LeishMANIAdb
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Endonuclease/exonuclease protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Endonuclease/exonuclease protein-like protein
Gene product:
endonuclease/exonuclease protein-like protein
Species:
Leishmania mexicana
UniProt:
E9ATW1_LEIMU
TriTrypDb:
LmxM.36.5270
Length:
736

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ATW1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATW1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006259 DNA metabolic process 4 10
GO:0006281 DNA repair 5 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0006950 response to stress 2 10
GO:0006974 DNA damage response 4 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0033554 cellular response to stress 3 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0043170 macromolecule metabolic process 3 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044260 obsolete cellular macromolecule metabolic process 3 10
GO:0046483 heterocycle metabolic process 3 10
GO:0050896 response to stimulus 1 10
GO:0051716 cellular response to stimulus 2 10
GO:0071704 organic substance metabolic process 2 10
GO:0090304 nucleic acid metabolic process 4 10
GO:1901360 organic cyclic compound metabolic process 3 10
GO:0006284 base-excision repair 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003677 DNA binding 4 10
GO:0003824 catalytic activity 1 10
GO:0004518 nuclease activity 4 10
GO:0004519 endonuclease activity 5 10
GO:0004527 exonuclease activity 5 7
GO:0005488 binding 1 10
GO:0016787 hydrolase activity 2 10
GO:0016788 hydrolase activity, acting on ester bonds 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4 3
GO:0004529 DNA exonuclease activity 5 1
GO:0004536 DNA nuclease activity 4 1
GO:0008081 phosphoric diester hydrolase activity 5 1
GO:0008296 3'-5'-DNA exonuclease activity 7 1
GO:0008309 double-stranded DNA exodeoxyribonuclease activity 7 1
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity 8 1
GO:0008408 3'-5' exonuclease activity 6 1
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 1
GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 6 1
GO:0042578 phosphoric ester hydrolase activity 4 1
GO:0140097 catalytic activity, acting on DNA 3 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:0016829 lyase activity 2 2
GO:0016835 carbon-oxygen lyase activity 3 2
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.245
CLV_C14_Caspase3-7 441 445 PF00656 0.336
CLV_NRD_NRD_1 134 136 PF00675 0.298
CLV_NRD_NRD_1 227 229 PF00675 0.297
CLV_NRD_NRD_1 486 488 PF00675 0.333
CLV_NRD_NRD_1 65 67 PF00675 0.391
