Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-D

Species:

Leishmania mexicana

UniProt:

E9ATU9_LEIMU

TriTrypDb:

LmxM.36.5150

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	6
GO:0005875	microtubule associated complex	2	2
GO:0015630	microtubule cytoskeleton	6	1
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	6
GO:0099081	supramolecular polymer	3	6
GO:0099512	supramolecular fiber	4	6
GO:0099513	polymeric cytoskeletal fiber	5	6
GO:0110165	cellular anatomical entity	1	6
GO:0020016	ciliary pocket	2	1
GO:0030863	cortical cytoskeleton	6	1

Expansion

Sequence features

E9ATU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATU9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	18
GO:0007018	microtubule-based movement	3	18
GO:0009987	cellular process	1	18
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000902	cell morphogenesis	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0009653	anatomical structure morphogenesis	2	1
GO:0016043	cellular component organization	3	1
GO:0030865	cortical cytoskeleton organization	6	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0032502	developmental process	1	1
GO:0043622	cortical microtubule organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003774	cytoskeletal motor activity	1	18
GO:0003777	microtubule motor activity	2	18
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0005524	ATP binding	5	18
GO:0008017	microtubule binding	5	18
GO:0008092	cytoskeletal protein binding	3	18
GO:0015631	tubulin binding	4	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140657	ATP-dependent activity	1	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18
GO:0003824	catalytic activity	1	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.421
CLV_NRD_NRD_1	367	369	PF00675	0.613
CLV_NRD_NRD_1	439	441	PF00675	0.592
CLV_NRD_NRD_1	510	512	PF00675	0.612
CLV_NRD_NRD_1	528	530	PF00675	0.685
CLV_NRD_NRD_1	58	60	PF00675	0.473
CLV_PCSK_KEX2_1	234	236	PF00082	0.490
CLV_PCSK_KEX2_1	265	267	PF00082	0.424
CLV_PCSK_KEX2_1	367	369	PF00082	0.675
CLV_PCSK_KEX2_1	450	452	PF00082	0.557
CLV_PCSK_KEX2_1	469	471	PF00082	0.698
CLV_PCSK_KEX2_1	528	530	PF00082	0.670
CLV_PCSK_KEX2_1	58	60	PF00082	0.555
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.505
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.592
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.698
CLV_PCSK_PC7_1	230	236	PF00082	0.465
CLV_PCSK_SKI1_1	138	142	PF00082	0.372
CLV_PCSK_SKI1_1	17	21	PF00082	0.470
CLV_PCSK_SKI1_1	35	39	PF00082	0.369
CLV_PCSK_SKI1_1	423	427	PF00082	0.589
CLV_PCSK_SKI1_1	528	532	PF00082	0.668
CLV_PCSK_SKI1_1	87	91	PF00082	0.414
DOC_CKS1_1	18	23	PF01111	0.570
DOC_CKS1_1	199	204	PF01111	0.466
DOC_MAPK_gen_1	263	272	PF00069	0.411
DOC_MAPK_gen_1	380	389	PF00069	0.636
DOC_MAPK_MEF2A_6	263	271	PF00069	0.449
DOC_MAPK_RevD_3	219	235	PF00069	0.429
DOC_PP1_SILK_1	35	40	PF00149	0.273
DOC_PP4_FxxP_1	251	254	PF00568	0.541
DOC_PP4_FxxP_1	72	75	PF00568	0.599
DOC_USP7_MATH_1	117	121	PF00917	0.414
DOC_USP7_MATH_1	28	32	PF00917	0.628
DOC_USP7_MATH_1	433	437	PF00917	0.629
DOC_USP7_MATH_1	579	583	PF00917	0.707
DOC_USP7_UBL2_3	81	85	PF12436	0.676
DOC_WW_Pin1_4	17	22	PF00397	0.500
DOC_WW_Pin1_4	198	203	PF00397	0.476
DOC_WW_Pin1_4	215	220	PF00397	0.476
DOC_WW_Pin1_4	326	331	PF00397	0.387
DOC_WW_Pin1_4	520	525	PF00397	0.630
LIG_14-3-3_CanoR_1	124	129	PF00244	0.366
LIG_14-3-3_CanoR_1	235	243	PF00244	0.470
LIG_14-3-3_CanoR_1	244	251	PF00244	0.519
LIG_14-3-3_CanoR_1	511	519	PF00244	0.518
LIG_14-3-3_CanoR_1	552	558	PF00244	0.757
LIG_APCC_ABBA_1	328	333	PF00400	0.431
LIG_BIR_III_4	214	218	PF00653	0.192
LIG_BRCT_BRCA1_1	121	125	PF00533	0.404
LIG_CaM_IQ_9	222	237	PF13499	0.434
LIG_CaM_IQ_9	339	354	PF13499	0.569
LIG_deltaCOP1_diTrp_1	67	72	PF00928	0.571
LIG_FHA_1	216	222	PF00498	0.439
LIG_FHA_1	236	242	PF00498	0.337
LIG_FHA_1	410	416	PF00498	0.627
LIG_FHA_1	511	517	PF00498	0.739
LIG_FHA_2	173	179	PF00498	0.393
LIG_FHA_2	18	24	PF00498	0.514
LIG_FHA_2	409	415	PF00498	0.576
LIG_FHA_2	600	606	PF00498	0.612
LIG_FHA_2	88	94	PF00498	0.362
LIG_KLC1_Yacidic_2	174	178	PF13176	0.435
LIG_LIR_Apic_2	248	254	PF02991	0.516
LIG_LIR_Apic_2	71	75	PF02991	0.541
LIG_LIR_Gen_1	12	21	PF02991	0.494
LIG_LIR_Gen_1	174	181	PF02991	0.341
LIG_LIR_Gen_1	305	316	PF02991	0.407
LIG_LIR_Gen_1	329	339	PF02991	0.509
LIG_LIR_Gen_1	360	370	PF02991	0.600
LIG_LIR_Gen_1	456	464	PF02991	0.564
LIG_LIR_Gen_1	93	103	PF02991	0.378
LIG_LIR_Nem_3	12	16	PF02991	0.456
LIG_LIR_Nem_3	122	128	PF02991	0.428
LIG_LIR_Nem_3	174	179	PF02991	0.362
LIG_LIR_Nem_3	305	311	PF02991	0.419
LIG_LIR_Nem_3	93	98	PF02991	0.382
LIG_NRBOX	269	275	PF00104	0.409
LIG_Pex14_2	308	312	PF04695	0.471
LIG_SH2_CRK	95	99	PF00017	0.371
LIG_SH2_NCK_1	110	114	PF00017	0.377
LIG_SH2_NCK_1	572	576	PF00017	0.616
LIG_SH2_PTP2	176	179	PF00017	0.399
LIG_SH2_STAP1	499	503	PF00017	0.704
LIG_SH2_STAP1	572	576	PF00017	0.637
LIG_SH2_STAP1	595	599	PF00017	0.562
LIG_SH2_STAT5	126	129	PF00017	0.436
LIG_SH2_STAT5	176	179	PF00017	0.396
LIG_SH2_STAT5	54	57	PF00017	0.451
LIG_SH3_1	15	21	PF00018	0.505
LIG_SH3_3	15	21	PF00018	0.505
LIG_SH3_3	199	205	PF00018	0.421
LIG_SH3_3	45	51	PF00018	0.532
LIG_SH3_3	518	524	PF00018	0.581
LIG_SH3_3	575	581	PF00018	0.424
LIG_SH3_3	95	101	PF00018	0.405
LIG_SH3_4	87	94	PF00018	0.192
LIG_SUMO_SIM_anti_2	174	182	PF11976	0.386
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.609
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.442
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.284
LIG_SUMO_SIM_par_1	44	50	PF11976	0.429
LIG_TRAF2_1	71	74	PF00917	0.568
LIG_TRAF2_1	75	78	PF00917	0.658
LIG_WRC_WIRS_1	149	154	PF05994	0.346
LIG_WRC_WIRS_1	69	74	PF05994	0.445
MOD_CK1_1	151	157	PF00069	0.492
MOD_CK1_1	160	166	PF00069	0.383
MOD_CK1_1	172	178	PF00069	0.403
MOD_CK1_1	192	198	PF00069	0.437
MOD_CK1_1	200	206	PF00069	0.424
MOD_CK1_1	326	332	PF00069	0.492
MOD_CK1_1	4	10	PF00069	0.562
MOD_CK1_1	44	50	PF00069	0.253
MOD_CK2_1	128	134	PF00069	0.321
MOD_CK2_1	17	23	PF00069	0.472
MOD_CK2_1	359	365	PF00069	0.648
MOD_CK2_1	408	414	PF00069	0.582
MOD_CK2_1	494	500	PF00069	0.573
MOD_CK2_1	520	526	PF00069	0.628
MOD_CK2_1	538	544	PF00069	0.643
MOD_CK2_1	597	603	PF00069	0.595
MOD_CK2_1	68	74	PF00069	0.518
MOD_DYRK1A_RPxSP_1	17	21	PF00069	0.560
MOD_GlcNHglycan	121	124	PF01048	0.386
MOD_GlcNHglycan	170	174	PF01048	0.486
MOD_GlcNHglycan	191	194	PF01048	0.479
MOD_GlcNHglycan	202	205	PF01048	0.378
MOD_GlcNHglycan	278	281	PF01048	0.482
MOD_GlcNHglycan	29	33	PF01048	0.613
MOD_GlcNHglycan	292	295	PF01048	0.383
MOD_GSK3_1	1	8	PF00069	0.710
MOD_GSK3_1	124	131	PF00069	0.385
MOD_GSK3_1	147	154	PF00069	0.401
MOD_GSK3_1	185	192	PF00069	0.452
MOD_GSK3_1	235	242	PF00069	0.445
MOD_GSK3_1	257	264	PF00069	0.595
MOD_GSK3_1	338	345	PF00069	0.497
MOD_GSK3_1	409	416	PF00069	0.533
MOD_GSK3_1	76	83	PF00069	0.694
MOD_N-GLC_1	158	163	PF02516	0.401
MOD_N-GLC_1	235	240	PF02516	0.533
MOD_N-GLC_1	257	262	PF02516	0.618
MOD_N-GLC_1	408	413	PF02516	0.600
MOD_N-GLC_1	494	499	PF02516	0.557
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	179	184	PF00069	0.445
MOD_NEK2_1	342	347	PF00069	0.511
MOD_NEK2_1	494	499	PF00069	0.538
MOD_NEK2_2	76	81	PF00069	0.745
MOD_PIKK_1	615	621	PF00454	0.636
MOD_PIKK_1	87	93	PF00454	0.389
MOD_PK_1	512	518	PF00069	0.520
MOD_PKA_1	380	386	PF00069	0.365
MOD_PKA_1	538	544	PF00069	0.595
MOD_PKA_1	615	621	PF00069	0.549
MOD_PKA_2	243	249	PF00069	0.479
MOD_PKA_2	510	516	PF00069	0.708
MOD_PKA_2	551	557	PF00069	0.744
MOD_Plk_1	158	164	PF00069	0.367
MOD_Plk_1	257	263	PF00069	0.608
MOD_Plk_1	28	34	PF00069	0.598
MOD_Plk_1	359	365	PF00069	0.610
MOD_Plk_1	494	500	PF00069	0.562
MOD_Plk_1	76	82	PF00069	0.724
MOD_Plk_4	124	130	PF00069	0.334
MOD_Plk_4	172	178	PF00069	0.373
MOD_Plk_4	311	317	PF00069	0.498
MOD_Plk_4	359	365	PF00069	0.633
MOD_Plk_4	385	391	PF00069	0.660
MOD_Plk_4	41	47	PF00069	0.306
MOD_Plk_4	494	500	PF00069	0.413
MOD_ProDKin_1	17	23	PF00069	0.496
MOD_ProDKin_1	198	204	PF00069	0.476
MOD_ProDKin_1	215	221	PF00069	0.476
MOD_ProDKin_1	326	332	PF00069	0.394
MOD_ProDKin_1	520	526	PF00069	0.628
MOD_SUMO_for_1	402	405	PF00179	0.559
MOD_SUMO_for_1	593	596	PF00179	0.584
MOD_SUMO_rev_2	22	26	PF00179	0.558
MOD_SUMO_rev_2	371	376	PF00179	0.545
MOD_SUMO_rev_2	474	480	PF00179	0.606
MOD_SUMO_rev_2	505	513	PF00179	0.667
MOD_SUMO_rev_2	533	541	PF00179	0.720
MOD_SUMO_rev_2	611	618	PF00179	0.639
TRG_ENDOCYTIC_2	176	179	PF00928	0.358
TRG_ENDOCYTIC_2	332	335	PF00928	0.548
TRG_ENDOCYTIC_2	54	57	PF00928	0.451
TRG_ENDOCYTIC_2	95	98	PF00928	0.351
TRG_ER_diArg_1	14	17	PF00400	0.377
TRG_ER_diArg_1	265	267	PF00400	0.424
TRG_ER_diArg_1	366	368	PF00400	0.677
TRG_ER_diArg_1	528	530	PF00400	0.646
TRG_ER_diArg_1	57	59	PF00400	0.565
TRG_NES_CRM1_1	337	350	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	529	534	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K9	Leptomonas seymouri	69%	100%
A0A0S4J0Q2	Bodo saltans	21%	75%
A0A0S4JFN9	Bodo saltans	22%	73%
A0A0S4JPE8	Bodo saltans	33%	69%
A0A1X0NPH9	Trypanosomatidae	21%	68%
A0A1X0P435	Trypanosomatidae	42%	100%
A0A3S7XBW9	Leishmania donovani	92%	100%
A0A422NMD1	Trypanosoma rangeli	45%	100%
A4HQ31	Leishmania braziliensis	75%	100%
A4IDT7	Leishmania infantum	92%	100%
D0A8T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
P46873	Caenorhabditis elegans	20%	89%
Q4Q0P7	Leishmania major	91%	100%
Q4QEL8	Leishmania major	22%	77%
V5B6Q5	Trypanosoma cruzi	44%	100%
V5BAR9	Trypanosoma cruzi	22%	98%
V5D733	Trypanosoma cruzi	22%	83%