START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATT4_LEIMU

TriTrypDb:

LmxM.36.5000

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 6
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ATT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.701
CLV_NRD_NRD_1	172	174	PF00675	0.689
CLV_NRD_NRD_1	208	210	PF00675	0.558
CLV_NRD_NRD_1	231	233	PF00675	0.288
CLV_NRD_NRD_1	291	293	PF00675	0.673
CLV_NRD_NRD_1	294	296	PF00675	0.692
CLV_NRD_NRD_1	346	348	PF00675	0.744
CLV_NRD_NRD_1	4	6	PF00675	0.427
CLV_PCSK_FUR_1	292	296	PF00082	0.526
CLV_PCSK_FUR_1	344	348	PF00082	0.769
CLV_PCSK_KEX2_1	169	171	PF00082	0.688
CLV_PCSK_KEX2_1	208	210	PF00082	0.558
CLV_PCSK_KEX2_1	231	233	PF00082	0.288
CLV_PCSK_KEX2_1	291	293	PF00082	0.673
CLV_PCSK_KEX2_1	294	296	PF00082	0.692
CLV_PCSK_KEX2_1	344	346	PF00082	0.678
CLV_PCSK_KEX2_1	4	6	PF00082	0.427
CLV_PCSK_PC7_1	341	347	PF00082	0.763
CLV_PCSK_SKI1_1	123	127	PF00082	0.495
CLV_PCSK_SKI1_1	209	213	PF00082	0.555
CLV_PCSK_SKI1_1	249	253	PF00082	0.615
CLV_PCSK_SKI1_1	70	74	PF00082	0.432
DEG_MDM2_SWIB_1	135	142	PF02201	0.539
DOC_CDC14_PxL_1	20	28	PF14671	0.515
DOC_CKS1_1	45	50	PF01111	0.519
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.519
DOC_MAPK_FxFP_2	218	221	PF00069	0.479
DOC_MAPK_gen_1	113	121	PF00069	0.466
DOC_MAPK_gen_1	208	214	PF00069	0.518
DOC_MAPK_gen_1	231	238	PF00069	0.338
DOC_MAPK_gen_1	254	263	PF00069	0.583
DOC_MAPK_gen_1	341	351	PF00069	0.744
DOC_MAPK_gen_1	4	10	PF00069	0.403
DOC_MAPK_JIP1_4	247	253	PF00069	0.555
DOC_MAPK_MEF2A_6	231	240	PF00069	0.359
DOC_MAPK_MEF2A_6	243	252	PF00069	0.502
DOC_PP1_RVXF_1	116	122	PF00149	0.496
DOC_PP1_RVXF_1	201	207	PF00149	0.428
DOC_PP2B_LxvP_1	21	24	PF13499	0.510
DOC_PP4_FxxP_1	218	221	PF00568	0.479
DOC_SPAK_OSR1_1	239	243	PF12202	0.457
DOC_USP7_MATH_1	305	309	PF00917	0.586
DOC_USP7_MATH_1	322	326	PF00917	0.730
DOC_USP7_MATH_1	33	37	PF00917	0.592
DOC_WW_Pin1_4	301	306	PF00397	0.545
DOC_WW_Pin1_4	44	49	PF00397	0.521
DOC_WW_Pin1_4	80	85	PF00397	0.680
LIG_14-3-3_CanoR_1	12	21	PF00244	0.565
LIG_14-3-3_CanoR_1	226	230	PF00244	0.511
LIG_14-3-3_CanoR_1	280	286	PF00244	0.698
LIG_14-3-3_CanoR_1	5	11	PF00244	0.429
LIG_14-3-3_CanoR_1	79	83	PF00244	0.438
LIG_APCC_ABBA_1	212	217	PF00400	0.499
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_BIR_III_4	88	92	PF00653	0.585
LIG_EH_1	73	77	PF12763	0.688
LIG_FHA_1	14	20	PF00498	0.570
LIG_FHA_1	153	159	PF00498	0.517
LIG_FHA_1	186	192	PF00498	0.580
LIG_FHA_1	258	264	PF00498	0.585
LIG_FHA_2	45	51	PF00498	0.548
LIG_LIR_Apic_2	217	221	PF02991	0.489
LIG_LIR_Gen_1	120	129	PF02991	0.356
LIG_LIR_Gen_1	40	48	PF02991	0.567
LIG_LIR_LC3C_4	260	263	PF02991	0.567
LIG_LIR_Nem_3	120	124	PF02991	0.282
LIG_LIR_Nem_3	228	233	PF02991	0.476
LIG_LIR_Nem_3	40	46	PF02991	0.558
LIG_PCNA_PIPBox_1	234	243	PF02747	0.564
LIG_PCNA_yPIPBox_3	231	241	PF02747	0.549
LIG_PDZ_Class_2	347	352	PF00595	0.662
LIG_Pex14_2	135	139	PF04695	0.539
LIG_SH2_SRC	184	187	PF00017	0.622
