Magnesium chelatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Magnesium chelatase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATU4_LEIMU

TriTrypDb:

LmxM.36.5100

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATU4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.735
CLV_C14_Caspase3-7	641	645	PF00656	0.639
CLV_C14_Caspase3-7	798	802	PF00656	0.558
CLV_NRD_NRD_1	273	275	PF00675	0.473
CLV_NRD_NRD_1	509	511	PF00675	0.403
CLV_NRD_NRD_1	629	631	PF00675	0.766
CLV_NRD_NRD_1	711	713	PF00675	0.608
CLV_NRD_NRD_1	773	775	PF00675	0.489
CLV_NRD_NRD_1	831	833	PF00675	0.378
CLV_PCSK_FUR_1	711	715	PF00082	0.494
CLV_PCSK_KEX2_1	489	491	PF00082	0.522
CLV_PCSK_KEX2_1	511	513	PF00082	0.372
CLV_PCSK_KEX2_1	635	637	PF00082	0.637
CLV_PCSK_KEX2_1	711	713	PF00082	0.606
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.522
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.400
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.620
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.569
CLV_PCSK_SKI1_1	275	279	PF00082	0.550
CLV_PCSK_SKI1_1	486	490	PF00082	0.718
CLV_PCSK_SKI1_1	503	507	PF00082	0.401
CLV_PCSK_SKI1_1	512	516	PF00082	0.376
CLV_PCSK_SKI1_1	571	575	PF00082	0.650
CLV_PCSK_SKI1_1	732	736	PF00082	0.445
CLV_PCSK_SKI1_1	754	758	PF00082	0.433
CLV_PCSK_SKI1_1	811	815	PF00082	0.461
CLV_PCSK_SKI1_1	832	836	PF00082	0.420
DEG_APCC_DBOX_1	810	818	PF00400	0.455
DEG_APCC_DBOX_1	831	839	PF00400	0.408
DEG_Nend_UBRbox_3	1	3	PF02207	0.758
DOC_CDC14_PxL_1	546	554	PF14671	0.470
DOC_CKS1_1	101	106	PF01111	0.623
DOC_CKS1_1	281	286	PF01111	0.339
DOC_CKS1_1	370	375	PF01111	0.468
DOC_CKS1_1	378	383	PF01111	0.653
DOC_CKS1_1	755	760	PF01111	0.260
DOC_CKS1_1	823	828	PF01111	0.473
DOC_CYCLIN_RxL_1	808	816	PF00134	0.368
DOC_CYCLIN_RxL_1	829	836	PF00134	0.297
DOC_CYCLIN_yClb5_NLxxxL_5	811	817	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.419
DOC_MAPK_gen_1	230	239	PF00069	0.489
DOC_MAPK_gen_1	293	301	PF00069	0.536
DOC_MAPK_gen_1	500	508	PF00069	0.449
DOC_MAPK_gen_1	510	516	PF00069	0.459
DOC_MAPK_MEF2A_6	295	303	PF00069	0.506
DOC_PP1_RVXF_1	510	517	PF00149	0.410
DOC_PP1_RVXF_1	531	537	PF00149	0.592
DOC_PP2B_LxvP_1	314	317	PF13499	0.496
DOC_PP4_FxxP_1	374	377	PF00568	0.571
DOC_USP7_MATH_1	289	293	PF00917	0.592
DOC_USP7_MATH_1	417	421	PF00917	0.494
DOC_USP7_MATH_1	640	644	PF00917	0.551
DOC_USP7_MATH_1	675	679	PF00917	0.337
DOC_USP7_MATH_1	883	887	PF00917	0.585
DOC_USP7_MATH_1	916	920	PF00917	0.553
DOC_USP7_UBL2_3	485	489	PF12436	0.707
DOC_USP7_UBL2_3	631	635	PF12436	0.626
DOC_WW_Pin1_4	100	105	PF00397	0.698
DOC_WW_Pin1_4	280	285	PF00397	0.460
DOC_WW_Pin1_4	369	374	PF00397	0.484
DOC_WW_Pin1_4	377	382	PF00397	0.638
DOC_WW_Pin1_4	492	497	PF00397	0.505
DOC_WW_Pin1_4	656	661	PF00397	0.587
DOC_WW_Pin1_4	664	669	PF00397	0.577
DOC_WW_Pin1_4	754	759	PF00397	0.291
DOC_WW_Pin1_4	767	772	PF00397	0.569
DOC_WW_Pin1_4	822	827	PF00397	0.357
DOC_WW_Pin1_4	890	895	PF00397	0.464
DOC_WW_Pin1_4	977	982	PF00397	0.777
LIG_14-3-3_CanoR_1	274	284	PF00244	0.503
LIG_14-3-3_CanoR_1	425	433	PF00244	0.424
LIG_14-3-3_CanoR_1	490	496	PF00244	0.500
LIG_14-3-3_CanoR_1	714	723	PF00244	0.610
LIG_14-3-3_CanoR_1	870	874	PF00244	0.436
LIG_Actin_WH2_2	527	543	PF00022	0.516
LIG_APCC_ABBAyCdc20_2	511	517	PF00400	0.489
LIG_CaM_IQ_9	236	252	PF13499	0.487
LIG_EH1_1	745	753	PF00400	0.233
LIG_eIF4E_1	742	748	PF01652	0.431
LIG_FHA_1	276	282	PF00498	0.489
LIG_FHA_1	296	302	PF00498	0.250
LIG_FHA_1	401	407	PF00498	0.453
LIG_FHA_1	870	876	PF00498	0.501
LIG_FHA_1	910	916	PF00498	0.420
LIG_FHA_1	935	941	PF00498	0.428
LIG_FHA_2	370	376	PF00498	0.536
LIG_FHA_2	378	384	PF00498	0.680
LIG_FHA_2	392	398	PF00498	0.374
LIG_FHA_2	823	829	PF00498	0.464
LIG_FHA_2	839	845	PF00498	0.296
LIG_GBD_Chelix_1	899	907	PF00786	0.362
LIG_IBAR_NPY_1	10	12	PF08397	0.739
LIG_IRF3_LxIS_1	887	893	PF10401	0.421
LIG_LIR_Apic_2	372	377	PF02991	0.556
LIG_LIR_Apic_2	87	93	PF02991	0.552
LIG_LIR_Gen_1	256	266	PF02991	0.432
LIG_LIR_Gen_1	408	417	PF02991	0.524
LIG_LIR_Gen_1	424	433	PF02991	0.440
LIG_LIR_Gen_1	554	565	PF02991	0.425
LIG_LIR_Gen_1	884	894	PF02991	0.394
LIG_LIR_Nem_3	256	261	PF02991	0.391
LIG_LIR_Nem_3	264	269	PF02991	0.374
LIG_LIR_Nem_3	331	336	PF02991	0.449
LIG_LIR_Nem_3	362	367	PF02991	0.527
LIG_LIR_Nem_3	408	412	PF02991	0.488
LIG_LIR_Nem_3	424	430	PF02991	0.438
LIG_LIR_Nem_3	554	560	PF02991	0.403
LIG_LIR_Nem_3	691	695	PF02991	0.352
LIG_LIR_Nem_3	884	890	PF02991	0.500
LIG_LIR_Nem_3	929	935	PF02991	0.429
LIG_LYPXL_yS_3	549	552	PF13949	0.474
LIG_NRBOX	366	372	PF00104	0.456
LIG_NRBOX	830	836	PF00104	0.413
LIG_PAM2_1	788	800	PF00658	0.427
LIG_Pex14_1	692	696	PF04695	0.400
LIG_PTAP_UEV_1	968	973	PF05743	0.456
LIG_PTB_Apo_2	169	176	PF02174	0.719
LIG_PTB_Apo_2	837	844	PF02174	0.435
LIG_PTB_Phospho_1	169	175	PF10480	0.718
LIG_REV1ctd_RIR_1	513	520	PF16727	0.510
LIG_SH2_CRK	258	262	PF00017	0.445
LIG_SH2_CRK	755	759	PF00017	0.423
LIG_SH2_CRK	810	814	PF00017	0.410
LIG_SH2_CRK	90	94	PF00017	0.599
LIG_SH2_GRB2like	170	173	PF00017	0.666
LIG_SH2_NCK_1	181	185	PF00017	0.665
LIG_SH2_NCK_1	696	700	PF00017	0.450
LIG_SH2_NCK_1	86	90	PF00017	0.660
LIG_SH2_SRC	181	184	PF00017	0.617
LIG_SH2_STAP1	409	413	PF00017	0.469
LIG_SH2_STAP1	86	90	PF00017	0.651
LIG_SH2_STAT3	162	165	PF00017	0.642
LIG_SH2_STAT3	170	173	PF00017	0.602
LIG_SH2_STAT3	19	22	PF00017	0.674
LIG_SH2_STAT3	194	197	PF00017	0.684
LIG_SH2_STAT3	28	31	PF00017	0.586
