Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATV7_LEIMU

TriTrypDb:

LmxM.36.5230

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ATV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.810
CLV_NRD_NRD_1	187	189	PF00675	0.645
CLV_NRD_NRD_1	295	297	PF00675	0.648
CLV_NRD_NRD_1	32	34	PF00675	0.530
CLV_NRD_NRD_1	321	323	PF00675	0.560
CLV_NRD_NRD_1	61	63	PF00675	0.555
CLV_PCSK_FUR_1	30	34	PF00082	0.496
CLV_PCSK_FUR_1	58	62	PF00082	0.473
CLV_PCSK_KEX2_1	103	105	PF00082	0.753
CLV_PCSK_KEX2_1	187	189	PF00082	0.624
CLV_PCSK_KEX2_1	295	297	PF00082	0.703
CLV_PCSK_KEX2_1	306	308	PF00082	0.607
CLV_PCSK_KEX2_1	32	34	PF00082	0.530
CLV_PCSK_KEX2_1	321	323	PF00082	0.522
CLV_PCSK_KEX2_1	60	62	PF00082	0.529
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.562
CLV_PCSK_SKI1_1	198	202	PF00082	0.583
CLV_PCSK_SKI1_1	373	377	PF00082	0.611
CLV_PCSK_SKI1_1	397	401	PF00082	0.430
DEG_APCC_DBOX_1	295	303	PF00400	0.493
DEG_APCC_DBOX_1	396	404	PF00400	0.226
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DOC_CDC14_PxL_1	129	137	PF14671	0.467
DOC_CKS1_1	406	411	PF01111	0.415
DOC_MAPK_gen_1	58	68	PF00069	0.586
DOC_MAPK_MEF2A_6	114	121	PF00069	0.421
DOC_MAPK_NFAT4_5	114	122	PF00069	0.386
DOC_PP4_FxxP_1	406	409	PF00568	0.448
DOC_USP7_MATH_1	190	194	PF00917	0.323
DOC_USP7_MATH_1	36	40	PF00917	0.761
DOC_WW_Pin1_4	259	264	PF00397	0.436
DOC_WW_Pin1_4	40	45	PF00397	0.596
DOC_WW_Pin1_4	405	410	PF00397	0.401
LIG_14-3-3_CanoR_1	20	29	PF00244	0.643
LIG_14-3-3_CanoR_1	218	224	PF00244	0.371
LIG_14-3-3_CanoR_1	264	269	PF00244	0.493
LIG_14-3-3_CanoR_1	322	328	PF00244	0.453
LIG_Actin_WH2_2	400	415	PF00022	0.431
LIG_BRCT_BRCA1_1	346	350	PF00533	0.451
LIG_BRCT_BRCA1_1	85	89	PF00533	0.497
LIG_FHA_1	121	127	PF00498	0.378
LIG_FHA_1	17	23	PF00498	0.697
LIG_FHA_1	212	218	PF00498	0.442
LIG_FHA_1	280	286	PF00498	0.512
LIG_FHA_1	362	368	PF00498	0.481
LIG_FHA_1	417	423	PF00498	0.275
LIG_FHA_1	481	487	PF00498	0.457
LIG_FHA_2	132	138	PF00498	0.390
LIG_FHA_2	324	330	PF00498	0.453
LIG_FHA_2	353	359	PF00498	0.539
LIG_LIR_Apic_2	404	409	PF02991	0.390
LIG_LIR_Apic_2	450	456	PF02991	0.418
LIG_LIR_Gen_1	191	202	PF02991	0.386
LIG_LIR_Gen_1	219	229	PF02991	0.222
LIG_LIR_Gen_1	314	324	PF02991	0.398
LIG_LIR_Gen_1	326	335	PF02991	0.445
LIG_LIR_Gen_1	347	357	PF02991	0.489
LIG_LIR_Nem_3	191	197	PF02991	0.380
LIG_LIR_Nem_3	237	241	PF02991	0.392
LIG_LIR_Nem_3	282	286	PF02991	0.453
LIG_LIR_Nem_3	314	319	PF02991	0.412
LIG_LIR_Nem_3	326	330	PF02991	0.425
LIG_LIR_Nem_3	336	340	PF02991	0.392
LIG_LIR_Nem_3	347	351	PF02991	0.406
LIG_LYPXL_yS_3	108	111	PF13949	0.466
LIG_NRBOX	462	468	PF00104	0.407
LIG_PDZ_Class_2	483	488	PF00595	0.468
LIG_SH2_CRK	149	153	PF00017	0.365
LIG_SH2_CRK	194	198	PF00017	0.399
LIG_SH2_CRK	231	235	PF00017	0.369
LIG_SH2_CRK	337	341	PF00017	0.386
LIG_SH2_CRK	453	457	PF00017	0.403
LIG_SH2_PTP2	80	83	PF00017	0.424
LIG_SH2_SRC	229	232	PF00017	0.418
LIG_SH2_SRC	344	347	PF00017	0.400
LIG_SH2_STAP1	149	153	PF00017	0.365
LIG_SH2_STAP1	221	225	PF00017	0.327
LIG_SH2_STAP1	231	235	PF00017	0.406
LIG_SH2_STAP1	327	331	PF00017	0.399
LIG_SH2_STAP1	344	348	PF00017	0.404
LIG_SH2_STAT3	239	242	PF00017	0.299
LIG_SH2_STAT5	229	232	PF00017	0.404
LIG_SH2_STAT5	239	242	PF00017	0.352
LIG_SH2_STAT5	80	83	PF00017	0.360
LIG_SH3_3	329	335	PF00018	0.414
LIG_SH3_3	392	398	PF00018	0.259