CLV_NRD_NRD_1 82 84 PF00675 0.391
CLV_PCSK_FUR_1 484 488 PF00082 0.298
CLV_PCSK_KEX2_1 227 229 PF00082 0.274
CLV_PCSK_KEX2_1 262 264 PF00082 0.460
CLV_PCSK_KEX2_1 486 488 PF00082 0.274
CLV_PCSK_KEX2_1 65 67 PF00082 0.391
CLV_PCSK_KEX2_1 686 688 PF00082 0.730
CLV_PCSK_KEX2_1 80 82 PF00082 0.391
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.336
CLV_PCSK_PC1ET2_1 686 688 PF00082 0.730
CLV_PCSK_PC1ET2_1 80 82 PF00082 0.282
CLV_PCSK_SKI1_1 136 140 PF00082 0.284
CLV_PCSK_SKI1_1 313 317 PF00082 0.371
CLV_PCSK_SKI1_1 653 657 PF00082 0.401
DEG_APCC_DBOX_1 227 235 PF00400 0.298
DEG_APCC_DBOX_1 312 320 PF00400 0.336
DEG_Nend_Nbox_1 1 3 PF02207 0.296
DEG_SPOP_SBC_1 289 293 PF00917 0.302
DEG_SPOP_SBC_1 402 406 PF00917 0.302
DOC_CKS1_1 595 600 PF01111 0.344
DOC_CYCLIN_yCln2_LP_2 322 325 PF00134 0.336
DOC_MAPK_MEF2A_6 395 403 PF00069 0.394
DOC_MAPK_MEF2A_6 634 643 PF00069 0.515
DOC_PP1_RVXF_1 134 141 PF00149 0.298
DOC_PP1_RVXF_1 183 189 PF00149 0.407
DOC_PP1_RVXF_1 580 587 PF00149 0.402
DOC_PP2B_LxvP_1 322 325 PF13499 0.336
DOC_PP2B_LxvP_1 399 402 PF13499 0.383
DOC_PP2B_PxIxI_1 205 211 PF00149 0.391
DOC_PP4_FxxP_1 595 598 PF00568 0.337
DOC_USP7_MATH_1 289 293 PF00917 0.385
DOC_USP7_MATH_1 325 329 PF00917 0.428
DOC_USP7_MATH_1 356 360 PF00917 0.302
DOC_USP7_MATH_1 368 372 PF00917 0.184
DOC_USP7_MATH_1 402 406 PF00917 0.302
DOC_USP7_MATH_1 533 537 PF00917 0.583
DOC_USP7_MATH_1 655 659 PF00917 0.566
DOC_USP7_MATH_1 660 664 PF00917 0.611
DOC_USP7_MATH_1 94 98 PF00917 0.386
DOC_USP7_UBL2_3 258 262 PF12436 0.481
DOC_WW_Pin1_4 362 367 PF00397 0.485
DOC_WW_Pin1_4 450 455 PF00397 0.480
DOC_WW_Pin1_4 49 54 PF00397 0.391
DOC_WW_Pin1_4 594 599 PF00397 0.340
LIG_14-3-3_CanoR_1 135 141 PF00244 0.298
LIG_14-3-3_CanoR_1 157 167 PF00244 0.298
LIG_14-3-3_CanoR_1 181 185 PF00244 0.262
LIG_14-3-3_CanoR_1 354 362 PF00244 0.406
LIG_14-3-3_CanoR_1 400 409 PF00244 0.403
LIG_14-3-3_CanoR_1 411 420 PF00244 0.336
LIG_14-3-3_CanoR_1 525 533 PF00244 0.599
LIG_APCC_ABBA_1 382 387 PF00400 0.298
LIG_BRCT_BRCA1_1 143 147 PF00533 0.315
LIG_BRCT_BRCA1_1 388 392 PF00533 0.298
LIG_BRCT_BRCA1_1 527 531 PF00533 0.463
LIG_CtBP_PxDLS_1 342 346 PF00389 0.336
LIG_CtBP_PxDLS_1 53 57 PF00389 0.374
LIG_deltaCOP1_diTrp_1 111 117 PF00928 0.277
LIG_EVH1_1 564 568 PF00568 0.519
LIG_EVH1_2 565 569 PF00568 0.543
LIG_FHA_1 181 187 PF00498 0.317
LIG_FHA_1 248 254 PF00498 0.310
LIG_FHA_1 293 299 PF00498 0.454
LIG_FHA_1 433 439 PF00498 0.380
LIG_FHA_1 654 660 PF00498 0.513
LIG_FHA_2 30 36 PF00498 0.282
LIG_FHA_2 476 482 PF00498 0.274
LIG_FHA_2 491 497 PF00498 0.274
LIG_FHA_2 616 622 PF00498 0.505
LIG_GBD_Chelix_1 264 272 PF00786 0.302
