Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATU7_LEIMU

TriTrypDb:

LmxM.36.5130

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.354
CLV_C14_Caspase3-7	272	276	PF00656	0.459
CLV_NRD_NRD_1	206	208	PF00675	0.495
CLV_PCSK_KEX2_1	152	154	PF00082	0.559
CLV_PCSK_KEX2_1	206	208	PF00082	0.511
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.559
CLV_PCSK_SKI1_1	157	161	PF00082	0.474
CLV_PCSK_SKI1_1	222	226	PF00082	0.483
DEG_APCC_DBOX_1	77	85	PF00400	0.490
DOC_PP1_RVXF_1	220	226	PF00149	0.247
DOC_PP2B_LxvP_1	190	193	PF13499	0.381
DOC_USP7_MATH_1	102	106	PF00917	0.368
DOC_USP7_MATH_1	110	114	PF00917	0.242
DOC_USP7_MATH_1	143	147	PF00917	0.365
DOC_USP7_MATH_1	151	155	PF00917	0.351
DOC_USP7_MATH_1	255	259	PF00917	0.504
DOC_USP7_MATH_1	44	48	PF00917	0.239
DOC_USP7_MATH_1	73	77	PF00917	0.487
DOC_USP7_UBL2_3	107	111	PF12436	0.512
DOC_WW_Pin1_4	119	124	PF00397	0.544
DOC_WW_Pin1_4	214	219	PF00397	0.400
LIG_BIR_II_1	1	5	PF00653	0.438
LIG_BRCT_BRCA1_1	36	40	PF00533	0.359
LIG_BRCT_BRCA1_1	70	74	PF00533	0.514
LIG_FHA_1	132	138	PF00498	0.389
LIG_FHA_1	158	164	PF00498	0.369
LIG_FHA_1	251	257	PF00498	0.375
LIG_FHA_2	194	200	PF00498	0.522
LIG_FHA_2	270	276	PF00498	0.447
LIG_FHA_2	91	97	PF00498	0.519
LIG_LIR_Apic_2	56	60	PF02991	0.362
LIG_LIR_Gen_1	158	167	PF02991	0.376
LIG_LIR_Gen_1	37	46	PF02991	0.384
LIG_LIR_Nem_3	158	162	PF02991	0.403
LIG_LIR_Nem_3	181	186	PF02991	0.246
LIG_LIR_Nem_3	37	43	PF02991	0.400
LIG_LIR_Nem_3	6	10	PF02991	0.357
LIG_LIR_Nem_3	75	80	PF02991	0.375
LIG_SH2_CRK	166	170	PF00017	0.459
LIG_SH2_CRK	7	11	PF00017	0.357
LIG_SH2_NCK_1	57	61	PF00017	0.424
LIG_SH2_STAP1	234	238	PF00017	0.543
LIG_SH2_STAT5	17	20	PF00017	0.431
LIG_SH2_STAT5	234	237	PF00017	0.466
LIG_SH2_STAT5	80	83	PF00017	0.478
LIG_WW_1	4	7	PF00397	0.475
MOD_CK1_1	118	124	PF00069	0.410
MOD_CK1_1	230	236	PF00069	0.469
MOD_CK1_1	61	67	PF00069	0.520
MOD_CK1_1	68	74	PF00069	0.487
MOD_CK2_1	73	79	PF00069	0.518
MOD_CK2_1	92	98	PF00069	0.229
MOD_GlcNHglycan	1	4	PF01048	0.574
MOD_GlcNHglycan	153	156	PF01048	0.396
MOD_GlcNHglycan	257	260	PF01048	0.514
MOD_GlcNHglycan	70	73	PF01048	0.434
MOD_GSK3_1	102	109	PF00069	0.454
MOD_GSK3_1	115	122	PF00069	0.454
MOD_GSK3_1	131	138	PF00069	0.273
MOD_GSK3_1	230	237	PF00069	0.423
MOD_GSK3_1	246	253	PF00069	0.292
MOD_GSK3_1	58	65	PF00069	0.382
MOD_GSK3_1	68	75	PF00069	0.351
MOD_N-GLC_1	115	120	PF02516	0.476
MOD_N-GLC_1	131	136	PF02516	0.360
MOD_N-GLC_1	227	232	PF02516	0.477
MOD_N-GLC_1	90	95	PF02516	0.390
MOD_NEK2_1	115	120	PF00069	0.428
MOD_NEK2_1	224	229	PF00069	0.408
MOD_NEK2_1	248	253	PF00069	0.406
MOD_NEK2_1	269	274	PF00069	0.505
MOD_NEK2_1	45	50	PF00069	0.487
MOD_NEK2_2	102	107	PF00069	0.494
MOD_NEK2_2	110	115	PF00069	0.243
MOD_NEK2_2	62	67	PF00069	0.500
MOD_Plk_1	157	163	PF00069	0.387
MOD_Plk_1	90	96	PF00069	0.265
MOD_Plk_4	110	116	PF00069	0.432
MOD_Plk_4	178	184	PF00069	0.281
MOD_Plk_4	80	86	PF00069	0.420
MOD_ProDKin_1	119	125	PF00069	0.550
MOD_ProDKin_1	214	220	PF00069	0.403
MOD_SUMO_rev_2	146	154	PF00179	0.508
TRG_DiLeu_BaEn_2	204	210	PF01217	0.437
TRG_ENDOCYTIC_2	7	10	PF00928	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P495	Leptomonas seymouri	61%	100%
A0A0S4JKK5	Bodo saltans	22%	98%
A0A1X0P327	Trypanosomatidae	33%	96%
A0A3Q8IPM4	Leishmania donovani	87%	100%
A0A422NMF9	Trypanosoma rangeli	34%	100%
A4HQ29	Leishmania braziliensis	74%	100%
A4IDT5	Leishmania infantum	86%	100%
D0A8T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q0P9	Leishmania major	87%	100%
V5BWK1	Trypanosoma cruzi	35%	100%