START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ATT0_LEIMU

TriTrypDb:

LmxM.36.4960

Length:

977

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATT0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008289	lipid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.347
CLV_C14_Caspase3-7	525	529	PF00656	0.588
CLV_C14_Caspase3-7	824	828	PF00656	0.525
CLV_C14_Caspase3-7	905	909	PF00656	0.620
CLV_MEL_PAP_1	452	458	PF00089	0.511
CLV_NRD_NRD_1	251	253	PF00675	0.613
CLV_NRD_NRD_1	373	375	PF00675	0.564
CLV_NRD_NRD_1	426	428	PF00675	0.732
CLV_NRD_NRD_1	531	533	PF00675	0.461
CLV_NRD_NRD_1	659	661	PF00675	0.653
CLV_NRD_NRD_1	668	670	PF00675	0.628
CLV_PCSK_FUR_1	657	661	PF00082	0.604
CLV_PCSK_FUR_1	665	669	PF00082	0.541
CLV_PCSK_KEX2_1	134	136	PF00082	0.524
CLV_PCSK_KEX2_1	373	375	PF00082	0.564
CLV_PCSK_KEX2_1	426	428	PF00082	0.727
CLV_PCSK_KEX2_1	531	533	PF00082	0.530
CLV_PCSK_KEX2_1	659	661	PF00082	0.662
CLV_PCSK_KEX2_1	667	669	PF00082	0.639
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.571
CLV_PCSK_SKI1_1	17	21	PF00082	0.504
CLV_PCSK_SKI1_1	762	766	PF00082	0.571
CLV_PCSK_SKI1_1	99	103	PF00082	0.496
CLV_Separin_Metazoa	483	487	PF03568	0.702
DEG_APCC_DBOX_1	796	804	PF00400	0.586
DEG_SCF_FBW7_1	312	318	PF00400	0.746
DEG_SCF_FBW7_1	353	360	PF00400	0.574
DEG_SCF_FBW7_1	622	629	PF00400	0.506
DEG_SCF_TRCP1_1	338	344	PF00400	0.658
DEG_SPOP_SBC_1	489	493	PF00917	0.697
DOC_ANK_TNKS_1	822	829	PF00023	0.550
DOC_CDC14_PxL_1	44	52	PF14671	0.514
DOC_CDC14_PxL_1	677	685	PF14671	0.559
DOC_CKS1_1	312	317	PF01111	0.748
DOC_CKS1_1	555	560	PF01111	0.763
DOC_CKS1_1	623	628	PF01111	0.503
DOC_CYCLIN_RxL_1	14	24	PF00134	0.290
DOC_CYCLIN_RxL_1	409	420	PF00134	0.461
DOC_CYCLIN_RxL_1	95	105	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.565
DOC_MAPK_gen_1	531	538	PF00069	0.451
DOC_MAPK_MEF2A_6	447	454	PF00069	0.558
DOC_PP2B_LxvP_1	113	116	PF13499	0.418
DOC_PP2B_LxvP_1	50	53	PF13499	0.528
DOC_PP4_FxxP_1	212	215	PF00568	0.601
DOC_PP4_FxxP_1	530	533	PF00568	0.752
DOC_PP4_FxxP_1	555	558	PF00568	0.773
DOC_USP7_MATH_1	145	149	PF00917	0.648
DOC_USP7_MATH_1	182	186	PF00917	0.662
DOC_USP7_MATH_1	2	6	PF00917	0.535
DOC_USP7_MATH_1	213	217	PF00917	0.516
DOC_USP7_MATH_1	264	268	PF00917	0.447
DOC_USP7_MATH_1	336	340	PF00917	0.728
DOC_USP7_MATH_1	357	361	PF00917	0.718
DOC_USP7_MATH_1	443	447	PF00917	0.740
DOC_USP7_MATH_1	490	494	PF00917	0.750
DOC_USP7_MATH_1	505	509	PF00917	0.675
DOC_USP7_MATH_1	526	530	PF00917	0.586
DOC_USP7_MATH_1	626	630	PF00917	0.604
DOC_USP7_MATH_1	791	795	PF00917	0.727
DOC_USP7_MATH_1	895	899	PF00917	0.528
