2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9ATS9_LEIMU

TriTrypDb:

LmxM.36.4950

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	607	611	PF00656	0.634
CLV_C14_Caspase3-7	71	75	PF00656	0.499
CLV_NRD_NRD_1	10	12	PF00675	0.593
CLV_NRD_NRD_1	198	200	PF00675	0.430
CLV_NRD_NRD_1	30	32	PF00675	0.699
CLV_NRD_NRD_1	478	480	PF00675	0.458
CLV_NRD_NRD_1	526	528	PF00675	0.458
CLV_NRD_NRD_1	708	710	PF00675	0.656
CLV_PCSK_KEX2_1	179	181	PF00082	0.413
CLV_PCSK_KEX2_1	198	200	PF00082	0.291
CLV_PCSK_KEX2_1	30	32	PF00082	0.699
CLV_PCSK_KEX2_1	363	365	PF00082	0.337
CLV_PCSK_KEX2_1	478	480	PF00082	0.458
CLV_PCSK_KEX2_1	526	528	PF00082	0.509
CLV_PCSK_KEX2_1	566	568	PF00082	0.318
CLV_PCSK_KEX2_1	619	621	PF00082	0.665
CLV_PCSK_KEX2_1	708	710	PF00082	0.680
CLV_PCSK_KEX2_1	9	11	PF00082	0.583
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.415
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.337
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.318
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.665
CLV_PCSK_PC1ET2_1	708	710	PF00082	0.680
CLV_PCSK_SKI1_1	179	183	PF00082	0.489
CLV_PCSK_SKI1_1	2	6	PF00082	0.488
CLV_PCSK_SKI1_1	304	308	PF00082	0.576
CLV_PCSK_SKI1_1	490	494	PF00082	0.324
CLV_PCSK_SKI1_1	526	530	PF00082	0.421
CLV_PCSK_SKI1_1	710	714	PF00082	0.587
DEG_APCC_DBOX_1	478	486	PF00400	0.488
DEG_SCF_FBW7_1	626	633	PF00400	0.448
DOC_CKS1_1	351	356	PF01111	0.450
DOC_CKS1_1	403	408	PF01111	0.319
DOC_CKS1_1	514	519	PF01111	0.406
DOC_CKS1_1	581	586	PF01111	0.467
DOC_MAPK_gen_1	526	536	PF00069	0.315
DOC_MAPK_HePTP_8	524	536	PF00069	0.262
DOC_MAPK_MEF2A_6	312	320	PF00069	0.452
DOC_MAPK_MEF2A_6	527	536	PF00069	0.418
DOC_MAPK_MEF2A_6	662	669	PF00069	0.480
DOC_MAPK_MEF2A_6	97	106	PF00069	0.328
DOC_PP2B_LxvP_1	575	578	PF13499	0.431
DOC_PP2B_LxvP_1	667	670	PF13499	0.506
DOC_SPAK_OSR1_1	31	35	PF12202	0.447
DOC_USP7_MATH_1	263	267	PF00917	0.503
DOC_USP7_MATH_1	43	47	PF00917	0.590
DOC_USP7_MATH_1	481	485	PF00917	0.381
DOC_USP7_MATH_1	576	580	PF00917	0.543
DOC_USP7_MATH_1	595	599	PF00917	0.467
DOC_USP7_MATH_1	76	80	PF00917	0.559
DOC_USP7_MATH_2	242	248	PF00917	0.492
DOC_WW_Pin1_4	226	231	PF00397	0.643
DOC_WW_Pin1_4	253	258	PF00397	0.415
DOC_WW_Pin1_4	34	39	PF00397	0.621
DOC_WW_Pin1_4	350	355	PF00397	0.379
DOC_WW_Pin1_4	402	407	PF00397	0.306