LIG_SH2_STAT5	146	149	PF00017	0.463
LIG_SH2_STAT5	157	160	PF00017	0.315
LIG_SH2_STAT5	241	244	PF00017	0.462
LIG_SH2_STAT5	41	44	PF00017	0.493
LIG_SH3_3	180	186	PF00018	0.714
LIG_SH3_3	275	281	PF00018	0.529
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.573
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.508
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.502
LIG_SUMO_SIM_par_1	16	22	PF11976	0.634
LIG_SUMO_SIM_par_1	23	28	PF11976	0.533
LIG_SUMO_SIM_par_1	259	265	PF11976	0.639
LIG_TRAF2_1	37	40	PF00917	0.565
LIG_ULM_U2AF65_1	344	349	PF00076	0.766
MOD_CK1_1	187	193	PF00069	0.608
MOD_CK1_1	199	205	PF00069	0.530
MOD_CK1_1	303	309	PF00069	0.755
MOD_CK1_1	44	50	PF00069	0.495
MOD_CK2_1	138	144	PF00069	0.484
MOD_CK2_1	169	175	PF00069	0.519
MOD_Cter_Amidation	167	170	PF01082	0.636
MOD_Cter_Amidation	342	345	PF01082	0.642
MOD_GlcNHglycan	307	310	PF01048	0.640
MOD_GlcNHglycan	311	314	PF01048	0.622
MOD_GlcNHglycan	317	321	PF01048	0.681
MOD_GlcNHglycan	324	327	PF01048	0.648
MOD_GlcNHglycan	328	331	PF01048	0.630
MOD_GlcNHglycan	34	38	PF01048	0.479
MOD_GSK3_1	158	165	PF00069	0.571
MOD_GSK3_1	281	288	PF00069	0.704
MOD_GSK3_1	297	304	PF00069	0.576
MOD_GSK3_1	305	312	PF00069	0.697
MOD_GSK3_1	322	329	PF00069	0.688
MOD_GSK3_1	6	13	PF00069	0.656
MOD_N-GLC_1	10	15	PF02516	0.622
MOD_N-GLC_1	285	290	PF02516	0.404
MOD_N-GLC_2	56	58	PF02516	0.421
MOD_NEK2_1	10	15	PF00069	0.526
MOD_NEK2_1	19	24	PF00069	0.508
MOD_NEK2_1	27	32	PF00069	0.475
MOD_NEK2_2	225	230	PF00069	0.586
MOD_PIKK_1	158	164	PF00454	0.606
MOD_PK_1	4	10	PF00069	0.403
MOD_PKA_1	169	175	PF00069	0.447
MOD_PKA_1	4	10	PF00069	0.403
MOD_PKA_2	169	175	PF00069	0.546
MOD_PKA_2	225	231	PF00069	0.554
MOD_PKA_2	257	263	PF00069	0.645
MOD_PKA_2	4	10	PF00069	0.674
MOD_PKA_2	78	84	PF00069	0.421
MOD_Plk_1	10	16	PF00069	0.646
MOD_Plk_1	162	168	PF00069	0.609
MOD_Plk_1	27	33	PF00069	0.301
MOD_Plk_4	106	112	PF00069	0.540
MOD_Plk_4	14	20	PF00069	0.531
MOD_Plk_4	153	159	PF00069	0.471
MOD_Plk_4	196	202	PF00069	0.519
MOD_Plk_4	225	231	PF00069	0.530
MOD_Plk_4	257	263	PF00069	0.531
MOD_ProDKin_1	301	307	PF00069	0.546
MOD_ProDKin_1	44	50	PF00069	0.519
MOD_ProDKin_1	80	86	PF00069	0.683
TRG_DiLeu_BaEn_1	196	201	PF01217	0.492
TRG_DiLeu_BaEn_1	63	68	PF01217	0.465
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.526
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.596
TRG_ER_diArg_1	207	209	PF00400	0.546
TRG_ER_diArg_1	230	232	PF00400	0.391
TRG_ER_diArg_1	253	256	PF00400	0.469
TRG_ER_diArg_1	291	294	PF00400	0.662
TRG_ER_diArg_1	3	5	PF00400	0.440
TRG_ER_diArg_1	344	347	PF00400	0.690
TRG_NES_CRM1_1	265	276	PF08389	0.597
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC1	Leptomonas seymouri	53%	100%
A0A1X0P309	Trypanosomatidae	29%	100%
A0A3Q8IJW1	Leishmania donovani	91%	100%
A0A3R7KTI3	Trypanosoma rangeli	26%	100%
A4HQ17	Leishmania braziliensis	73%	100%
A4IDS3	Leishmania infantum	91%	100%
Q4Q0R2	Leishmania major	86%	100%
V5D4Y6	Trypanosoma cruzi	25%	100%