VHS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VHS domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATU8_LEIMU

TriTrypDb:

LmxM.36.5140

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATU8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006886	intracellular protein transport	4	9
GO:0007034	vacuolar transport	4	9
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0016192	vesicle-mediated transport	4	9
GO:0016197	endosomal transport	4	9
GO:0032509	endosome transport via multivesicular body sorting pathway	5	9
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	9
GO:0033036	macromolecule localization	2	9
GO:0033365	protein localization to organelle	5	9
GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	5	9
GO:0045184	establishment of protein localization	3	9
GO:0045324	late endosome to vacuole transport	5	9
GO:0046907	intracellular transport	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0051649	establishment of localization in cell	3	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0071985	multivesicular body sorting pathway	5	9
GO:0072594	establishment of protein localization to organelle	4	9
GO:0072665	protein localization to vacuole	6	9
GO:0072666	establishment of protein localization to vacuole	5	9

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0005543	phospholipid binding	3	9
GO:0008289	lipid binding	2	9
GO:0032182	ubiquitin-like protein binding	3	9
GO:0035091	phosphatidylinositol binding	4	9
GO:0043130	ubiquitin binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.447
CLV_NRD_NRD_1	187	189	PF00675	0.726
CLV_NRD_NRD_1	65	67	PF00675	0.314
CLV_PCSK_FUR_1	210	214	PF00082	0.635
CLV_PCSK_KEX2_1	187	189	PF00082	0.747
CLV_PCSK_KEX2_1	212	214	PF00082	0.756
CLV_PCSK_KEX2_1	64	66	PF00082	0.314
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.653
CLV_PCSK_PC7_1	61	67	PF00082	0.314
CLV_PCSK_SKI1_1	101	105	PF00082	0.314
CLV_PCSK_SKI1_1	286	290	PF00082	0.464
CLV_PCSK_SKI1_1	75	79	PF00082	0.326
DEG_APCC_DBOX_1	285	293	PF00400	0.427
DEG_COP1_1	415	425	PF00400	0.503
DEG_SCF_FBW7_1	417	424	PF00400	0.502
DOC_CKS1_1	378	383	PF01111	0.658
DOC_CYCLIN_RxL_1	98	106	PF00134	0.369
DOC_MAPK_gen_1	172	180	PF00069	0.569
DOC_MAPK_gen_1	51	59	PF00069	0.432
DOC_MAPK_MEF2A_6	124	132	PF00069	0.360
DOC_MAPK_MEF2A_6	172	180	PF00069	0.563
DOC_MAPK_MEF2A_6	268	276	PF00069	0.515
DOC_PP2B_LxvP_1	34	37	PF13499	0.406
DOC_PP2B_LxvP_1	356	359	PF13499	0.619
DOC_USP7_MATH_1	123	127	PF00917	0.442
DOC_USP7_MATH_1	316	320	PF00917	0.679
DOC_USP7_MATH_1	321	325	PF00917	0.632
DOC_USP7_MATH_1	402	406	PF00917	0.703
DOC_USP7_MATH_1	440	444	PF00917	0.754
DOC_USP7_MATH_1	456	460	PF00917	0.759
DOC_USP7_MATH_1	471	475	PF00917	0.652
DOC_WW_Pin1_4	312	317	PF00397	0.627
DOC_WW_Pin1_4	371	376	PF00397	0.676
DOC_WW_Pin1_4	377	382	PF00397	0.681
DOC_WW_Pin1_4	406	411	PF00397	0.598
DOC_WW_Pin1_4	417	422	PF00397	0.685
DOC_WW_Pin1_4	426	431	PF00397	0.705
DOC_WW_Pin1_4	436	441	PF00397	0.805
DOC_WW_Pin1_4	444	449	PF00397	0.546
DOC_WW_Pin1_4	461	466	PF00397	0.517
LIG_14-3-3_CanoR_1	290	299	PF00244	0.593
LIG_Actin_WH2_2	275	292	PF00022	0.444
LIG_Actin_WH2_2	3	18	PF00022	0.293
LIG_BH_BH3_1	141	157	PF00452	0.478
LIG_BIR_III_2	313	317	PF00653	0.659
LIG_BRCT_BRCA1_1	134	138	PF00533	0.371
LIG_BRCT_BRCA1_1	89	93	PF00533	0.432
LIG_FHA_1	129	135	PF00498	0.438
LIG_FHA_1	273	279	PF00498	0.494
LIG_FHA_1	378	384	PF00498	0.660
LIG_FHA_1	401	407	PF00498	0.535
LIG_FHA_1	486	492	PF00498	0.586
LIG_FHA_1	54	60	PF00498	0.469
LIG_FHA_1	76	82	PF00498	0.314
LIG_FHA_2	149	155	PF00498	0.380
LIG_FHA_2	236	242	PF00498	0.458
LIG_FHA_2	246	252	PF00498	0.491
LIG_FHA_2	289	295	PF00498	0.455
LIG_GBD_Chelix_1	215	223	PF00786	0.647
LIG_HCF-1_HBM_1	270	273	PF13415	0.475
LIG_LIR_Gen_1	21	26	PF02991	0.339
LIG_LIR_Gen_1	270	278	PF02991	0.482
LIG_LIR_Gen_1	38	45	PF02991	0.386
LIG_LIR_Gen_1	496	502	PF02991	0.604
LIG_LIR_Nem_3	21	25	PF02991	0.348
LIG_LIR_Nem_3	238	242	PF02991	0.505
LIG_LIR_Nem_3	270	276	PF02991	0.510
LIG_LIR_Nem_3	38	42	PF02991	0.386
LIG_LIR_Nem_3	496	501	PF02991	0.604
LIG_SH2_GRB2like	242	245	PF00017	0.423
LIG_SH2_PTP2	22	25	PF00017	0.246
LIG_SH2_PTP2	273	276	PF00017	0.515
LIG_SH2_SRC	22	25	PF00017	0.364
LIG_SH2_SRC	39	42	PF00017	0.324
LIG_SH2_STAT3	263	266	PF00017	0.520
LIG_SH2_STAT5	147	150	PF00017	0.405
LIG_SH2_STAT5	22	25	PF00017	0.290
LIG_SH2_STAT5	242	245	PF00017	0.442
LIG_SH2_STAT5	263	266	PF00017	0.538
LIG_SH2_STAT5	273	276	PF00017	0.433
LIG_SH3_3	177	183	PF00018	0.616
LIG_SH3_3	375	381	PF00018	0.733
LIG_SH3_3	404	410	PF00018	0.792
LIG_SH3_3	419	425	PF00018	0.643
LIG_SH3_3	481	487	PF00018	0.711
LIG_SUMO_SIM_anti_2	21	28	PF11976	0.253
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.406
LIG_SUMO_SIM_par_1	274	280	PF11976	0.442
LIG_SUMO_SIM_par_1	409	416	PF11976	0.512
LIG_TRAF2_1	142	145	PF00917	0.524
LIG_TRAF2_1	346	349	PF00917	0.695
LIG_TRAF2_1	413	416	PF00917	0.631
LIG_TRAF2_1	455	458	PF00917	0.569
LIG_TRAF2_2	190	195	PF00917	0.682
LIG_UBA3_1	6	13	PF00899	0.388
LIG_UBA3_1	81	87	PF00899	0.354
LIG_WW_3	357	361	PF00397	0.724
MOD_CK1_1	191	197	PF00069	0.579
MOD_CK1_1	262	268	PF00069	0.518
MOD_CK2_1	2	8	PF00069	0.456
MOD_CK2_1	245	251	PF00069	0.422
MOD_CK2_1	410	416	PF00069	0.755
MOD_CK2_1	456	462	PF00069	0.647
MOD_GlcNHglycan	125	128	PF01048	0.453