LIG_Integrin_RGD_1 723 725 PF01839 0.497
LIG_LIR_Apic_2 592 598 PF02991 0.334
LIG_LIR_Gen_1 111 119 PF02991 0.298
LIG_LIR_Gen_1 371 382 PF02991 0.336
LIG_LIR_Gen_1 496 505 PF02991 0.274
LIG_LIR_Gen_1 540 551 PF02991 0.406
LIG_LIR_Nem_3 111 116 PF02991 0.277
LIG_LIR_Nem_3 20 25 PF02991 0.274
LIG_LIR_Nem_3 371 377 PF02991 0.322
LIG_LIR_Nem_3 496 500 PF02991 0.274
LIG_LIR_Nem_3 540 546 PF02991 0.419
LIG_LIR_Nem_3 583 589 PF02991 0.449
LIG_MYND_1 467 471 PF01753 0.391
LIG_NRBOX 230 236 PF00104 0.391
LIG_OCRL_FandH_1 21 33 PF00620 0.313
LIG_PCNA_yPIPBox_3 363 377 PF02747 0.333
LIG_PDZ_Class_3 731 736 PF00595 0.583
LIG_Pex14_2 184 188 PF04695 0.298
LIG_Pex14_2 2 6 PF04695 0.313
LIG_PTB_Apo_2 558 565 PF02174 0.508
LIG_PTB_Phospho_1 558 564 PF10480 0.505
LIG_Rb_pABgroove_1 343 351 PF01858 0.336
LIG_SH2_CRK 374 378 PF00017 0.332
LIG_SH2_CRK 637 641 PF00017 0.410
LIG_SH2_NCK_1 338 342 PF00017 0.391
LIG_SH2_PTP2 497 500 PF00017 0.274
LIG_SH2_STAP1 357 361 PF00017 0.391
LIG_SH2_STAT5 172 175 PF00017 0.307
LIG_SH2_STAT5 217 220 PF00017 0.302
LIG_SH2_STAT5 357 360 PF00017 0.257
LIG_SH2_STAT5 472 475 PF00017 0.291
LIG_SH2_STAT5 477 480 PF00017 0.257
LIG_SH2_STAT5 497 500 PF00017 0.274
LIG_SH3_1 468 474 PF00018 0.336
LIG_SH3_3 168 174 PF00018 0.391
LIG_SH3_3 461 467 PF00018 0.328
LIG_SH3_3 468 474 PF00018 0.279
LIG_SH3_3 562 568 PF00018 0.429
LIG_SH3_3 593 599 PF00018 0.376
LIG_SH3_3 65 71 PF00018 0.462
LIG_SH3_3 656 662 PF00018 0.653
LIG_SH3_4 661 668 PF00018 0.482
LIG_SUMO_SIM_anti_2 457 463 PF11976 0.423
LIG_SUMO_SIM_par_1 206 212 PF11976 0.298
LIG_SUMO_SIM_par_1 295 303 PF11976 0.349
LIG_SUMO_SIM_par_1 729 735 PF11976 0.619
LIG_TRAF2_2 598 603 PF00917 0.346
LIG_TYR_ITIM 495 500 PF00017 0.274
LIG_UBA3_1 36 43 PF00899 0.391
LIG_WRC_WIRS_1 130 135 PF05994 0.325
LIG_WRC_WIRS_1 643 648 PF05994 0.515
LIG_WRC_WIRS_1 695 700 PF05994 0.574
LIG_WW_3 323 327 PF00397 0.336
MOD_CK1_1 115 121 PF00069 0.337
MOD_CK1_1 12 18 PF00069 0.333
MOD_CK1_1 21 27 PF00069 0.333
MOD_CK1_1 282 288 PF00069 0.410
MOD_CK1_1 292 298 PF00069 0.375
MOD_CK1_1 299 305 PF00069 0.426
MOD_CK1_1 307 313 PF00069 0.466
MOD_CK1_1 386 392 PF00069 0.403
MOD_CK1_1 691 697 PF00069 0.708
MOD_CK1_1 93 99 PF00069 0.395
MOD_CK2_1 145 151 PF00069 0.240
MOD_CK2_1 615 621 PF00069 0.501
MOD_CK2_1 710 716 PF00069 0.670
MOD_GlcNHglycan 119 122 PF01048 0.298
MOD_GlcNHglycan 284 287 PF01048 0.391
MOD_GlcNHglycan 292 295 PF01048 0.412
MOD_GlcNHglycan 328 331 PF01048 0.395
MOD_GlcNHglycan 387 391 PF01048 0.391
MOD_GlcNHglycan 405 408 PF01048 0.444
MOD_GlcNHglycan 49 52 PF01048 0.476
MOD_GlcNHglycan 501 504 PF01048 0.343
MOD_GlcNHglycan 527 530 PF01048 0.609