DOC_USP7_UBL2_3	249	253	PF12436	0.620
DOC_WW_Pin1_4	105	110	PF00397	0.490
DOC_WW_Pin1_4	23	28	PF00397	0.468
DOC_WW_Pin1_4	311	316	PF00397	0.804
DOC_WW_Pin1_4	324	329	PF00397	0.736
DOC_WW_Pin1_4	341	346	PF00397	0.741
DOC_WW_Pin1_4	353	358	PF00397	0.815
DOC_WW_Pin1_4	360	365	PF00397	0.554
DOC_WW_Pin1_4	373	378	PF00397	0.624
DOC_WW_Pin1_4	554	559	PF00397	0.723
DOC_WW_Pin1_4	622	627	PF00397	0.607
DOC_WW_Pin1_4	697	702	PF00397	0.582
DOC_WW_Pin1_4	719	724	PF00397	0.551
DOC_WW_Pin1_4	755	760	PF00397	0.618
DOC_WW_Pin1_4	774	779	PF00397	0.395
DOC_WW_Pin1_4	813	818	PF00397	0.441
DOC_WW_Pin1_4	885	890	PF00397	0.699
LIG_14-3-3_CanoR_1	222	229	PF00244	0.492
LIG_14-3-3_CanoR_1	373	377	PF00244	0.674
LIG_14-3-3_CanoR_1	384	393	PF00244	0.828
LIG_14-3-3_CanoR_1	455	460	PF00244	0.510
LIG_14-3-3_CanoR_1	461	465	PF00244	0.582
LIG_14-3-3_CanoR_1	609	616	PF00244	0.534
LIG_14-3-3_CanoR_1	668	677	PF00244	0.703
LIG_14-3-3_CanoR_1	921	930	PF00244	0.503
LIG_BIR_III_4	941	945	PF00653	0.611
LIG_BRCT_BRCA1_1	739	743	PF00533	0.502
LIG_BRCT_BRCA1_1	791	795	PF00533	0.657
LIG_BRCT_BRCA1_1	840	844	PF00533	0.576
LIG_EVH1_1	44	48	PF00568	0.632
LIG_FHA_1	171	177	PF00498	0.448
LIG_FHA_1	246	252	PF00498	0.477
LIG_FHA_1	316	322	PF00498	0.525
LIG_FHA_1	555	561	PF00498	0.659
LIG_FHA_1	57	63	PF00498	0.500
LIG_FHA_1	781	787	PF00498	0.468
LIG_FHA_1	816	822	PF00498	0.546
LIG_FHA_1	923	929	PF00498	0.531
LIG_FHA_2	126	132	PF00498	0.381
LIG_FHA_2	179	185	PF00498	0.528
LIG_FHA_2	367	373	PF00498	0.640
LIG_FHA_2	423	429	PF00498	0.626
LIG_FHA_2	513	519	PF00498	0.733
LIG_FHA_2	539	545	PF00498	0.744
LIG_FHA_2	727	733	PF00498	0.503
LIG_FHA_2	769	775	PF00498	0.536
LIG_FHA_2	799	805	PF00498	0.648
LIG_FHA_2	822	828	PF00498	0.505
LIG_FHA_2	84	90	PF00498	0.414
LIG_FHA_2	866	872	PF00498	0.475
LIG_HP1_1	735	739	PF01393	0.556
LIG_LIR_Apic_2	104	109	PF02991	0.500
LIG_LIR_Apic_2	528	533	PF02991	0.749
LIG_LIR_Gen_1	224	232	PF02991	0.480
LIG_LIR_Gen_1	431	441	PF02991	0.601
LIG_LIR_Gen_1	465	475	PF02991	0.548
LIG_LIR_Gen_1	564	570	PF02991	0.440
LIG_LIR_Gen_1	611	621	PF02991	0.555
LIG_LIR_Gen_1	68	74	PF02991	0.586
LIG_LIR_Gen_1	771	779	PF02991	0.548
LIG_LIR_Gen_1	780	788	PF02991	0.607
LIG_LIR_Gen_1	925	935	PF02991	0.552
LIG_LIR_LC3C_4	733	738	PF02991	0.471
LIG_LIR_Nem_3	100	106	PF02991	0.468
LIG_LIR_Nem_3	224	229	PF02991	0.413
LIG_LIR_Nem_3	29	33	PF02991	0.608
LIG_LIR_Nem_3	42	47	PF02991	0.373
LIG_LIR_Nem_3	431	437	PF02991	0.589
LIG_LIR_Nem_3	465	470	PF02991	0.523
LIG_LIR_Nem_3	564	568	PF02991	0.511
LIG_LIR_Nem_3	574	580	PF02991	0.769
LIG_LIR_Nem_3	611	616	PF02991	0.529
LIG_LIR_Nem_3	68	73	PF02991	0.587
LIG_LIR_Nem_3	771	775	PF02991	0.522
LIG_LIR_Nem_3	780	784	PF02991	0.672
LIG_LIR_Nem_3	792	798	PF02991	0.397
LIG_LIR_Nem_3	804	809	PF02991	0.465
LIG_LIR_Nem_3	841	847	PF02991	0.663
LIG_LIR_Nem_3	925	930	PF02991	0.513
LIG_MYND_1	14	18	PF01753	0.514
LIG_MYND_1	474	478	PF01753	0.700
LIG_Pex14_1	630	634	PF04695	0.756
LIG_Pex14_2	530	534	PF04695	0.648
LIG_Pex14_2	861	865	PF04695	0.651
LIG_SH2_CRK	106	110	PF00017	0.407
LIG_SH2_CRK	577	581	PF00017	0.717
LIG_SH2_NCK_1	106	110	PF00017	0.407
LIG_SH2_STAP1	103	107	PF00017	0.473
LIG_SH2_STAP1	763	767	PF00017	0.510
LIG_SH2_STAT3	57	60	PF00017	0.561
LIG_SH2_STAT5	103	106	PF00017	0.466
LIG_SH2_STAT5	175	178	PF00017	0.512
LIG_SH2_STAT5	205	208	PF00017	0.474
LIG_SH2_STAT5	209	212	PF00017	0.507
LIG_SH2_STAT5	226	229	PF00017	0.571
LIG_SH2_STAT5	424	427	PF00017	0.435
LIG_SH2_STAT5	565	568	PF00017	0.461
LIG_SH2_STAT5	927	930	PF00017	0.523
LIG_SH3_1	374	380	PF00018	0.722
LIG_SH3_3	12	18	PF00018	0.504
LIG_SH3_3	309	315	PF00018	0.755
LIG_SH3_3	325	331	PF00018	0.523
LIG_SH3_3	374	380	PF00018	0.789
LIG_SH3_3	395	401	PF00018	0.835
LIG_SH3_3	42	48	PF00018	0.615
LIG_SH3_3	555	561	PF00018	0.761
LIG_SH3_3	596	602	PF00018	0.590
LIG_SH3_3	809	815	PF00018	0.624
LIG_SH3_3	927	933	PF00018	0.370
LIG_SUMO_SIM_anti_2	465	472	PF11976	0.570
LIG_SUMO_SIM_par_1	672	678	PF11976	0.727
LIG_SUMO_SIM_par_1	731	741	PF11976	0.584
LIG_SUMO_SIM_par_1	816	822	PF11976	0.654
LIG_TRAF2_1	285	288	PF00917	0.550
LIG_TRAF2_1	299	302	PF00917	0.803
LIG_TRAF2_1	303	306	PF00917	0.814
LIG_TRAF2_1	639	642	PF00917	0.667
LIG_TRAF2_1	771	774	PF00917	0.556
LIG_TYR_ITSM	222	229	PF00017	0.570
LIG_TYR_ITSM	923	930	PF00017	0.509
LIG_UBA3_1	126	134	PF00899	0.506
LIG_WRC_WIRS_1	464	469	PF05994	0.529
LIG_WRC_WIRS_1	67	72	PF05994	0.459
MOD_CDK_SPK_2	755	760	PF00069	0.531
MOD_CDK_SPxxK_3	719	726	PF00069	0.521
MOD_CDK_SPxxK_3	755	762	PF00069	0.528
MOD_CK1_1	105	111	PF00069	0.481
MOD_CK1_1	138	144	PF00069	0.709
MOD_CK1_1	148	154	PF00069	0.623
MOD_CK1_1	26	32	PF00069	0.495
MOD_CK1_1	360	366	PF00069	0.793
MOD_CK1_1	376	382	PF00069	0.692
MOD_CK1_1	392	398	PF00069	0.752
MOD_CK1_1	491	497	PF00069	0.753
MOD_CK1_1	604	610	PF00069	0.677
MOD_CK1_1	645	651	PF00069	0.663
MOD_CK1_1	724	730	PF00069	0.681
MOD_CK1_1	888	894	PF00069	0.731
MOD_CK2_1	125	131	PF00069	0.524
MOD_CK2_1	178	184	PF00069	0.495
MOD_CK2_1	264	270	PF00069	0.536
MOD_CK2_1	296	302	PF00069	0.660
MOD_CK2_1	366	372	PF00069	0.639
MOD_CK2_1	422	428	PF00069	0.627
MOD_CK2_1	512	518	PF00069	0.739
MOD_CK2_1	538	544	PF00069	0.674
MOD_CK2_1	768	774	PF00069	0.564
MOD_CK2_1	798	804	PF00069	0.553
