	178	184	PF00149	0.559
DOC_PP1_RVXF_1	227	234	PF00149	0.620
DOC_PP2B_LxvP_1	407	410	PF13499	0.521
DOC_PP4_FxxP_1	505	508	PF00568	0.503
DOC_USP7_MATH_1	101	105	PF00917	0.711
DOC_USP7_MATH_1	136	140	PF00917	0.419
DOC_USP7_MATH_1	311	315	PF00917	0.622
DOC_USP7_MATH_1	341	345	PF00917	0.597
DOC_USP7_MATH_1	43	47	PF00917	0.654
DOC_USP7_MATH_1	442	446	PF00917	0.693
DOC_USP7_MATH_1	449	453	PF00917	0.789
DOC_USP7_UBL2_3	27	31	PF12436	0.737
DOC_WW_Pin1_4	109	114	PF00397	0.625
DOC_WW_Pin1_4	272	277	PF00397	0.608
DOC_WW_Pin1_4	405	410	PF00397	0.616
DOC_WW_Pin1_4	497	502	PF00397	0.541
LIG_14-3-3_CanoR_1	102	110	PF00244	0.650
LIG_14-3-3_CanoR_1	180	184	PF00244	0.490
LIG_14-3-3_CanoR_1	399	407	PF00244	0.529
LIG_14-3-3_CanoR_1	75	79	PF00244	0.617
LIG_14-3-3_CanoR_1	92	100	PF00244	0.596
LIG_BRCT_BRCA1_1	429	433	PF00533	0.467
LIG_BRCT_BRCA1_1	501	505	PF00533	0.510
LIG_BRCT_BRCA1_1	64	68	PF00533	0.741
LIG_CSL_BTD_1	498	501	PF09270	0.547
LIG_FHA_1	223	229	PF00498	0.591
LIG_FHA_1	244	250	PF00498	0.439
LIG_FHA_1	253	259	PF00498	0.412
LIG_FHA_1	264	270	PF00498	0.213
LIG_FHA_1	294	300	PF00498	0.690
LIG_FHA_1	365	371	PF00498	0.481
LIG_FHA_1	446	452	PF00498	0.711
LIG_FHA_1	525	531	PF00498	0.350
LIG_FHA_2	122	128	PF00498	0.568
LIG_FHA_2	249	255	PF00498	0.502
LIG_FHA_2	304	310	PF00498	0.443
LIG_GBD_Chelix_1	187	195	PF00786	0.263
LIG_GBD_Chelix_1	48	56	PF00786	0.439
LIG_LIR_Apic_2	502	508	PF02991	0.517
LIG_LIR_Gen_1	139	146	PF02991	0.440
LIG_LIR_Gen_1	385	393	PF02991	0.602
LIG_LIR_Gen_1	77	88	PF02991	0.492
LIG_LIR_Nem_3	139	144	PF02991	0.444
LIG_LIR_Nem_3	182	186	PF02991	0.501
LIG_LIR_Nem_3	3	9	PF02991	0.475
LIG_LIR_Nem_3	385	390	PF02991	0.537
LIG_LIR_Nem_3	430	436	PF02991	0.432
LIG_LIR_Nem_3	77	83	PF02991	0.617
LIG_LYPXL_S_1	422	426	PF13949	0.453
LIG_LYPXL_yS_3	423	426	PF13949	0.455
LIG_MLH1_MIPbox_1	64	68	PF16413	0.747
LIG_Pex14_2	467	471	PF04695	0.712
LIG_Pex14_2	505	509	PF04695	0.496
LIG_Rb_pABgroove_1	535	543	PF01858	0.293
LIG_SH2_SRC	132	135	PF00017	0.546
LIG_SH2_SRC	38	41	PF00017	0.704
LIG_SH2_SRC	434	437	PF00017	0.563
LIG_SH2_STAP1	38	42	PF00017	0.702
LIG_SH2_STAT5	132	135	PF00017	0.534
LIG_SH3_3	12	18	PF00018	0.688
LIG_SH3_3	280	286	PF00018	0.630
LIG_SH3_3	351	357	PF00018	0.503
LIG_SH3_3	473	479	PF00018	0.704
LIG_SUMO_SIM_par_1	162	170	PF11976	0.539
LIG_SUMO_SIM_par_1	246	255	PF11976	0.447
LIG_SUMO_SIM_par_1	325	332	PF11976	0.487
LIG_SUMO_SIM_par_1	338	344	PF11976	0.527
LIG_TRAF2_1	386	389	PF00917	0.531
LIG_TYR_ITIM	421	426	PF00017	0.453
LIG_UBA3_1	327	335	PF00899	0.515
LIG_WRC_WIRS_1	114	119	PF05994	0.542
LIG_WRC_WIRS_1	384	389	PF05994	0.329
MOD_CDC14_SPxK_1	408	411	PF00782	0.590
MOD_CDK_SPxK_1	405	411	PF00069	0.612
MOD_CK1_1	120	126	PF00069	0.506
MOD_CK1_1	194	200	PF00069	0.469
MOD_CK1_1	244	250	PF00069	0.559
MOD_CK1_1	398	404	PF00069	0.539
MOD_CK1_1	427	433	PF00069	0.461
MOD_CK1_1	445	451	PF00069	0.706
MOD_CK1_1	452	458	PF00069	0.522
MOD_CK1_1	497	503	PF00069	0.552
MOD_CK1_1	510	516	PF00069	0.509
MOD_CK2_1	145	151	PF00069	0.384
