LeishMANIAdb
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Putative glycosyl hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glycosyl hydrolase
Gene product:
glycosyl hydrolase, putative
Species:
Leishmania mexicana
UniProt:
E9ATV8_LEIMU
TriTrypDb:
LmxM.36.5240
Length:
1153

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Expansion

Sequence features

E9ATV8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATV8

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 11
GO:0008152 metabolic process 1 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 7
GO:0004555 alpha,alpha-trehalase activity 6 7
GO:0005488 binding 1 11
GO:0015927 trehalase activity 5 7
GO:0016787 hydrolase activity 2 11
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 7
GO:0030246 carbohydrate binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1091 1095 PF00656 0.418
CLV_C14_Caspase3-7 610 614 PF00656 0.425
CLV_C14_Caspase3-7 695 699 PF00656 0.425
CLV_C14_Caspase3-7 751 755 PF00656 0.332
CLV_NRD_NRD_1 17 19 PF00675 0.714
CLV_NRD_NRD_1 192 194 PF00675 0.326
CLV_NRD_NRD_1 203 205 PF00675 0.299
CLV_NRD_NRD_1 221 223 PF00675 0.332
CLV_NRD_NRD_1 227 229 PF00675 0.288
CLV_NRD_NRD_1 686 688 PF00675 0.305
CLV_NRD_NRD_1 88 90 PF00675 0.457
CLV_NRD_NRD_1 991 993 PF00675 0.359
CLV_PCSK_KEX2_1 17 19 PF00082 0.714
CLV_PCSK_KEX2_1 192 194 PF00082 0.325
CLV_PCSK_KEX2_1 203 205 PF00082 0.300
CLV_PCSK_KEX2_1 221 223 PF00082 0.239
CLV_PCSK_KEX2_1 854 856 PF00082 0.310
CLV_PCSK_KEX2_1 88 90 PF00082 0.457
CLV_PCSK_PC1ET2_1 854 856 PF00082 0.380
CLV_PCSK_PC7_1 188 194 PF00082 0.411
CLV_PCSK_SKI1_1 1098 1102 PF00082 0.386
CLV_PCSK_SKI1_1 214 218 PF00082 0.332
CLV_PCSK_SKI1_1 253 257 PF00082 0.374
CLV_PCSK_SKI1_1 469 473 PF00082 0.425
CLV_PCSK_SKI1_1 501 505 PF00082 0.313
CLV_PCSK_SKI1_1 525 529 PF00082 0.315
CLV_PCSK_SKI1_1 532 536 PF00082 0.310
CLV_PCSK_SKI1_1 594 598 PF00082 0.457
CLV_PCSK_SKI1_1 667 671 PF00082 0.386
CLV_PCSK_SKI1_1 855 859 PF00082 0.313
CLV_PCSK_SKI1_1 952 956 PF00082 0.583
DEG_APCC_DBOX_1 843 851 PF00400 0.386
DEG_Nend_Nbox_1 1 3 PF02207 0.690
DEG_SCF_FBW7_1 1110 1117 PF00400 0.528
DOC_CKS1_1 163 168 PF01111 0.457
DOC_CYCLIN_RxL_1 188 200 PF00134 0.334
DOC_CYCLIN_RxL_1 498 505 PF00134 0.425
DOC_CYCLIN_RxL_1 989 999 PF00134 0.515
DOC_MAPK_DCC_7 717 726 PF00069 0.380
DOC_MAPK_gen_1 1103 1110 PF00069 0.456
DOC_MAPK_gen_1 17 25 PF00069 0.644
DOC_MAPK_gen_1 498 506 PF00069 0.357
DOC_MAPK_gen_1 842 850 PF00069 0.386
DOC_MAPK_MEF2A_6 1103 1110 PF00069 0.439
DOC_MAPK_MEF2A_6 717 726 PF00069 0.420
DOC_MAPK_MEF2A_6 844 852 PF00069 0.386
DOC_PP1_RVXF_1 130 137 PF00149 0.425
