S4 RNA-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATU1_LEIMU

TriTrypDb:

LmxM.36.5070

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	329	331	PF00675	0.420
CLV_NRD_NRD_1	373	375	PF00675	0.423
CLV_NRD_NRD_1	57	59	PF00675	0.526
CLV_PCSK_FUR_1	55	59	PF00082	0.554
CLV_PCSK_KEX2_1	160	162	PF00082	0.429
CLV_PCSK_KEX2_1	329	331	PF00082	0.484
CLV_PCSK_KEX2_1	373	375	PF00082	0.491
CLV_PCSK_KEX2_1	57	59	PF00082	0.516
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.442
CLV_PCSK_SKI1_1	10	14	PF00082	0.736
CLV_PCSK_SKI1_1	160	164	PF00082	0.426
CLV_PCSK_SKI1_1	373	377	PF00082	0.424
CLV_PCSK_SKI1_1	379	383	PF00082	0.453
CLV_PCSK_SKI1_1	46	50	PF00082	0.556
DOC_CDC14_PxL_1	305	313	PF14671	0.524
DOC_CKS1_1	318	323	PF01111	0.417
DOC_MAPK_gen_1	248	257	PF00069	0.563
DOC_MAPK_gen_1	329	340	PF00069	0.457
DOC_MAPK_gen_1	34	42	PF00069	0.584
DOC_MAPK_gen_1	373	382	PF00069	0.424
DOC_MAPK_gen_1	97	105	PF00069	0.575
DOC_MAPK_MEF2A_6	376	384	PF00069	0.458
DOC_PP1_RVXF_1	208	215	PF00149	0.437
DOC_USP7_MATH_1	133	137	PF00917	0.643
DOC_USP7_MATH_1	174	178	PF00917	0.486
DOC_WW_Pin1_4	198	203	PF00397	0.511
DOC_WW_Pin1_4	250	255	PF00397	0.545
DOC_WW_Pin1_4	317	322	PF00397	0.382
LIG_14-3-3_CanoR_1	14	19	PF00244	0.601
LIG_14-3-3_CanoR_1	165	170	PF00244	0.474
LIG_14-3-3_CanoR_1	315	321	PF00244	0.433
LIG_14-3-3_CanoR_1	358	367	PF00244	0.322
LIG_14-3-3_CanoR_1	379	385	PF00244	0.479
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_Clathr_ClatBox_1	368	372	PF01394	0.489
LIG_CSL_BTD_1	154	157	PF09270	0.458
LIG_FHA_1	317	323	PF00498	0.419
LIG_FHA_1	49	55	PF00498	0.584
LIG_FHA_1	87	93	PF00498	0.416
LIG_FHA_2	107	113	PF00498	0.582
LIG_FHA_2	251	257	PF00498	0.554
LIG_LIR_Apic_2	168	174	PF02991	0.349
LIG_LIR_Gen_1	116	125	PF02991	0.449
LIG_LIR_Gen_1	166	176	PF02991	0.496
LIG_LIR_Gen_1	73	79	PF02991	0.384
LIG_LIR_Nem_3	116	120	PF02991	0.460
LIG_LIR_Nem_3	166	172	PF02991	0.463
LIG_LIR_Nem_3	73	78	PF02991	0.372
LIG_PTB_Apo_2	299	306	PF02174	0.472
LIG_PTB_Apo_2	340	347	PF02174	0.524
LIG_SH2_CRK	167	171	PF00017	0.486
LIG_SH2_GRB2like	233	236	PF00017	0.444
LIG_SH2_SRC	171	174	PF00017	0.431
LIG_SH2_STAP1	167	171	PF00017	0.442
LIG_SH2_STAP1	245	249	PF00017	0.365
LIG_SH2_STAT5	167	170	PF00017	0.370
LIG_SH2_STAT5	171	174	PF00017	0.412
LIG_SH2_STAT5	28	31	PF00017	0.700
LIG_SH3_2	292	297	PF14604	0.573
LIG_SH3_2	321	326	PF14604	0.418
LIG_SH3_3	205	211	PF00018	0.515
LIG_SH3_3	244	250	PF00018	0.458
LIG_SH3_3	285	291	PF00018	0.461
LIG_SH3_3	315	321	PF00018	0.388
LIG_SUMO_SIM_anti_2	253	259	PF11976	0.568
LIG_SUMO_SIM_anti_2	363	370	PF11976	0.423
LIG_SUMO_SIM_par_1	380	386	PF11976	0.491
