Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATV4_LEIMU

TriTrypDb:

LmxM.36.5200

Length:

986

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	898	902	PF00656	0.601
CLV_NRD_NRD_1	151	153	PF00675	0.365
CLV_NRD_NRD_1	371	373	PF00675	0.561
CLV_NRD_NRD_1	481	483	PF00675	0.699
CLV_NRD_NRD_1	751	753	PF00675	0.622
CLV_NRD_NRD_1	954	956	PF00675	0.607
CLV_NRD_NRD_1	967	969	PF00675	0.523
CLV_PCSK_KEX2_1	151	153	PF00082	0.365
CLV_PCSK_KEX2_1	309	311	PF00082	0.536
CLV_PCSK_KEX2_1	371	373	PF00082	0.561
CLV_PCSK_KEX2_1	481	483	PF00082	0.659
CLV_PCSK_KEX2_1	509	511	PF00082	0.525
CLV_PCSK_KEX2_1	751	753	PF00082	0.622
CLV_PCSK_KEX2_1	87	89	PF00082	0.470
CLV_PCSK_KEX2_1	953	955	PF00082	0.624
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.686
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.525
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.470
CLV_PCSK_PC7_1	83	89	PF00082	0.569
CLV_PCSK_SKI1_1	119	123	PF00082	0.465
CLV_PCSK_SKI1_1	688	692	PF00082	0.426
CLV_PCSK_SKI1_1	780	784	PF00082	0.638
CLV_PCSK_SKI1_1	83	87	PF00082	0.473
CLV_PCSK_SKI1_1	954	958	PF00082	0.514
CLV_Separin_Metazoa	757	761	PF03568	0.496
DEG_COP1_1	53	61	PF00400	0.367
DEG_SPOP_SBC_1	166	170	PF00917	0.307
DEG_SPOP_SBC_1	697	701	PF00917	0.581
DOC_CDC14_PxL_1	455	463	PF14671	0.513
DOC_CKS1_1	289	294	PF01111	0.458
DOC_CKS1_1	545	550	PF01111	0.686
DOC_CYCLIN_RxL_1	521	531	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	829	835	PF00134	0.565
DOC_MAPK_gen_1	151	159	PF00069	0.319
DOC_MAPK_gen_1	34	42	PF00069	0.625
DOC_MAPK_gen_1	371	378	PF00069	0.513
DOC_MAPK_gen_1	654	664	PF00069	0.346
DOC_MAPK_gen_1	764	772	PF00069	0.599
DOC_MAPK_gen_1	953	959	PF00069	0.518
DOC_MAPK_gen_1	968	975	PF00069	0.400
DOC_MAPK_MEF2A_6	34	42	PF00069	0.591
DOC_MAPK_MEF2A_6	371	378	PF00069	0.513
DOC_MAPK_MEF2A_6	638	647	PF00069	0.730
DOC_MAPK_MEF2A_6	654	662	PF00069	0.339
DOC_MAPK_MEF2A_6	764	772	PF00069	0.586
DOC_PP1_RVXF_1	191	198	PF00149	0.572
DOC_PP1_RVXF_1	758	764	PF00149	0.578
DOC_PP2B_LxvP_1	221	224	PF13499	0.550
DOC_PP2B_LxvP_1	503	506	PF13499	0.548
DOC_SPAK_OSR1_1	410	414	PF12202	0.563
DOC_USP7_MATH_1	106	110	PF00917	0.692
DOC_USP7_MATH_1	17	21	PF00917	0.373
DOC_USP7_MATH_1	230	234	PF00917	0.663
DOC_USP7_MATH_1	3	7	PF00917	0.545
DOC_USP7_MATH_1	334	338	PF00917	0.634
DOC_USP7_MATH_1	532	536	PF00917	0.758
DOC_USP7_MATH_1	696	700	PF00917	0.599
DOC_USP7_MATH_1	872	876	PF00917	0.641
DOC_USP7_MATH_1	894	898	PF00917	0.435
DOC_USP7_MATH_1	912	916	PF00917	0.722