DOC_WW_Pin1_4	513	518	PF00397	0.446
DOC_WW_Pin1_4	580	585	PF00397	0.445
DOC_WW_Pin1_4	599	604	PF00397	0.478
DOC_WW_Pin1_4	61	66	PF00397	0.463
DOC_WW_Pin1_4	620	625	PF00397	0.555
DOC_WW_Pin1_4	626	631	PF00397	0.483
LIG_14-3-3_CanoR_1	16	26	PF00244	0.497
LIG_14-3-3_CanoR_1	180	188	PF00244	0.520
LIG_14-3-3_CanoR_1	214	221	PF00244	0.691
LIG_14-3-3_CanoR_1	542	551	PF00244	0.344
LIG_14-3-3_CanoR_1	709	713	PF00244	0.507
LIG_APCC_ABBA_1	424	429	PF00400	0.367
LIG_BRCT_BRCA1_1	246	250	PF00533	0.435
LIG_BRCT_BRCA1_1	578	582	PF00533	0.466
LIG_Clathr_ClatBox_1	315	319	PF01394	0.421
LIG_CtBP_PxDLS_1	230	234	PF00389	0.557
LIG_EH1_1	171	179	PF00400	0.483
LIG_eIF4E_1	188	194	PF01652	0.335
LIG_EVH1_2	630	634	PF00568	0.431
LIG_FHA_1	105	111	PF00498	0.491
LIG_FHA_1	148	154	PF00498	0.374
LIG_FHA_1	159	165	PF00498	0.406
LIG_FHA_1	169	175	PF00498	0.381
LIG_FHA_1	188	194	PF00498	0.244
LIG_FHA_1	323	329	PF00498	0.368
LIG_FHA_1	46	52	PF00498	0.616
LIG_FHA_1	509	515	PF00498	0.502
LIG_FHA_1	545	551	PF00498	0.343
LIG_FHA_1	631	637	PF00498	0.600
LIG_FHA_1	677	683	PF00498	0.556
LIG_FHA_2	217	223	PF00498	0.449
LIG_FHA_2	351	357	PF00498	0.400
LIG_FHA_2	363	369	PF00498	0.327
LIG_FHA_2	370	376	PF00498	0.344
LIG_LIR_Apic_2	498	504	PF02991	0.353
LIG_LIR_Gen_1	185	196	PF02991	0.356
LIG_LIR_Gen_1	275	285	PF02991	0.505
LIG_LIR_Gen_1	39	47	PF02991	0.537
LIG_LIR_Nem_3	119	124	PF02991	0.399
LIG_LIR_Nem_3	185	191	PF02991	0.376
LIG_LIR_Nem_3	275	280	PF02991	0.512
LIG_LIR_Nem_3	39	44	PF02991	0.538
LIG_LIR_Nem_3	498	503	PF02991	0.378
LIG_MYND_1	207	211	PF01753	0.473
LIG_PCNA_yPIPBox_3	265	277	PF02747	0.456
LIG_Pex14_2	277	281	PF04695	0.365
LIG_PTB_Apo_2	522	529	PF02174	0.492
LIG_SH2_CRK	400	404	PF00017	0.366
LIG_SH2_CRK	501	505	PF00017	0.471
LIG_SH2_STAP1	645	649	PF00017	0.468
LIG_SH2_STAT3	156	159	PF00017	0.502
LIG_SH2_STAT3	451	454	PF00017	0.469
LIG_SH2_STAT5	188	191	PF00017	0.470
LIG_SH2_STAT5	333	336	PF00017	0.320
LIG_SH2_STAT5	337	340	PF00017	0.318
LIG_SH2_STAT5	433	436	PF00017	0.313
LIG_SH2_STAT5	570	573	PF00017	0.383
LIG_SH3_1	254	260	PF00018	0.433
LIG_SH3_3	254	260	PF00018	0.425
LIG_SH3_3	449	455	PF00018	0.402
LIG_SH3_3	483	489	PF00018	0.312
LIG_SH3_3	511	517	PF00018	0.537
LIG_SH3_3	618	624	PF00018	0.580
LIG_SUMO_SIM_par_1	435	441	PF11976	0.288
LIG_SUMO_SIM_par_1	663	668	PF11976	0.486
LIG_TRAF2_1	340	343	PF00917	0.334