MOD_CK2_1	303	309	PF00069	0.513
MOD_CK2_1	382	388	PF00069	0.490
MOD_CK2_1	438	444	PF00069	0.505
MOD_Cter_Amidation	73	76	PF01082	0.678
MOD_DYRK1A_RPxSP_1	272	276	PF00069	0.323
MOD_GlcNHglycan	10	13	PF01048	0.603
MOD_GlcNHglycan	138	141	PF01048	0.550
MOD_GlcNHglycan	201	204	PF01048	0.467
MOD_GlcNHglycan	243	246	PF01048	0.586
MOD_GlcNHglycan	289	292	PF01048	0.643
MOD_GlcNHglycan	373	376	PF01048	0.565
MOD_GlcNHglycan	403	406	PF01048	0.575
MOD_GlcNHglycan	440	443	PF01048	0.492
MOD_GlcNHglycan	519	522	PF01048	0.424
MOD_GlcNHglycan	542	545	PF01048	0.417
MOD_GlcNHglycan	64	67	PF01048	0.697
MOD_GSK3_1	109	116	PF00069	0.344
MOD_GSK3_1	117	124	PF00069	0.472
MOD_GSK3_1	190	197	PF00069	0.561
MOD_GSK3_1	244	251	PF00069	0.448
MOD_GSK3_1	259	266	PF00069	0.357
MOD_GSK3_1	378	385	PF00069	0.496
MOD_GSK3_1	388	395	PF00069	0.419
MOD_GSK3_1	401	408	PF00069	0.559
MOD_GSK3_1	438	445	PF00069	0.672
MOD_GSK3_1	495	502	PF00069	0.647
MOD_GSK3_1	503	510	PF00069	0.443
MOD_GSK3_1	515	522	PF00069	0.370
MOD_GSK3_1	90	97	PF00069	0.574
MOD_N-GLC_2	263	265	PF02516	0.479
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	117	122	PF00069	0.533
MOD_NEK2_1	144	149	PF00069	0.446
MOD_NEK2_1	166	171	PF00069	0.335
MOD_NEK2_1	190	195	PF00069	0.509
MOD_NEK2_1	403	408	PF00069	0.535
MOD_NEK2_1	494	499	PF00069	0.604
MOD_NEK2_1	503	508	PF00069	0.425
MOD_NEK2_1	540	545	PF00069	0.574
MOD_NEK2_1	68	73	PF00069	0.728
MOD_NEK2_1	8	13	PF00069	0.635
MOD_NEK2_2	113	118	PF00069	0.620
MOD_NEK2_2	357	362	PF00069	0.649
MOD_PIKK_1	398	404	PF00454	0.589
MOD_PIKK_1	43	49	PF00454	0.579
MOD_PIKK_1	51	57	PF00454	0.644
MOD_PKA_1	20	26	PF00069	0.530
MOD_PKA_1	495	501	PF00069	0.595
MOD_PKA_2	101	107	PF00069	0.666
MOD_PKA_2	117	123	PF00069	0.382
MOD_PKA_2	179	185	PF00069	0.537
MOD_PKA_2	20	26	PF00069	0.620
MOD_PKA_2	391	397	PF00069	0.517
MOD_PKA_2	398	404	PF00069	0.502
MOD_PKA_2	480	486	PF00069	0.749
MOD_PKA_2	74	80	PF00069	0.616
MOD_Plk_1	388	394	PF00069	0.497
MOD_Plk_2-3	480	486	PF00069	0.719
MOD_Plk_4	1	7	PF00069	0.584
MOD_Plk_4	117	123	PF00069	0.519
MOD_Plk_4	145	151	PF00069	0.562
MOD_Plk_4	364	370	PF00069	0.535
MOD_Plk_4	410	416	PF00069	0.413
MOD_Plk_4	427	433	PF00069	0.435
MOD_Plk_4	463	469	PF00069	0.706
MOD_Plk_4	499	505	PF00069	0.520
MOD_ProDKin_1	109	115	PF00069	0.618
MOD_ProDKin_1	272	278	PF00069	0.605
MOD_ProDKin_1	405	411	PF00069	0.612
MOD_ProDKin_1	497	503	PF00069	0.538
MOD_SUMO_for_1	19	22	PF00179	0.589
MOD_SUMO_rev_2	160	169	PF00179	0.538
MOD_SUMO_rev_2	466	474	PF00179	0.492
MOD_SUMO_rev_2	492	497	PF00179	0.674
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.483
TRG_ENDOCYTIC_2	423	426	PF00928	0.455
TRG_ER_diArg_1	297	299	PF00400	0.716
TRG_ER_diArg_1	333	336	PF00400	0.625
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC59	Leptomonas seymouri	42%	84%
A0A1X0P468	Trypanosomatidae	25%	94%
A0A3Q8IGL8	Leishmania donovani	89%	100%
A4HQ51	Leishmania braziliensis	75%	100%
A4IC79	Leishmania infantum	89%	100%
Q4Q0M5	Leishmania major	89%	100%