MOD_GlcNHglycan 625 628 PF01048 0.622
MOD_GlcNHglycan 84 87 PF01048 0.258
MOD_GlcNHglycan 92 95 PF01048 0.292
MOD_GlcNHglycan 96 99 PF01048 0.305
MOD_GSK3_1 141 148 PF00069 0.366
MOD_GSK3_1 285 292 PF00069 0.363
MOD_GSK3_1 299 306 PF00069 0.389
MOD_GSK3_1 432 439 PF00069 0.430
MOD_GSK3_1 649 656 PF00069 0.442
MOD_GSK3_1 693 700 PF00069 0.745
MOD_GSK3_1 90 97 PF00069 0.395
MOD_N-GLC_1 213 218 PF02516 0.274
MOD_N-GLC_1 304 309 PF02516 0.330
MOD_N-GLC_1 525 530 PF02516 0.437
MOD_N-GLC_1 698 703 PF02516 0.547
MOD_NEK2_1 2 7 PF00069 0.291
MOD_NEK2_1 213 218 PF00069 0.280
MOD_NEK2_1 361 366 PF00069 0.368
MOD_NEK2_1 432 437 PF00069 0.316
MOD_NEK2_1 499 504 PF00069 0.336
MOD_NEK2_1 527 532 PF00069 0.442
MOD_NEK2_1 546 551 PF00069 0.271
MOD_NEK2_1 569 574 PF00069 0.448
MOD_NEK2_1 623 628 PF00069 0.543
MOD_NEK2_1 698 703 PF00069 0.729
MOD_NEK2_2 180 185 PF00069 0.245
MOD_NEK2_2 222 227 PF00069 0.333
MOD_NEK2_2 642 647 PF00069 0.599
MOD_OFUCOSY 473 479 PF10250 0.335
MOD_PIKK_1 12 18 PF00454 0.370
MOD_PIKK_1 141 147 PF00454 0.329
MOD_PKA_1 653 659 PF00069 0.460
MOD_PKA_1 82 88 PF00069 0.211
MOD_PKA_2 18 24 PF00069 0.328
MOD_PKA_2 180 186 PF00069 0.282
MOD_PKA_2 325 331 PF00069 0.455
MOD_PKA_2 82 88 PF00069 0.344
MOD_Plk_1 213 219 PF00069 0.274
MOD_Plk_1 307 313 PF00069 0.268
MOD_Plk_4 112 118 PF00069 0.314
MOD_Plk_4 230 236 PF00069 0.280
MOD_Plk_4 432 438 PF00069 0.333
MOD_Plk_4 642 648 PF00069 0.515
MOD_ProDKin_1 362 368 PF00069 0.485
MOD_ProDKin_1 450 456 PF00069 0.480
MOD_ProDKin_1 49 55 PF00069 0.391
MOD_ProDKin_1 594 600 PF00069 0.344
MOD_SUMO_rev_2 35 45 PF00179 0.274
MOD_SUMO_rev_2 626 636 PF00179 0.526
TRG_AP2beta_CARGO_1 540 550 PF09066 0.443
TRG_DiLeu_BaLyEn_6 392 397 PF01217 0.391
TRG_DiLeu_BaLyEn_6 451 456 PF01217 0.336
TRG_ENDOCYTIC_2 374 377 PF00928 0.332
TRG_ENDOCYTIC_2 497 500 PF00928 0.274
TRG_ER_diArg_1 226 228 PF00400 0.275
TRG_ER_diArg_1 429 432 PF00400 0.268
TRG_ER_diArg_1 466 469 PF00400 0.468
TRG_ER_diArg_1 484 487 PF00400 0.231
TRG_ER_diArg_1 65 67 PF00400 0.391
TRG_ER_diArg_1 81 83 PF00400 0.391
TRG_NLS_Bipartite_1 65 84 PF00514 0.177
TRG_NLS_MonoCore_2 79 84 PF00514 0.177
TRG_Pf-PMV_PEXEL_1 346 350 PF00026 0.391
TRG_Pf-PMV_PEXEL_1 486 491 PF00026 0.336

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB73 Leptomonas seymouri 58% 99%
A0A1X0P3V4 Trypanosomatidae 36% 100%
A0A3R7M024 Trypanosoma rangeli 41% 100%
A0A3S7XBT9 Leishmania donovani 89% 100%
A4IDU8 Leishmania infantum 89% 100%
D0A8S3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AIY2 Leishmania braziliensis 80% 100%
Q4Q0N5 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS