Putative delta tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin delta chain

Species:

Leishmania mexicana

UniProt:

E9ATT3_LEIMU

TriTrypDb:

LmxM.36.4990

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	9
GO:0099080	supramolecular complex	2	9
GO:0099081	supramolecular polymer	3	9
GO:0099512	supramolecular fiber	4	9
GO:0099513	polymeric cytoskeletal fiber	5	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005634	nucleus	5	2
GO:0005814	centriole	5	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9ATT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATT3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	9
GO:0009987	cellular process	1	9
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000278	mitotic cell cycle	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007049	cell cycle	2	1
GO:0016043	cellular component organization	3	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0030030	cell projection organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0017076	purine nucleotide binding	4	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0005198	structural molecule activity	1	3
GO:0005200	structural constituent of cytoskeleton	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.539
CLV_C14_Caspase3-7	517	521	PF00656	0.527
CLV_C14_Caspase3-7	547	551	PF00656	0.412
CLV_NRD_NRD_1	150	152	PF00675	0.544
CLV_NRD_NRD_1	182	184	PF00675	0.302
CLV_NRD_NRD_1	191	193	PF00675	0.255
CLV_NRD_NRD_1	523	525	PF00675	0.339
CLV_NRD_NRD_1	54	56	PF00675	0.632
CLV_NRD_NRD_1	78	80	PF00675	0.769
CLV_PCSK_KEX2_1	150	152	PF00082	0.544
CLV_PCSK_KEX2_1	182	184	PF00082	0.313
CLV_PCSK_KEX2_1	191	193	PF00082	0.243
CLV_PCSK_KEX2_1	523	525	PF00082	0.242
CLV_PCSK_KEX2_1	54	56	PF00082	0.634
CLV_PCSK_KEX2_1	78	80	PF00082	0.714
CLV_PCSK_SKI1_1	108	112	PF00082	0.474
CLV_PCSK_SKI1_1	227	231	PF00082	0.291
CLV_PCSK_SKI1_1	288	292	PF00082	0.592
CLV_PCSK_SKI1_1	342	346	PF00082	0.731
CLV_PCSK_SKI1_1	361	365	PF00082	0.402
CLV_PCSK_SKI1_1	379	383	PF00082	0.424
CLV_PCSK_SKI1_1	45	49	PF00082	0.663
DEG_APCC_DBOX_1	107	115	PF00400	0.439
DEG_APCC_DBOX_1	447	455	PF00400	0.400
DEG_SPOP_SBC_1	137	141	PF00917	0.794
DOC_MAPK_DCC_7	304	314	PF00069	0.447
DOC_MAPK_gen_1	288	298	PF00069	0.583
DOC_MAPK_gen_1	523	531	PF00069	0.345
DOC_PP2B_LxvP_1	312	315	PF13499	0.374
DOC_PP2B_LxvP_1	48	51	PF13499	0.691
DOC_PP4_FxxP_1	411	414	PF00568	0.604
DOC_PP4_FxxP_1	485	488	PF00568	0.479
DOC_USP7_MATH_1	137	141	PF00917	0.751
DOC_USP7_MATH_1	27	31	PF00917	0.452
DOC_USP7_MATH_1	407	411	PF00917	0.507
DOC_USP7_MATH_1	438	442	PF00917	0.676
DOC_USP7_MATH_1	480	484	PF00917	0.469
DOC_USP7_MATH_1	494	498	PF00917	0.702
DOC_USP7_MATH_1	501	505	PF00917	0.457
DOC_USP7_MATH_1	62	66	PF00917	0.728
DOC_USP7_UBL2_3	326	330	PF12436	0.675
DOC_WW_Pin1_4	133	138	PF00397	0.746