DOC_PP1_RVXF_1 202 209 PF00149 0.349
DOC_PP2B_LxvP_1 1119 1122 PF13499 0.466
DOC_PP2B_LxvP_1 487 490 PF13499 0.425
DOC_PP2B_LxvP_1 521 524 PF13499 0.411
DOC_SPAK_OSR1_1 448 452 PF12202 0.386
DOC_USP7_MATH_1 338 342 PF00917 0.723
DOC_USP7_MATH_1 41 45 PF00917 0.421
DOC_USP7_MATH_1 703 707 PF00917 0.457
DOC_USP7_MATH_1 752 756 PF00917 0.374
DOC_USP7_MATH_1 76 80 PF00917 0.427
DOC_USP7_MATH_1 803 807 PF00917 0.332
DOC_WW_Pin1_4 1108 1113 PF00397 0.555
DOC_WW_Pin1_4 162 167 PF00397 0.462
DOC_WW_Pin1_4 314 319 PF00397 0.642
DOC_WW_Pin1_4 329 334 PF00397 0.659
DOC_WW_Pin1_4 340 345 PF00397 0.719
DOC_WW_Pin1_4 348 353 PF00397 0.602
DOC_WW_Pin1_4 538 543 PF00397 0.407
DOC_WW_Pin1_4 637 642 PF00397 0.166
LIG_14-3-3_CanoR_1 221 231 PF00244 0.316
LIG_14-3-3_CanoR_1 253 263 PF00244 0.379
LIG_14-3-3_CanoR_1 282 292 PF00244 0.376
LIG_14-3-3_CanoR_1 346 352 PF00244 0.419
LIG_14-3-3_CanoR_1 507 512 PF00244 0.425
LIG_14-3-3_CanoR_1 650 659 PF00244 0.313
LIG_14-3-3_CanoR_1 75 84 PF00244 0.381
LIG_14-3-3_CanoR_1 855 860 PF00244 0.334
LIG_14-3-3_CanoR_1 880 884 PF00244 0.502
LIG_14-3-3_CanoR_1 998 1008 PF00244 0.481
LIG_Actin_WH2_2 743 760 PF00022 0.451
LIG_Actin_WH2_2 939 954 PF00022 0.466
LIG_AP2alpha_2 167 169 PF02296 0.380
LIG_APCC_ABBA_1 891 896 PF00400 0.477
LIG_BRCT_BRCA1_1 1045 1049 PF00533 0.551
LIG_BRCT_BRCA1_1 251 255 PF00533 0.411
LIG_BRCT_BRCA1_1 276 280 PF00533 0.267
LIG_CtBP_PxDLS_1 1058 1064 PF00389 0.540
LIG_eIF4E_1 140 146 PF01652 0.425
LIG_eIF4E_1 543 549 PF01652 0.425
LIG_eIF4E_1 778 784 PF01652 0.386
LIG_FHA_1 1116 1122 PF00498 0.516
LIG_FHA_1 189 195 PF00498 0.341
LIG_FHA_1 196 202 PF00498 0.358
LIG_FHA_1 32 38 PF00498 0.546
LIG_FHA_1 369 375 PF00498 0.414
LIG_FHA_1 394 400 PF00498 0.554
LIG_FHA_1 405 411 PF00498 0.513
LIG_FHA_1 430 436 PF00498 0.456
LIG_FHA_1 466 472 PF00498 0.425
LIG_FHA_1 566 572 PF00498 0.326
LIG_FHA_1 579 585 PF00498 0.287
LIG_FHA_1 673 679 PF00498 0.446
LIG_FHA_1 851 857 PF00498 0.386
LIG_FHA_1 867 873 PF00498 0.328
LIG_FHA_1 880 886 PF00498 0.362
LIG_FHA_1 888 894 PF00498 0.414
LIG_FHA_1 923 929 PF00498 0.447
LIG_FHA_1 941 947 PF00498 0.238
LIG_FHA_1 972 978 PF00498 0.558
LIG_FHA_2 1111 1117 PF00498 0.539
LIG_FHA_2 1134 1140 PF00498 0.468
LIG_FHA_2 321 327 PF00498 0.729
LIG_FHA_2 393 399 PF00498 0.523
LIG_FHA_2 456 462 PF00498 0.443
LIG_FHA_2 508 514 PF00498 0.425
LIG_FHA_2 605 611 PF00498 0.425
LIG_FHA_2 652 658 PF00498 0.297
LIG_FHA_2 743 749 PF00498 0.351
LIG_FHA_2 925 931 PF00498 0.481
LIG_Integrin_RGD_1 89 91 PF01839 0.282
LIG_LIR_Apic_2 461 467 PF02991 0.425
LIG_LIR_Gen_1 1046 1053 PF02991 0.535
