RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATW8_LEIMU

TriTrypDb:

LmxM.36.5340

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.658
CLV_C14_Caspase3-7	777	781	PF00656	0.670
CLV_NRD_NRD_1	124	126	PF00675	0.486
CLV_NRD_NRD_1	158	160	PF00675	0.645
CLV_NRD_NRD_1	251	253	PF00675	0.523
CLV_NRD_NRD_1	297	299	PF00675	0.572
CLV_NRD_NRD_1	429	431	PF00675	0.562
CLV_NRD_NRD_1	525	527	PF00675	0.632
CLV_NRD_NRD_1	53	55	PF00675	0.533
CLV_NRD_NRD_1	560	562	PF00675	0.558
CLV_NRD_NRD_1	607	609	PF00675	0.537
CLV_NRD_NRD_1	727	729	PF00675	0.579
CLV_NRD_NRD_1	75	77	PF00675	0.524
CLV_NRD_NRD_1	820	822	PF00675	0.705
CLV_PCSK_KEX2_1	124	126	PF00082	0.486
CLV_PCSK_KEX2_1	277	279	PF00082	0.511
CLV_PCSK_KEX2_1	285	287	PF00082	0.511
CLV_PCSK_KEX2_1	297	299	PF00082	0.325
CLV_PCSK_KEX2_1	494	496	PF00082	0.668
CLV_PCSK_KEX2_1	560	562	PF00082	0.565
CLV_PCSK_KEX2_1	607	609	PF00082	0.478
CLV_PCSK_KEX2_1	649	651	PF00082	0.439
CLV_PCSK_KEX2_1	727	729	PF00082	0.557
CLV_PCSK_KEX2_1	820	822	PF00082	0.552
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.511
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.511
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.594
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.439
CLV_PCSK_PC7_1	273	279	PF00082	0.507
CLV_PCSK_SKI1_1	178	182	PF00082	0.435
CLV_PCSK_SKI1_1	407	411	PF00082	0.507
CLV_PCSK_SKI1_1	433	437	PF00082	0.544
CLV_PCSK_SKI1_1	478	482	PF00082	0.613
CLV_PCSK_SKI1_1	54	58	PF00082	0.499
CLV_PCSK_SKI1_1	666	670	PF00082	0.592
CLV_PCSK_SKI1_1	831	835	PF00082	0.587
CLV_Separin_Metazoa	27	31	PF03568	0.624
DEG_APCC_DBOX_1	481	489	PF00400	0.671
DEG_APCC_DBOX_1	67	75	PF00400	0.627
DOC_CYCLIN_RxL_1	320	328	PF00134	0.590
DOC_CYCLIN_yCln2_LP_2	731	737	PF00134	0.593
DOC_MAPK_gen_1	386	393	PF00069	0.593
DOC_MAPK_gen_1	4	15	PF00069	0.672
DOC_MAPK_gen_1	639	647	PF00069	0.556
DOC_MAPK_gen_1	690	698	PF00069	0.653
DOC_MAPK_gen_1	727	735	PF00069	0.578
DOC_MAPK_MEF2A_6	257	264	PF00069	0.493
DOC_MAPK_MEF2A_6	323	331	PF00069	0.490
DOC_MAPK_MEF2A_6	386	393	PF00069	0.591
DOC_MAPK_MEF2A_6	690	698	PF00069	0.653
DOC_MAPK_MEF2A_6	727	735	PF00069	0.578
DOC_MIT_MIM_1	415	424	PF04212	0.488
DOC_PP2B_LxvP_1	731	734	PF13499	0.652
DOC_USP7_MATH_1	209	213	PF00917	0.725
DOC_USP7_MATH_1	303	307	PF00917	0.642
DOC_USP7_MATH_1	770	774	PF00917	0.655
DOC_USP7_MATH_1	822	826	PF00917	0.664
DOC_USP7_MATH_1	9	13	PF00917	0.669
DOC_USP7_UBL2_3	253	257	PF12436	0.649
DOC_USP7_UBL2_3	403	407	PF12436	0.610
DOC_USP7_UBL2_3	775	779	PF12436	0.679
DOC_WW_Pin1_4	810	815	PF00397	0.758
LIG_14-3-3_CanoR_1	139	147	PF00244	0.602
LIG_14-3-3_CanoR_1	208	217	PF00244	0.717
LIG_14-3-3_CanoR_1	236	244	PF00244	0.662
LIG_14-3-3_CanoR_1	304	312	PF00244	0.653
LIG_14-3-3_CanoR_1	482	486	PF00244	0.397
LIG_14-3-3_CanoR_1	509	517	PF00244	0.553
LIG_14-3-3_CanoR_1	666	675	PF00244	0.602
LIG_14-3-3_CanoR_1	68	72	PF00244	0.511
LIG_14-3-3_CanoR_1	684	690	PF00244	0.433
LIG_14-3-3_CanoR_1	764	769	PF00244	0.681
LIG_14-3-3_CanoR_1	8	14	PF00244	0.745
LIG_14-3-3_CanoR_1	808	814	PF00244	0.573
LIG_14-3-3_CanoR_1	839	843	PF00244	0.514
LIG_Actin_WH2_2	126	141	PF00022	0.641
LIG_CaM_IQ_9	676	692	PF13499	0.615
LIG_FHA_1	102	108	PF00498	0.618
LIG_FHA_1	118	124	PF00498	0.355
LIG_FHA_1	128	134	PF00498	0.602
LIG_FHA_1	179	185	PF00498	0.390
LIG_FHA_1	221	227	PF00498	0.606
LIG_FHA_1	436	442	PF00498	0.490
LIG_FHA_1	533	539	PF00498	0.567
LIG_FHA_1	562	568	PF00498	0.609
LIG_FHA_1	674	680	PF00498	0.588
LIG_FHA_1	691	697	PF00498	0.612
LIG_FHA_1	764	770	PF00498	0.641
LIG_FHA_1	791	797	PF00498	0.776
LIG_FHA_1	800	806	PF00498	0.478
LIG_FHA_1	811	817	PF00498	0.660
LIG_FHA_1	828	834	PF00498	0.611
LIG_FHA_2	238	244	PF00498	0.659
LIG_FHA_2	265	271	PF00498	0.541
LIG_FHA_2	332	338	PF00498	0.640
LIG_FHA_2	396	402	PF00498	0.550
LIG_FHA_2	408	414	PF00498	0.618
LIG_FHA_2	470	476	PF00498	0.672
LIG_FHA_2	491	497	PF00498	0.531
LIG_FHA_2	510	516	PF00498	0.565
LIG_FHA_2	68	74	PF00498	0.517
LIG_FHA_2	686	692	PF00498	0.578
LIG_FHA_2	843	849	PF00498	0.716
LIG_GBD_Chelix_1	261	269	PF00786	0.522
LIG_LIR_Apic_2	749	753	PF02991	0.680
LIG_LIR_Gen_1	162	171	PF02991	0.552
LIG_LIR_Gen_1	434	444	PF02991	0.487
LIG_LIR_Gen_1	498	508	PF02991	0.552
LIG_LIR_Gen_1	754	762	PF02991	0.589
LIG_LIR_Nem_3	162	168	PF02991	0.557
LIG_LIR_Nem_3	434	439	PF02991	0.488
LIG_LIR_Nem_3	498	503	PF02991	0.555
LIG_LIR_Nem_3	50	56	PF02991	0.534
LIG_LIR_Nem_3	726	732	PF02991	0.642
LIG_LIR_Nem_3	754	759	PF02991	0.619
LIG_PCNA_yPIPBox_3	298	312	PF02747	0.531
LIG_PDZ_Class_1	858	863	PF00595	0.679
LIG_PTB_Apo_2	531	538	PF02174	0.480
LIG_PTB_Phospho_1	531	537	PF10480	0.542
LIG_SH2_CRK	165	169	PF00017	0.590
LIG_SH2_CRK	665	669	PF00017	0.523
LIG_SH2_CRK	729	733	PF00017	0.656
LIG_SH2_CRK	756	760	PF00017	0.587
LIG_SH2_GRB2like	537	540	PF00017	0.533
LIG_SH2_SRC	537	540	PF00017	0.533
LIG_SH2_SRC	750	753	PF00017	0.655
LIG_SH2_STAT3	762	765	PF00017	0.689
LIG_SH2_STAT5	531	534	PF00017	0.585
LIG_SH2_STAT5	537	540	PF00017	0.569
LIG_SH2_STAT5	746	749	PF00017	0.651
LIG_SH2_STAT5	750	753	PF00017	0.655
LIG_SH3_3	813	819	PF00018	0.653
LIG_SUMO_SIM_anti_2	218	228	PF11976	0.652
LIG_SUMO_SIM_anti_2	437	443	PF11976	0.473
LIG_SUMO_SIM_par_1	180	185	PF11976	0.368
LIG_TRAF2_1	153	156	PF00917	0.656
LIG_TRAF2_1	171	174	PF00917	0.516
LIG_TRAF2_1	201	204	PF00917	0.791
LIG_TRAF2_1	346	349	PF00917	0.522
LIG_TRAF2_1	447	450	PF00917	0.567
LIG_TRAF2_1	487	490	PF00917	0.605
LIG_TRAF2_1	513	516	PF00917	0.604
LIG_TRAF2_1	711	714	PF00917	0.634
LIG_TRAF2_1	804	807	PF00917	0.745
MOD_CK1_1	306	312	PF00069	0.609
MOD_CK1_1	416	422	PF00069	0.582
MOD_CK1_1	550	556	PF00069	0.603
MOD_CK1_1	579	585	PF00069	0.555
MOD_CK1_1	824	830	PF00069	0.707
MOD_CK1_1	837	843	PF00069	0.702
MOD_CK2_1	188	194	PF00069	0.613
MOD_CK2_1	215	221	PF00069	0.600
MOD_CK2_1	237	243	PF00069	0.623
MOD_CK2_1	264	270	PF00069	0.487
MOD_CK2_1	331	337	PF00069	0.579
MOD_CK2_1	407	413	PF00069	0.580
MOD_CK2_1	469	475	PF00069	0.635
MOD_CK2_1	484	490	PF00069	0.531
MOD_CK2_1	509	515	PF00069	0.554
MOD_CK2_1	67	73	PF00069	0.510
MOD_GlcNHglycan	120	123	PF01048	0.497
MOD_GlcNHglycan	190	193	PF01048	0.721
MOD_GlcNHglycan	211	214	PF01048	0.753
MOD_GlcNHglycan	305	308	PF01048	0.593
MOD_GlcNHglycan	315	318	PF01048	0.461
MOD_GlcNHglycan	450	453	PF01048	0.558
MOD_GlcNHglycan	588	592	PF01048	0.523
MOD_GSK3_1	264	271	PF00069	0.549
MOD_GSK3_1	367	374	PF00069	0.624
MOD_GSK3_1	466	473	PF00069	0.681
MOD_GSK3_1	476	483	PF00069	0.546
MOD_GSK3_1	484	491	PF00069	0.396
MOD_GSK3_1	504	511	PF00069	0.655
MOD_GSK3_1	550	557	PF00069	0.512
MOD_GSK3_1	770	777	PF00069	0.685
MOD_GSK3_1	787	794	PF00069	0.756
MOD_GSK3_1	820	827	PF00069	0.663
MOD_GSK3_1	834	841	PF00069	0.606
MOD_N-GLC_1	684	689	PF02516	0.508
MOD_N-GLC_1	771	776	PF02516	0.742
MOD_N-GLC_1	834	839	PF02516	0.740
MOD_NEK2_1	133	138	PF00069	0.633
MOD_NEK2_1	480	485	PF00069	0.699
MOD_NEK2_1	488	493	PF00069	0.644
MOD_NEK2_1	552	557	PF00069	0.641
MOD_NEK2_1	771	776	PF00069	0.726
MOD_NEK2_1	842	847	PF00069	0.436
MOD_NEK2_1	87	92	PF00069	0.489
MOD_PIKK_1	133	139	PF00454	0.636
MOD_PIKK_1	140	146	PF00454	0.538
MOD_PIKK_1	264	270	PF00454	0.487
MOD_PIKK_1	466	472	PF00454	0.617
MOD_PIKK_1	554	560	PF00454	0.508
MOD_PK_1	834	840	PF00069	0.730
MOD_PKA_1	526	532	PF00069	0.628
MOD_PKA_1	820	826	PF00069	0.473
MOD_PKA_2	138	144	PF00069	0.624
MOD_PKA_2	303	309	PF00069	0.650
MOD_PKA_2	481	487	PF00069	0.461
MOD_PKA_2	508	514	PF00069	0.580
MOD_PKA_2	579	585	PF00069	0.642
MOD_PKA_2	67	73	PF00069	0.594
MOD_PKA_2	763	769	PF00069	0.593
MOD_PKA_2	807	813	PF00069	0.613
MOD_PKA_2	820	826	PF00069	0.740
MOD_PKA_2	838	844	PF00069	0.718
MOD_PKB_1	519	527	PF00069	0.562
MOD_Plk_1	133	139	PF00069	0.636
MOD_Plk_1	220	226	PF00069	0.685
MOD_Plk_1	355	361	PF00069	0.568
MOD_Plk_1	476	482	PF00069	0.532
MOD_Plk_1	684	690	PF00069	0.540
MOD_Plk_1	834	840	PF00069	0.730
MOD_Plk_4	220	226	PF00069	0.705
MOD_Plk_4	532	538	PF00069	0.561
MOD_Plk_4	746	752	PF00069	0.677
MOD_Plk_4	764	770	PF00069	0.421
MOD_Plk_4	838	844	PF00069	0.713
MOD_ProDKin_1	810	816	PF00069	0.763
MOD_SUMO_for_1	353	356	PF00179	0.626
MOD_SUMO_for_1	447	450	PF00179	0.638
MOD_SUMO_rev_2	174	180	PF00179	0.649
MOD_SUMO_rev_2	249	258	PF00179	0.513
MOD_SUMO_rev_2	270	279	PF00179	0.500
MOD_SUMO_rev_2	397	404	PF00179	0.545
MOD_SUMO_rev_2	73	78	PF00179	0.557
TRG_DiLeu_BaEn_1	222	227	PF01217	0.583
TRG_DiLeu_BaEn_1	256	261	PF01217	0.579
TRG_DiLeu_BaEn_1	44	49	PF01217	0.581
TRG_DiLeu_BaEn_1	52	57	PF01217	0.516
TRG_DiLeu_BaEn_1	713	718	PF01217	0.674
TRG_DiLeu_BaEn_4	515	521	PF01217	0.573
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.660
TRG_DiLeu_BaLyEn_6	828	833	PF01217	0.468
TRG_ENDOCYTIC_2	165	168	PF00928	0.566
TRG_ENDOCYTIC_2	500	503	PF00928	0.590
TRG_ENDOCYTIC_2	665	668	PF00928	0.528
TRG_ENDOCYTIC_2	729	732	PF00928	0.592
TRG_ENDOCYTIC_2	756	759	PF00928	0.617
TRG_ER_diArg_1	123	125	PF00400	0.488
TRG_ER_diArg_1	296	298	PF00400	0.595
TRG_ER_diArg_1	560	562	PF00400	0.368
TRG_ER_diArg_1	606	608	PF00400	0.532
TRG_ER_diArg_1	727	729	PF00400	0.582
TRG_ER_diArg_1	819	821	PF00400	0.719
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	639	644	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	715	719	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	720	724	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ64	Leptomonas seymouri	52%	100%
A0A1X0P393	Trypanosomatidae	35%	100%
A0A3S7XBY8	Leishmania donovani	94%	100%
A0A422NT20	Trypanosoma rangeli	34%	100%
A4HQ48	Leishmania braziliensis	77%	99%
A4IC76	Leishmania infantum	94%	100%
D0A8R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q0M8	Leishmania major	92%	100%