DOC_WW_Pin1_4	139	144	PF00397	0.711
DOC_WW_Pin1_4	320	325	PF00397	0.528
DOC_WW_Pin1_4	415	420	PF00397	0.618
DOC_WW_Pin1_4	474	479	PF00397	0.535
DOC_WW_Pin1_4	484	489	PF00397	0.456
DOC_WW_Pin1_4	506	511	PF00397	0.446
LIG_14-3-3_CanoR_1	150	156	PF00244	0.534
LIG_14-3-3_CanoR_1	232	236	PF00244	0.518
LIG_14-3-3_CanoR_1	361	369	PF00244	0.466
LIG_14-3-3_CanoR_1	38	46	PF00244	0.536
LIG_14-3-3_CanoR_1	493	501	PF00244	0.394
LIG_14-3-3_CanoR_1	83	89	PF00244	0.547
LIG_BIR_II_1	1	5	PF00653	0.378
LIG_BRCT_BRCA1_1	475	479	PF00533	0.613
LIG_Clathr_ClatBox_1	111	115	PF01394	0.440
LIG_FHA_1	1	7	PF00498	0.418
LIG_FHA_1	15	21	PF00498	0.359
LIG_FHA_1	201	207	PF00498	0.534
LIG_FHA_1	380	386	PF00498	0.469
LIG_FHA_1	432	438	PF00498	0.698
LIG_FHA_1	459	465	PF00498	0.498
LIG_FHA_1	470	476	PF00498	0.556
LIG_FHA_1	509	515	PF00498	0.420
LIG_FHA_2	160	166	PF00498	0.480
LIG_FHA_2	362	368	PF00498	0.501
LIG_FHA_2	497	503	PF00498	0.641
LIG_LIR_Apic_2	410	414	PF02991	0.617
LIG_LIR_Apic_2	482	488	PF02991	0.464
LIG_LIR_Gen_1	202	211	PF02991	0.481
LIG_LIR_Gen_1	250	259	PF02991	0.463
LIG_LIR_Gen_1	295	305	PF02991	0.453
LIG_LIR_Gen_1	393	404	PF02991	0.441
LIG_LIR_Nem_3	202	207	PF02991	0.481
LIG_LIR_Nem_3	250	256	PF02991	0.463
LIG_LIR_Nem_3	267	273	PF02991	0.463
LIG_LIR_Nem_3	295	301	PF02991	0.409
LIG_LIR_Nem_3	393	399	PF02991	0.433
LIG_MYND_1	46	50	PF01753	0.672
LIG_PDZ_Class_2	559	564	PF00595	0.545
LIG_Pex14_1	171	175	PF04695	0.463
LIG_Pex14_2	534	538	PF04695	0.482
LIG_SH2_CRK	253	257	PF00017	0.460
LIG_SH2_CRK	319	323	PF00017	0.526
LIG_SH2_NCK_1	153	157	PF00017	0.416
LIG_SH2_NCK_1	319	323	PF00017	0.526
LIG_SH2_NCK_1	362	366	PF00017	0.551
LIG_SH2_NCK_1	556	560	PF00017	0.526
LIG_SH2_STAP1	556	560	PF00017	0.526
LIG_SH2_STAP1	86	90	PF00017	0.669
LIG_SH2_STAT3	175	178	PF00017	0.463
LIG_SH2_STAT3	90	93	PF00017	0.676
LIG_SH2_STAT5	319	322	PF00017	0.551
LIG_SH3_3	236	242	PF00018	0.464
LIG_SH3_3	305	311	PF00018	0.477
LIG_SH3_3	472	478	PF00018	0.330
LIG_TRAF2_1	488	491	PF00917	0.531
LIG_TRAF2_1	92	95	PF00917	0.696
LIG_TRFH_1	153	157	PF08558	0.416
LIG_UBA3_1	317	326	PF00899	0.560
LIG_WRC_WIRS_1	201	206	PF05994	0.534
MOD_CDC14_SPxK_1	323	326	PF00782	0.596
MOD_CDK_SPxK_1	320	326	PF00069	0.566
MOD_CK1_1	136	142	PF00069	0.780
MOD_CK1_1	144	150	PF00069	0.589
MOD_CK1_1	216	222	PF00069	0.534
MOD_CK1_1	347	353	PF00069	0.625
MOD_CK1_1	415	421	PF00069	0.718
MOD_CK1_1	496	502	PF00069	0.531
MOD_CK2_1	159	165	PF00069	0.463
MOD_CK2_1	22	28	PF00069	0.511
MOD_CK2_1	241	247	PF00069	0.428
MOD_CK2_1	423	429	PF00069	0.738
MOD_CK2_1	484	490	PF00069	0.487
MOD_CK2_1	541	547	PF00069	0.491
MOD_CK2_1	66	72	PF00069	0.598
MOD_GlcNHglycan	146	149	PF01048	0.687
MOD_GlcNHglycan	165	169	PF01048	0.155
MOD_GlcNHglycan	215	218	PF01048	0.261
MOD_GlcNHglycan	305	308	PF01048	0.483
MOD_GlcNHglycan	346	349	PF01048	0.641