MOD_GlcNHglycan	229	232	PF01048	0.490
MOD_GlcNHglycan	296	299	PF01048	0.457
MOD_GlcNHglycan	319	322	PF01048	0.666
MOD_GlcNHglycan	323	326	PF01048	0.637
MOD_GlcNHglycan	332	335	PF01048	0.626
MOD_GlcNHglycan	340	343	PF01048	0.620
MOD_GlcNHglycan	344	347	PF01048	0.586
MOD_GlcNHglycan	364	367	PF01048	0.713
MOD_GlcNHglycan	397	400	PF01048	0.715
MOD_GlcNHglycan	457	461	PF01048	0.789
MOD_GlcNHglycan	473	476	PF01048	0.734
MOD_GSK3_1	128	135	PF00069	0.451
MOD_GSK3_1	223	230	PF00069	0.524
MOD_GSK3_1	272	279	PF00069	0.483
MOD_GSK3_1	288	295	PF00069	0.358
MOD_GSK3_1	312	319	PF00069	0.586
MOD_GSK3_1	326	333	PF00069	0.635
MOD_GSK3_1	334	341	PF00069	0.647
MOD_GSK3_1	402	409	PF00069	0.628
MOD_GSK3_1	417	424	PF00069	0.694
MOD_GSK3_1	434	441	PF00069	0.673
MOD_N-GLC_1	132	137	PF02516	0.355
MOD_N-GLC_1	87	92	PF02516	0.193
MOD_NEK2_1	128	133	PF00069	0.373
MOD_NEK2_1	232	237	PF00069	0.441
MOD_NEK2_1	277	282	PF00069	0.519
MOD_NEK2_1	288	293	PF00069	0.513
MOD_NEK2_1	330	335	PF00069	0.721
MOD_NEK2_1	435	440	PF00069	0.728
MOD_NEK2_1	45	50	PF00069	0.319
MOD_NEK2_1	81	86	PF00069	0.406
MOD_PIKK_1	188	194	PF00454	0.762
MOD_PIKK_1	262	268	PF00454	0.492
MOD_PIKK_1	292	298	PF00454	0.444
MOD_PIKK_1	96	102	PF00454	0.314
MOD_PKA_2	227	233	PF00069	0.502
MOD_PKA_2	368	374	PF00069	0.512
MOD_Plk_1	132	138	PF00069	0.352
MOD_Plk_1	303	309	PF00069	0.516
MOD_Plk_1	342	348	PF00069	0.655
MOD_Plk_1	53	59	PF00069	0.369
MOD_Plk_4	132	138	PF00069	0.380
MOD_Plk_4	18	24	PF00069	0.391
MOD_Plk_4	2	8	PF00069	0.421
MOD_Plk_4	259	265	PF00069	0.561
MOD_Plk_4	272	278	PF00069	0.402
MOD_Plk_4	326	332	PF00069	0.680
MOD_Plk_4	81	87	PF00069	0.334
MOD_ProDKin_1	312	318	PF00069	0.628
MOD_ProDKin_1	371	377	PF00069	0.672
MOD_ProDKin_1	406	412	PF00069	0.600
MOD_ProDKin_1	417	423	PF00069	0.684
MOD_ProDKin_1	426	432	PF00069	0.708
MOD_ProDKin_1	436	442	PF00069	0.806
MOD_ProDKin_1	444	450	PF00069	0.541
MOD_ProDKin_1	461	467	PF00069	0.510
MOD_SUMO_for_1	176	179	PF00179	0.595
MOD_SUMO_for_1	301	304	PF00179	0.551
TRG_DiLeu_BaEn_1	125	130	PF01217	0.456
TRG_DiLeu_BaEn_2	39	45	PF01217	0.406
TRG_DiLeu_BaEn_4	144	150	PF01217	0.514
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.335
TRG_ENDOCYTIC_2	22	25	PF00928	0.381
TRG_ENDOCYTIC_2	273	276	PF00928	0.489
TRG_ENDOCYTIC_2	39	42	PF00928	0.452
TRG_ER_diArg_1	63	66	PF00400	0.314
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB53	Leptomonas seymouri	63%	94%
A0A3Q8IJX3	Leishmania donovani	85%	98%
A0A3R7M014	Trypanosoma rangeli	36%	100%
A4HQ30	Leishmania braziliensis	69%	100%
A4IDT6	Leishmania infantum	85%	98%
Q4Q0P8	Leishmania major	80%	100%
V5BM99	Trypanosoma cruzi	36%	100%