DOC_WW_Pin1_4	102	107	PF00397	0.713
DOC_WW_Pin1_4	288	293	PF00397	0.494
DOC_WW_Pin1_4	404	409	PF00397	0.542
DOC_WW_Pin1_4	439	444	PF00397	0.728
DOC_WW_Pin1_4	461	466	PF00397	0.599
DOC_WW_Pin1_4	51	56	PF00397	0.470
DOC_WW_Pin1_4	544	549	PF00397	0.686
DOC_WW_Pin1_4	573	578	PF00397	0.696
DOC_WW_Pin1_4	639	644	PF00397	0.736
DOC_WW_Pin1_4	719	724	PF00397	0.569
DOC_WW_Pin1_4	828	833	PF00397	0.555
DOC_WW_Pin1_4	868	873	PF00397	0.373
LIG_14-3-3_CanoR_1	16	26	PF00244	0.598
LIG_14-3-3_CanoR_1	202	206	PF00244	0.486
LIG_14-3-3_CanoR_1	28	35	PF00244	0.432
LIG_14-3-3_CanoR_1	336	341	PF00244	0.685
LIG_14-3-3_CanoR_1	391	401	PF00244	0.569
LIG_14-3-3_CanoR_1	474	480	PF00244	0.589
LIG_14-3-3_CanoR_1	493	499	PF00244	0.316
LIG_14-3-3_CanoR_1	510	520	PF00244	0.487
LIG_14-3-3_CanoR_1	536	545	PF00244	0.773
LIG_14-3-3_CanoR_1	69	74	PF00244	0.585
LIG_14-3-3_CanoR_1	846	850	PF00244	0.464
LIG_Actin_WH2_2	20	36	PF00022	0.613
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BRCT_BRCA1_1	193	197	PF00533	0.487
LIG_BRCT_BRCA1_1	336	340	PF00533	0.600
LIG_BRCT_BRCA1_1	493	497	PF00533	0.579
LIG_BRCT_BRCA1_1	728	732	PF00533	0.356
LIG_BRCT_BRCA1_1	933	937	PF00533	0.449
LIG_CSL_BTD_1	800	803	PF09270	0.578
LIG_DLG_GKlike_1	336	343	PF00625	0.699
LIG_EH1_1	410	418	PF00400	0.457
LIG_EH1_1	658	666	PF00400	0.618
LIG_eIF4E_1	520	526	PF01652	0.504
LIG_eIF4E_1	659	665	PF01652	0.390
LIG_FHA_1	105	111	PF00498	0.696
LIG_FHA_1	135	141	PF00498	0.579
LIG_FHA_1	170	176	PF00498	0.577
LIG_FHA_1	179	185	PF00498	0.639
LIG_FHA_1	284	290	PF00498	0.522
LIG_FHA_1	540	546	PF00498	0.816
LIG_FHA_1	58	64	PF00498	0.388
LIG_FHA_1	613	619	PF00498	0.685
LIG_FHA_1	640	646	PF00498	0.696
LIG_FHA_1	685	691	PF00498	0.636
LIG_FHA_1	861	867	PF00498	0.523
LIG_FHA_1	869	875	PF00498	0.622
LIG_FHA_2	393	399	PF00498	0.624
LIG_FHA_2	684	690	PF00498	0.442
LIG_FHA_2	722	728	PF00498	0.621
LIG_FHA_2	846	852	PF00498	0.586
LIG_GBD_Chelix_1	212	220	PF00786	0.443
LIG_GBD_Chelix_1	565	573	PF00786	0.612
LIG_LIR_Gen_1	264	274	PF02991	0.305
LIG_LIR_Gen_1	337	346	PF02991	0.723
LIG_LIR_Gen_1	517	528	PF02991	0.346
LIG_LIR_Gen_1	848	857	PF02991	0.508
LIG_LIR_Gen_1	934	944	PF02991	0.471
LIG_LIR_Nem_3	247	252	PF02991	0.607
LIG_LIR_Nem_3	264	270	PF02991	0.294
LIG_LIR_Nem_3	337	343	PF02991	0.712
LIG_LIR_Nem_3	368	373	PF02991	0.484
LIG_LIR_Nem_3	517	523	PF02991	0.346
LIG_LIR_Nem_3	848	853	PF02991	0.488
LIG_LIR_Nem_3	934	940	PF02991	0.453
LIG_NRBOX	143	149	PF00104	0.484
LIG_NRBOX	215	221	PF00104	0.437