LIG_TRAF2_1	179	182	PF00917	0.574
LIG_WRC_WIRS_1	368	373	PF05994	0.414
MOD_CK1_1	106	112	PF00069	0.595
MOD_CK1_1	113	119	PF00069	0.555
MOD_CK1_1	136	142	PF00069	0.654
MOD_CK1_1	177	183	PF00069	0.450
MOD_CK1_1	296	302	PF00069	0.584
MOD_CK2_1	106	112	PF00069	0.518
MOD_CK2_1	176	182	PF00069	0.556
MOD_CK2_1	250	256	PF00069	0.550
MOD_CK2_1	380	386	PF00069	0.476
MOD_GlcNHglycan	106	109	PF01048	0.476
MOD_GlcNHglycan	333	336	PF01048	0.451
MOD_GlcNHglycan	360	363	PF01048	0.481
MOD_GlcNHglycan	94	97	PF01048	0.451
MOD_GSK3_1	10	17	PF00069	0.594
MOD_GSK3_1	106	113	PF00069	0.580
MOD_GSK3_1	133	140	PF00069	0.584
MOD_GSK3_1	176	183	PF00069	0.446
MOD_GSK3_1	222	229	PF00069	0.385
MOD_LATS_1	143	149	PF00433	0.593
MOD_LATS_1	44	50	PF00433	0.557
MOD_N-GLC_1	235	240	PF02516	0.521
MOD_NEK2_1	134	139	PF00069	0.716
MOD_NEK2_1	163	168	PF00069	0.449
MOD_NEK2_1	304	309	PF00069	0.391
MOD_NEK2_1	316	321	PF00069	0.418
MOD_NEK2_1	331	336	PF00069	0.436
MOD_NEK2_1	348	353	PF00069	0.344
MOD_NEK2_1	380	385	PF00069	0.555
MOD_NEK2_1	48	53	PF00069	0.516
MOD_NEK2_1	86	91	PF00069	0.420
MOD_NEK2_1	92	97	PF00069	0.402
MOD_PIKK_1	110	116	PF00454	0.505
MOD_PIKK_1	86	92	PF00454	0.441
MOD_PK_1	14	20	PF00069	0.607
MOD_PKA_2	144	150	PF00069	0.662
MOD_PKA_2	296	302	PF00069	0.544
MOD_Plk_1	226	232	PF00069	0.406
MOD_Plk_1	235	241	PF00069	0.397
MOD_Plk_1	265	271	PF00069	0.578
MOD_Plk_4	151	157	PF00069	0.478
MOD_Plk_4	165	171	PF00069	0.333
MOD_Plk_4	226	232	PF00069	0.421
MOD_Plk_4	348	354	PF00069	0.487
MOD_Plk_4	70	76	PF00069	0.413
MOD_ProDKin_1	198	204	PF00069	0.509
MOD_ProDKin_1	250	256	PF00069	0.550
MOD_ProDKin_1	317	323	PF00069	0.383
MOD_SUMO_rev_2	386	393	PF00179	0.390
TRG_DiLeu_BaEn_1	313	318	PF01217	0.498
TRG_DiLeu_BaEn_2	183	189	PF01217	0.385
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.573
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.535
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.401
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.370
TRG_ENDOCYTIC_2	167	170	PF00928	0.344
TRG_ENDOCYTIC_2	75	78	PF00928	0.386
TRG_ER_diArg_1	269	272	PF00400	0.495
TRG_ER_diArg_1	329	331	PF00400	0.480
TRG_ER_diArg_1	373	375	PF00400	0.491
TRG_ER_diArg_1	54	57	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSQ0	Leptomonas seymouri	74%	99%
A0A0S4JP54	Bodo saltans	36%	81%
A0A1X0NDW4	Trypanosomatidae	50%	93%
A0A3Q8IHT7	Leishmania donovani	95%	100%
A0A3R7K3H2	Trypanosoma rangeli	55%	95%
A4HQ23	Leishmania braziliensis	88%	100%
A4IDT0	Leishmania infantum	95%	100%
D0A8U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	94%
Q4Q0Q5	Leishmania major	92%	100%
V5AZJ2	Trypanosoma cruzi	53%	86%