LIG_TRAF2_1	365	368	PF00917	0.326
LIG_TRAF2_1	649	652	PF00917	0.583
LIG_WRC_WIRS_1	188	193	PF05994	0.353
LIG_WRC_WIRS_1	447	452	PF05994	0.445
MOD_CDK_SPxxK_3	599	606	PF00069	0.538
MOD_CK1_1	183	189	PF00069	0.431
MOD_CK1_1	216	222	PF00069	0.662
MOD_CK1_1	229	235	PF00069	0.746
MOD_CK1_1	359	365	PF00069	0.438
MOD_CK1_1	380	386	PF00069	0.347
MOD_CK1_1	441	447	PF00069	0.364
MOD_CK1_1	45	51	PF00069	0.459
MOD_CK1_1	508	514	PF00069	0.332
MOD_CK1_1	544	550	PF00069	0.344
MOD_CK1_1	598	604	PF00069	0.615
MOD_CK1_1	605	611	PF00069	0.665
MOD_CK1_1	668	674	PF00069	0.449
MOD_CK2_1	216	222	PF00069	0.434
MOD_CK2_1	258	264	PF00069	0.335
MOD_CK2_1	336	342	PF00069	0.374
MOD_CK2_1	362	368	PF00069	0.342
MOD_CK2_1	369	375	PF00069	0.320
MOD_Cter_Amidation	476	479	PF01082	0.444
MOD_DYRK1A_RPxSP_1	620	624	PF00069	0.483
MOD_GlcNHglycan	246	249	PF01048	0.462
MOD_GlcNHglycan	308	311	PF01048	0.598
MOD_GlcNHglycan	338	341	PF01048	0.302
MOD_GlcNHglycan	45	48	PF01048	0.651
MOD_GlcNHglycan	495	498	PF01048	0.448
MOD_GlcNHglycan	593	596	PF01048	0.599
MOD_GlcNHglycan	610	614	PF01048	0.686
MOD_GlcNHglycan	705	708	PF01048	0.630
MOD_GlcNHglycan	88	91	PF01048	0.554
MOD_GSK3_1	154	161	PF00069	0.369
MOD_GSK3_1	168	175	PF00069	0.364
MOD_GSK3_1	179	186	PF00069	0.325
MOD_GSK3_1	209	216	PF00069	0.469
MOD_GSK3_1	222	229	PF00069	0.759
MOD_GSK3_1	259	266	PF00069	0.354
MOD_GSK3_1	32	39	PF00069	0.605
MOD_GSK3_1	369	376	PF00069	0.436
MOD_GSK3_1	405	412	PF00069	0.346
MOD_GSK3_1	42	49	PF00069	0.414
MOD_GSK3_1	438	445	PF00069	0.383
MOD_GSK3_1	537	544	PF00069	0.475
MOD_GSK3_1	576	583	PF00069	0.497
MOD_GSK3_1	591	598	PF00069	0.495
MOD_GSK3_1	602	609	PF00069	0.621
MOD_GSK3_1	626	633	PF00069	0.464
MOD_GSK3_1	66	73	PF00069	0.577
MOD_GSK3_1	674	681	PF00069	0.590
MOD_GSK3_1	708	715	PF00069	0.597
MOD_N-GLC_1	465	470	PF02516	0.447
MOD_NEK2_1	172	177	PF00069	0.397
MOD_NEK2_1	306	311	PF00069	0.572
MOD_NEK2_1	32	37	PF00069	0.520
MOD_NEK2_1	373	378	PF00069	0.503
MOD_NEK2_1	442	447	PF00069	0.349
MOD_NEK2_1	456	461	PF00069	0.455
MOD_NEK2_1	60	65	PF00069	0.467
MOD_NEK2_1	686	691	PF00069	0.504
MOD_NEK2_2	446	451	PF00069	0.420
MOD_NEK2_2	465	470	PF00069	0.337
MOD_OFUCOSY	371	377	PF10250	0.445
MOD_PIKK_1	209	215	PF00454	0.587
MOD_PIKK_1	297	303	PF00454	0.514
MOD_PIKK_1	586	592	PF00454	0.470
MOD_PIKK_1	614	620	PF00454	0.623