LIG_LIR_Gen_1 381 389 PF02991 0.446
LIG_LIR_Gen_1 606 616 PF02991 0.414
LIG_LIR_Gen_1 745 752 PF02991 0.379
LIG_LIR_Gen_1 781 791 PF02991 0.358
LIG_LIR_Gen_1 806 814 PF02991 0.457
LIG_LIR_Gen_1 858 865 PF02991 0.358
LIG_LIR_Gen_1 901 909 PF02991 0.345
LIG_LIR_Nem_3 1046 1052 PF02991 0.543
LIG_LIR_Nem_3 1102 1107 PF02991 0.386
LIG_LIR_Nem_3 381 385 PF02991 0.445
LIG_LIR_Nem_3 461 466 PF02991 0.400
LIG_LIR_Nem_3 606 611 PF02991 0.327
LIG_LIR_Nem_3 642 647 PF02991 0.316
LIG_LIR_Nem_3 743 747 PF02991 0.373
LIG_LIR_Nem_3 781 787 PF02991 0.358
LIG_LIR_Nem_3 858 862 PF02991 0.316
LIG_LIR_Nem_3 901 905 PF02991 0.359
LIG_LIR_Nem_3 91 97 PF02991 0.411
LIG_LIR_Nem_3 945 950 PF02991 0.387
LIG_LIR_Nem_3 962 967 PF02991 0.417
LIG_NRBOX 1014 1020 PF00104 0.525
LIG_SH2_CRK 464 468 PF00017 0.387
LIG_SH2_CRK 531 535 PF00017 0.443
LIG_SH2_CRK 859 863 PF00017 0.425
LIG_SH2_GRB2like 84 87 PF00017 0.380
LIG_SH2_NCK_1 608 612 PF00017 0.457
LIG_SH2_NCK_1 747 751 PF00017 0.313
LIG_SH2_NCK_1 859 863 PF00017 0.386
LIG_SH2_STAP1 370 374 PF00017 0.402
LIG_SH2_STAT5 1071 1074 PF00017 0.362
LIG_SH2_STAT5 1140 1143 PF00017 0.575
LIG_SH2_STAT5 135 138 PF00017 0.332
LIG_SH2_STAT5 370 373 PF00017 0.411
LIG_SH2_STAT5 464 467 PF00017 0.382
LIG_SH2_STAT5 543 546 PF00017 0.396
LIG_SH2_STAT5 561 564 PF00017 0.163
LIG_SH2_STAT5 77 80 PF00017 0.413
LIG_SH2_STAT5 778 781 PF00017 0.386
LIG_SH2_STAT5 859 862 PF00017 0.386
LIG_SH2_STAT5 947 950 PF00017 0.420
LIG_SH3_3 122 128 PF00018 0.380
LIG_SH3_3 341 347 PF00018 0.777
LIG_SH3_3 599 605 PF00018 0.332
LIG_SH3_3 859 865 PF00018 0.425
LIG_SH3_5 1067 1071 PF00018 0.379
LIG_SUMO_SIM_anti_2 869 875 PF11976 0.393
LIG_SUMO_SIM_par_1 1106 1111 PF11976 0.492
LIG_SUMO_SIM_par_1 395 404 PF11976 0.600
LIG_TRAF2_1 1113 1116 PF00917 0.555
LIG_TRAF2_1 395 398 PF00917 0.589
LIG_TRAF2_1 927 930 PF00917 0.477
LIG_TYR_ITIM 413 418 PF00017 0.441
LIG_TYR_ITIM 857 862 PF00017 0.313
LIG_TYR_ITSM 743 750 PF00017 0.425
MOD_CDC14_SPxK_1 343 346 PF00782 0.480
MOD_CDK_SPxK_1 340 346 PF00069 0.485
MOD_CDK_SPxxK_3 353 360 PF00069 0.586
MOD_CK1_1 121 127 PF00069 0.433
MOD_CK1_1 294 300 PF00069 0.400
MOD_CK1_1 3 9 PF00069 0.705
MOD_CK1_1 334 340 PF00069 0.587
MOD_CK1_1 351 357 PF00069 0.527
MOD_CK1_1 359 365 PF00069 0.412
MOD_CK1_1 369 375 PF00069 0.281
MOD_CK1_1 806 812 PF00069 0.425
MOD_CK1_1 938 944 PF00069 0.556
MOD_CK1_1 999 1005 PF00069 0.560
MOD_CK2_1 1110 1116 PF00069 0.553
MOD_CK2_1 1133 1139 PF00069 0.518
MOD_CK2_1 153 159 PF00069 0.425
MOD_CK2_1 254 260 PF00069 0.425
MOD_CK2_1 392 398 PF00069 0.591
MOD_CK2_1 507 513 PF00069 0.425
MOD_CK2_1 733 739 PF00069 0.313
MOD_CK2_1 742 748 PF00069 0.313