MOD_GlcNHglycan	39	42	PF01048	0.450
MOD_GlcNHglycan	414	417	PF01048	0.662
MOD_GlcNHglycan	419	422	PF01048	0.659
MOD_GlcNHglycan	439	443	PF01048	0.373
MOD_GlcNHglycan	59	62	PF01048	0.452
MOD_GlcNHglycan	64	67	PF01048	0.699
MOD_GlcNHglycan	72	76	PF01048	0.468
MOD_GSK3_1	133	140	PF00069	0.793
MOD_GSK3_1	196	203	PF00069	0.520
MOD_GSK3_1	231	238	PF00069	0.498
MOD_GSK3_1	388	395	PF00069	0.512
MOD_GSK3_1	403	410	PF00069	0.504
MOD_GSK3_1	469	476	PF00069	0.463
MOD_GSK3_1	480	487	PF00069	0.494
MOD_GSK3_1	492	499	PF00069	0.350
MOD_GSK3_1	62	69	PF00069	0.658
MOD_GSK3_1	96	103	PF00069	0.456
MOD_N-GLC_1	273	278	PF02516	0.238
MOD_N-GLC_1	473	478	PF02516	0.338
MOD_NEK2_1	19	24	PF00069	0.424
MOD_NEK2_1	235	240	PF00069	0.479
MOD_NEK2_1	257	262	PF00069	0.463
MOD_NEK2_1	317	322	PF00069	0.524
MOD_NEK2_1	334	339	PF00069	0.401
MOD_NEK2_1	37	42	PF00069	0.500
MOD_NEK2_1	381	386	PF00069	0.421
MOD_NEK2_1	555	560	PF00069	0.405
MOD_NEK2_2	480	485	PF00069	0.498
MOD_PIKK_1	247	253	PF00454	0.463
MOD_PKA_1	191	197	PF00069	0.534
MOD_PKA_2	191	197	PF00069	0.516
MOD_PKA_2	231	237	PF00069	0.461
MOD_PKA_2	303	309	PF00069	0.494
MOD_PKA_2	37	43	PF00069	0.515
MOD_PKA_2	492	498	PF00069	0.394
MOD_PKA_2	96	102	PF00069	0.382
MOD_Plk_1	100	106	PF00069	0.630
MOD_Plk_1	27	33	PF00069	0.570
MOD_Plk_1	273	279	PF00069	0.438
MOD_Plk_1	294	300	PF00069	0.443
MOD_Plk_1	438	444	PF00069	0.632
MOD_Plk_1	501	507	PF00069	0.535
MOD_Plk_2-3	370	376	PF00069	0.501
MOD_Plk_2-3	96	102	PF00069	0.382
MOD_Plk_4	196	202	PF00069	0.561
MOD_Plk_4	225	231	PF00069	0.490
MOD_Plk_4	235	241	PF00069	0.431
MOD_Plk_4	480	486	PF00069	0.447
MOD_Plk_4	503	509	PF00069	0.405
MOD_Plk_4	86	92	PF00069	0.709
MOD_ProDKin_1	133	139	PF00069	0.746
MOD_ProDKin_1	141	147	PF00069	0.700
MOD_ProDKin_1	320	326	PF00069	0.539
MOD_ProDKin_1	415	421	PF00069	0.618
MOD_ProDKin_1	474	480	PF00069	0.526
MOD_ProDKin_1	484	490	PF00069	0.463
MOD_ProDKin_1	506	512	PF00069	0.450
MOD_SUMO_rev_2	113	119	PF00179	0.417
MOD_SUMO_rev_2	193	199	PF00179	0.361
MOD_SUMO_rev_2	219	229	PF00179	0.534
MOD_SUMO_rev_2	275	284	PF00179	0.598
MOD_SUMO_rev_2	426	433	PF00179	0.727
TRG_DiLeu_BaEn_1	466	471	PF01217	0.514
TRG_ENDOCYTIC_2	253	256	PF00928	0.460
TRG_ENDOCYTIC_2	85	88	PF00928	0.636
TRG_ER_diArg_1	150	152	PF00400	0.585
TRG_ER_diArg_1	190	192	PF00400	0.480
TRG_ER_diArg_1	78	80	PF00400	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R4	Leptomonas seymouri	63%	100%
A0A0S4JK93	Bodo saltans	33%	97%
A0A3Q8IPL1	Leishmania donovani	92%	100%
A0A422NC27	Trypanosoma rangeli	37%	100%
A4IDS2	Leishmania infantum	92%	100%
D0A8V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q0R3	Leishmania major	93%	99%
Q4R7T7	Macaca fascicularis	22%	100%
Q8HZV4	Canis lupus familiaris	22%	100%
Q9R1K7	Mus musculus	22%	100%
Q9UJT1	Homo sapiens	22%	100%