MOD_PIKK_1	668	674	PF00454	0.452
MOD_PKA_1	179	185	PF00069	0.505
MOD_PKA_1	708	714	PF00069	0.565
MOD_PKA_2	17	23	PF00069	0.714
MOD_PKA_2	179	185	PF00069	0.505
MOD_PKA_2	197	203	PF00069	0.309
MOD_PKA_2	213	219	PF00069	0.630
MOD_PKA_2	541	547	PF00069	0.343
MOD_PKA_2	552	558	PF00069	0.414
MOD_PKA_2	605	611	PF00069	0.632
MOD_PKA_2	708	714	PF00069	0.565
MOD_PKB_1	284	292	PF00069	0.443
MOD_Plk_1	186	192	PF00069	0.377
MOD_Plk_1	263	269	PF00069	0.439
MOD_Plk_1	465	471	PF00069	0.440
MOD_Plk_4	160	166	PF00069	0.495
MOD_Plk_4	272	278	PF00069	0.399
MOD_Plk_4	311	317	PF00069	0.491
MOD_Plk_4	345	351	PF00069	0.565
MOD_Plk_4	377	383	PF00069	0.361
MOD_Plk_4	435	441	PF00069	0.302
MOD_Plk_4	446	452	PF00069	0.363
MOD_Plk_4	481	487	PF00069	0.373
MOD_Plk_4	678	684	PF00069	0.484
MOD_Plk_4	686	692	PF00069	0.461
MOD_ProDKin_1	226	232	PF00069	0.644
MOD_ProDKin_1	253	259	PF00069	0.417
MOD_ProDKin_1	34	40	PF00069	0.617
MOD_ProDKin_1	350	356	PF00069	0.387
MOD_ProDKin_1	402	408	PF00069	0.306
MOD_ProDKin_1	513	519	PF00069	0.448
MOD_ProDKin_1	580	586	PF00069	0.447
MOD_ProDKin_1	599	605	PF00069	0.478
MOD_ProDKin_1	61	67	PF00069	0.455
MOD_ProDKin_1	620	626	PF00069	0.552
MOD_SUMO_rev_2	355	359	PF00179	0.425
MOD_SUMO_rev_2	659	664	PF00179	0.597
MOD_SUMO_rev_2	688	697	PF00179	0.493
TRG_DiLeu_BaEn_1	488	493	PF01217	0.294
TRG_DiLeu_BaEn_1	660	665	PF01217	0.536
TRG_DiLeu_BaEn_4	342	348	PF01217	0.409
TRG_ENDOCYTIC_2	188	191	PF00928	0.349
TRG_ENDOCYTIC_2	400	403	PF00928	0.350
TRG_ENDOCYTIC_2	41	44	PF00928	0.547
TRG_ENDOCYTIC_2	433	436	PF00928	0.338
TRG_ENDOCYTIC_2	572	575	PF00928	0.390
TRG_ER_diArg_1	197	199	PF00400	0.494
TRG_ER_diArg_1	284	287	PF00400	0.505
TRG_ER_diArg_1	30	32	PF00400	0.622
TRG_ER_diArg_1	478	480	PF00400	0.458
TRG_ER_diArg_1	526	528	PF00400	0.509
TRG_ER_diArg_1	647	650	PF00400	0.613
TRG_ER_diArg_1	9	11	PF00400	0.587
TRG_NES_CRM1_1	659	672	PF08389	0.530
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL8	Leptomonas seymouri	63%	100%
A0A0S4JGT6	Bodo saltans	44%	100%
A0A1X0P422	Trypanosomatidae	45%	100%
A0A3S7XBU8	Leishmania donovani	90%	100%
A0A422NC22	Trypanosoma rangeli	48%	100%
A4HQ12	Leishmania braziliensis	78%	100%
A4ICE7	Leishmania infantum	90%	100%
D0A8V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q0R7	Leishmania major	89%	100%
V5AP55	Trypanosoma cruzi	44%	100%