LIG_NRBOX	592	598	PF00104	0.618
LIG_PCNA_PIPBox_1	628	637	PF02747	0.626
LIG_PCNA_PIPBox_1	956	965	PF02747	0.345
LIG_PCNA_yPIPBox_3	628	638	PF02747	0.631
LIG_PDZ_Class_3	981	986	PF00595	0.531
LIG_Pex14_2	249	253	PF04695	0.587
LIG_Pex14_2	270	274	PF04695	0.456
LIG_RPA_C_Fungi	652	664	PF08784	0.472
LIG_SH2_CRK	520	524	PF00017	0.491
LIG_SH2_GRB2like	165	168	PF00017	0.537
LIG_SH2_GRB2like	741	744	PF00017	0.586
LIG_SH2_PTP2	161	164	PF00017	0.436
LIG_SH2_PTP2	522	525	PF00017	0.339
LIG_SH2_PTP2	659	662	PF00017	0.346
LIG_SH2_SRC	165	168	PF00017	0.537
LIG_SH2_SRC	520	523	PF00017	0.579
LIG_SH2_SRC	962	965	PF00017	0.358
LIG_SH2_STAP1	171	175	PF00017	0.577
LIG_SH2_STAT3	171	174	PF00017	0.541
LIG_SH2_STAT3	18	21	PF00017	0.505
LIG_SH2_STAT5	161	164	PF00017	0.415
LIG_SH2_STAT5	165	168	PF00017	0.435
LIG_SH2_STAT5	171	174	PF00017	0.513
LIG_SH2_STAT5	252	255	PF00017	0.601
LIG_SH2_STAT5	267	270	PF00017	0.307
LIG_SH2_STAT5	502	505	PF00017	0.582
LIG_SH2_STAT5	522	525	PF00017	0.411
LIG_SH2_STAT5	635	638	PF00017	0.571
LIG_SH2_STAT5	659	662	PF00017	0.348
LIG_SH2_STAT5	741	744	PF00017	0.391
LIG_SH2_STAT5	962	965	PF00017	0.477
LIG_SH3_3	108	114	PF00018	0.721
LIG_SH3_3	219	225	PF00018	0.455
LIG_SH3_3	32	38	PF00018	0.430
LIG_SH3_3	402	408	PF00018	0.689
LIG_SH3_3	437	443	PF00018	0.639
LIG_SH3_3	545	551	PF00018	0.664
LIG_SH3_3	874	880	PF00018	0.620
LIG_SH3_3	98	104	PF00018	0.706
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.501
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.432
LIG_SUMO_SIM_anti_2	727	733	PF11976	0.483
LIG_SUMO_SIM_anti_2	851	858	PF11976	0.486
LIG_SUMO_SIM_anti_2	971	977	PF11976	0.497
LIG_SUMO_SIM_par_1	285	291	PF11976	0.429
LIG_SUMO_SIM_par_1	704	710	PF11976	0.359
LIG_TYR_ITIM	159	164	PF00017	0.530
LIG_TYR_ITSM	516	523	PF00017	0.315
LIG_UBA3_1	289	298	PF00899	0.567
LIG_UBA3_1	592	601	PF00899	0.622
LIG_Vh1_VBS_1	885	903	PF01044	0.574
LIG_WRC_WIRS_1	271	276	PF05994	0.457
MOD_CDC14_SPxK_1	407	410	PF00782	0.603
MOD_CDK_SPxK_1	404	410	PF00069	0.643
MOD_CDK_SPxK_1	544	550	PF00069	0.687
MOD_CDK_SPxxK_3	288	295	PF00069	0.465
MOD_CK1_1	105	111	PF00069	0.650
MOD_CK1_1	169	175	PF00069	0.623
MOD_CK1_1	187	193	PF00069	0.329
MOD_CK1_1	226	232	PF00069	0.595
MOD_CK1_1	233	239	PF00069	0.628
MOD_CK1_1	273	279	PF00069	0.541
MOD_CK1_1	356	362	PF00069	0.619
MOD_CK1_1	442	448	PF00069	0.513
MOD_CK1_1	475	481	PF00069	0.495
MOD_CK1_1	50	56	PF00069	0.501
MOD_CK1_1	534	540	PF00069	0.707
MOD_CK1_1	614	620	PF00069	0.662
