Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATW3_LEIMU

TriTrypDb:

LmxM.36.5290

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.495
CLV_NRD_NRD_1	64	66	PF00675	0.463
CLV_PCSK_KEX2_1	52	54	PF00082	0.491
CLV_PCSK_KEX2_1	64	66	PF00082	0.443
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.462
CLV_PCSK_SKI1_1	12	16	PF00082	0.554
CLV_PCSK_SKI1_1	120	124	PF00082	0.450
CLV_PCSK_SKI1_1	131	135	PF00082	0.447
CLV_PCSK_SKI1_1	137	141	PF00082	0.403
CLV_PCSK_SKI1_1	47	51	PF00082	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DEG_SCF_FBW7_2	91	96	PF00400	0.388
DOC_MAPK_gen_1	152	160	PF00069	0.441
DOC_MAPK_gen_1	25	34	PF00069	0.558
DOC_MAPK_gen_1	81	88	PF00069	0.628
DOC_MAPK_MEF2A_6	28	36	PF00069	0.547
DOC_PP2B_LxvP_1	170	173	PF13499	0.358
DOC_USP7_UBL2_3	132	136	PF12436	0.568
DOC_USP7_UBL2_3	33	37	PF12436	0.447
DOC_WW_Pin1_4	89	94	PF00397	0.631
LIG_14-3-3_CanoR_1	25	34	PF00244	0.509
LIG_FHA_1	128	134	PF00498	0.522
LIG_FHA_1	83	89	PF00498	0.580
LIG_FHA_2	1	7	PF00498	0.670
LIG_FHA_2	13	19	PF00498	0.486
LIG_FHA_2	138	144	PF00498	0.318
LIG_FHA_2	174	180	PF00498	0.457
LIG_FHA_2	186	192	PF00498	0.558
LIG_FHA_2	90	96	PF00498	0.482
LIG_LIR_Nem_3	116	122	PF02991	0.311
LIG_Rb_pABgroove_1	52	60	PF01858	0.508
LIG_Rb_pABgroove_1	98	106	PF01858	0.466
LIG_SH2_CRK	119	123	PF00017	0.402
LIG_SH2_SRC	58	61	PF00017	0.435
LIG_SH2_STAP1	104	108	PF00017	0.413
LIG_SH2_STAP1	161	165	PF00017	0.522
LIG_SH2_STAP1	58	62	PF00017	0.475
LIG_SH2_STAT5	164	167	PF00017	0.494
LIG_SH2_STAT5	2	5	PF00017	0.523
LIG_SH3_3	35	41	PF00018	0.495
LIG_SUMO_SIM_par_1	83	89	PF11976	0.493
LIG_TRAF2_1	15	18	PF00917	0.510
LIG_TRAF2_1	93	96	PF00917	0.484
MOD_CK1_1	43	49	PF00069	0.577
MOD_CK2_1	12	18	PF00069	0.479
MOD_CK2_1	121	127	PF00069	0.651
MOD_CK2_1	173	179	PF00069	0.430
MOD_CK2_1	185	191	PF00069	0.514
MOD_CK2_1	89	95	PF00069	0.485
MOD_GlcNHglycan	182	185	PF01048	0.488
MOD_GSK3_1	127	134	PF00069	0.514
MOD_GSK3_1	4	11	PF00069	0.525
MOD_GSK3_1	82	89	PF00069	0.565
MOD_PKA_1	131	137	PF00069	0.530
MOD_PKA_1	81	87	PF00069	0.452
MOD_PKA_2	127	133	PF00069	0.530
MOD_PKA_2	24	30	PF00069	0.506
MOD_Plk_1	104	110	PF00069	0.405
MOD_Plk_1	58	64	PF00069	0.467
MOD_Plk_1	82	88	PF00069	0.596
MOD_Plk_4	40	46	PF00069	0.370
MOD_ProDKin_1	89	95	PF00069	0.627
MOD_SUMO_for_1	32	35	PF00179	0.354
MOD_SUMO_rev_2	29	39	PF00179	0.471
TRG_DiLeu_BaEn_1	95	100	PF01217	0.464
TRG_ENDOCYTIC_2	119	122	PF00928	0.503
TRG_ER_diArg_1	64	67	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU2	Leptomonas seymouri	66%	100%
A0A0S4ITG8	Bodo saltans	30%	94%
A0A0S4ITU7	Bodo saltans	33%	100%
A0A0S4IZ88	Bodo saltans	26%	100%
A0A0S4KH12	Bodo saltans	33%	98%
A0A1X0P384	Trypanosomatidae	39%	100%
A0A1X0P828	Trypanosomatidae	26%	100%
A0A3Q8IJ52	Leishmania donovani	91%	100%
A0A3S7XAJ8	Leishmania donovani	25%	100%
A0A422NMA5	Trypanosoma rangeli	41%	100%
A4HQ43	Leishmania braziliensis	76%	100%
A4ICK7	Leishmania infantum	26%	100%
A4IDV0	Leishmania infantum	91%	100%
D0A8S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIX6	Leishmania braziliensis	30%	100%
E9ASP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q0N3	Leishmania major	88%	100%