MOD_CK2_1 860 866 PF00069 0.420
MOD_CK2_1 908 914 PF00069 0.358
MOD_CK2_1 924 930 PF00069 0.427
MOD_CMANNOS 586 589 PF00535 0.313
MOD_Cter_Amidation 15 18 PF01082 0.650
MOD_GlcNHglycan 1029 1032 PF01048 0.399
MOD_GlcNHglycan 11 14 PF01048 0.635
MOD_GlcNHglycan 120 123 PF01048 0.347
MOD_GlcNHglycan 125 128 PF01048 0.376
MOD_GlcNHglycan 136 139 PF01048 0.430
MOD_GlcNHglycan 151 154 PF01048 0.297
MOD_GlcNHglycan 175 178 PF01048 0.387
MOD_GlcNHglycan 224 227 PF01048 0.448
MOD_GlcNHglycan 231 234 PF01048 0.386
MOD_GlcNHglycan 256 259 PF01048 0.413
MOD_GlcNHglycan 333 336 PF01048 0.759
MOD_GlcNHglycan 340 343 PF01048 0.705
MOD_GlcNHglycan 458 461 PF01048 0.429
MOD_GlcNHglycan 602 605 PF01048 0.328
MOD_GlcNHglycan 754 757 PF01048 0.411
MOD_GlcNHglycan 793 796 PF01048 0.351
MOD_GlcNHglycan 862 865 PF01048 0.474
MOD_GSK3_1 1039 1046 PF00069 0.540
MOD_GSK3_1 1110 1117 PF00069 0.528
MOD_GSK3_1 117 124 PF00069 0.359
MOD_GSK3_1 149 156 PF00069 0.425
MOD_GSK3_1 184 191 PF00069 0.346
MOD_GSK3_1 316 323 PF00069 0.669
MOD_GSK3_1 324 331 PF00069 0.596
MOD_GSK3_1 334 341 PF00069 0.536
MOD_GSK3_1 347 354 PF00069 0.529
MOD_GSK3_1 359 366 PF00069 0.478
MOD_GSK3_1 368 375 PF00069 0.394
MOD_GSK3_1 451 458 PF00069 0.410
MOD_GSK3_1 465 472 PF00069 0.404
MOD_GSK3_1 562 569 PF00069 0.348
MOD_GSK3_1 600 607 PF00069 0.398
MOD_GSK3_1 748 755 PF00069 0.290
MOD_GSK3_1 996 1003 PF00069 0.537
MOD_LATS_1 147 153 PF00433 0.414
MOD_LATS_1 598 604 PF00433 0.425
MOD_N-GLC_1 1039 1044 PF02516 0.516
MOD_N-GLC_1 188 193 PF02516 0.166
MOD_N-GLC_1 229 234 PF02516 0.368
MOD_N-GLC_1 565 570 PF02516 0.366
MOD_N-GLC_1 691 696 PF02516 0.411
MOD_N-GLC_2 285 287 PF02516 0.313
MOD_NEK2_1 267 272 PF00069 0.439
MOD_NEK2_1 280 285 PF00069 0.301
MOD_NEK2_1 578 583 PF00069 0.358
MOD_NEK2_1 672 677 PF00069 0.420
MOD_NEK2_1 681 686 PF00069 0.330
MOD_NEK2_1 769 774 PF00069 0.346
MOD_NEK2_1 779 784 PF00069 0.328
MOD_NEK2_1 798 803 PF00069 0.275
MOD_NEK2_1 996 1001 PF00069 0.522
MOD_NEK2_2 236 241 PF00069 0.422
MOD_NEK2_2 703 708 PF00069 0.418
MOD_NEK2_2 742 747 PF00069 0.425
MOD_PIKK_1 265 271 PF00454 0.425
MOD_PIKK_1 316 322 PF00454 0.775
MOD_PIKK_1 922 928 PF00454 0.477
MOD_PK_1 1044 1050 PF00069 0.559
MOD_PKA_2 283 289 PF00069 0.386
MOD_PKA_2 359 365 PF00069 0.565
MOD_PKA_2 769 775 PF00069 0.411
MOD_PKA_2 879 885 PF00069 0.509
MOD_PKB_1 73 81 PF00069 0.263
MOD_Plk_1 1114 1120 PF00069 0.532
MOD_Plk_1 1130 1136 PF00069 0.350
MOD_Plk_1 1138 1144 PF00069 0.502
MOD_Plk_1 214 220 PF00069 0.313
MOD_Plk_1 229 235 PF00069 0.313
MOD_Plk_1 31 37 PF00069 0.498
MOD_Plk_1 366 372 PF00069 0.432
MOD_Plk_1 519 525 PF00069 0.386