MOD_CK1_1	672	678	PF00069	0.596
MOD_CK1_1	722	728	PF00069	0.416
MOD_CK1_1	793	799	PF00069	0.461
MOD_CK1_1	868	874	PF00069	0.625
MOD_CK2_1	33	39	PF00069	0.633
MOD_CK2_1	51	57	PF00069	0.521
MOD_CK2_1	511	517	PF00069	0.491
MOD_CK2_1	683	689	PF00069	0.401
MOD_CK2_1	845	851	PF00069	0.581
MOD_Cter_Amidation	479	482	PF01082	0.389
MOD_Cter_Amidation	749	752	PF01082	0.638
MOD_GlcNHglycan	1	4	PF01048	0.611
MOD_GlcNHglycan	208	211	PF01048	0.500
MOD_GlcNHglycan	228	231	PF01048	0.393
MOD_GlcNHglycan	236	239	PF01048	0.609
MOD_GlcNHglycan	254	257	PF01048	0.365
MOD_GlcNHglycan	30	33	PF01048	0.459
MOD_GlcNHglycan	301	304	PF01048	0.689
MOD_GlcNHglycan	320	323	PF01048	0.482
MOD_GlcNHglycan	336	339	PF01048	0.655
MOD_GlcNHglycan	362	365	PF01048	0.495
MOD_GlcNHglycan	429	432	PF01048	0.696
MOD_GlcNHglycan	447	450	PF01048	0.603
MOD_GlcNHglycan	451	454	PF01048	0.498
MOD_GlcNHglycan	494	497	PF01048	0.492
MOD_GlcNHglycan	559	562	PF01048	0.580
MOD_GlcNHglycan	606	609	PF01048	0.631
MOD_GlcNHglycan	674	677	PF01048	0.537
MOD_GlcNHglycan	74	77	PF01048	0.497
MOD_GlcNHglycan	964	968	PF01048	0.653
MOD_GSK3_1	102	109	PF00069	0.729
MOD_GSK3_1	165	172	PF00069	0.570
MOD_GSK3_1	187	194	PF00069	0.487
MOD_GSK3_1	226	233	PF00069	0.560
MOD_GSK3_1	314	321	PF00069	0.553
MOD_GSK3_1	325	332	PF00069	0.251
MOD_GSK3_1	349	356	PF00069	0.646
MOD_GSK3_1	445	452	PF00069	0.608
MOD_GSK3_1	47	54	PF00069	0.430
MOD_GSK3_1	511	518	PF00069	0.487
MOD_GSK3_1	532	539	PF00069	0.782
MOD_GSK3_1	602	609	PF00069	0.543
MOD_GSK3_1	668	675	PF00069	0.682
MOD_GSK3_1	684	691	PF00069	0.372
MOD_GSK3_1	717	724	PF00069	0.616
MOD_GSK3_1	726	733	PF00069	0.522
MOD_GSK3_1	824	831	PF00069	0.565
MOD_GSK3_1	868	875	PF00069	0.529
MOD_GSK3_1	895	902	PF00069	0.576
MOD_N-GLC_1	166	171	PF02516	0.437
MOD_N-GLC_1	793	798	PF02516	0.686
MOD_N-GLC_1	868	873	PF02516	0.627
MOD_NEK2_1	184	189	PF00069	0.514
MOD_NEK2_1	191	196	PF00069	0.483
MOD_NEK2_1	270	275	PF00069	0.453
MOD_NEK2_1	283	288	PF00069	0.463
MOD_NEK2_1	33	38	PF00069	0.653
MOD_NEK2_1	360	365	PF00069	0.480
MOD_NEK2_1	376	381	PF00069	0.444
MOD_NEK2_1	392	397	PF00069	0.591
MOD_NEK2_1	416	421	PF00069	0.532
MOD_NEK2_1	447	452	PF00069	0.464
MOD_NEK2_1	472	477	PF00069	0.409
MOD_NEK2_1	491	496	PF00069	0.349
MOD_NEK2_1	592	597	PF00069	0.491
MOD_NEK2_1	627	632	PF00069	0.571
MOD_NEK2_1	726	731	PF00069	0.570
MOD_NEK2_1	784	789	PF00069	0.626
MOD_NEK2_1	790	795	PF00069	0.628
MOD_NEK2_1	845	850	PF00069	0.512
MOD_NEK2_1	865	870	PF00069	0.267
MOD_NEK2_1	899	904	PF00069	0.611
