Guanylate cyclase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4496), putative

Species:

Leishmania mexicana

UniProt:

E9ATU5_LEIMU

TriTrypDb:

LmxM.36.5110

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ATU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.496
CLV_C14_Caspase3-7	24	28	PF00656	0.424
CLV_C14_Caspase3-7	249	253	PF00656	0.601
CLV_NRD_NRD_1	260	262	PF00675	0.669
CLV_PCSK_KEX2_1	260	262	PF00082	0.696
CLV_PCSK_KEX2_1	35	37	PF00082	0.419
CLV_PCSK_KEX2_1	61	63	PF00082	0.369
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.419
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.369
CLV_PCSK_SKI1_1	107	111	PF00082	0.588
CLV_PCSK_SKI1_1	78	82	PF00082	0.408
DEG_Nend_UBRbox_2	1	3	PF02207	0.686
DOC_CKS1_1	201	206	PF01111	0.580
DOC_MAPK_gen_1	60	69	PF00069	0.432
DOC_MAPK_MEF2A_6	60	69	PF00069	0.444
DOC_MAPK_NFAT4_5	62	70	PF00069	0.444
DOC_SPAK_OSR1_1	138	142	PF12202	0.369
DOC_USP7_UBL2_3	103	107	PF12436	0.444
DOC_WW_Pin1_4	200	205	PF00397	0.524
LIG_14-3-3_CanoR_1	158	168	PF00244	0.444
LIG_14-3-3_CanoR_1	181	189	PF00244	0.370
LIG_14-3-3_CanoR_1	191	197	PF00244	0.433
LIG_14-3-3_CanoR_1	244	250	PF00244	0.597
LIG_BRCT_BRCA1_1	184	188	PF00533	0.401
LIG_FHA_1	161	167	PF00498	0.394
LIG_FHA_2	201	207	PF00498	0.568
LIG_FHA_2	22	28	PF00498	0.424
LIG_LIR_Apic_2	203	208	PF02991	0.495
LIG_LIR_Gen_1	124	134	PF02991	0.373
LIG_LIR_Nem_3	124	130	PF02991	0.349
LIG_Pex14_1	184	188	PF04695	0.344
LIG_Pex14_2	100	104	PF04695	0.369
LIG_PTAP_UEV_1	214	219	PF05743	0.587
LIG_SH2_CRK	205	209	PF00017	0.526
LIG_SH2_NCK_1	205	209	PF00017	0.526
LIG_SH2_PTP2	127	130	PF00017	0.408
LIG_SH2_SRC	205	208	PF00017	0.503
LIG_SH2_STAT3	30	33	PF00017	0.344
LIG_SH2_STAT5	127	130	PF00017	0.429
LIG_SH2_STAT5	155	158	PF00017	0.328
LIG_SH3_2	215	220	PF14604	0.712
LIG_SH3_3	198	204	PF00018	0.477
LIG_SH3_3	212	218	PF00018	0.557
LIG_SH3_3	92	98	PF00018	0.321
LIG_SUMO_SIM_par_1	162	167	PF11976	0.401
LIG_SUMO_SIM_par_1	93	99	PF11976	0.346
LIG_TYR_ITIM	125	130	PF00017	0.369
MOD_CK1_1	126	132	PF00069	0.397
MOD_CK1_1	162	168	PF00069	0.485
MOD_CK1_1	243	249	PF00069	0.661
MOD_CK1_1	5	11	PF00069	0.599
MOD_CK2_1	145	151	PF00069	0.359
MOD_CK2_1	243	249	PF00069	0.628
MOD_GlcNHglycan	246	249	PF01048	0.653
MOD_GlcNHglycan	62	65	PF01048	0.444
MOD_GlcNHglycan	7	10	PF01048	0.619
MOD_GSK3_1	1	8	PF00069	0.742
MOD_GSK3_1	117	124	PF00069	0.558
MOD_GSK3_1	129	136	PF00069	0.454
MOD_GSK3_1	240	247	PF00069	0.659
MOD_GSK3_1	255	262	PF00069	0.576
MOD_NEK2_1	1	6	PF00069	0.752
MOD_NEK2_1	192	197	PF00069	0.485
MOD_NEK2_1	230	235	PF00069	0.520
MOD_NEK2_1	240	245	PF00069	0.559
MOD_NEK2_1	254	259	PF00069	0.522
MOD_NEK2_1	31	36	PF00069	0.408
MOD_NEK2_1	70	75	PF00069	0.344
MOD_NEK2_1	82	87	PF00069	0.280
MOD_PIKK_1	230	236	PF00454	0.608
MOD_PKA_1	60	66	PF00069	0.401
MOD_PKA_2	192	198	PF00069	0.389
MOD_PKA_2	243	249	PF00069	0.576
MOD_Plk_1	176	182	PF00069	0.485
MOD_Plk_1	82	88	PF00069	0.443
MOD_Plk_4	123	129	PF00069	0.485
MOD_Plk_4	235	241	PF00069	0.584
MOD_ProDKin_1	200	206	PF00069	0.531
MOD_SUMO_rev_2	83	92	PF00179	0.429
TRG_ENDOCYTIC_2	127	130	PF00928	0.369
TRG_ENDOCYTIC_2	16	19	PF00928	0.422
TRG_ER_diArg_1	259	261	PF00400	0.709
TRG_NES_CRM1_1	21	33	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P360	Leptomonas seymouri	79%	100%
A0A1X0NFH5	Trypanosomatidae	54%	100%
A0A3Q8IJR1	Leishmania donovani	95%	100%
A0A422N6F8	Trypanosoma rangeli	55%	83%
A4HQ27	Leishmania braziliensis	88%	100%
A4IDT3	Leishmania infantum	95%	100%
D0A8U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q0Q1	Leishmania major	96%	100%