MOD_CK2_1	83	89	PF00069	0.423
MOD_CK2_1	847	853	PF00069	0.600
MOD_CK2_1	865	871	PF00069	0.482
MOD_CK2_1	971	977	PF00069	0.651
MOD_GlcNHglycan	122	125	PF01048	0.432
MOD_GlcNHglycan	142	146	PF01048	0.520
MOD_GlcNHglycan	186	189	PF01048	0.686
MOD_GlcNHglycan	266	269	PF01048	0.560
MOD_GlcNHglycan	279	282	PF01048	0.622
MOD_GlcNHglycan	298	301	PF01048	0.778
MOD_GlcNHglycan	338	341	PF01048	0.709
MOD_GlcNHglycan	493	496	PF01048	0.777
MOD_GlcNHglycan	507	510	PF01048	0.623
MOD_GlcNHglycan	603	606	PF01048	0.628
MOD_GlcNHglycan	671	674	PF01048	0.699
MOD_GlcNHglycan	791	794	PF01048	0.732
MOD_GlcNHglycan	849	852	PF01048	0.756
MOD_GlcNHglycan	862	865	PF01048	0.453
MOD_GlcNHglycan	871	875	PF01048	0.662
MOD_GlcNHglycan	890	893	PF01048	0.511
MOD_GlcNHglycan	933	936	PF01048	0.644
MOD_GSK3_1	134	141	PF00069	0.586
MOD_GSK3_1	144	151	PF00069	0.628
MOD_GSK3_1	178	185	PF00069	0.488
MOD_GSK3_1	22	29	PF00069	0.406
MOD_GSK3_1	292	299	PF00069	0.750
MOD_GSK3_1	311	318	PF00069	0.781
MOD_GSK3_1	353	360	PF00069	0.766
MOD_GSK3_1	372	379	PF00069	0.612
MOD_GSK3_1	385	392	PF00069	0.695
MOD_GSK3_1	490	497	PF00069	0.774
MOD_GSK3_1	499	506	PF00069	0.703
MOD_GSK3_1	604	611	PF00069	0.621
MOD_GSK3_1	621	628	PF00069	0.515
MOD_GSK3_1	724	731	PF00069	0.709
MOD_GSK3_1	815	822	PF00069	0.672
MOD_GSK3_1	866	873	PF00069	0.595
MOD_GSK3_1	895	902	PF00069	0.651
MOD_GSK3_1	922	929	PF00069	0.593
MOD_GSK3_1	963	970	PF00069	0.688
MOD_GSK3_1	97	104	PF00069	0.446
MOD_N-GLC_1	148	153	PF02516	0.534
MOD_N-GLC_1	39	44	PF02516	0.289
MOD_N-GLC_1	526	531	PF02516	0.663
MOD_N-GLC_1	571	576	PF02516	0.600
MOD_NEK2_1	101	106	PF00069	0.457
MOD_NEK2_1	157	162	PF00069	0.609
MOD_NEK2_1	176	181	PF00069	0.289
MOD_NEK2_1	22	27	PF00069	0.528
MOD_NEK2_1	221	226	PF00069	0.442
MOD_NEK2_1	454	459	PF00069	0.493
MOD_NEK2_1	543	548	PF00069	0.694
MOD_NEK2_1	594	599	PF00069	0.600
MOD_NEK2_1	643	648	PF00069	0.455
MOD_NEK2_1	754	759	PF00069	0.420
MOD_NEK2_1	819	824	PF00069	0.661
MOD_NEK2_1	83	88	PF00069	0.557
MOD_NEK2_1	870	875	PF00069	0.672
MOD_NEK2_2	170	175	PF00069	0.513
MOD_NEK2_2	526	531	PF00069	0.586
MOD_PIKK_1	158	164	PF00454	0.415
MOD_PIKK_1	32	38	PF00454	0.348
MOD_PIKK_1	543	549	PF00454	0.740
MOD_PIKK_1	56	62	PF00454	0.462
MOD_PIKK_1	608	614	PF00454	0.531
MOD_PIKK_1	872	878	PF00454	0.709
MOD_PIKK_1	922	928	PF00454	0.471
MOD_PK_1	967	973	PF00069	0.451
MOD_PKA_1	134	140	PF00069	0.396
MOD_PKA_1	659	665	PF00069	0.648
MOD_PKA_2	134	140	PF00069	0.396
MOD_PKA_2	221	227	PF00069	0.496
MOD_PKA_2	372	378	PF00069	0.675
MOD_PKA_2	383	389	PF00069	0.830
MOD_PKA_2	454	460	PF00069	0.495
MOD_PKA_2	608	614	PF00069	0.531