MOD_NEK2_1	931	936	PF00069	0.568
MOD_NEK2_1	963	968	PF00069	0.568
MOD_OFUCOSY	807	814	PF10250	0.594
MOD_PIKK_1	17	23	PF00454	0.593
MOD_PIKK_1	170	176	PF00454	0.633
MOD_PIKK_1	224	230	PF00454	0.653
MOD_PIKK_1	304	310	PF00454	0.764
MOD_PIKK_1	353	359	PF00454	0.620
MOD_PIKK_1	793	799	PF00454	0.567
MOD_PIKK_1	824	830	PF00454	0.563
MOD_PIKK_1	872	878	PF00454	0.542
MOD_PIKK_1	912	918	PF00454	0.713
MOD_PIKK_1	931	937	PF00454	0.460
MOD_PK_1	602	608	PF00069	0.423
MOD_PKA_2	201	207	PF00069	0.489
MOD_PKA_2	33	39	PF00069	0.633
MOD_PKA_2	492	498	PF00069	0.376
MOD_PKA_2	684	690	PF00069	0.528
MOD_PKA_2	845	851	PF00069	0.479
MOD_Plk_1	166	172	PF00069	0.448
MOD_Plk_1	688	694	PF00069	0.430
MOD_Plk_1	726	732	PF00069	0.364
MOD_Plk_1	784	790	PF00069	0.583
MOD_Plk_1	900	906	PF00069	0.440
MOD_Plk_2-3	583	589	PF00069	0.418
MOD_Plk_4	3	9	PF00069	0.618
MOD_Plk_4	442	448	PF00069	0.439
MOD_Plk_4	464	470	PF00069	0.528
MOD_Plk_4	515	521	PF00069	0.474
MOD_Plk_4	592	598	PF00069	0.491
MOD_Plk_4	688	694	PF00069	0.571
MOD_Plk_4	698	704	PF00069	0.413
MOD_Plk_4	726	732	PF00069	0.415
MOD_Plk_4	785	791	PF00069	0.585
MOD_Plk_4	845	851	PF00069	0.494
MOD_Plk_4	895	901	PF00069	0.481
MOD_ProDKin_1	102	108	PF00069	0.714
MOD_ProDKin_1	288	294	PF00069	0.496
MOD_ProDKin_1	404	410	PF00069	0.535
MOD_ProDKin_1	439	445	PF00069	0.721
MOD_ProDKin_1	461	467	PF00069	0.604
MOD_ProDKin_1	51	57	PF00069	0.478
MOD_ProDKin_1	544	550	PF00069	0.687
MOD_ProDKin_1	573	579	PF00069	0.707
MOD_ProDKin_1	639	645	PF00069	0.737
MOD_ProDKin_1	719	725	PF00069	0.567
MOD_ProDKin_1	828	834	PF00069	0.554
MOD_ProDKin_1	868	874	PF00069	0.370
TRG_DiLeu_BaEn_2	932	938	PF01217	0.325
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.484
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.600
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.468
TRG_DiLeu_BaLyEn_6	861	866	PF01217	0.479
TRG_DiLeu_BaLyEn_6	923	928	PF01217	0.327
TRG_DiLeu_LyEn_5	619	624	PF01217	0.680
TRG_ENDOCYTIC_2	161	164	PF00928	0.436
TRG_ENDOCYTIC_2	267	270	PF00928	0.453
TRG_ENDOCYTIC_2	520	523	PF00928	0.480
TRG_ENDOCYTIC_2	659	662	PF00928	0.346
TRG_ER_diArg_1	370	372	PF00400	0.563
TRG_ER_diArg_1	763	766	PF00400	0.499
TRG_ER_diArg_1	952	955	PF00400	0.615
TRG_NES_CRM1_1	517	531	PF08389	0.371
TRG_NLS_MonoExtN_4	506	512	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P493	Leptomonas seymouri	35%	98%
A0A3S7XBS3	Leishmania donovani	85%	100%
E9AHY3	Leishmania infantum	85%	100%
Q4Q0P2	Leishmania major	85%	100%