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.409
LIG_SUMO_SIM_par_1	249	255	PF11976	0.363
LIG_SUMO_SIM_par_1	398	404	PF11976	0.377
LIG_TRAF2_1	158	161	PF00917	0.432
LIG_TRAF2_1	326	329	PF00917	0.452
LIG_TYR_ITIM	192	197	PF00017	0.391
LIG_TYR_ITIM	78	83	PF00017	0.430
LIG_UBA3_1	463	469	PF00899	0.336
MOD_CDK_SPK_2	259	264	PF00069	0.412
MOD_CK1_1	124	130	PF00069	0.279
MOD_CK1_1	13	19	PF00069	0.702
MOD_CK1_1	181	187	PF00069	0.434
MOD_CK1_1	311	317	PF00069	0.384
MOD_CK1_1	380	386	PF00069	0.459
MOD_CK2_1	138	144	PF00069	0.409
MOD_CK2_1	323	329	PF00069	0.455
MOD_CK2_1	380	386	PF00069	0.415
MOD_CK2_1	427	433	PF00069	0.431
MOD_Cter_Amidation	101	104	PF01082	0.610
MOD_GlcNHglycan	140	143	PF01048	0.581
MOD_GlcNHglycan	163	167	PF01048	0.527
MOD_GlcNHglycan	22	25	PF01048	0.545
MOD_GlcNHglycan	231	234	PF01048	0.622
MOD_GlcNHglycan	269	272	PF01048	0.627
MOD_GlcNHglycan	288	291	PF01048	0.727
MOD_GlcNHglycan	34	37	PF01048	0.574
MOD_GlcNHglycan	368	373	PF01048	0.641
MOD_GlcNHglycan	38	41	PF01048	0.514
MOD_GlcNHglycan	449	452	PF01048	0.521
MOD_GlcNHglycan	91	94	PF01048	0.730
MOD_GSK3_1	120	127	PF00069	0.294
MOD_GSK3_1	16	23	PF00069	0.723
MOD_GSK3_1	177	184	PF00069	0.430
MOD_GSK3_1	212	219	PF00069	0.423
MOD_GSK3_1	308	315	PF00069	0.374
MOD_GSK3_1	32	39	PF00069	0.704
MOD_GSK3_1	380	387	PF00069	0.279
MOD_GSK3_1	416	423	PF00069	0.292
MOD_N-GLC_1	286	291	PF02516	0.669
MOD_NEK2_1	138	143	PF00069	0.388
MOD_NEK2_1	172	177	PF00069	0.444
MOD_NEK2_1	216	221	PF00069	0.400
MOD_NEK2_1	252	257	PF00069	0.336
MOD_NEK2_1	286	291	PF00069	0.520
MOD_NEK2_1	308	313	PF00069	0.364
MOD_NEK2_1	385	390	PF00069	0.508
MOD_NEK2_1	439	444	PF00069	0.445
MOD_NEK2_1	83	88	PF00069	0.707
MOD_NEK2_1	89	94	PF00069	0.524
MOD_NEK2_2	480	485	PF00069	0.396
MOD_PIKK_1	121	127	PF00454	0.410
MOD_PIKK_1	172	178	PF00454	0.408
MOD_PIKK_1	361	367	PF00454	0.575
MOD_PIKK_1	416	422	PF00454	0.296
MOD_PKA_1	32	38	PF00069	0.696
MOD_PKA_2	217	223	PF00069	0.376
MOD_PKA_2	32	38	PF00069	0.775
MOD_PKB_1	30	38	PF00069	0.780
MOD_Plk_1	190	196	PF00069	0.366
MOD_Plk_1	309	315	PF00069	0.414
MOD_Plk_1	385	391	PF00069	0.429
MOD_Plk_1	439	445	PF00069	0.430
MOD_Plk_4	212	218	PF00069	0.416
MOD_Plk_4	219	225	PF00069	0.321
MOD_Plk_4	83	89	PF00069	0.646
MOD_ProDKin_1	259	265	PF00069	0.436
MOD_ProDKin_1	40	46	PF00069	0.594
MOD_ProDKin_1	405	411	PF00069	0.410
TRG_DiLeu_BaEn_4	328	334	PF01217	0.371
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.377
TRG_ENDOCYTIC_2	108	111	PF00928	0.478
TRG_ENDOCYTIC_2	149	152	PF00928	0.366
TRG_ENDOCYTIC_2	194	197	PF00928	0.397
TRG_ENDOCYTIC_2	221	224	PF00928	0.381
TRG_ENDOCYTIC_2	231	234	PF00928	0.332
TRG_ENDOCYTIC_2	238	241	PF00928	0.421
TRG_ENDOCYTIC_2	283	286	PF00928	0.448
TRG_ENDOCYTIC_2	327	330	PF00928	0.380
TRG_ENDOCYTIC_2	337	340	PF00928	0.359
TRG_ENDOCYTIC_2	80	83	PF00928	0.430
TRG_ER_diArg_1	103	106	PF00400	0.503
TRG_ER_diArg_1	186	188	PF00400	0.447
TRG_ER_diArg_1	29	32	PF00400	0.746
TRG_ER_diArg_1	295	298	PF00400	0.297
TRG_ER_diArg_1	321	323	PF00400	0.400
TRG_ER_diArg_1	59	62	PF00400	0.744
TRG_NES_CRM1_1	462	476	PF08389	0.253
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P492	Leptomonas seymouri	54%	100%
A0A3S7XBP8	Leishmania donovani	85%	100%
A4HQ38	Leishmania braziliensis	76%	100%
A4IDU4	Leishmania infantum	86%	100%
Q4Q0N9	Leishmania major	86%	100%
V5B6R4	Trypanosoma cruzi	25%	100%