LIG_SH2_STAT3	41	44	PF00017	0.538
LIG_SH2_STAT3	590	593	PF00017	0.412
LIG_SH2_STAT5	742	745	PF00017	0.426
LIG_SH2_STAT5	830	833	PF00017	0.373
LIG_SH2_STAT5	850	853	PF00017	0.428
LIG_SH2_STAT5	898	901	PF00017	0.349
LIG_SH2_STAT5	933	936	PF00017	0.335
LIG_SH3_1	518	524	PF00018	0.515
LIG_SH3_1	820	826	PF00018	0.453
LIG_SH3_3	161	167	PF00018	0.534
LIG_SH3_3	314	320	PF00018	0.531
LIG_SH3_3	331	337	PF00018	0.453
LIG_SH3_3	45	51	PF00018	0.666
LIG_SH3_3	518	524	PF00018	0.602
LIG_SH3_3	820	826	PF00018	0.474
LIG_SH3_3	966	972	PF00018	0.639
LIG_SH3_3	975	981	PF00018	0.729
LIG_SH3_3	99	105	PF00018	0.628
LIG_SH3_4	631	638	PF00018	0.716
LIG_SUMO_SIM_anti_2	603	609	PF11976	0.436
LIG_TRAF2_1	446	449	PF00917	0.684
LIG_TRAF2_1	624	627	PF00917	0.650
LIG_TYR_ITIM	547	552	PF00017	0.434
LIG_UBA3_1	367	376	PF00899	0.520
LIG_UBA3_1	398	404	PF00899	0.482
LIG_UBA3_1	764	769	PF00899	0.319
LIG_WRC_WIRS_1	361	366	PF05994	0.446
LIG_WRC_WIRS_1	932	937	PF05994	0.346
MOD_CDK_SPxxK_3	369	376	PF00069	0.365
MOD_CDK_SPxxK_3	767	774	PF00069	0.348
MOD_CK1_1	326	332	PF00069	0.457
MOD_CK1_1	420	426	PF00069	0.493
MOD_CK1_1	596	602	PF00069	0.473
MOD_CK1_1	667	673	PF00069	0.523
MOD_CK1_1	701	707	PF00069	0.475
MOD_CK1_1	770	776	PF00069	0.371
MOD_CK1_1	816	822	PF00069	0.456
MOD_CK1_1	967	973	PF00069	0.607
MOD_CK1_1	976	982	PF00069	0.693
MOD_CK2_1	377	383	PF00069	0.705
MOD_CK2_1	391	397	PF00069	0.388
MOD_CK2_1	431	437	PF00069	0.645
MOD_CK2_1	616	622	PF00069	0.613
MOD_CK2_1	676	682	PF00069	0.502
MOD_CK2_1	822	828	PF00069	0.377
MOD_CK2_1	838	844	PF00069	0.295
MOD_Cter_Amidation	272	275	PF01082	0.511
MOD_GlcNHglycan	287	290	PF01048	0.607
MOD_GlcNHglycan	535	539	PF01048	0.523
MOD_GlcNHglycan	596	599	PF01048	0.458
MOD_GlcNHglycan	685	688	PF01048	0.428
MOD_GlcNHglycan	765	768	PF01048	0.353
MOD_GlcNHglycan	894	897	PF01048	0.440
MOD_GlcNHglycan	966	969	PF01048	0.555
MOD_GlcNHglycan	972	975	PF01048	0.558
MOD_GSK3_1	285	292	PF00069	0.566
MOD_GSK3_1	359	366	PF00069	0.548
MOD_GSK3_1	417	424	PF00069	0.463
MOD_GSK3_1	488	495	PF00069	0.463
MOD_GSK3_1	592	599	PF00069	0.366
MOD_GSK3_1	712	719	PF00069	0.594
MOD_GSK3_1	763	770	PF00069	0.422
MOD_GSK3_1	785	792	PF00069	0.433
MOD_GSK3_1	796	803	PF00069	0.479
MOD_GSK3_1	812	819	PF00069	0.293
MOD_GSK3_1	838	845	PF00069	0.415
MOD_GSK3_1	905	912	PF00069	0.460
MOD_GSK3_1	972	979	PF00069	0.729
MOD_NEK2_1	254	259	PF00069	0.531
MOD_NEK2_1	506	511	PF00069	0.502
MOD_NEK2_1	594	599	PF00069	0.394
MOD_NEK2_1	747	752	PF00069	0.509
MOD_NEK2_1	813	818	PF00069	0.382
MOD_NEK2_2	536	541	PF00069	0.515
MOD_PIKK_1	205	211	PF00454	0.547
MOD_PIKK_1	53	59	PF00454	0.569
MOD_PIKK_1	61	67	PF00454	0.561
MOD_PIKK_1	667	673	PF00454	0.566