MOD_PKA_2	659	665	PF00069	0.648
MOD_PKA_2	714	720	PF00069	0.672
MOD_PKA_2	798	804	PF00069	0.655
MOD_PKA_2	847	853	PF00069	0.716
MOD_PKA_2	903	909	PF00069	0.542
MOD_PKB_1	657	665	PF00069	0.603
MOD_PKB_1	667	675	PF00069	0.553
MOD_Plk_1	148	154	PF00069	0.576
MOD_Plk_1	292	298	PF00069	0.627
MOD_Plk_1	526	532	PF00069	0.727
MOD_Plk_1	543	549	PF00069	0.602
MOD_Plk_1	75	81	PF00069	0.607
MOD_Plk_1	779	785	PF00069	0.681
MOD_Plk_1	83	89	PF00069	0.491
MOD_Plk_2-3	301	307	PF00069	0.761
MOD_Plk_2-3	728	734	PF00069	0.487
MOD_Plk_4	170	176	PF00069	0.504
MOD_Plk_4	412	418	PF00069	0.688
MOD_Plk_4	455	461	PF00069	0.473
MOD_Plk_4	463	469	PF00069	0.556
MOD_Plk_4	561	567	PF00069	0.476
MOD_Plk_4	738	744	PF00069	0.526
MOD_Plk_4	798	804	PF00069	0.655
MOD_Plk_4	815	821	PF00069	0.400
MOD_Plk_4	97	103	PF00069	0.488
MOD_ProDKin_1	105	111	PF00069	0.499
MOD_ProDKin_1	23	29	PF00069	0.470
MOD_ProDKin_1	311	317	PF00069	0.803
MOD_ProDKin_1	324	330	PF00069	0.739
MOD_ProDKin_1	341	347	PF00069	0.739
MOD_ProDKin_1	353	359	PF00069	0.815
MOD_ProDKin_1	360	366	PF00069	0.554
MOD_ProDKin_1	373	379	PF00069	0.625
MOD_ProDKin_1	554	560	PF00069	0.717
MOD_ProDKin_1	622	628	PF00069	0.606
MOD_ProDKin_1	697	703	PF00069	0.573
MOD_ProDKin_1	719	725	PF00069	0.553
MOD_ProDKin_1	755	761	PF00069	0.620
MOD_ProDKin_1	774	780	PF00069	0.399
MOD_ProDKin_1	813	819	PF00069	0.435
MOD_ProDKin_1	885	891	PF00069	0.700
MOD_SUMO_for_1	307	310	PF00179	0.763
MOD_SUMO_for_1	830	833	PF00179	0.489
MOD_SUMO_for_1	909	912	PF00179	0.504
MOD_SUMO_rev_2	903	911	PF00179	0.687
TRG_DiLeu_BaEn_1	952	957	PF01217	0.567
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.495
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.518
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.653
TRG_ENDOCYTIC_2	209	212	PF00928	0.445
TRG_ENDOCYTIC_2	226	229	PF00928	0.571
TRG_ENDOCYTIC_2	434	437	PF00928	0.566
TRG_ENDOCYTIC_2	565	568	PF00928	0.487
TRG_ENDOCYTIC_2	577	580	PF00928	0.788
TRG_ENDOCYTIC_2	613	616	PF00928	0.534
TRG_ENDOCYTIC_2	706	709	PF00928	0.538
TRG_ENDOCYTIC_2	772	775	PF00928	0.393
TRG_ENDOCYTIC_2	927	930	PF00928	0.523
TRG_ER_diArg_1	530	532	PF00400	0.464
TRG_ER_diArg_1	657	660	PF00400	0.638
TRG_ER_diArg_1	665	668	PF00400	0.608
TRG_ER_diArg_1	759	762	PF00400	0.543
TRG_ER_diArg_1	796	799	PF00400	0.604
TRG_NLS_MonoExtC_3	248	253	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	649	653	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B5	Leptomonas seymouri	35%	94%
A0A3Q8IJ30	Leishmania donovani	83%	100%
A4HQ13	Leishmania braziliensis	65%	100%
A4ICE8	Leishmania infantum	83%	100%
Q4Q0R6	Leishmania major	82%	100%