MI domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA-splicing factor CWC22, putative

Species:

Leishmania mexicana

UniProt:

E9ATV0_LEIMU

TriTrypDb:

LmxM.36.5160

Length:

565

Annotations

LeishMANIAdb annotations

Certainly not TM

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

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Expansion

Sequence features

E9ATV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATV0

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.558
CLV_C14_Caspase3-7	350	354	PF00656	0.420
CLV_NRD_NRD_1	109	111	PF00675	0.261
CLV_NRD_NRD_1	120	122	PF00675	0.267
CLV_NRD_NRD_1	185	187	PF00675	0.605
CLV_NRD_NRD_1	229	231	PF00675	0.615
CLV_NRD_NRD_1	285	287	PF00675	0.547
CLV_NRD_NRD_1	356	358	PF00675	0.432
CLV_NRD_NRD_1	360	362	PF00675	0.226
CLV_NRD_NRD_1	406	408	PF00675	0.281

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA4	Leptomonas seymouri	79%	99%
A0A0S4JKH9	Bodo saltans	37%	100%
A0A1X0P4F9	Trypanosomatidae	52%	93%
A0A3S5IRG5	Trypanosoma rangeli	56%	95%
A0A3S7XBU7	Leishmania donovani	97%	100%
A4HQ32	Leishmania braziliensis	88%	100%
A4IDT8	Leishmania infantum	97%	100%
D0A8T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	97%
P0CM96	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	30%	68%
P0CM97	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	30%	68%

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