MOD_PIKK_1	69	75	PF00454	0.634
MOD_PIKK_1	716	722	PF00454	0.532
MOD_PIKK_1	84	90	PF00454	0.503
MOD_PKA_1	712	718	PF00069	0.597
MOD_PKA_2	294	300	PF00069	0.616
MOD_PKA_2	715	721	PF00069	0.557
MOD_PKA_2	862	868	PF00069	0.506
MOD_PKA_2	869	875	PF00069	0.472
MOD_PKB_1	293	301	PF00069	0.604
MOD_PKB_1	714	722	PF00069	0.540
MOD_Plk_1	320	326	PF00069	0.547
MOD_Plk_1	421	427	PF00069	0.489
MOD_Plk_1	800	806	PF00069	0.438
MOD_Plk_1	883	889	PF00069	0.460
MOD_Plk_2-3	405	411	PF00069	0.575
MOD_Plk_4	277	283	PF00069	0.469
MOD_Plk_4	320	326	PF00069	0.561
MOD_Plk_4	329	335	PF00069	0.443
MOD_Plk_4	600	606	PF00069	0.389
MOD_Plk_4	747	753	PF00069	0.365
MOD_Plk_4	785	791	PF00069	0.449
MOD_Plk_4	838	844	PF00069	0.387
MOD_Plk_4	883	889	PF00069	0.516
MOD_Plk_4	931	937	PF00069	0.351
MOD_ProDKin_1	100	106	PF00069	0.699
MOD_ProDKin_1	280	286	PF00069	0.460
MOD_ProDKin_1	369	375	PF00069	0.489
MOD_ProDKin_1	377	383	PF00069	0.646
MOD_ProDKin_1	492	498	PF00069	0.502
MOD_ProDKin_1	656	662	PF00069	0.586
MOD_ProDKin_1	664	670	PF00069	0.574
MOD_ProDKin_1	754	760	PF00069	0.289
MOD_ProDKin_1	767	773	PF00069	0.569
MOD_ProDKin_1	822	828	PF00069	0.356
MOD_ProDKin_1	890	896	PF00069	0.460
MOD_ProDKin_1	977	983	PF00069	0.777
MOD_SUMO_for_1	654	657	PF00179	0.649
MOD_SUMO_rev_2	462	472	PF00179	0.742
MOD_SUMO_rev_2	678	686	PF00179	0.517
MOD_SUMO_rev_2	918	928	PF00179	0.439
TRG_DiLeu_BaEn_2	777	783	PF01217	0.477
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.456
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.476
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.474
TRG_ENDOCYTIC_2	161	164	PF00928	0.608
TRG_ENDOCYTIC_2	258	261	PF00928	0.405
TRG_ENDOCYTIC_2	266	269	PF00928	0.386
TRG_ENDOCYTIC_2	409	412	PF00928	0.497
TRG_ENDOCYTIC_2	549	552	PF00928	0.429
TRG_ENDOCYTIC_2	695	698	PF00928	0.382
TRG_ENDOCYTIC_2	810	813	PF00928	0.453
TRG_ENDOCYTIC_2	932	935	PF00928	0.403
TRG_ER_diArg_1	290	293	PF00400	0.593
TRG_ER_diArg_1	710	712	PF00400	0.555
TRG_ER_diArg_1	714	717	PF00400	0.542
TRG_ER_diArg_1	739	742	PF00400	0.394
TRG_NES_CRM1_1	554	568	PF08389	0.407
TRG_NLS_MonoExtC_3	711	716	PF00514	0.610
TRG_NLS_MonoExtN_4	711	717	PF00514	0.607
TRG_Pf-PMV_PEXEL_1	832	836	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	877	881	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	901	906	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II64	Leptomonas seymouri	61%	100%
A0A1X0NFU9	Trypanosomatidae	28%	100%
A0A3Q8IRM7	Leishmania donovani	88%	100%
A0A422N6K0	Trypanosoma rangeli	26%	100%
A4HQ26	Leishmania braziliensis	83%	100%
A4IDT2	Leishmania infantum	88%	100%
D0A8U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
Q4Q0Q2	Leishmania major	89%	100%