MOD_Plk_1 565 571 PF00069 0.366
MOD_Plk_1 681 687 PF00069 0.425
MOD_Plk_1 691 697 PF00069 0.425
MOD_Plk_1 742 748 PF00069 0.371
MOD_Plk_1 938 944 PF00069 0.543
MOD_Plk_2-3 393 399 PF00069 0.597
MOD_Plk_2-3 733 739 PF00069 0.457
MOD_Plk_2-3 908 914 PF00069 0.374
MOD_Plk_4 1044 1050 PF00069 0.520
MOD_Plk_4 262 268 PF00069 0.361
MOD_Plk_4 274 280 PF00069 0.348
MOD_Plk_4 43 49 PF00069 0.325
MOD_Plk_4 451 457 PF00069 0.412
MOD_Plk_4 566 572 PF00069 0.364
MOD_Plk_4 681 687 PF00069 0.380
MOD_Plk_4 703 709 PF00069 0.332
MOD_Plk_4 779 785 PF00069 0.358
MOD_Plk_4 857 863 PF00069 0.425
MOD_Plk_4 908 914 PF00069 0.354
MOD_Plk_4 982 988 PF00069 0.391
MOD_ProDKin_1 1108 1114 PF00069 0.560
MOD_ProDKin_1 162 168 PF00069 0.462
MOD_ProDKin_1 314 320 PF00069 0.642
MOD_ProDKin_1 329 335 PF00069 0.658
MOD_ProDKin_1 340 346 PF00069 0.716
MOD_ProDKin_1 348 354 PF00069 0.595
MOD_ProDKin_1 538 544 PF00069 0.407
MOD_ProDKin_1 637 643 PF00069 0.166
MOD_SUMO_rev_2 733 742 PF00179 0.425
TRG_DiLeu_BaEn_2 218 224 PF01217 0.332
TRG_DiLeu_BaLyEn_6 246 251 PF01217 0.425
TRG_ENDOCYTIC_2 415 418 PF00928 0.387
TRG_ENDOCYTIC_2 463 466 PF00928 0.379
TRG_ENDOCYTIC_2 531 534 PF00928 0.443
TRG_ENDOCYTIC_2 608 611 PF00928 0.321
TRG_ENDOCYTIC_2 747 750 PF00928 0.313
TRG_ENDOCYTIC_2 859 862 PF00928 0.313
TRG_ENDOCYTIC_2 94 97 PF00928 0.392
TRG_ER_diArg_1 161 164 PF00400 0.407
TRG_ER_diArg_1 17 19 PF00400 0.679
TRG_ER_diArg_1 192 194 PF00400 0.333
TRG_ER_diArg_1 203 205 PF00400 0.288
TRG_ER_diArg_1 221 223 PF00400 0.238
TRG_ER_diArg_1 281 284 PF00400 0.356
TRG_ER_diArg_1 506 509 PF00400 0.425
TRG_ER_diArg_1 714 717 PF00400 0.380
TRG_ER_FFAT_2 367 376 PF00635 0.513
TRG_NLS_MonoExtN_4 497 502 PF00514 0.457
TRG_Pf-PMV_PEXEL_1 469 474 PF00026 0.356
TRG_Pf-PMV_PEXEL_1 501 505 PF00026 0.332
TRG_Pf-PMV_PEXEL_1 509 513 PF00026 0.330

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBB4 Leptomonas seymouri 78% 100%
A0A1X0P446 Trypanosomatidae 50% 91%
A0A3Q8ILK5 Leishmania donovani 97% 100%
A0A3R7NRI4 Trypanosoma rangeli 45% 100%
A4HQ39 Leishmania braziliensis 88% 100%
A4IDU5 Leishmania infantum 97% 100%
D0A8S7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 95%
E6ENP7 Enterococcus faecalis (strain TX4000 / JH2-2) 23% 100%
P9WN12 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 27% 100%
P9WN13 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 27% 100%
Q49736 Mycobacterium leprae (strain TN) 27% 100%
Q4Q0N8 Leishmania major 95% 100%
Q8RBL8 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) 22% 100%
V5DNC7 Trypanosoma cruzi 43% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS