Glutathione_S-transferase_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glutathione S-transferase, C-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATW6_LEIMU

TriTrypDb:

LmxM.36.5320

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATW6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.769
CLV_NRD_NRD_1	126	128	PF00675	0.441
CLV_NRD_NRD_1	433	435	PF00675	0.584
CLV_NRD_NRD_1	507	509	PF00675	0.569
CLV_NRD_NRD_1	605	607	PF00675	0.459
CLV_NRD_NRD_1	621	623	PF00675	0.427
CLV_PCSK_KEX2_1	433	435	PF00082	0.584
CLV_PCSK_KEX2_1	507	509	PF00082	0.591
CLV_PCSK_KEX2_1	605	607	PF00082	0.474
CLV_PCSK_KEX2_1	621	623	PF00082	0.356
CLV_PCSK_SKI1_1	172	176	PF00082	0.369
CLV_PCSK_SKI1_1	195	199	PF00082	0.272
CLV_PCSK_SKI1_1	40	44	PF00082	0.469
CLV_PCSK_SKI1_1	421	425	PF00082	0.428
CLV_PCSK_SKI1_1	55	59	PF00082	0.479
CLV_PCSK_SKI1_1	561	565	PF00082	0.480
CLV_PCSK_SKI1_1	89	93	PF00082	0.562
DEG_ODPH_VHL_1	337	350	PF01847	0.478
DEG_SCF_FBW7_1	235	242	PF00400	0.553
DEG_SCF_FBW7_1	61	66	PF00400	0.616
DOC_CKS1_1	236	241	PF01111	0.558
DOC_CYCLIN_RxL_1	189	201	PF00134	0.468
DOC_MAPK_DCC_7	172	182	PF00069	0.444
DOC_MAPK_gen_1	157	166	PF00069	0.426
DOC_MAPK_gen_1	605	611	PF00069	0.585
DOC_MAPK_HePTP_8	124	136	PF00069	0.654
DOC_MAPK_MEF2A_6	127	136	PF00069	0.549
DOC_MAPK_MEF2A_6	409	417	PF00069	0.580
DOC_PP4_FxxP_1	13	16	PF00568	0.637
DOC_PP4_FxxP_1	175	178	PF00568	0.444
DOC_PP4_FxxP_1	518	521	PF00568	0.751
DOC_USP7_MATH_1	109	113	PF00917	0.729
DOC_USP7_MATH_1	251	255	PF00917	0.535
DOC_USP7_MATH_1	296	300	PF00917	0.735
DOC_USP7_MATH_1	456	460	PF00917	0.780
DOC_USP7_MATH_1	461	465	PF00917	0.769
DOC_USP7_MATH_1	478	482	PF00917	0.647
DOC_USP7_MATH_1	589	593	PF00917	0.659
DOC_USP7_MATH_1	628	632	PF00917	0.683
DOC_USP7_MATH_1	63	67	PF00917	0.653
DOC_USP7_MATH_1	633	637	PF00917	0.641
DOC_WW_Pin1_4	12	17	PF00397	0.572
DOC_WW_Pin1_4	235	240	PF00397	0.562
DOC_WW_Pin1_4	439	444	PF00397	0.748
DOC_WW_Pin1_4	5	10	PF00397	0.670
DOC_WW_Pin1_4	59	64	PF00397	0.591
LIG_14-3-3_CanoR_1	325	333	PF00244	0.706
LIG_14-3-3_CanoR_1	40	50	PF00244	0.625
LIG_14-3-3_CanoR_1	53	58	PF00244	0.578
LIG_14-3-3_CanoR_1	561	571	PF00244	0.739
LIG_BIR_II_1	1	5	PF00653	0.763
LIG_BRCT_BRCA1_1	252	256	PF00533	0.536
LIG_Clathr_ClatBox_1	255	259	PF01394	0.599
LIG_Clathr_ClatBox_1	396	400	PF01394	0.630
LIG_CtBP_PxDLS_1	334	338	PF00389	0.582
LIG_FHA_1	119	125	PF00498	0.681
LIG_FHA_1	16	22	PF00498	0.660
LIG_FHA_1	272	278	PF00498	0.644
LIG_FHA_1	290	296	PF00498	0.558
LIG_FHA_1	309	315	PF00498	0.559
LIG_FHA_1	343	349	PF00498	0.413
LIG_FHA_1	381	387	PF00498	0.711
LIG_FHA_1	41	47	PF00498	0.635
LIG_FHA_1	567	573	PF00498	0.771
LIG_FHA_2	240	246	PF00498	0.535
LIG_FHA_2	289	295	PF00498	0.745
LIG_FHA_2	296	302	PF00498	0.750
LIG_FHA_2	307	313	PF00498	0.704
LIG_FHA_2	330	336	PF00498	0.646
LIG_FHA_2	425	431	PF00498	0.673
LIG_FHA_2	497	503	PF00498	0.790
LIG_FHA_2	581	587	PF00498	0.595
LIG_Integrin_RGD_1	160	162	PF01839	0.661
LIG_LIR_Apic_2	383	388	PF02991	0.654
LIG_LIR_Gen_1	138	144	PF02991	0.369
LIG_LIR_Gen_1	212	222	PF02991	0.546
LIG_LIR_Gen_1	26	35	PF02991	0.653
LIG_LIR_Gen_1	357	363	PF02991	0.640
LIG_LIR_Gen_1	56	63	PF02991	0.617
LIG_LIR_Gen_1	583	591	PF02991	0.625
LIG_LIR_Nem_3	138	142	PF02991	0.369
LIG_LIR_Nem_3	168	173	PF02991	0.290
LIG_LIR_Nem_3	212	218	PF02991	0.530
LIG_LIR_Nem_3	26	30	PF02991	0.552
LIG_LIR_Nem_3	268	273	PF02991	0.612
LIG_LIR_Nem_3	357	361	PF02991	0.612
LIG_LIR_Nem_3	45	51	PF02991	0.593
LIG_LIR_Nem_3	533	538	PF02991	0.666
LIG_LIR_Nem_3	56	61	PF02991	0.570
LIG_LIR_Nem_3	583	588	PF02991	0.620
LIG_LIR_Nem_3	8	13	PF02991	0.620
LIG_Pex14_2	252	256	PF04695	0.542
LIG_SH2_NCK_1	538	542	PF00017	0.724
LIG_SH2_PTP2	608	611	PF00017	0.632
LIG_SH2_STAP1	144	148	PF00017	0.369
LIG_SH2_STAP1	17	21	PF00017	0.606
LIG_SH2_STAP1	48	52	PF00017	0.611
LIG_SH2_STAP1	585	589	PF00017	0.659
LIG_SH2_STAT3	640	643	PF00017	0.550
LIG_SH2_STAT5	144	147	PF00017	0.480
LIG_SH2_STAT5	158	161	PF00017	0.316
LIG_SH2_STAT5	17	20	PF00017	0.616
LIG_SH2_STAT5	170	173	PF00017	0.263
LIG_SH2_STAT5	27	30	PF00017	0.554
LIG_SH2_STAT5	276	279	PF00017	0.548
LIG_SH2_STAT5	38	41	PF00017	0.607
LIG_SH2_STAT5	385	388	PF00017	0.621
LIG_SH2_STAT5	538	541	PF00017	0.759
LIG_SH2_STAT5	596	599	PF00017	0.590
LIG_SH2_STAT5	608	611	PF00017	0.566
LIG_SH2_STAT5	640	643	PF00017	0.550
LIG_SH3_3	203	209	PF00018	0.606
LIG_SH3_3	448	454	PF00018	0.798
LIG_SH3_3	518	524	PF00018	0.749
LIG_SH3_3	553	559	PF00018	0.714
LIG_SH3_3	570	576	PF00018	0.542
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.408
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.625
LIG_TRAF2_1	487	490	PF00917	0.740
LIG_TRAF2_1	623	626	PF00917	0.702
LIG_TYR_ITIM	25	30	PF00017	0.477
MOD_CDK_SPxK_1	5	11	PF00069	0.659
MOD_CK1_1	15	21	PF00069	0.541
MOD_CK1_1	204	210	PF00069	0.428
MOD_CK1_1	284	290	PF00069	0.417
MOD_CK1_1	303	309	PF00069	0.663
MOD_CK1_1	41	47	PF00069	0.636
MOD_CK1_1	565	571	PF00069	0.714
MOD_CK1_1	64	70	PF00069	0.594
MOD_CK2_1	329	335	PF00069	0.603
MOD_CK2_1	496	502	PF00069	0.750
MOD_CK2_1	580	586	PF00069	0.526
MOD_CK2_1	633	639	PF00069	0.411
MOD_Cter_Amidation	431	434	PF01082	0.743
MOD_Cter_Amidation	603	606	PF01082	0.585
MOD_GlcNHglycan	1	4	PF01048	0.658
MOD_GlcNHglycan	101	105	PF01048	0.724
MOD_GlcNHglycan	111	114	PF01048	0.698
MOD_GlcNHglycan	198	201	PF01048	0.627
MOD_GlcNHglycan	283	286	PF01048	0.559
MOD_GlcNHglycan	305	308	PF01048	0.750
MOD_GlcNHglycan	320	323	PF01048	0.715
MOD_GlcNHglycan	439	442	PF01048	0.642
MOD_GlcNHglycan	458	461	PF01048	0.779
MOD_GlcNHglycan	463	466	PF01048	0.747
MOD_GlcNHglycan	472	475	PF01048	0.605
MOD_GlcNHglycan	512	516	PF01048	0.724
MOD_GlcNHglycan	63	66	PF01048	0.591
MOD_GlcNHglycan	89	92	PF01048	0.560
MOD_GSK3_1	109	116	PF00069	0.721
MOD_GSK3_1	235	242	PF00069	0.442
MOD_GSK3_1	284	291	PF00069	0.631
MOD_GSK3_1	296	303	PF00069	0.652
MOD_GSK3_1	306	313	PF00069	0.765
MOD_GSK3_1	314	321	PF00069	0.708
MOD_GSK3_1	329	336	PF00069	0.555
MOD_GSK3_1	350	357	PF00069	0.498
MOD_GSK3_1	38	45	PF00069	0.496
MOD_GSK3_1	435	442	PF00069	0.686
MOD_GSK3_1	53	60	PF00069	0.439
MOD_GSK3_1	561	568	PF00069	0.683
MOD_GSK3_1	628	635	PF00069	0.594
MOD_N-GLC_1	401	406	PF02516	0.700
MOD_NEK2_1	149	154	PF00069	0.386
MOD_NEK2_1	182	187	PF00069	0.444
MOD_NEK2_1	198	203	PF00069	0.291
MOD_NEK2_1	318	323	PF00069	0.525
MOD_NEK2_1	350	355	PF00069	0.432
MOD_NEK2_1	42	47	PF00069	0.490
MOD_NEK2_1	424	429	PF00069	0.581
MOD_NEK2_2	17	22	PF00069	0.620
MOD_NEK2_2	251	256	PF00069	0.454
MOD_NEK2_2	366	371	PF00069	0.630
MOD_OFUCOSY	140	146	PF10250	0.429
MOD_PIKK_1	118	124	PF00454	0.636
MOD_PIKK_1	350	356	PF00454	0.437
MOD_PIKK_1	407	413	PF00454	0.572
MOD_PIKK_1	478	484	PF00454	0.604
MOD_PIKK_1	639	645	PF00454	0.513
MOD_PK_1	53	59	PF00069	0.599
MOD_PKA_1	127	133	PF00069	0.544
MOD_PKA_1	629	635	PF00069	0.672
MOD_PKA_2	278	284	PF00069	0.518
MOD_PKA_2	3	9	PF00069	0.745
MOD_PKA_2	324	330	PF00069	0.683
MOD_Plk_1	244	250	PF00069	0.454
MOD_Plk_1	300	306	PF00069	0.705
MOD_Plk_1	401	407	PF00069	0.651
MOD_Plk_1	424	430	PF00069	0.645
MOD_Plk_1	93	99	PF00069	0.705
MOD_Plk_4	23	29	PF00069	0.592
MOD_Plk_4	251	257	PF00069	0.451
MOD_Plk_4	261	267	PF00069	0.453
MOD_Plk_4	284	290	PF00069	0.656
MOD_Plk_4	42	48	PF00069	0.471
MOD_Plk_4	580	586	PF00069	0.477
MOD_ProDKin_1	12	18	PF00069	0.455
MOD_ProDKin_1	235	241	PF00069	0.443
MOD_ProDKin_1	439	445	PF00069	0.707
MOD_ProDKin_1	5	11	PF00069	0.585
MOD_ProDKin_1	59	65	PF00069	0.492
MOD_SUMO_for_1	91	94	PF00179	0.702
TRG_DiLeu_BaEn_2	345	351	PF01217	0.493
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.596
TRG_ENDOCYTIC_2	27	30	PF00928	0.567
TRG_ENDOCYTIC_2	585	588	PF00928	0.533
TRG_ENDOCYTIC_2	608	611	PF00928	0.542
TRG_ER_diArg_1	506	508	PF00400	0.618
TRG_ER_diArg_1	52	55	PF00400	0.489
TRG_ER_diArg_1	605	607	PF00400	0.615
TRG_ER_diArg_1	620	622	PF00400	0.564
TRG_NES_CRM1_1	389	401	PF08389	0.589
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U3	Leptomonas seymouri	59%	99%
A0A0S4ITV1	Bodo saltans	31%	100%
A0A3Q8IPN5	Leishmania donovani	90%	100%
A4HQ46	Leishmania braziliensis	80%	100%
A4IC82	Leishmania infantum	90%	100%
D0A8R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q0N0	Leishmania major	91%	100%
V5B6S7	Trypanosoma cruzi	42%	100%